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effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/hypertensive-disorders-pregnancy-protocol-amendment.pdf
April 20, 2022 - KQ 2: What are the effectiveness, comparative effectiveness, and harms of pharmacological
treatments … Are there harms associated with the concomitant use of particular antihypertensive
medications during … )
● Other Harms
o Generation or exacerbation of health disparities*
o Anxiety associated with use … )
● Harms
o Severe adverse events* (e.g., electrolyte abnormalities, severe hypotension)
o Infant … We expect to primarily rely on reported within-study
differences in effects (or harms).
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/disruptive-behavior-disorders-protocol.pdf
January 31, 2023 - We added age-inappropriate temper outburst to behavioral
outcomes and fatigue to harms outcomes. … What are the harms associated with treating children under 18 years of age for
disruptive behaviors … Do interventions for disruptive behaviors vary in effectiveness and harms
based on treatment history … We will consider NRSIs for harms when the study is designed
specifically to assess harms. … our experience that few trials of
psychosocial interventions report harms.
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-principles_methods.pdf
August 01, 2009 - Reviews are systematic reviews of existing research on the effectiveness,
comparative effectiveness, and harms … Balance of Benefits and Harms
CERs aim to present benefits and harms for different treatments and tests … The decisionmakers, not the reviewers, must weigh the
benefits, harms, and costs of the alternatives … • Assessing harms.
• Assessing the quality of studies.
• Finding evidence. … Challenges in systematic
reviews that assess treatment harms [review].
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/ptsd-adults-trauma-interventions_executive.pdf
April 01, 2013 - Scope and Key Questions
This review compares the efficacy, effectiveness, and
harms of psychological … KQ 3: For adults exposed to psychological trauma,
how does efficacy, effectiveness, or harms of early … KQ 4: For adults exposed to psychological trauma,
what are the absolute and comparative risks of harms … For assessment of the risk of harms, we
also included retrospective controlled cohort studies. … effectiveness or risk of harms.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/depression-treatment-ssri_executive.pdf
April 01, 2012 - How do the harms compare across
different interventions?
Key Question 3. … This trial had low risk of bias, and harms were well
monitored and reported. … How do the harms compare
across different interventions? … The reporting and collecting of harms was problematic,
particularly for predefining harms, including … Better
reporting of harms in randomized trials: An extension of the
CONSORT statement.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/ear-infection_executive.pdf
May 01, 2013 - Harms or Tolerability
Six of the treatment comparisons included in the
review reported on harms. … Evidence was insufficient for other harms. … Low for harms
of TT
TT plus
adenoidectomy vs. … Moderate for
harms of TT
Adenoidectomy vs. … Low for no
difference
15
safety and harms.
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/medical-interventions-comparing_methods.pdf
November 01, 2008 - Reviews are systematic reviews of existing research on the effectiveness,
comparative effectiveness, and harms … broad variety of reviews
that assess the effectiveness, comparative effectiveness, and comparative harms … The aim of a Comparative Effectiveness Review is to depict how the relative benefits and
harms of a … Evidence on harms is often hard to determine from tightly controlled
randomized trials. … Attempts to explore subgroups for which benefits or
harms of specific interventions vary may be needed
-
effectivehealthcare.ahrq.gov/sites/default/files/methodsguide_slutsky_comparing_medical_interventions.pdf
November 01, 2008 - Reviews are systematic reviews of existing research on the effectiveness,
comparative effectiveness, and harms … broad variety of reviews
that assess the effectiveness, comparative effectiveness, and comparative harms … The aim of a Comparative Effectiveness Review is to depict how the relative benefits and
harms of a … Evidence on harms is often hard to determine from tightly controlled
randomized trials. … Attempts to explore subgroups for which benefits or
harms of specific interventions vary may be needed
-
effectivehealthcare.ahrq.gov/products/chronic-urinary-retention/research
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-276-ocd-executive-summary.pdf
December 01, 2024 - KQ 2: What are the comparative effects and harms of treatment
interventions, used alone or in combination … KQ 2.a: How do the effectiveness and harms vary with patient,
family, social, or other characteristics … Harms: The side effects of SSRIs and clomipramine were
inconsistently reported, precluding graded conclusions … No study collected or reported
potential harms of behavioral interventions. … No
study collected or reported potential harms of behavioral interventions.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/osteoporosis-vibration-therapy_technical-brief.pdf
January 01, 2020 - Reviewed studies offered little information on potential harms. … What primary and secondary outcomes and harms were examined?
e. … What comparators were used to examine benefits and harms?
f. … Only two studies reported minor harms
from the vibration intervention.52,71 It was not clear that harms … Harms have been minimally reported and it is not clear whether harms information
was systematically
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/stem-cell-children_surveillance.pdf
October 29, 2012 - For pediatric patients with malignant solid tumors, what are the comparative harms of
HSCT and conventional … For pediatric patients with inherited metabolic diseases, what are the comparative harms
of HSCT, ERT … Key question 6: For pediatric patients with autoimmune diseases, what are the comparative harms of HSCT … Key question # 2: For pediatric patients with malignant solid tumors, what are the comparative harms … Key question # 6: For pediatric patients with autoimmune diseases, what are the comparative harms of
-
effectivehealthcare.ahrq.gov/sites/default/files/back-pain-treatment_research_executive.pdf
February 01, 2016 - serious harms. … When reported,
harms were typically related to muscle soreness and increased pain,
or no harms were … and no harms were reported. … and no harms were reported. … and no harms were reported.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/ace-inhibitor-arb-future_research.pdf
March 01, 2012 - Summary of Evidence on Comparative Long-Term Benefits and Harms of ACEIs,
ARBs, and DRIs in Patients … Summary of evidence on comparative long-term benefits and harms of ACEIs, ARBs, and
DRIs in patients … Summary of Evidence on Comparative Long-Term Benefits and Harms of ACEIs, ARBs,
and DRIs in patients … Summary of Evidence on Comparative Long-Term Benefits and Harms of ACEIs, ARBs,
and DRIs in patients … Summary of Evidence on Comparative Long-Term Benefits and Harms of ACEIs, ARBs,
and DRIs in patients
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/chronic-fatigue_executive.pdf
July 01, 2016 - (c) What harms are associated with diagnosing ME/CFS?
Key Question 2. … What are the (a) benefits and (b) harms
of therapeutic interventions for patients with ME/CFS, and … Studies of potential harms from
diagnosis were also included, such as psychological harms,
labeling … What harms are associated with
diagnosing ME/CFS? … Harms were not reported in the
studies.
Table C.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/colorectal-cancer-screening_research-protocol.pdf
May 18, 2011 - Question 6: Harms
What are the potential harms of fecal DNA testing? … Decreased Colorectal
Cancer or All-Cause
Mortality
Colorectal Cancer Treatment
Screening
Harms … Draft analytic framework the benefits and harms of
Fecal DNA Testing in Screening for Colorectal Cancer … KQ 6: Any reported harms, including test inaccuracy (i.e., false-positive
or false–negative results … The quality
assessment of adverse effects and harms data will be informed by the methods guidance
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/renal-cancer_clinician.pdf
July 01, 2017 - 16 (2,422)b A small but notable proportion of patients experienced harms. … Studies in which harms, if any, were reported were inconsistent.
���
N = number of subjects
a All … Transfusion: RR 1.62 (1.07 to 2.46) ���
Harms 21 (3,746) Urological and nonurological complications … Transfusion: RR 0.75 (0.60 to 0.94) ���
Harms 32
(16,965)
RCT: 1
Ret: 31
The RCT showed higher rates … Transfusion: RR 1.08 (0.63 to 1.87) ���
Harms 7 (2,000) Inconsistently reported.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/disruptive-behavior-disorders-protocol-amendment.pdf
March 22, 2023 - We added age-
inappropriate temper outburst to behavioral outcomes and fatigue to harms outcomes. … What are the harms associated with treating children under 18 years of age for
disruptive behaviors … Do interventions for disruptive behaviors vary in effectiveness and harms based
on treatment history … We will consider NRSIs for harms when the study is designed specifically to assess
harms. … our experience that few trials of psychosocial interventions report harms.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/engaging-caregivers-protocol.pdf
August 04, 2023 - What is the frequency and severity of harms associated with care transitions?
2. … What patient safety measures or indicators have been used to examine these harms?
3. … For this topic, we may need
to consider a number of different PSPs that focus on the targeted harms … For this topic that focuses on preventing or mitigating harms associated with care transitions, we … We will also report unintended harms of this PSP as described in relevant studies.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/skin-lesions-evaluation_research-protocol.pdf
August 23, 2010 - What are the potential safety issues and harms associated with the use of non-invasive
diagnostic techniques … For potential harms with the relevant devices, we will query the FDA Manufacturer and
User Facility … Device Experience (MAUDE) database for any reported harms with the use
of the relevant devices. … have been delayed or not detected
• Probability/prevalence of unnecessary biopsies
• Reduction of harms … We will
also record the outcomes being assessed in each study, including harms related to the
particular