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www.uspreventiveservicestaskforce.org/home/getfilebytoken/Z3BVaJRtyu8drWSHWYT_Yf
Clinical Summary: Medication Use to Reduce Risk of Breast Cancer
Clinical Summary: Medication Use … to Reduce Risk of Breast Cancer
Population Women aged ≥35 y at increased risk for breast cancer Women … medications, such as tamoxifen,
raloxifene, or aromatase inhibitors
Grade: B
Do not routinely use … risk-reducing medications, such as
tamoxifen, raloxifene, or aromatase inhibitors
Grade: D … The National Cancer Institute Breast Cancer Risk Assessment Tool
and the Breast Cancer Surveillance
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/c-7ARQE9RuXKjjpeLABkaH
March 01, 2007 - This is a grade D
recommendation. … More than 80% of colorectal cancers arise from adeno-
matous polyps. … Annual report to the nation on the status of cancer (1973 through 1998), featur-
ing cancers with recent … Low-dose
aspirin and incidence of colorectal tumors in a randomized trial. … of nonsteroidal antiinflammatory drugs and other chemopreventors and risk of
subsequent colorectal neoplasia
-
www.uspreventiveservicestaskforce.org/home/getfilebytoken/eUBUXRUJHua5Q44j_THFn2
MEDICATIONS FOR RISK REDUCTION OF PRIMARY BREAST CANCER IN WOMEN
CLINICAL SUMMARY OF U.S. … Grade: B
Do not prescribe risk-reducing medications. … Grade: D
Risk Assessment
Important risk factors for breast cancer include patient age, race/ … Potential harms include thromboembolic events, endometrial
cancer, and cataracts. … , as well as
screening for breast cancer.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/head-neck-cancer-update_executive.pdf
December 01, 2014 - carcinoma of the head and
neck (SCCHN) constitutes approximately 90 percent of all
head and neck cancers … The overall strength of evidence (SOE) grade is classified
into four categories, as shown in Table A … Gupta et al. reported aggregated survival results in patients
with tumors in different sites. … Intensity-modulated radiation
therapy in head and neck cancers: an update. … Head and neck cancers.
J Nat Compr Cancer Netw. 2011 Jun 1;9(6):596-650.
PMID: 21636536.
9.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/menopause_research-protocol.pdf
March 25, 2012 - D. … “Colorectal Neoplasms” (mh) OR ((colorectal OR colon) AND (neoplasm* OR cancer OR
carcinoma)) AND … OR ((ovarian OR breast OR colorectal
OR colon OR endometrial) AND (cancer OR cancers OR carcinoma OR … #59 ‘colorectal neoplasms’/exp OR (colorectal OR ‘colon’/exp OR intestinal AND
(‘neoplasm’/exp OR … /lim
#60 #17 AND #59
#61 #56 AND #60
Ovarian Cancer
#61 ‘ovarian’/exp AND (‘neoplasm’/exp OR
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www.uspreventiveservicestaskforce.org/uspstf/recommendation/prostate-cancer-screening-1996
January 01, 1996 - A large proportion of cancers detected by PSA screening may be latent cancers, indolent tumors that are … cancers but only 53% for nonaggressive cancers (i.e., small, well-differentiated tumors), suggesting … The patient's age and the tumor stage did not significantly influence survival rates, but tumor grade … of the study note that the data were adjusted for age and tumor grade (but not stage). … with DRE, serum tumor markers (e.g., PSA), or TRUS is not recommended ("D" recommendation).
-
www.uspreventiveservicestaskforce.org/uspstf/sites/default/files/inline-files/annual-report-to-congress-2017%20(2).pdf
January 01, 2017 - The Task Force assigns each of its recommendations a letter grade (A, B, C, or D) or issues an “I statement … When the USPSTF issues a recommendation for or against
providing a service (i.e., an A, B, C, or D grade … Preventive Services Task Force | 41
Grade Title
D
Beta-Carotene and Vitamin E to Prevent Cancer … have a history of a high-grade precancerous lesion (cervical
intraepithelial neoplasia grade 2 or 3) … Preventive Services Task Force | 43
Grade Title
D
Testicular Cancer: Screening in Adolescents and
-
www.uspreventiveservicestaskforce.org/uspstf/sites/default/files/inline-files/annlrpt2013%20(4).pdf
November 01, 2013 - Services with a grade of “D” are those for which there is no overall benefit, or the harms outweigh … (Grade B)
Vitamin D and Calcium:
Preventing Fractures
The USPSTF concludes that the current evidence … (Grade D)
U.S. Preventive Services Task Force | 10
IV. … have a history of a high-grade precancerous lesion (cervical intraepithelial neoplasia
[CIN] grade 2 … Preventive Services Task Force | 33
Grade Title
D
Prostate Cancer: Prostate-Specific Antigen (PSA
-
www.uspreventiveservicestaskforce.org/uspstf/sites/default/files/inline-files/2015annlrpt%20(4).pdf
January 01, 2016 - The Task Force assigns each of its recommendations a letter grade (A, B, C, or D) or issues an “I” statement … Services assigned a “D” grade are those for which there is no
overall benefit, or the harms outweigh … Screening for Cancer
Breast Cancer
Breast cancer is one of the most common cancers in women, and is … have a history of a high-grade precancerous lesion (cervical intraepithelial
neoplasia grade 2 or 3) … Preventive Services Task Force | 39
Grade Title
D
*Genital Herpes: Screening in Pregnant Women
-
www.uspreventiveservicestaskforce.org/uspstf/sites/default/files/inline-files/2015annlrpt%20(4)_0.pdf
January 01, 2016 - The Task Force assigns each of its recommendations a letter grade (A, B, C, or D) or issues an “I” statement … Services assigned a “D” grade are those for which there is no
overall benefit, or the harms outweigh … Screening for Cancer
Breast Cancer
Breast cancer is one of the most common cancers in women, and is … have a history of a high-grade precancerous lesion (cervical intraepithelial
neoplasia grade 2 or 3) … Preventive Services Task Force | 39
Grade Title
D
*Genital Herpes: Screening in Pregnant Women
-
www.uspreventiveservicestaskforce.org/uspstf/sites/default/files/inline-files/inevidup.pdf
September 01, 2009 - No recommendation was made, and no letter grade was
assigned. … Barton MB, Miller T, Wolff T, Petitti D, LeFevre M, Sawaya G, et al. U.S. … Atkins D, Best D, Briss PA, Eccles M, Falck-Ytter Y, Flottorp S, et al.
GRADE Working Group. … Atkins D, Eccles M, Flottorp S, Guyatt GH, Henry D, Hill S, et al.
GRADE Working Group. … Atkins D, Briss PA, Eccles M, Flottorp S, Guyatt GH, Harbour RT, et al.
GRADE Working Group.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/colorectal-cancer-liver-metastases-therapies_executive.pdf
December 01, 2012 - Most colorectal cancers are
adenocarcinomas, meaning that they are
a cancer of the epithelium originating … Is extended
hepatectomy for hepatobiliary malignancy justified? … Extended hepatectomy
in patients with hepatobiliary malignancies with and without
preoperative portal … HIF1A overexpression is
associated with poor prognosis in a cohort of 731 colorectal
cancers. … Recommendations for
radioembolization of hepatic malignancies using Yttrium-90
microsphere brachytherapy
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/dcis-mri-utilization_research.pdf
August 01, 2012 - Among women with
invasive cancer, rates of MRI use de-
creased with higher grade disease. … Use was higher for women
with larger or higher grade tumors. … bilateral breast cancers. … In general, women with higher risk DCIS
(larger tumor size, higher grade disease, or
ER-negative tumors … Siegel R, Naishadham D, Jemal A. Cancer statistics, 2012. CA: Cancer J Clin
2012;62(1):10-29.
2.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/prostate-cancer-surveillance_executive.pdf
December 01, 2011 - Tumor grade
Five studies (covering 1973–2005) reported prostate cancer
incidence rates stratified by … tumor grade (level of tumor
differentiation or Gleason score). … Tumor grade
Three studies reported information on prostate cancer
mortality stratified by tumor grade … One required that less than 25
percent of the tumor was Gleason grade 4 and less than 5
percent grade … grade (≥7) tumors, and a concomitant
increase in intermediate grade tumors (Gleason 5–6).
-
www.uspreventiveservicestaskforce.org/uspstf/sites/default/files/file/supporting_documents/falls-prevention-older-adults-draft-rec-bulletin.pdf
January 08, 2024 - This is a B grade. … This is a C grade.
Grade(s) in this recommendation:
B: Recommended. … , this draft recommendation does not address whether
or not someone should consider taking vitamin D … He is also the director of population health at UVA Health and co-leader of
the Cancer Prevention and … Population Health program at the UVA Comprehensive Cancer Center.
-
www.uspreventiveservicestaskforce.org/home/getfilebytoken/hWPZYvUZJXUQghbFtSDC42
August 01, 2011 - The stages of bladder cancer include superficial (Ta
or T1) and muscle-invasive tumors. … Population
No recommendation
Grade: I (Insufficient Evidence)
SCREENING FOR BLADDER CANCER
CLINICAL … Treatment
Once bladder cancer has been diagnosed, several fac-
tors determine treatment, including tumor … grade, cancer
stage (superficial vs. invasive), whether the tumor is recur-
rent, the patient’s age … D The USPSTF recommends against the service.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cell-free-dna-executive-summary.pdf
May 01, 2025 - Klein EA, Richards D, Cohn A, et al. … Neoplasia. Dec
2023;46:100941.
doi:10.1016/j.neo.2023.100941
12. … Integrative
modeling of tumor genomes and
epigenomes for enhanced cancer diagnosis
by cell-free DNA … Xiong D, Han T, Li Y, et al. … TOTEM: a
multi-cancer detection and localization
approach using circulating tumor DNA
methylation
-
www.uspreventiveservicestaskforce.org/home/getfilebytoken/zxXWqacXvfKPyQB9LCrZjX
August 01, 2008 - Do not screen for prostate cancer in men age 75 years or older
(Grade D recommendation). … This is a grade D
recommendation. … Interval cancers in pros-
tate cancer screening: comparing 2- and 4-year screening intervals in the Euro … rectal exam
ination (D
R
E). … Ilic D, O’Connor D, Green S, Wilt T. Screening for prostate cancer.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/lung-cancer-staging_research-protocol.pdf
December 08, 2014 - Lung cancers are classified based on the size
of the main tumor, whether it has locally invaded other … Tumor response
d. Harms due to overtreatment or undertreatment
e. Survival
f. … d. … Testing
for recurrent small cell lung cancer will be excluded.
d. … '/de OR cancer OR tumor* OR tumour* OR mass* OR
neoplasm* AND (stage OR 'staging'/de OR staging OR class
-
www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary14/bladder-cancer-in-adults-screening
October 15, 2010 - tissue) tumors. … 25% present as invasive tumors 12 . … invasive tumor 7 . … tumor marker. … [PMID: 9850170]
Madeb R, Golijanin D, Knopf J, Messing EM.