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81. Diagnosis of Celiac Disease: Current State of the Evidence (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/celiac-disease_clinician.pdf
    July 01, 2016 - * The overall evidence grade was assessed based on the ratings for the following domains: study limitations … Marsh grade 1 or grade 2 lesions—in the absence of clinical or serological evidence—are nonspecific … Marsh grade 3 lesions are the classic celiac disease lesions and are characteristic but not diagnostic

82. Glaucoma-Treatment Research-Protocol (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/glaucoma-treatment_research-protocol.pdf
    November 16, 2010 - We will use an evidence grading scheme recommended by the GRADE Working Group,13 adapted by AHRQ in … evaluated by at least one randomized controlled trial and by observational studies, our evidence grade … If an outcome is evaluated by one or no randomized controlled trials, our evidence grade will be based … Effectiveness Reviews14 and by Owens and colleagues.15 For each outcome of interest, two reviewers will grade

83. Weight-Gain-Prevention Executive (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/weight-gain-prevention_executive.pdf
    January 01, 2020 - We used four domains to yield a final evidence grade: Risk of Bias, Consistency, Directness, and Precision … We classified evidence pertaining to Key Questions 1 through 6 into four categories: (1) “high” grade … research is very unlikely to change our confidence in the estimate of the effect); (2) “moderate” grade … The team members discussed the process they used to grade the evidence throughout the report writing … When a team member felt the evidence grade was questionable, this comparison-outcome evidence grade

84. Disposition of Comments for Strategies To Prevent Weight Gain Among Adults (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/weight-gain-prevention_disposition-comments.pdf
    March 25, 2013 - We reported our findings consistent with GRADE. … in the grading of the evidence Evidence was graded consistent with the EPC Methods Guide using GRADE … We have graded outcomes consistent with the EPC Methods Guide, which is based upon the GRADE system … We used GRADE as stated in the EPC Methods Guide. … Observational studies are given a lower starting SOE according to GRADE.

85. Evidence Report on the (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/measuring-blood-pressure_research-protocol.pdf
    April 11, 2011 - Each Key Question We will follow the AHRQ Methods Guide for Comparative Effectiveness Reviews to grade … For each outcome (or set of outcomes), we will assign a grade for the strength of evidence: high, moderate

86. Medical Therapies for Locally Advanced Gastric Adenocarcinoma (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/gastric-cancers-protocol-amended.pdf
    February 07, 2025 - 3, 4, 5) • Direct mild treatment adverse events (grade 1, 2) • Indirect adverse events from treatment … long-term opioid use for pain management) N/A Timing All KQs: Any follow-up duration for grade … 3-5 or indirect adverse events and quality of life; minimum of 1 year for grade 1-2 adverse events … Grade 1-2 AEs will be characterized as mild, and grades 3-5 characterized as moderate. … otherwise.21 Grading the Strength of Evidence (SOE) for Major Comparisons and Outcomes: We will grade

87. Assessing-The-Risk-Of-Bias-In-Systematic-Reviews-Of-Health-Care-Interventions (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/assessing-the-risk-of-bias-in-systematic-reviews-of-health-care-interventions-01_0.pdf
    May 01, 2005 - from randomized controlled trials a high grade. … GRADE guidelines 6. Rating the quality of evidence- imprecision. … GRADE guidelines: 8. Rating the quality of evidence- indirectness. … GRADE guidelines: 7. Rating the quality of evidence- inconsistency. … GRADE guidelines: 5. Rating the quality of evidence-publication bias.

88. Medication-Therapy-Management Executive (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/medication-therapy-management_executive.pdf
    November 01, 2014 - of greatest importance to decisionmakers and those commonly reported in the literature; we did not grade … Definitions of the grades of overall strength of evidence Grade Definition High High confidence that … KQ 1 was descriptive in nature, so we did not grade strength of evidence. … GRADE guidelines 6. Rating the quality of evidence--imprecision. … GRADE guidelines: 4. Rating the quality of evidence--study limitations (risk of bias).

89. Liver-Cancer-Therapy Executive (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/liver-cancer-therapy_executive.pdf
    May 01, 2013 - Summary GRADE strength of evidence for KQ1 and KQ2 Key Question, Comparison, and Outcome Strength … Summary GRADE strength of evidence for KQ1 and KQ2 (continued) Key Question, Comparison, and Outcome … Summary GRADE strength of evidence for KQ1 and KQ2 (continued) Key Question, Comparison, and Outcome … Summary GRADE strength of evidence for KQ1 and KQ2 (continued) Key Question, Comparison, and Outcome … The GRADE Working Group. BMC Health Serv Res. 2004 Dec 22;4(1):38. PMID: 15615589. 38.

90. Menopause-Protocol-130612 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/menopause-protocol-130612.pdf
    June 12, 2013 - primary evidence base34 (supplemented by any more recent RCTs and observational studies when the GRADE … members concur that if obtained, evidence could impact results meaningfully (i.e., alter evidence GRADE … Moreover, all observational data are considered lesser (low) GRADE strength.35 The perspective here … The GRADE definitions are as follows: • High: High confidence that the evidence reflects the true … GRADE guidelines: 3. Rating the quality of evidence. J Clin Epidemiol. 2011 Apr;64(4):401-6.

91. Protocol: Imaging for Pretreatment Staging of Small Cell Lung Cancer (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/lung-cancer-staging_research-protocol.pdf
    December 08, 2014 - The reason that we will consider sensitivity and specificity together for a single grade is that the … The output is a grade for the strength of evidence: High, Moderate, Low, or Insufficient. … This grade is provided separately for each outcome of each comparison of each Key Question. … This domain will generally increase the strength of evidence grade. … If true, this domain will generally increase the strength of evidence grade.

92. The Role of Immunotherapy and the Management of Asthma: Systematic Review (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/asthma-immunotherapy_research-protocol.pdf
    September 14, 2016 - Grading the Evidence for Each Key Question For key questions 1 and 3 we will grade asthma control composite … For key questions 2 and 4 we will grade harms: anaphylaxis, hypersensitivity adverse effects and death … tables.40 We will classify evidence pertaining to the Key Questions into four categories: (1) “High” grade … research is very unlikely to change our confidence in the estimate of the effect); (2) “Moderate” grade … could change our confidence in the estimate of the effect and may change the estimate); (3) “Low” grade

93. Evidence-based Practice Center Systematic Review Protocol (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/adhd_research-protocol.pdf
    August 10, 2010 - Preschoolers with ADHD may continue to have difficulties with attention, learning and behavior in grade … Evidence for Each Key Question We will assess the overall strength of the body of the evidence using the GRADE … certainty surrounding an effect estimate for a specific outcome) There are factors recommended by the GRADE … importance of the outcome being evaluated) that may be taken into consideration when assigning a GRADE … Grade Working Group.

94. Arthritis-Psoriatric Executive (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/arthritis-psoriatric_executive.pdf
    April 01, 2012 - Summary of findings Key Comparisons Efficacy and Effectiveness Strength of Evidence Grade Harms … Strength of Evidence Grade Oral DMARDs Leflunomide No head-to-head studies met inclusion criteria; … Summary of findings (continued) Key Comparisons Efficacy and Effectiveness Strength of Evidence Grade … Harms Strength of Evidence Grade Biologic DMARDs (continued) Biologic No head-to-head trials met

95. Radiotherapy Treatments for Head and Neck Cancer (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/head-neck-cancer-update_clinician.pdf
    August 01, 2015 - PBT Tumor control and survival ��� ��� ��� Grade ≥2 late xerostomia* Significantly reduced incidence … � Quality of life related to late xerostomia Improved with IMRT (���) ��� ��� Other RT-associated grade

96. Evidence-based Practice Center Systematic Review Protocol (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/weight-gain-prevention_research-protocol.pdf
    January 01, 2020 - Grading the Evidence for Each Key Question At the completion of our review, we will grade the quantity … We will classify evidence pertaining to Key Questions 1 – 6 into four basic categories: (1) “high” grade … research is very unlikely to change our confidence in the estimate of the effect); (2) “moderate” grade … confidence in the estimate of the effect and is likely to change the estimate); and (4) “insufficient” grade … The grade of evidence for each key question will be based on consensus. G.

97. Assessing-The-Risk-Of-Bias-In-Systematic-Reviews-Of-Health-Care-Interventions (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/assessing-the-risk-of-bias-in-systematic-reviews-of-health-care-interventions-01.pdf
    May 01, 2005 - from randomized controlled trials a high grade. … GRADE guidelines 6. Rating the quality of evidence- imprecision. … GRADE guidelines: 8. Rating the quality of evidence- indirectness. … GRADE guidelines: 7. Rating the quality of evidence- inconsistency. … GRADE guidelines: 5. Rating the quality of evidence-publication bias.

98. Disposition of Comments_Systematic Review_Evaluation of Dietary Protein and Amino Acid Requirements: A Systematic Review (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/dietary-protein-intake-disposition-comments.pdf
    November 22, 2024 - Public Reviewer #1 ES-1-2 The strength of evidence grade noted in the “main points”, i.e. … describe strength of evidence in executive summary main points) or, if “inconclusive” is not an evidence grade

99. Moyer_ECCS2012 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/moyer_eccs2012.pdf
    January 01, 2012 - Preventive Services  Task Force Recommendation Grades Grade Definition A The U.S.

100. Antipsychotics for the Prevention and Treatment of Delirium: A Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/delirium-research-protocol.pdf
     June 01, 2018 - Strength of Evidence (SOE) for Major Comparisons and Outcomes At the completion of our review, we will grade … We will classify evidence pertaining to the Key Questions into four categories: (1) “high” grade (indicating … research is very unlikely to change our confidence in the estimate of the effect); (2) “moderate” grade … could change our confidence in the estimate of the effect and may change the estimate); (3) “low” grade … confidence in the estimate of the effect and is likely to change the estimate); and (4) “insufficient” grade