-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/rheumatoid-arthritis-medicine_executive.pdf
April 01, 2012 - Objectives
This report summarizes the evidence on the comparative
efficacy, effectiveness, and harms … KQ3: For patients with RA, do drug therapies differ in
harms, tolerability, patient adherence, or adverse … KQ4: What are the comparative benefits and harms of
drug therapies for RA in subgroups of patients based … Our major findings are presented in this section by type of
drug comparison for benefits and harms ( … Summary of findings with strength of evidence
Key Comparisons
Efficacy
Strength of Evidence
Harms
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0210_12-07-2009.pdf
January 01, 2009 - Public payer
Nomination
Summary:
The nominator questions the comparative effectiveness and harms … The nominator also
questions whether there are differences in the effectiveness or harms of these
treatments … For patients, what are the potential harms of TBI treatment interventions?
3.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/delirium-research-protocol.pdf
June 01, 2018 - Geriatrics Society (AGS) is seeking a new updated systematic review to
focus on evaluating both the harms … The Key Questions
Question 1: What are the benefits and harms for antipsychotics compared to each other … What are the benefits and harms for antipsychotics compared to each other,
placebo, or non-drug approaches … What are the benefits and harms for antipsychotics compared to each other,
placebo, or non-drug approaches … What are the benefits and harms for antipsychotics compared to each other,
placebo, or non-drug approaches
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/episodic-migraine-surveillance-report-2.pdf
June 01, 2022 - harms, infections, cardiovascular events, cognitive harms, and
psychological harms (e.g., depression … gastrointestinal-related harms, cardiovascular-related harms, kidney-
related harms, falls, fractures … , motor vehicle accidents, endocrinological
A-3
harms, infections, cognitive harms, and psychological … harms (e.g.,
depression)? … Misuse, opioid use disorder, overdose and other harms
KQ2.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/nonpharm-treatment-chronic-pain-protocol.pdf
December 11, 2018 - What are the benefits and harms of noninvasive nonpharmacologic
therapies compared with exercise? … What are the benefits and harms of noninvasive nonpharmacologic
therapies compared with exercise? … What are the benefits and harms of noninvasive nonpharmacologic
therapies compared with exercise? … What are the benefits and harms of noninvasive nonpharmacologic
therapies compared with exercise? … What are the benefits and harms of noninvasive nonpharmacologic
therapies compared with biofeedback?
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/high-risk-drugs-protocol.pdf
July 27, 2023 - What are the frequency and severity of harms associated with anticoagulant use in
the inpatient and … For this topic that focuses on a PSP that may address a variety of different harms, we will
answer … Review Questions 1 and 2 by focusing on the harms and patient safety measures
or indicators that are … Intervention RQs 1-4: Not applicable (description of harms
associated with anticoagulant use in the … Harms Due to Anticoagulants.
-
effectivehealthcare.ahrq.gov/sites/default/files/cer-243-prehospital-airway-management-appendix-f-1_0.xlsx
January 01, 2016 - , p<0.05 NR NA 164 28 NA 20 71 NA
Bendinelli, 2018 4 ETI RSI 175 ETI No RSI (no medication ETI) 85 Harms … 0.53 NR NA 27 148 15.4% 10 75 11.7%
Bendinelli, 2018 4 ETI RSI 192 ETI No RSI (no medication ETI) 91 Harms … , p=0.59 NR NA 28 164 NA 16 75 NA
Bendinelli, 2018 4 ETI RSI 171 ETI No RSI (no medication ETI) 89 Harms … 0.83 NR NA 20 151 11.7% 8 81 9.0%
Bendinelli, 2018 4 ETI RSI 187 ETI No RSI (no medication ETI) 85 Harms … ETI RSI using fentayl, midazolam, and succinylcholine; preceded by ≥3 minutes of preoxygenation 157 Harms
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/restless-legs-future_research.pdf
February 01, 2013 - KQ 2: What are the harms of RLS treatments? … For KQ 2 (What are the harms of RLS treatments?) … What are the harms from RLS treatments?
a. … What are the long-term harms from treatment?
KQ 3. … KQ 2: What are the harms of RLS treatments?
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/assessing-applicability.ppt
January 01, 2009 - Factors influencing benefits and harms often depend on distinct physiologic processes. … Describe whether or not these outcomes reflect the most important benefits or harms. … Describe whether these outcomes reflect the most important benefits or harms. … No harms were being evaluated. … No harms were being evaluated.
-
effectivehealthcare.ahrq.gov/sites/default/files/assessing-applicability.ppt
January 01, 2009 - Factors influencing benefits and harms often depend on distinct physiologic processes. … Describe whether or not these outcomes reflect the most important benefits or harms. … Describe whether these outcomes reflect the most important benefits or harms. … No harms were being evaluated. … No harms were being evaluated.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/long-term-care-adults_executive.pdf
November 01, 2012 - KQ 1c: Harms in HCBS and NHs
Two studies provided low-strength evidence that harms
differed between … of other
harms. … KQ 1c
Harms • Two studies provided low-strength evidence (high risk of bias) that harms differed. … other harms … and social harms
11
Table B.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/ehc-presentation-quantitative-synthesis-chapter-1.pdf
July 01, 2019 - Systematic Reviews Methods Guide
www.ahrq.gov
Presenter
Presentation Notes
Prioritization and Selection of Harms … for Inclusion in Systematic Reviews
This presentation entitled: Prioritization and Selection of Harms … Prioritization and Selection of Harms for Inclusion in Systematic Reviews. … Focuses on Comparative Effectiveness Reviews (CERs):
− Systematic reviews comparing effectiveness and harms … heterogeneity may also explain widely
varying results.
► If an intervention truly benefits some patients and harms
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/rural-telehealth-disposition-comments.pdf
December 26, 2022 - • Harms. … Peer reviewers requested additional information on whether the studies have
addressed potential harms … We have added text about the
lack of harms to the limitations of the literature and the implications … Reported
outcomes,
including harms,
varied widely
across studies. … Many studies
did not explicitly
define, and
then measure
potential harms
or unintended
negative
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/prehospital-airway-management-protocol.pdf
December 20, 2019 - Specifically, this review will focus on comparing the benefit and harms across three different
airway … What are the comparative benefits and harms of bag valve mask versus supraglottic
airway for patients … Are the comparative benefits and harms modified by:
i. Techniques or devices used?
ii. … Are the comparative benefits and harms modified by:
i. Techniques or devices used?
ii. … Are the comparative benefits and harms modified by:
i. Techniques or devices used?
ii.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/osteoarthritis-pain-2006_executive.pdf
January 01, 2006 - How do these benefits and harms
change with dosage and duration of treatment, and
what is the evidence … Do the comparative benefits and harms of oral
treatments for osteoarthritis vary for certain
demographic … Harms: hypertension, congestive heart failure
(CHF), edema, and impaired renal function
• All NSAIDs … Harms: hepatotoxicity
• Clinically significant hepatotoxicity was rare. … Balance of evidence and harms
Each of the analgesics evaluated in this report was
associated with a
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/restless-legs_research-protocol.pdf
December 16, 2011 - benefits and harms of treatments for RLS. … Question 2
What are the harms from RLS treatments?
a. … What are the harms from RLS treatments when compared to placebo or no treatment?
b. … What are the harms from RLS treatments when compared to other active treatments?
c. … What are the long-term harms from treatment?
-
effectivehealthcare.ahrq.gov/sites/default/files/protocol-social-isolation.pdf
January 01, 2013 - Among older adults, what are the harms associated with interventions (e.g.,
volunteerism, peer support … limited to Emergency Department visits,
hospitalizations, primary and specialty care appointments)
• Harms … social
isolation and loneliness
Adults 60+
years old
Health outcomes
Health care
utilization
Harms … arrow labeled "Question 2" connects "Interventions that target social isolation and
loneliness" to harms
-
effectivehealthcare.ahrq.gov/sites/default/files/tech-brief-37-opiod-use-adults-comments.pdf
November 03, 2020 - A
few studies evaluated outcomes pertaining to
opioid-related harms (such as overdose or opioid
use … They balance the
need/indication for opioids with the potential
harms well. … This is also true for
factors associated with harms. … All interventions where harms outweigh
benefits should be minimized. … If the question is “what harms are
associated with opioid prescribing?”
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/ankyloglossia_research-protocol.pdf
June 30, 2014 - Key Question 1 (KQ1)
What are the benefits and harms of various treatments in breastfeeding newborns … Key Question 2a + b (KQ2)
KQ 2a What are the benefits and harms of various treatments* in newborns, … Harms may occur at any point after the intervention is received. … Harms may occur at any point after the intervention is
received.
Figure 2. … (McHarm) for harms outcomes
Two senior investigators will independently assess each included study
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/protocol-pharm-pregnant-women_0.pdf
December 05, 2018 - to women of not being treated with pharmacotherapy11, 23-25 or
harms to infants of not being breastfed … Key Questions (KQs) 3 and 4 focus on maternal and fetal harms and comparative
harms of pharmacologic … A Contextual Question (CQ) asks about the
harms of not treating a disorder or stopping or switching … • Maternal harms
All other outcomes
7
PICOTS Inclusion Exclusion
o Harms specific … For harms, we may elect to summarize studies by both medication and disorder,
depending on the volume