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301. CER 244 Evidence Summary: Safety of Vaccines Used for Routine Immunization in the United States: An Update (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/cer-244-safety-vaccines-update-evidence-summary.pdf
     May 01, 2021 - SoE was assessed based on the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE … AHRQ Methods Guide for Effectiveness and Comparative Effectiveness Reviews.6 We used four criteria to grade

302. Template for Reports Developed (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/allergy-seasonal_research-protocol.pdf
     March 08, 2012 - evidence will be based on the Evidence- based Practice Center (EPC) approach, which is similar to the GRADE … treatment comparison of interest, the body of evidence will be evaluated separately to derive a single GRADE … The GRADE definitions are as follows: • High: high confidence that the evidence reflects the true … that is hard to tolerate; causes interference with activities of daily living and/or sleeping) GRADE

303. Psychological and Pharmacological Treatments for Adults with Posttraumatic (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/ptsd-adult-treatment-update_research-protocol.pdf
     December 31, 2017 - Grading the SOE for Major Comparisons and Outcomes We will grade the SOE based on the guidance established … for the Evidence-based Practice Center (EPC) Program.33 Developed to grade the overall strength of … We will grade the SOE for the outcomes deemed to be of greatest importance to decisionmakers and those … Definitions of the grades of overall SOE34 Grade Definition High High confidence that the evidence

304. Heart-Failure-Transition-Care Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/heart-failure-transition-care_executive.pdf
     May 01, 2014 - Developed to grade the overall strength of a body of evidence, the approach incorporates four key domains … Two reviewers assessed each domain for each key outcome and determined an overall SOE grade based on … In the event of disagreements on the domain rating or overall grade, we resolved differences by discussion … It documents our results when data met the following three criteria: (1) sufficient evidence to grade

305. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/management-adhd-adults-protocol-amendment.pdf
     January 08, 2025 - definitions for a wide range of events, organized by organ system and severity levels ranging from Grade … 1 (mild) to Grade 5 (fatal), with clear criteria for grading. … the magnitude of effect) as described in the AHRQ Methods guides.117 A final strength of evidence grade … We will differentiate an overall grade of high, moderate, low, or insufficient according to a four-level

306. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/management-adhd-adults-protocol.pdf
     June 10, 2024 - definitions for a wide range of events, organized by organ system and severity levels ranging from Grade … 1 (mild) to Grade 5 (fatal), with clear criteria for grading. … the magnitude of effect) as described in the AHRQ Methods guides.117 A final strength of evidence grade … We will differentiate an overall grade of high, moderate, low, or insufficient according to a four-level

307. Colorectal-Cancer-Protocol_130520 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/colorectal-cancer-staging_research-protocol.pdf
     May 20, 2013 - Disease characteristics (e.g., tumor grade) iii. … Disease characteristics (e.g., tumor grade) iii. … (on medical interventions and medical tests) on grading the strength of evidence.12,33 We will grade … The grade is developed by considering four important domains: the risk of bias in the evidence base, … indirectly related to health outcomes, and because the KQ asks directly about test accuracy, we will grade

308. Hemorrhage-Postpartum Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/hemorrhage-postpartum_executive.pdf
     April 01, 2015 - addressing effectiveness of interventions (KQ1) Category Intervention Key Outcome(s) Strength of Evidence Grade … effectiveness of interventions (KQ1) (continued) Category Intervention Key Outcome(s) Strength of Evidence Grade … of interventions (KQ3) Intervention Category Intervention Key Outcome(s) Strength of Evidence Grade … addressing interventions for anemia after PPH (KQ4) Intervention Key Outcome(s) Strength of Evidence Grade … addressing systems-level interventions for PPH (KQ5) Intervention Key Outcome(s) Strength of Evidence Grade

309. Organisation (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cancer-radiation_appendixes.pdf
     June 16, 2008 - Conformal proton radiation therapy for pediatric low-grade astrocytomas. … Radiotherapy for chordomas and low-grade chondrosarcomas of the skull base with carbon ions. … Carbon ion radiotherapy for chordomas and low-grade chondrosarcomas of the skull base. … Pion radiation for high grade astrocytoma: results of a randomized study. … Successful use of intracavitary bleomycin for low- grade astrocytoma tumor cyst.

310. Gout-managment-protocol-141103 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/gout_research-protocol.pdf
     November 03, 2014 - guidance suggested by the Effective Health Care Program.19 This method is based on one developed by the GRADE … Working Group and classifies the grade of evidence as High, Moderate, Low or Insufficient. … The evidence grade is based on five required domains: study limitations, consistency, directness, precision … GRADE: an emerging consensus on rating quality of evidence and strength of recommendations.

311. Labor-Nitrous-Oxide Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/labor-nitrous-oxide_executive.pdf
     August 01, 2012 - 1 Comparative Effectiveness Review Number 67 Nitrous Oxide for the Management of Labor Pain Executive Summary Background More than 4 million births occur in the United States each year; in 2008, there were 4,247,694 births.1 The most commonly used labor pain management method in the United States is epidural…

312. Disposition of Comments Report for Biologic and Nonbiologic Systemic Agents and Phottherapy for Treatment of Chronic Plaque Psoriasis (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/psoriasis-chronic_disposition-comments.pdf
     November 27, 2012 - Disposition of Comments Report for Biologic and Nonbiologic Systemic Agents and Phottherapy for Treatment of Chronic Plaque Psoriasis Source: http://effectivehealthcare.ahrq.gov/search-for-guides-reviews-and- reports/?pageaction=displayproduct&productID=1325 Published Online: November 27, 2012 Comparative…

313. Prostate-Cancer-Test Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/prostate-cancer-test_research-protocol.pdf
     October 14, 2011 - measures Participant Characteristics  Age  Race  Benign prostatic hyperplasia  High-grade … Grading the Evidence for Each Key Question We will grade the strength of evidence for primary outcomes … standard process of the Evidence-based Practice Centers as outlined in the Methods Guide.10,20 The grade … Strength of evidence grades and definitions20 Grade Definition High High confidence that evidence

314. CER 173 Executive Summary: Diabetes Medications for Adults With Type 2 Diabetes: An Update (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/diabetes-update-2015_executive.pdf
     January 01, 2015 - We graded the evidence separately for the RCTs and the observational studies.17 The final evidence grade … and conclusion were typically based on the RCT grade and could be strengthened by evidence from the … We classified evidence pertaining to the Key Questions into four categories: (1) high grade (indicating … For heart rate, only two comparisons had sufficient data to grade the evidence as more than insufficient … Only two comparisons had sufficient data to grade the evidence as more than insufficient or low.

315. Use of Observational Studies in Systematic Reviews of (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/methodsguidenorris_060420101.pdf
     June 01, 2010 - These criteria closely resemble those criteria used by the GRADE group14 and by AHRQ Evidence-based … strength of a body of evidence of observational studies according to well-accepted approaches.33 In the GRADE … GRADE Working Group. Grading quality of evidence and strength of recommendations. … GRADE: an emerging consensus on rating quality of evidence and strength of recommendations.

316. Evidence Report on the (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/depression-treatment-ssri_research-protocol.pdf
     June 15, 2010 - for Each Key Question We will assess the overall strength of the body of the evidence using the GRADE … certainty surrounding an effect estimate for a specific outcome) There are factors recommended by the GRADE … importance of the outcome being evaluated) that may be taken into consideration when assigning a GRADE … GRADE Working Group. Grading the quality of evidence and the strength of recommendations".

317. Use of Observational Studies in Systematic Reviews of (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-observational-studies_methods.pdf
     June 01, 2010 - These criteria closely resemble those criteria used by the GRADE group14 and by AHRQ Evidence-based … strength of a body of evidence of observational studies according to well-accepted approaches.33 In the GRADE … GRADE Working Group. Grading quality of evidence and strength of recommendations. … GRADE: an emerging consensus on rating quality of evidence and strength of recommendations.

318. Evidence-based Practice Center Systematic Review Protocol: Management of High-Need, High-Cost Patients: A Realist and Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/mgmt-hnhc-patients-protocol.pdf
     November 07, 2019 - Systematic Review: Grading the Strength of Evidence For KQ 3, we will grade the strength of evidence … (SOE) based on the guidance established for the EPC Program.42 Developed to grade the overall strength … Definitions of the grades of overall strength of evidence42 Grade Definition High High confidence

319. Migraine-Emergency Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/migraine-emergency_executive.pdf
     November 01, 2012 - body of evidence using the EPC Grading of Recommendations Assessment, Development, and Evaluation (GRADE … For KQ 3, we did not grade outcomes because there were no comparative effectiveness analyses.

320. Evidence Report on the (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/antidepressants-update_research-protocol.pdf
     July 13, 2011 - of evidence and the strength of recommendations I: Critical appraisal of existing approaches: The GRADE