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effectivehealthcare.ahrq.gov/sites/default/files/pdf/research-protocol-osteoporosis_2.pdf
October 05, 2018 - Long-Term Drug Therapy and Drug Holidays for Osteoporotic Fracture Prevention
1
Evidence-based Practice Center Systematic Review Protocol
Project Title: Long-term Drug Therapy and Drug Holidays for Osteoporotic
Fracture Prevention
Initial publication date: April 13, 2018
Amendment Date: October 5,…
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-224-depression-children-comments.pdf
April 10, 2020 - Public reviewer:
AACAP
Analysis of
Number
Needed to
Harm or
Treat
For other conditions, epidemiological … measures are used that indicate
the number needed to harm (NNH) and number needed to treat. … TEP member #1 Results I am glad that there was an explicit discussion about suicidality as a
harm on … We have added a table for numbers
needed to treat and harm, and we hope
that this table will help focus
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/hemorrhage-postpartum_executive.pdf
April 01, 2015 - not at reducing
the occurrence of PPH but at diminishing associated
morbidity, mortality, personal harm
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/migraine-treatments-research-amended-protocol.pdf
January 09, 2020 - EHC Research Protocol (Amended): Treatments for Acute Episodic Migraine
1
Evidence-based Practice Center Systematic Review Protocol
Project Title: Acute Treatments for Episodic Migraine
Initial Publication Date: January 8, 2020
Amendment Date: January 9, 2020
(Amendments Details-see Section VII)
I. Backgro…
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/catd-protocol-draft_0.pdf
November 02, 2018 - Table 1 Confusion listed as
a treatment harm. … Table 1 Mortality listed as
a treatment harm.
Changed to mortality (all-
cause, CVD, non-CVD).
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/kidney-disease-medicine_executive.pdf
January 01, 2012 - 1
Comparative Effectiveness Review
Number 37
Chronic Kidney Disease Stages 1–3: Screening,
Monitoring, and Treatment
Executive Summary
Objectives
This systematic review evaluates the
evidence regarding the potential benefits
and harms of: (1) screening adults for
early-stage chronic kidney disease (CKD
stages…
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-f2-surv-report-3-nonopioid-pharmacol-chronic-pain.xlsx
May 29, 2025 - TCA_PCT
Table F-2a. Harms of tricyclic antidepressants versus placebo
Author, Year Quality Pain Population Drug Class Drug Assessment Time (Wk) Time Category WAE: n WAE: N SAE: n SAE: N Cardiac Rhythm Abnormalities: Specific AE Cardiac Rhythm Abnormalities: n Cardiac Rhythm Abnormalities: N N Randomized Cognitive Eff…
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/diverticulitis-research-protocol.pdf
January 01, 2019 - The evidence regarding this potential harm has not
been summarized to date.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-234-headaches-pregnancy-revised-comments.pdf
November 12, 2020 - Disposition of Comments: CER 234 Management of Primary Headaches in Pregnancy
Comparative Effectiveness Review Disposition of Comments Report
Research Review Title: Management of Primary Headaches in Pregnancy
Draft review available for public comment from June 2, 2020 through June 30, 2020. …
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/cancer-ovarian-contraceptives_disposition-comments.pdf
June 07, 2013 - restrictive range for ovarian
cancer, it would seem that given one of the main goals
was to assess the harm … We state in the beginning of the presentation of the
acceptability curves (in the Harm/Benefit
Acceptability … Section Comment Response
Peer Reviewer 3 General The sentence “Overall, the model predicted that the
harm … increased risk of untoward events, this also needs to be
taken into account in calculating the benefit/harm … as though they were not
comprehensive such as the complete elimination of
pregnancy as a potential harm
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/deprescribing-protocol.pdf
July 01, 2023 - What patient safety measures or indicators have been used to examine the harm associated
with polypharmacy … What deprescribing interventions have been used to prevent or mitigate the harm and in what
settings … What is the rationale for deprescribing to prevent or mitigate the harm?
5.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/mhs4-opioid-stewardship-protocol.pdf
July 01, 2023 - guidelines, noting a concern that previous guidance had been misapplied, leading to
unintended patient harm … deciding duration, dosage and
followup for prescriptions, and assessing risk and addressing potential harm … questions, and will include author, year, study design, frequency and severity of the
harms, measures of harm
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effectivehealthcare.ahrq.gov/sites/default/files/cer-238-cervical-ripening-outpatient-setting-comments.pdf
March 22, 2021 - Other examples of language that were improved was the use of the word
“safe” when referring to harm … Conclusions are based on a total small sample
that was unable to fully evaluate potential
maternal or fetal harm … findings to the population of childbearing
women in the United States will likely increase
risk of harm
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-218-osteoporosis-fracture-prevention-evidence-summary.pdf
April 01, 2019 - CER 218 Evidence Summary: Long-Term Drug Therapy and Drug Holidays for Osteoporosis Fracture Prevention: A Systematic Review
Purpose of Review
To summarize the effects of long-term osteoporosis
drug treatment and of osteoporosis drug treatment
discontinuation and holidays.
Key Messages
• Evidence on the effects …
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/colorectal-cancer-staging_executive.pdf
September 01, 2014 - The major harm from PET/CT is radiation exposure. … PET/CT were appropriate, suggesting that
using PET/CT for staging may result in significant patient
harm … While
all four imaging modalities appear to be reasonably safe,
long-range harm from radiation exposure
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/autism-update_clinician.pdf
September 01, 2014 - Even when used under
medical supervision, these products can cause serious harm,
including dehydration
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/depression-treatment-ssri_surveillance.pdf
January 01, 2013 - augmenting agents were given a rating of
insufficient for evaluating both the outcomes
of benefit and harm … grading
SOE; the overall grade was assigned as
insufficient for both the outcomes of benefit
and harm … or 66 or 67 or 68 or 69
71 limit 70 to yr="2011 - 2012"
72 limit 48 to yr="2011 - 2012"
73 (harm … augmenting agents were
given a rating of insufficient for evaluating
both the outcomes of benefit and harm … grading SOE; the overall grade was
assigned as insufficient for both the
outcomes of benefit and harm
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/headaches-pregnancy.pdf
March 23, 2019 - Treatments for primary headaches may harm the fetus and breastfed
newborn. … Radiation and/or contrast agents may harm the fetuses of pregnant women who
undergo diagnostic testing … abnormalities, drug-
induced”[MESH] OR birth defect OR congenital abnormality OR ((adverse or undesirable or
harm … analog” OR octreotide)
AND
(birth defect OR congenital abnormality OR ((adverse or undesirable or harm
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/kidney-disease-medicine_research-protocol.pdf
November 01, 2010 - Evidence Report on the
Source: www.effectivehealthcare.ahrq.gov
Published Online: July 28, 2010
Evidence-based Practice Center Systematic Review Protocol
Project Title: Screening for and Management of Chronic Kidney
Disease Stages 1-3
I. Background and Objectives for the Systematic Review
T…
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-265-radiation-bone-disease-disposition-comments.pdf
August 29, 2023 - Disposition of Comments_Comparative Effectiveness Review No. 265_Radiation Therapy for Metastatic Bone Disease: Effectiveness and Harms
Comparative Effectiveness Review Disposition of Comments Report
Title: Radiation Therapy for Metastatic Bone Disease: Effectiveness and Harms
Draft report ava…