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effectivehealthcare.ahrq.gov/sites/default/files/module-i-ahrqs-vision-for-theory-and-principles-of-stakeholder-engagement.pdf
August 10, 2017 - Key Questions
Open for comment until Aug. 10, 2017
Harms
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effectivehealthcare.ahrq.gov/sites/default/files/han.pdf
December 26, 2012 - o Benefits and harms of communicating uncertainty in clinical practice
Slide 5: Uncertainty
• Main … Communicating
uncertainty in clinical evidence:
ethical
problems
• Patient autonomy
• Benefits and harms
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/back-pain-imaging_clinician.pdf
April 01, 2016 - studies, which may lead to followup interventions that are not beneficial and may
be associated with harms … could lead to subsequent interventions that might not be benefi-
cial and that might be associated with harms
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/quantitative-synthesis-expanded-methods_methods.pdf
March 01, 2013 - with higher underlying risk for mortality and other outcomes may experience
different benefits or harms … Comparative benefits and harms of second-
generation antidepressants: background
paper for the American
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/glaucoma-treatment_disposition-comments.pdf
April 01, 2012 - It is
the balance of the benefits and harms that needs to be
better evaluated. … This would require that such harms be reported with
enough detail to do so. … If the included studies were to
report harms in a more systematic fashion, this might be
possible. … This would require that such harms be reported with
enough detail to do so. … Comparison of differential harms of medical versus
surgical treatment would require that those harms
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/cad-women-treatment-future_research.pdf
February 01, 2013 - What are the potential harms in women of:
a. PCI vs. fibrinolysis/supportive therapy with STEMI? … CABG in women with stable or unstable angina
4
What are the potential harms in women of PCI vs. … 1
What are the potential harms in women of PCI vs. fibrinolysis/supportive therapy with STEMI? … What are the potential harms in women of PCI vs. … 1
What are the potential harms in women of PCI vs. fibrinolysis/supportive therapy
with STEMI?
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/colorectal-cancer-staging_disposition-comments.pdf
November 20, 2014 - We chose to examine the most recent
studies for harms data, and chose the
previous 5 years to manage … Peer Reviewer 4 Results In general, the harms section could benefit from further synthesis
with clearer … We have extensively edited the harms
section. … It is important for clinicians to consider both
the accuracy and risk of harms associated
with the
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/study-design-framework_research.pdf
March 01, 2012 - Effectiveness Research
CER is the ―generation and synthesis of evidence that compares the benefits and harms … gaps regarding generalizability of findings from RCTs and
methods issues or to identify possible harms … sample size
is large, this design may be the best method to assess subgroup effect or incidence of harms … The usual ethical issues of informing subjects of potential
benefits and harms will apply.
H.
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effectivehealthcare.ahrq.gov/sites/default/files/coronary-artery-disease-testing_disposition-comments.pdf
March 29, 2016 - studies to suggest that any testing technology is
superior to the others in terms of effectiveness or harms … A statement regarding potential harms of
invasive treatments in the absence of
clinical benefit has … Response
Peer Reviewer 2 General This report aims to evaluate the comparative effectiveness
and harms … explicit statement that
vascular complications including stroke are included as
adverse effects and harms
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/gout_executive-2016.pdf
January 01, 2016 - 2 assesses potential adverse effects that might be
associated with testing: short- and long-term harms … are the adverse effects (including
pain, infection at the aspiration site, radiation
exposure) or harms … assessed patient and practitioner
factors that affect the diagnostic accuracy of these tests
or assessed harms … are the adverse effects (including
pain, infection at the aspiration site, radiation
exposure) or harms
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effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/impact-healthcare-algorithms-racial-ethnic-disparities-March-3.pdf
July 01, 2023 - Focuses heavily on harms associated with label bias.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/mrsa-screening-2010_disposition-comments.pdf
January 01, 2010 - compared to the harms of no
screening/limited screening. … This CER evaluated the harms of screening for
MRSA-carriage compared to the harms of not
screening … the
harms of not screening, and the harms of
screening limited populations compared to the
harms … An
evaluation of the harms of screening (without a
comparison of the harms of not screening) was
outside … , understanding the comparative harms of
screening for MRSA carriage is important.
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/heart-failure-transition-care_research-protocol.pdf
June 10, 2013 - An assessment of the effectiveness and harms of transitional care
interventions is needed to support … Potential harms or unintended consequences of
interventions do not appear to have been widely considered … Question 5
Do transitional care interventions differ in effectiveness or harms for subgroups of patients … health outcomes (KQ 2), rather than asking about the same outcomes in a separate question
devoted to harms … strength of
the body of evidence to answer the KQs on the comparative effectiveness, efficacy, and harms
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/hepatitis-c-treatment-adherence_research-protocol.pdf
September 13, 2011 - or dose reduction, which is
usually based on a medical plan or a desire to avoid treatment-related harms … Question 4
What are the harms associated with hepatitis C antiviral treatment adherence interventions … of HCV
• Adverse Effects
○ Paradoxical decrease in adherence
○ Increase in treatment-related harms … Treatment
Adherence
Interventions
Adults undergoing
antiviral therapy
Treatment
Adherence
Harms … In addition, the quality assessment of adverse effects and harms data will be
informed by the Methods
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/public-reporting-quality-improvement_research-protocol.pdf
August 17, 2011 - Question 2
What harms result from public reporting?
B. … Harms include any negative consequence or adverse events for any members of
the populations listed … Examples of harms could include:
a. … These negative changes could result in
harms. … Analytic framework
Harms
(e.g ., reduced access to services
for patients or misclassification
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-updates_methods.pdf
July 01, 2011 - Reviews are systematic reviews of existing research on the effectiveness,
comparative effectiveness, and harms … topic, beyond the effectiveness of a single
intervention, by comparing the relative benefits and harms … Identifying new
evidence on harms warrants at least the same rigor in surveillance search as that for … searched for new studies reporting adverse events or SRs, meta-analyses
and HTA reports focusing on harms … need for updating now) were based on changes in
four indicators: (a) evidence on the benefits and harms
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/pain-chronic_research-protocol.pdf
July 28, 2010 - populations were studied, the detailed components of the treatment program, and the
health outcomes and harms … What are the potential safety issues and harms that may be associated with an MPP? … Potential Safety Issues or Harms
E. … Potential Safety Issues or Harms
Study Safety Issues or
Harms Assessed MPP Therapy Comparison
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/nephropathy-contrast-induced_executive-2016.pdf
January 01, 2016 - Key Question
Key Question: What are the comparative benefits and
harms of different contrast media in … How do benefits or harms of contrast media differ by
patient characteristics (known risk factors such … How do benefits or harms differ by the
dose of contrast medium (i.e., by volume of dose and
number … How do benefits or harms of contrast media differ
according to the type of preventive strategy used? … We did not
find any studies that examined whether the benefits or
harms of contrast media differed
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/c-diff-infections_research-protocol.pdf
May 24, 2010 - What are the harms associated with prevention strategies?
c. … Question 3: What is the comparative effectiveness and harms of different antibiotic treatments?
a. … Question 4: What are the effectiveness and harms of non-antibiotic adjunctive interventions?
a. … environmental
cultures
Days to resolution of
diarrhea (choice of faster
working treatment)
Harms … Treatment of false
positives
Increased
resistance
Isolation harms
Prevention
Patient Specific
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/advanced-care-decision-aids_research-protocol.pdf
December 09, 2013 - Were harms or adverse effects collected in the studies; what were they?
f. … What comparators were used to examine benefits and harms?
4. … different populations (possibly by study design)
Decision Clinical Inclusion Exclusion Sample Comparator Harms … (ethical/
Aid/Use population/ criteria- criteria size/Study emotional
design harms) General
Table