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41. Implementation of Recommended Screening and Counseling Interventions to Prevent Mental Health Disorders in Children and Adolescents (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/screening-counseling-interventions-protocol.pdf
    October 01, 2023 - Depression and Suicide Risk (B and I Grades) − Screening for Eating Disorders (adolescents only; I Grade … Grading the Strength of Evidence for Major Comparisons and Outcomes We will grade the strength of evidence … the guidance established by the Grading of Recommendations Assessment, Development and Evaluation (GRADE … We will grade the seven outcomes, rated as most important for decision making. … GRADE guidelines: 3. Rating the quality of evidence.

42. Supplemental Project To Assess the Transparency of Reporting Requirements for Studies Evaluating the Effectiveness of Treatment Options for Symptoms of Diabetic Peripheral Neuropathy (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/transparency-neuropathy_research.pdf
    March 01, 2018 - grade remained “Insufficient.” … No effect Although we now have a body of evidence to grade, the overall evidence grade remained “ … , the overall evidence grade remained “Insufficient.” … No effect Although we now have a body of evidence to grade, the overall evidence grade remained “ … The overall evidence grade would remain “Insufficient.”

43. Improving the Management of Menopausal Symptoms in Perimenopausal and Early Postmenopausal Women: A Systematic Review (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/menopausal-symptoms-protocol-final.pdf
    October 15, 2024 - Overview of the GRADE Approach. In: Neumann I SH, ed The GRADE Book. … .: The GRADE Working Group; 2025:https://book.gradepro.org/guideline/overview-of-the-grade-approach. … GRADE Guidance 34: update on rating imprecision using a minimally contextualized approach. … https://book.gradepro.org/guideline/overview-of-the-grade-approach 20 VI. … Certainty of Evidence Grades Definitions (based on GRADE definitions) V. References VII.

44. Dietary-Supplements Executive (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/dietary-supplements_executive.pdf
    April 01, 2012 - Objectives The objective of this Comparative Effectiveness Review was to systematically synthesize and grade … Overall, no significant differences (grade: insufficient; results inconclusive) were seen between the … The mean SBP was significantly lowered in the supplement-statin combination group (grade: low) in 22 … : low), and triglycerides (grade: low), but not HDL-C (inconclusive, grade: insufficient) or SBP (inconclusive … Likewise, there was no significant difference in blood pressure (inconclusive; grade: insufficient)

45. Data Points 13: Use of Preoperative Breast MRI among older women with ductal carcinoma in situ and locally invasive breast cancer (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/dcis-mri-utilization_research.pdf
    August 01, 2012 - Grade: We defined grade using the field provided by SEER: well dif- ferentiated, moderately/intermediately … Increasing size and higher grade are related to higher rates of MRI use for women with DCIS but not … Among women with invasive cancer, rates of MRI use de- creased with higher grade disease. … Use was higher for women with larger or higher grade tumors. … Size <1 cm (incl micro) 438 13.9 1,801 19.0 <2 cm 274 17.5 2,643 19.4 ≥2 cm 240 22.5 1,669 17.7 Grade

46. Effective Health Care (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0210_12-07-2009.pdf
    January 01, 2009 - adolescents, and adults with sustained cognitive, physical, and/or psychological impairments from a grade … Staff-Generated PICO Population(s): Children, adolescents, and adults six months post an initial grade

47. Slide 1 (ppt file)
    effectivehealthcare.ahrq.gov/sites/default/files/marketing_evidence_evans.ppt
    September 13, 2006 - 0.564 _Idma* All Grades Trend in actual smoking Predicted trend if truth did not exist 8th Grade … 0.8132422 0.000 pctotfund2 0.973652 0.033 rprice 0.9999468 1.000 _Idma* 10th Grade … medumiss 0.9907165 0.883 pctotfund2 1.004672 0.752 rprice 1.00859 0.92 _Idma* 12th Grade … 0.564 _Idma* All Grades Trend in actual smoking Predicted trend if truth did not exist 8th Grade … 0.8132422 0.000 pctotfund2 0.973652 0.033 rprice 0.9999468 1.000 _Idma* 10th Grade

48. head-neck-cancer-update-140204 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/head-neck-cancer-update_research-protocol.pdf
    February 04, 2014 - The EPC should specify the comparison and outcome for which the SOE grade applies. … In the EPC grading system, a body of evidence including RCTs is assigned a provisional SOE grade of … This type of evidence is generally assigned a provisional initial SOE grade of “low”. … The overall SOE grade is classified into four categories as shown in Table 2. … The overall SOE grade for each outcome will be specifically reported in this table. Table 2.

49. EHC Protocol: Recurrent Nephrolithiasis in Adults and Children: Comparative Effectiveness of Preventive Medical Strategies (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/kidney-stones-protocol.pdf
    September 24, 2024 - (Grading of Recommendations Assessment, Development and Evaluation) working group.21 We will grade … We will grade SOE for the outcomes detailed in Table 2 as they are critical or important to decision … Otherwise, we will assign an overall SOE grade for each comparison and outcome as high, moderate, low … GRADE Working Group. Welcome to the GRADE working group. 2024. https://www.gradeworkinggroup.org/. … GRADE Guidance 34: update on rating imprecision using a minimally contextualized approach.

50. Disposition of Comments for CER 153 Non-Muscle-Invasive Bladder Cancer (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/bladder-cancer-non-muscle-invasive_disposition-comments.pdf
    October 27, 2015 - On one end of the spectrum are patients with low grade noninvasive tumors that rarely develop tumors … Suggest deleting this retaining the description as a flat high grade cancer confined to the inside … As noted by the reviewer, accuracy increased with higher tumor stage and grade. … I assume that these (low and high grade) were lumped together. … As noted by the reviewer, accuracy increased with higher tumor stage and grade.

51. 04-E029-1 Summary (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/prostate-cancer-surveillance_executive.pdf
    December 01, 2011 - The quality grade was confirmed by at least one other team member. … tumor grade (level of tumor differentiation or Gleason score). … Tumor grade Three studies reported information on prostate cancer mortality stratified by tumor grade … One required that less than 25 percent of the tumor was Gleason grade 4 and less than 5 percent grade … grade (≥7) tumors, and a concomitant increase in intermediate grade tumors (Gleason 5–6).

52. Disposition of Comments for Treatments for Seasonal Allergic Rhinitis (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/allergy-seasonal_disposition-comments.pdf
    July 17, 2013 - of “insufficient evidence” is not included in the GRADE approach and it might be reasonable to admit … that the grading used here was a modification of the GRADE approach. … The reference cited in the report states, “Strength of evidence receives a single grade: high, moderate … AHRQ Methods Guide states:5 “EPCs should grade strength of evidence separately for each major outcome … The translation of USPSTF quality ratings of individual trials to GRADE risk of bias assessments is

53. Data Points 14: Use of Endocrine Therapy (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/dcis-endocrine-therapy_research.pdf
    August 01, 2012 - With early inva- sive disease, use increased with increasing tumor size and declined with higher grade … Grade: We defined grade using the fields provided by SEER: well differentiated, moderately/intermediately … Use did not vary greatly across tumor size or grade. … Tumor Grade DCIS Early Invasive 0 25 50 75 100 Not Done Positive Negative Unknown Pa tie nt … With early invasive dis- ease, use increased with increasing tumor size and declined with higher grade

54. Evidence-based Practice Center Systematic Review Protocol (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/cystic-fibrosis-hgh_research-protocol.pdf
    August 22, 2008 - A separate grade will be given for all major outcomes, including benefits and harms. … We will then use the subsequent domains to modify the overall grade. … The evidence report will also include the definitions used, and the final grade of high, moderate, low … GRADE handbook for grading quality of evidence and strength of recommendation. … The GRADE Working Group, 2008.

55. Research to Improve the Delivery of Clinical Preventive Services to People with Disabilities (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/stakeholder-report_0824.pdf
    August 01, 2024 - It focused on 20 high-priority clinical preventive services with Grade A or B recommendations from the … Grade Definition A The USPSTF recommends the service. … available at https://www.uspreventiveservicestaskforce.org/uspstf/about-uspstf/methods-and- processes/grade-definitions … https://www.uspreventiveservicestaskforce.org/uspstf/about-uspstf/methods-and-processes/grade-definitions … https://www.uspreventiveservicestaskforce.org/uspstf/about-uspstf/methods-and-processes/grade-definitions

56. Frameworks for Determining Research Gaps During Systematic Reviews (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-future-research-steps-framework_research.pdf
    June 01, 2011 - • GRADE: The GRADE Working Group advises decreasing the grade of the quality of the evidence if … • GRADE: Consistency is a key element. … o GRADE: The GRADE Working Group advises decreasing the grade of the quality of the evidence if the … o GRADE: Consistency is a key element. … o GRADE: Directness is a key element.

57. Renal-Cancer Research-Protocol (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/renal-cancer_research-protocol.pdf
    April 20, 2015 - with cytopathology or surgical pathology) in establishing a diagnosis (malignancy, histology and grade … Major Comparisons and Outcomes: At the completion of our review, two reviewers will independently grade … We will grade the strength of evidence addressing management studies using the evidence grading scheme … ; 2) “moderate” grade; 3) “low” grade; and 4) “insufficient” grade. … Table 7 defines each strength of evidence grade. Table 7.

58. Cancer-Pancreas Executive (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/cancer-pancreas_executive.pdf
    September 01, 2014 - The output is a grade of the strength of evidence: high, moderate, low, or insufficient. … This grade is made separately for each outcome of each comparison of each KQ. … The grade was provided by two independent raters, and discrepancies were resolved by consensus. … We did not grade the strength of the evidence from systematic reviews. … We did not grade the strength of evidence for harms.

59. Layout 1 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/antidepressants-update_executive.pdf
    December 01, 2011 - Some results are now supported by better evidence than in 2007, which is reflected in a higher grade … Some results are now supported by better evidence than in 2007, which is reflected in a higher grade

60. Evidence-based Practice Center Review Protocol (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/prostate-cancer-surveillance_research-protocol.pdf
    May 19, 2011 - either regional lymph node involvement (N0–X) or metastases (M0–X), regardless of age, histologic grade … Grading the Strength of Evidence When it is appropriate to do so, we will grade the strength of