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1741. Phenylketonuria Executive (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/phenylketonuria_executive.pdf
      February 01, 2012 - provide a correlation between Phe level and a measure of executive function • Did not include a control group … Only the RCT,55 however, provides comparative data with a placebo group. … At a dosage of 20 mg/kg/day over 10 weeks, participants in the treatment group increased their Phe … However, response varied substantially within the treatment group, with 33 percent tolerating an increase … The strongest associations are seen in the group for which historical measurements were taken during

1742. Slide 1
      effectivehealthcare.ahrq.gov/sites/default/files/sensitivity-analysis-chapter-11.pptx
      January 01, 2013 - Slide 1 Sensitivity Analysis for Observational Comparative Effectiveness Research Prepared for: Agency for Healthcare Research and Quality (AHRQ) www.ahrq.gov Sensitivity Analysis for Observational Comparative Effectiveness Research This slide set is based on a user guide titled Developing a Protocol for Observati…

1743. Evidence-based Practice Center Systematic Review Protocol (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/insulin-blood-sugar-2010_research-protocol.pdf
      January 01, 2010 - Systematic Review Burden of Diabetes and Its Classification Diabetes mellitus is defined as a group … We will exclude studies that do not have a concurrent comparison group. … UK Prospective Diabetes Study (UKPDS) Group. … Diabetes Control and Complications Trial Research Group. … The DCCT Research Group.

1744. S149 (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/s149.pdf
      October 01, 2007 - Choose a treatment group, construct a propensity score for each subject, and categorize subjects into … Estimate the average, over all patients, of the potential outcome for a longitudinal treatment group … Choose an alternate treatment group, say Insulin- Insulin-Insulin, and perform the same series of steps … see an endocrinologist) would have a high probability of transi- tioning from exenatide to another group … These meth- ods have also let us make stable inferences about outcomes for a small treatment group; the

1745. Kidney-Disease-Medicine Surveillance (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/kidney-disease-medicine_surveillance.pdf
      October 01, 2012 - (+3.3+/-8.5 ml/min) and decreased in placebo group (-2.2 +/-4.8 ml/min) (P=0.026) Lewis, 201114 … differences per minute per 1.73 m2 of 8.2+/- 1.5 ml in 25mg group, 11.4+/-1.5ml in 75mg group and … 10.4=/-1.5 ml in 150mg group (P<0.001). … Adverse effects were more common in bardoxolone group including mild, dose-related muscle spasms, … the placebo group.

1746. Urinary-Incontinence-Treatment Research-Protocol (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/urinary-incontinence-treatment_research-protocol.pdf
      September 30, 2010 - We will group different definitions of continence and improvement in incontinence to have an overall … event rate - treatment group event rate). … event rate - treatment group event rate)*1000 We will calculate diagnostic values of different tests … A focus group study. Scand J Prim Health Care 2006; 24:56-61. 33. … Continence Program for Women Research Group. Am J Obstet Gynecol 1998; 179:999-1007. 50.

1747. antibiotics-respiratory-infection-protocol-140922 (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/antibiotics-respiratory-infection_research-protocol.pdf
      September 22, 2014 - The topic was nominated by a diverse group … We will group together studies that use similar definitions of appropriateness and categorize the different … direct comparative evidence is lacking, we will include before-after studies, with or without a control group … On the other hand, education programs for clinicians may involve small group discussion with a local … Technical Experts Technical Experts comprise a multidisciplinary group of clinical, content, and

1748. Atrial-Fibrillation-Ablation Surveillance (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/atrial-fibrillation-ablation_surveillance.pdf
      May 16, 2013 - atrial flutter, found no significant difference in AF recurrence at 12 months followup between the group … that had ostial-antral PVI and the group that had ostial-antral PVI with cavotricuspid isthmus ablation … (Three publications from the same group of investigators each reported one death from atrioesophageal … 0.295 (MS as a predictor of AF recurrence in NPAF but not PAF patients) QOL-(FU=12 mo) MS group …  that  had  ostial-­‐ antral  PVI  and  the  group  that  had  ostial-­‐antral

1749. Methods Research Report: Linking Evidence Reviews to Organizational Guideline Planning: A Pilot Test of an Interactive Web-Based Presentation and Discussion of Evidence (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/linking-evidence-reviews-methods_0.pdf
      October 01, 2018 - GDT typically formulates its evidence-based guidance, then this guidance is circulated to a larger group … We aimed to include and engage this larger group of stakeholders by introducing them to the key evidence … First was the involvement of a broader group of stakeholders early in the guideline development process … ) that the RR 0.57 or 43% reduction in diabetes incidence in the lifestyle compared to usual care group … Quite an adherent group as evidence by 50% meeting wt loss goals and ¾ meeting exercise goals during

1750. Arthritis and Nontraumatic Joint Disease (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/arthritis-horizon-scan-high-impact-1512.pdf
      December 29, 2015 - At week 16, 66.9% of patients in 75 mg SC group and 69.6% in the 150 mg SC group experienced an adverse … Serious adverse events were reported in 5.5% of the secukinumab 75 mg group, 5.6% of the 150 mg group … and 58.2% of patients in the placebo group reported an adverse event. … (ECRI Institute, Applied Solutions Group). Horizon Scanning Structured Comment Form. … (ECRI Institute, Applied Solutions Group). Horizon Scanning Structured Comment Form.

1751. Research White Paper: A Framework To Facilitate the Use of Systematic Reviews and Meta-analyses in the Design of Primary Research Studies (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/primary-research-design_research.pdf
      January 01, 2012 - In phase 2, we convened a multidisciplinary group with varied expertise to develop a stepwise framework … Over a series of meetings, this group used an iterative process to develop a stepwise framework. … Patient group 2. Intervention 3. Control or comparator 4. Outcomes (main/important outcomes) 5. … Patient group in the SR: Are they relevant to proposed study? 2. … Patient group: Compare details of planned included population, eligibility, and exclusion criteria.

1752. Measuring-Blood-Pressure Executive (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/measuring-blood-pressure_executive.pdf
      January 01, 2012 - reduction in SBP (ranging from 3.4 to 8.9 mmHg) or DBP (ranging from 1.9 to 4.4 mmHg) in the intervention group … no difference between groups, one study finding fewer visits in the SMBP plus additional support group … , one finding more visits in the SMBP plus additional support group, and one reporting mixed findings … National High Blood Pressure Education Working Group on High Blood Pressure in Children and Adolescents … adherence. 19 Note: BP = blood pressure; DBP = diastolic blood pressure; Euro QoL 5D = Euro QoL Group

1753. Fecal-Incontinence Research-Protocol (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/fecal-incontinence_research-protocol.pdf
      November 30, 2014 - Items included from the RTI Item Bank address participant selection, group membership, efforts to address … Technical Experts Technical Experts constitute a multidisciplinary group of clinical, content, and … Outcome had not occurred when study was initiated; information was collected over time Mixed One group … Is the selection of the comparison group appropriate? … Did attrition result in differences in group characteristics between baseline and followup?

1754. Telehealth for Acute and Chronic Care Consultations (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/telehealth-acute-chronic_research-protocol.pdf
      February 15, 2017 - and/or distance, on the assessment, diagnosis, and/or clinical management of a specific patient or group … of information and telecommunications technology in health care delivery for a specific patient or group … and/or distance, on the assessment, diagnosis, and/or clinical management of a specific patient or group … not be involved in the consultation, the consultation is required to be about a specific patient or group … Technical Experts Technical Experts constitute a multi-disciplinary group of clinical, content, and

1755. Evidence Report on the (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/hypothyroidism-hyperthyroidism-screening-treatment_research-protocol.pdf
      March 11, 2010 - Evidence Report on the Source: www.effectivehealthcare.ahrq.gov Published Online: March 11, 2010 Evidence-based Practice Center Systematic Review Protocol Project Title: Effectiveness of Screening and Treatment of Subclinical Hypothyroidism or Hyperthyroidism I. Background and Objectives for th…

1756. Serum Free Light Chain Analysis for the Diagnosis, Management, and Prognosis of Plasma Cell Dyscrasias: Future Research Needs (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/plasma-cell-dyscrasias-sflc-assay-future_research.pdf
      September 01, 2012 - Director of the Division of Items and Devices Coverage Analysis Group Centers for Medicare and Medicaid … The International Myeloma Working Group (IMWG) currently considers the SFLC assay to be an adjunct to … • Lack of studies of a nondiseased population as a comparison group (in order to accurately assess … Taking the additional topics suggested by the stakeholder group during or immediately following the … J Gen Intern Med. 2012:1-7. 1 Background Plasma cell dyscrasias (PCDs) are a group of clonal

1757. Assessing the Risk of Bias of Individual Studies in Systematic Reviews of Health Care Interventions (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-bias-individual-studies_methods.pdf
      March 01, 2012 - inferential error.”4 The Grading of Recommendations Assessment, Development and Evaluation Working Group … Attrition bias can potentially change the collective (group) characteristics of the relevant groups … CONSORT 2010 statement: updated guidelines for reporting parallel group randomized trials. … • Does the report provide numerical data by intervention group? … Did the author(s) specify the NUMBER for each TYPE of harmful event for each study group? 15.

1758. Future Research Needs for Diagnosis of Obstructive Sleep Apnea (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/sleep-apnea-diagnosis-future_research.pdf
      February 01, 2012 - Patients and the public: This group represents current and potential consumers of patient-centered … Policymakers: This group includes organizations such as the White House, the U.S. … Product makers: This group represents drug and device manufacturers. … Topics in this group are listed in the Results section without further discussion. … The first would be to discover the form of the relationship between specific risk-group criteria in

1759. Disposition of Comments Report for Procalcitonin-Guides Antibiotic Therapy (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer78_procalcitonin_disposition_20121210.pdf
      October 05, 2012 - report a reduction in overall antibiotic use of about 20%, consistent with the PCT findings in this group … and total antibiotic exposure in number of days on antibiotics per total patient-days for an entire group … Whether a small between-group difference should be considered no difference depends on statistical power … a senior investigator (not listed in papers, but publicly presented in lectures by this research group … In order for this to cause a 10% rise in mortality in the overall study group, such discontinuation

1760. Module II: Stakeholders and Stakeholder Engagement (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/module-ii-stakeholders-and-stakeholder-engagement.pdf
      June 01, 2011 - ways; as key informants, as participants on Technical Expert Panels or as part of larger stakeholder group … One way is to systematically engage a broader group of stakeholders is as key informants to solicit … These discussions provide the opportunity for a diverse group of stakeholders (clinicians, patients