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effectivehealthcare.ahrq.gov/sites/default/files/methodsguide_slutsky_comparing_medical_interventions.pdf
November 01, 2008 - Despite steadily increasing health care expenditures in the United States, improved health outcomes and quality remain elusive
Methods Guide for Comparative Effectiveness
Reviews
Comparing Medical Interventions: AHRQ and the
Effective Health Care Program
Comparative Effectivenes…
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/medical-interventions-comparing_methods.pdf
November 01, 2008 - Despite steadily increasing health care expenditures in the United States, improved health outcomes and quality remain elusive
Methods Guide for Comparative Effectiveness
Reviews
Comparing Medical Interventions: AHRQ and the
Effective Health Care Program
Comparative Effectivenes…
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/restless-legs-future_research.pdf
February 01, 2013 - Treatment for Restless Legs Syndrome: Future Research Needs
Future Research Needs Paper
Number 38
Treatment for Restless
Legs Syndrome: Future
Research Needs
Future Research Needs Paper
Number 38
Treatment for Restless Legs Syndrome:
Future Research Needs
Identification of Future Research Needs From Co…
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/ear-infection_disposition-comments.pdf
May 04, 2013 - most fundamental and
of greatest clinical and societal concern--namely, whether OME causes
important harm … ES-17, line 3-6: The wording of this statement is deceptive, and
implies equipoise of harm vs. benefit … A number of the
studies utilized in this review did not evaluate for harm or effectively look
for this … broader studies (and
those with better methodology) looking at this procedure there exists
evidence of harm
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/osteoporosis-vibration-therapy_technical-brief.pdf
January 01, 2020 - Whole-Body Vibration Therapy for Osteoporosis
Whole-Body Vibration
Therapy for Osteoporosis
Technical Brief
Number 10
Technical Brief
Number 10
Whole-Body Vibration Therapy for Osteoporosis
Prepared for:
Agency for Healthcare Research and Quality
U.S. Department of Health and Human Services
540 G…
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/episodic-migraine-surveillance-report-2.pdf
June 01, 2022 - Acute Treatment for Episodic Migraine: Surveillance Report 2
Acute Treatments for Episodic Migraine:
Surveillance Report 2
Literature Update Period: September 2, 2021, Through December 30, 2021
Background and Purpose
This report is the second surveillance report for the Agency for Healthcare Research and
Quali…
-
effectivehealthcare.ahrq.gov/sites/default/files/nonopioid-chronic-pain-summary.pdf
April 01, 2020 - Nonopioid Pharmacologic Treatments for Chronic Pain: Evidence Summary
Purpose of Review
Evaluate the benefits and harms of nonopioid drugs
in randomized controlled trials of patients with spe-
cific types of chronic pain, considering the effects on
pain, function, quality of life, and adverse events.
Key Messages…
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/disruptive-behavior-disorders-protocol.pdf
January 31, 2023 - Psychosocial and Pharmacologic Interventions for Disruptive Behavior in Children and Adolescents
Evidence-based Practice Center Systematic Review Protocol
Project Title: Psychosocial and Pharmacologic Interventions for Disruptive
Behavior in Children and Adolescents
I. Background and Objectives for t…
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/prostate-cancer-therapies-protocol_amended110619.pdf
November 02, 2019 - Evidence-based Practice Center Systematic Review Protocol: Therapies for Clinically Localized Prostate Cancer
Evidence-based Practice Center Systematic Review Protocol
Project Title: Therapies for Clinically Localized Prostate Cancer
Initial Publication Date: September 12, 2019
Amendment Date: November 2,…
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-220-analgesics-acute-pain-summary.pdf
September 01, 2019 - CER 220 Evidence Summary: Comparative Effectiveness of Analgesics To Reduce Acute Pain in the Prehospital Setting
Purpose of Review
To evaluate effectiveness and harms of opioids compared to
nonopioid analgesics as treatment of moderate to severe acute
pain in the prehospital setting.
Key Messages
• As initial…
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/ear-infection_executive.pdf
May 01, 2013 - KQ 3 concerns harm (various
types of adverse events).
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/binge-eating_executive.pdf
December 01, 2015 - 2 RCTs (N = 468, 89) Topiramate: higher number of events related to sleep
disturbance
Low for harm … 2 RCTs (N = 468, 73) Topiramate: higher number of headaches Moderate for harm
2 RCTs (N = 468, 179 … placebo
2 RCTs (N = 105, 24) Fluvoxamine: higher number of events related to GI
upset
Low for harm … 2 RCTs (N = 105, 57) Fluvoxamine: higher number of events related to
sleep disturbance
Low for harm … 3 RCTs (N = 938, 119) Lisdexamfetamine: higher number of events related
to GI upset
Moderate for harm
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/antipsychotics-children-update_research-protocol.pdf
December 04, 2015 - as across all conditions,
and conducting additional analyses for capturing differential benefit and harm … clinically important benefit and harm, as suitable to the measure.51 For other outcomes, we will
seek … For the latter, we may be able to
model factors thought to modify treatment effectiveness, or harm, … First do no harm: promoting an evidence-based
approach to atypical antipsychotic use in children and … $(self$adj$(destruct*$or$harm*$or$injur*$or$mutilat*)).tw,kf.$
73.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-215-depression-older-adults-executive-summary.pdf
March 01, 2019 - We calculated
number needed to treat (NNT) or harm (NNH)
for graded outcomes with statistically significant … statements based on findings and statistical significancea (continued)
Abbreviations: NNH=number needed to harm … statements based on findings and statistical significancea (continued)
Abbreviations: NNH=number needed to harm
-
effectivehealthcare.ahrq.gov/sites/default/files/back-pain-treatment_research_executive.pdf
February 01, 2016 - Noninvasive Treatments for Low Back Pain
1
Comparative Effectiveness Review
Number 169
Noninvasive Treatments for Low Back Pain
Executive Summary
Background
Nature and Burden of Low
Back Pain
Low back pain is one of the most
frequently encountered conditions in
clinical practice. Up to 84 percent of
adults …
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/stakeholder-engagement_research.pdf
September 01, 2011 - • When is shorter term evidence appropriate (e.g., if no obvious harm is identified), and
under what
-
effectivehealthcare.ahrq.gov/products/clinical-care/protocol
-
effectivehealthcare.ahrq.gov/products/clinical-care/rapid-research
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/hepatitis-c-screening_executive.pdf
November 01, 2012 - 1
Comparative Effectiveness Review
Number 69
Screening for Hepatitis C Virus
Infection in Adults
Executive Summary
Background
Hepatitis C virus (HCV) is a single-
stranded, positive-sense RNA virus of
the family Flaviviridae. HCV is the
most common chronic bloodborne
pathogen in the United States. The
prev…
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-updates_methods.pdf
July 01, 2011 - redundant or
ineffective health care, failure to implement more effective health care, and possibly cause harm … However, if newly identified evidence
includes a new PICO element (e.g., new harm and/or new subpopulation … When newly identified evidence through an update includes a new PICO element (e.g., new
harm, new subpopulation … ‘A’ more effective than ‘No
Tx’ in males
No
— — — 1
1.6 (1.2, 2.0)
Outcome-2 (e.g.,
new harm … )
‘A’ more effective than ‘No
Tx’ in females
— — — 1
1.1 (0.7, 1.3)
Outcome-2 (e.g.,
new harm