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461. Long-Term Drug Therapy and Drug Holidays for Osteoporotic Fracture Prevention (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/research-protocol-osteoporosis_2.pdf
     October 05, 2018 - Two investigators will independently assess five required domains and other possible factors to grade

462. Cad-Women-Diagnosis Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cad-women-diagnosis_executive.pdf
     June 01, 2012 - The strength of evidence was assigned an overall grade of High, Moderate, Low, or Insufficient according

463. Disposition of Comments_Comparative Effectiveness Review No. 253: Maternal and Child Outcomes Associated With the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/maternal-child-outcomes-wic-disposition-comments.pdf
     April 19, 2022 - Disposition of Comments_Comparative Effectiveness Review No. 253: Maternal and Child Outcomes Associated With the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) Comparative Effectiveness Review Disposition of Comments Report Title: Maternal and Child Outcomes Associated W…

464. Living Systematic Review on Plant-Based Treatment for Chronic Pain (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/plant-based-treatments-revised-protocol.pdf
     March 29, 2023 - strength of evidence will be reviewed by the entire team of investigators prior to assigning a final grade … publication bias (suspected or undetected) The strength of evidence will be assigned an overall grade

465. Disposition of Comments Report for Local Hepatic Therapies for Metastases to the Liver From Unresectable Colorectal Cancer (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/colorectal-cancer-liver-metastases-therapies_disposition-comments.pdf
     December 11, 2012 - confounding may occur here and have attempted to reflect this low strength of evidence in our insufficient GRADE … This will not impact the overall GRADE conclusions. … Additionally as non- comparative study this study would not have impacted the overall GRADE conclusions … The paper used CTC criteria, absence of higher grade indicates severe complications such as biloma and

466. Disposition of Comments Report for CER 132 Combination Therapy Versus Intensification of Statin Monotherapy: An Update (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/high-cholestorol-medicines-update_disposition-comments.pdf
     September 01, 2014 - ES16: “We were unable to grade any strength of evidence as high, despite numerous trials within some

467. Microsoft Word - 3-DKE274__ACEI-ARB-DRI__Comments_Disposition_Table-21_Jan_2011 cyk _2_.docx (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/ace-inhibitor-arb-update_disposition-comments.pdf
     October 07, 2011 - Summary The GRADE table (pg. 78) is a welcome summary item, but requires We now include descriptions … Rather than having readers find the original GRADE papers, a very brief description of the relevant … Summary and Discussion The GRADE balance sheet (pg. 81) should include absolute measures, not just

468. Assessing Applicability (ppt file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/assessing-applicability.ppt
     January 01, 2009 - Some evidence hierarchies (GRADE) consider applicability “or directness” when assessing the quality of … Some evidence hierarchies (GRADE) consider applicability “or directness” when assessing the quality of … GRADE = Grading of Recommendations Assessment, Development and Evaluation.

469. Assessing the Risk of Bias in Systematic Reviews of Health Care Interventions (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/ehc-presentation-risk-of-bias.pdf
     December 01, 2017 - estimates of effect or heterogeneity • Use risk of bias assessments to explore heterogeneity and grade … Finally, use risk of bias assessments to explore heterogeneity and grade strength of evidence.

470. Disposition of Comments Report for CER 207 on PTSD (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-207-ptsd-disposition-comments.pdf
     May 17, 2018 - The strength of evidence grade is given after carefully considering more than just the risk of bias … The SOE grade reflects the strength of the body of evidence to answer KQs on the comparative effectiveness … Has GRADE recommended this? … The strength of evidence grades were used to grade the evidence supporting each intervention of interest

471. Impact of Healthcare Worker Safety and Wellness: A Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/worker-safety-wellness-protocol.pdf
     October 26, 2024 - and Outcomes: For the full synthesis, we will structure our evidence profiles to be compatible with GRADE … We will grade the strength of the body of evidence as per the Agency for Healthcare Research and Quality … evidence “any estimate of effect is very uncertain,” the definition of very low-quality evidence per GRADE

472. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/health-careassociated-infections_research-protocol.pdf
     August 26, 2011 - specific prevention interventions used to reduce infections will be selected from recommendations with a grade … guidelines, 21 which is analogous to the approach used in the 2007 Evidence Report, 16 or with a grade … Grading the Evidence for Each Key Question The GRADE criteria as modified by AHRQ 26 and by the … The Technical Expert Panel will be consulted on how the GRADE criteria should be applied in this case

473. Disposition of Comments for Imaging Tests for the Staging of Colorectal Cancer (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/colorectal-cancer-staging_disposition-comments.pdf
     November 20, 2014 - Also “not statistically significant” should not be a reason for the grade to be “insufficient”.

474. Medical Therapies for Children With Autism Spectrum Disorder—An Update (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/asd-medical-executive-170505.pdf
     May 01, 2017 - comparator Number/Type of Studies (Total N Participants) Key Outcome(s) Strength of Evidence (SOE) Grade … comparator Number/Type of Studies (Total N Participants) Key Outcome(s) Strength of Evidence (SOE) Grade

475. Disposition of Comments for CER 211: Drug Therapy for Early Rheumatoid Arthritis: A Systematic Review Update (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-211-rheumatoid-arthritis-disposition-comments.pdf
     December 20, 2018 - In a few instances, the grade of SOE is moderate. … and Outcomes; we note that SOE was graded using the EPC approach, but it should be noted that the GRADE … guidance does not offer much detail about grading strength of evidence for NWMA, we used the new GRADE … In general, the principal approaches of GRADE and EPC guidance towards strength of evidence are very … Advances in the GRADE approach to rate the certainty in estimates from a network meta-analysis.

476. Digestible Carbohydrate Intake and Maternal-Infant Outcomes: A Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/carbohydrate-intake-protocol.pdf
     April 08, 2024 - The strength of evidence will be assigned an overall grade of high, moderate, low, or insufficient (

477. Disposition of Comments for Technical Brief 22 Environmental Cleaning for the Prevention of Healthcare-Associated Infections (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/healthcare-infections_disposition-comments.pdf
     August 10, 2015 - Please note that a technical brief is a narrative report and does not critically appraise or grade … relative to its strength and quality.There are tools that can score these studies accordingly such as GRADE … While we agree that GRADE is a useful tool to assess quality of an evidence base, the technical brief … is not intended to critically appraise, grade, or synthesize evidence or make recommendations, but … for Disease Control and Prevention EPA=Environmental Protection Agency EVS=environmental services GRADE

478. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/atrial-fibrillation-ablation_disposition-comments.pdf
     October 01, 2010 - Comment Response Methods The authors need to clarify their statement that “we assigned an overall grade

479. Management of Insomnia Disorder in Adults: Current State of the Evidence (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/insomnia_clinician.pdf
     August 01, 2017 - † The overall evidence grade was assessed based on the ratings for the following domains: study limitations

480. Disposition of Comments_Comparative Effectiveness Review No. 262_Pharmacotherapy for Adults With Alcohol Use Disorder in Outpatient Settings: Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-262-pharmacotherapy-alcohol-disposition-comments.pdf
     November 07, 2023 - Public Comment #3 (APA) Appendices A-19 Grading line 2 I've not seen the phrase "short GRADE" before … May wish to add "to grade the overall strength of a body of evidence." after Program and start the next … The sample size issues addressed in the last sentence seem like less of a focus of the GRADE and EBPC … It's never been clear to me why AHRQ, GRADE, and RoB determinations don't incorporate those factors