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201. ASSESSING THE QUALITY OF INCLUDED STUDIES (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/assessing-the-risk-of-bias_draft-report.pdf
     June 02, 2011 - At that stage, EPCs generally give evidence derived from observational studies a low starting grade … and evidence from randomized controlled trials a high grade. … GRADE guidelines: 3. Rating the quality of evidence. Journal of Clinical Epidemiology. … GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. … GRADE guidelines: 4.

202. Improving Health Care and Palliative Care for Advanced and Serious Illness Disposition of Comments Report (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/quality-gap-palliative-hospice_disposition-comments.pdf
     October 01, 2012 - report clinically meaningful in the sense that most of the key data for the QI settings resulted in a grade

203. Medication-Therapy-Management Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/medication-therapy-management_research-protocol.pdf
     January 01, 2014 - Grading the Strength of Evidence for Individual Comparisons and Outcomes We will grade the strength … based on the guidance established for the Evidence- based Practice Center Program.17 Developed to grade … We will grade the strength of evidence for the outcomes deemed to be of greatest importance to decisionmakers … Definitions of the grades of overall strength of evidence15 Grade Definition 19 Source: www.effectivehealthcare.ahrq.gov

204. rheumatoid-arthritis-medicine-update-protocol-170515 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/rheumatoid-arthritis-medicine-update_research-protocol.pdf
     May 15, 2017 - Grading the SOE for Major Comparisons and Outcomes We will grade SOE based on the guidance established … for the Evidence-based Practice Center (EPC) Program.33 Developed to grade the overall strength of … Definitions of the Grades of Overall Strength of Evidence Grade Definition High We are very confident … Source: www.effectivehealthcare.ahrq.gov Published online: May 15, 2017 12 We will grade

205. Psoriasis-Chronic Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/psoriasis-chronic_executive.pdf
     November 01, 2012 - The overall grade for strength of evidence for each comparison and outcome evaluated was rated and … There was insufficient evidence to grade death, and no other final health outcomes were reported. … There was insufficient evidence to grade BSA, and no other intermediate outcomes were reported. … When comparing ustekinumab with methotrexate, there was insufficient evidence to grade HRQoL, and no … However, there was insufficient evidence to grade HRQoL, BSA, PASI, PGA, psoriatic arthritis (PsA)

206. Liver-Cancer-Therapy Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/liver-cancer-therapy_research-protocol.pdf
     November 28, 2012 - authors concur that if obtained, evidence could impact results meaningfully (i.e., alter evidence GRADE … EPC approach, which is outlined in the Methods Guide43 and is based on a system developed by the GRADE … The grade of evidence strength is classified into the following four categories: • High. … The grade rating will be made by independent reviewers, and disagreements will be resolved by consensus

207. Executive Summary: Radiation Therapy for Metastatic Bone Disease: Effectiveness and Harms (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-265-radiation-bone-disease-summary.pdf
     August 01, 2023 - Effect Size/SOE)a Any time No evidence No difference + No evidence Harms/AEs – Toxicity, Acute Grade … Use of dexamethasone with EBRT may improve pain and quality of life and reduce pain flare and acute Grade

208. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/progestogens-preterm-birth_research-protocol.pdf
     June 01, 2010 - Evidence-based Practice Center Systematic Review Protocol Source: www.effectivehealthcare.ahrq.gov Published Online: April 15, 2010 1 Evidence-based Practice Center Systematic Review Protocol Project Title: Comparative Effectiveness of Progestogens for the Prevention of Preterm B…

209. Safety of Vaccines Used for Routine Immunization in the United States (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/vaccine-safety_executive.pdf
     January 01, 2020 - For each AE associated with a particular vaccine, what is the average severity (grade 1/mild; grade 2 … For each AE associated with a particular vaccine, what is the average severity (grade 1/mild; grade 2 … For each AE associated with a particular vaccine, what is the average severity (grade 1/mild; grade 2 … For each AE associated with a particular vaccine, what is the average severity (grade 1/mild; grade 2 … The evidence grade is based on four primary (required) domains and four optional domains.

210. Effective Health Care (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0251_05-20-2010.pdf
     January 01, 2010 - Wound care dressings with a cytolytic agent or antibiotics (e.g., silver, cadexomer iodine, medical-grade

211. Ptsd-Adults-Trauma-Interventions Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/ptsd-adults-trauma-interventions_executive.pdf
     April 01, 2013 - based on the guidance established for the Evidence-based Practice Center program.10 Developed to grade … Two reviewers assessed each domain for each key outcome and determined an overall SOE grade based on … In the event of disagreements on the domain or overall grade, they resolved differences by consensus

212. Fiber Intake and Laxation Outcomes (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/fiber-intake-protocol.pdf
     August 15, 2023 - low-quality evidence per the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE … Healthcare Research and Quality DRI Dietary reference intake EPC Evidence-based Practice Center GRADE

213. CER 210: Disposition of Comments for Breastfeeding Programs and Policies, Breastfeeding Uptake, and Maternal Health Outcomes in Developed Countries (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-210-breastfeeding-disposition-comments.pdf
     January 01, 2020 - This is one example of why a SOE grade might be “low” rather than “insufficient” when only one study … Yes, this evidence was considered in the SOE grade. … We have clarified when the grade refers to no association (for fracture). … We have reviewed this SOE grade. … Information on magnitude helps us interpret the strength of association and the final grade.

214. Strategies To Improve Mental Health Care for Children and Adolescents (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/mental-health-children_executive.pdf
     December 01, 2016 - Definitions of the grades of overall strength of evidence30 Grade Definition High We are very confident … In keeping with GRADE and strength of evidence guidance, we rated observational studies as having high … described above, study design and study limitations together set the baseline strength of evidence grade … Other domains then could either reduce or increase the grade. … GRADE guidelines 6. Rating the quality of evidence--imprecision.

215. Systematic Review Update: Noninvasive Nonpharmacologic Treatment for Chronic Pain (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/nonpharm-treatment-chronic-pain-protocol.pdf
     December 11, 2018 - determining strength of evidence for each primary clinical outcome by following the principles for adapting GRADE … unmeasured confounders) as described in the AHRQ Methods guides.16,19 A final strength of evidence grade … The strength of evidence will be assigned an overall grade of high, moderate, low, or insufficient

216. Mrsa-Screening-2010 Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/mrsa-screening-2010_research-protocol.pdf
     January 01, 2010 - for Healthcare Research and Quality for its Methods Guide,33,38 based on a system developed by the GRADE … The grade of evidence strength is classified into the following four categories:  High. … Atkins D, Eccles M, Flottorp S, et al, for the GRADE Working Group.

217. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/vte-prophyalaxis_research-protocol.pdf
     March 01, 2011 - that anticoagulant medications that bioaccumulate should be avoided, dose adjusted, or monitored (Grade … Grading the Evidence for Each Key Question At the completion of our review, we will grade the quantity … We will classify evidence pertaining to KQs 1–8 into four basic categories: 1) “high” grade (indicating … research may change our confidence in the estimate of the effect and may change the estimate); 3) “low” grade … confidence in the estimate of the effect and is likely to change the estimate); and 4) “insufficient” grade

218. High-Cholestorol-Medicines-Update Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/high-cholestorol-medicines-update_executive.pdf
     February 01, 2014 - We used four domains to yield a final evidence grade: risk of bias, consistency, directness and precision … The final strength-of-evidence (SOE) grades were: (1) “high” grade (indicating high confidence that … final.cfm. 6 very unlikely to change our confidence in the estimate of the effect); (2) “moderate” grade … research may change our confidence in the estimate of the effect and may change the estimate); (3) “low” grade … confidence in the estimate of the effect and is likely to change the estimate); and (4) “insufficient” grade

219. uterine-fibroids-protocol-160301 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/uterine-fibroids_research-protocol.pdf
     March 01, 2016 - Intervention-outcomes pairs will be given an overall evidence grade based on the ratings for the individual … We assign an overall grade (high, moderate, low or insufficient) for the strength of evidence for each … Strength of evidence grades and definitions Grade   Definition     High     We  are  very  confident … Two senior staff will independently grade the body of evidence; disagreements will be resolved as needed … When no studies are available for an outcome or comparison of interest, we will grade the evidence

220. Diagnosis and Treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/chronic-fatigue_executive.pdf
     July 01, 2016 - Diagnosis and Treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Evidence-Based Practice Evidence-based Practice Program The Agency for Healthcare Research and Quality (AHRQ), through its Evidence- based Practice Centers (EPCs), sponsors the development of evidence reports and technology assessme…