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21. White Paper: Narratively Describing Effects of Interventions in Systematic Reviews (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/white-paper-roadmap-interventions.pdf
    November 01, 2020 - Informative Statements To Communicate Results of Systematic Reviews From GRADE Appendix C. … The GRADE Working Group developed in 2004 an approach for rating the certainty in evidence that has … Recently, the GRADE Working Group has proposed an approach for making narrative statements. … Using EPOC and GRADE suggestions, we developed a framework (Figure 1) for key overlapping constructs … Informative Statements To Communicate Results of Systematic Reviews From GRADE Appendix C.

22. Integrating Bodies of Evidence: Existing Systematic Reviews and Primary Studies (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/integrating-evidence_methods.pdf
    February 01, 2015 - assessment of bodies of evidence again using their own criteria and judgment, while others do not grade … Assessments that are compatible include the EPC SOE, GRADE, and USPTF tools.16-18 However, no matter … However, the process for how to determine if there is sufficient evidence to change a prior grade is … What is enough, in terms of studies/type of evidence, to prompt a change in grade? 4. … What is enough, in terms of studies/type of evidence, to prompt a change in grade? 5.

23. Layout 1 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/gerd-2005_executive.pdf
    January 01, 2005 - followup was 8 months, and all three studies had significant bias that may invalidate the results (Grade … These analyses had minimal bias and their results are considered valid (Grade A). … (Grade C) nonrandomized study. … This one study on Stretta™ versus sham had a small number of patients and short duration of followup (Grade … antireflux medications compared to medical patients; less bodily pain; no difference in esophagitis grade

24. Executive Summary_Comparative Effectiveness Review No. 273_Treatment of Stages I-III Squamous Cell Anal Cancer: A Systematic Review (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-273-anal-cancer-executive-summary.pdf
    August 01, 2024 - RT alone, frequency: 1 vs.0 grade 4 events (n=110); or 20 vs.0 overall events (n=585). … cisplatin, with grade 3+ toxicity frequency of 61% vs. 42% (p<0.001, n=682) and 26% vs. 16% (p<0.001 … Low Neutropenia (grade 3 or 4) 1; RCT; n=144 No significant difference, imprecise estimates. … Low Note: Remaining comparisons not mentioned in the table received an insufficient grade. … All harms are grade 3 or 4 unless specified otherwise.

25. Treatment of Stage I-III Squamous Cell Anal Cancer (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/anal-cancer-protocol.pdf
    September 26, 2023 - Guyatt GH OA, Kunz R, Vist GE, Falck-Ytter Y, Schünemann HJ; GRADE Working Group. … GRADE guidelines: 11. … Reference 21: Guyatt GH OA, Kunz R, Vist GE, Falck-Ytter Y, Schünemann HJ; GRADE Working Group. … GRADE guidelines: 11. … r) adj2 (assess* or burden or grade or grading or invasive* or metastas?

26. Standardized Library of Lung Cancer Outcome Measures (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/white-paper-lung-cancer.pdf
    August 01, 2021 - Regarding toxicity, over 750 Grade 3 or Grade 4 complications are listed in CTCAE v5 for radiation therapy … Rather than model each complication, observations were created for “CTCAE grade 3” and “CTCAE grade … This approach also allows the definition to capture Grade 3 or Grade 4 complications, regardless of … infarction Unexpected return to operating room (any cause) Radiation therapy complications CTCAE grade … 3 or 4 complications due to radiotherapy Systemic therapy complications CTCAE grade 3 or 4 complications

27. Testing the Predictive Validity of Strength of Evidence Grades | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/grades-predictive-values/abstract

28. Meditation Research-Protocol (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/meditation_research-protocol.pdf
    October 17, 2012 - research is very unlikely to change our confidence in the estimate of the effect); (2) “moderate” grade … We will classify evidence pertaining to Key Questions into four basic categories: (1) “high” grade … research is very unlikely to change our confidence in the estimate of the effect); (2) “moderate” grade … but there are more direct measures of those domains. 3) To specify the details of how we will grade … Protocol Revised Protocol Rationale and is likely to change the estimate); and (4) “insufficient” grade

29. Disposition of Comments Report for Allergen-Specific Immunotherapy for the Treatment of Allergic Rhinoconjunctivitis and/or Asthma (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/asthma-immunotherapy-2010_disposition-comments.pdf
    January 01, 2010 - Our group did not use statistical significance/precision to grade articles. … Instead, as described in our methods section, In our grade assignments, we considered the limitations … We used the GRADE tool, as a recognized method when performing effectiveness reviews. … In our grade assignments, we considered the limitations of each individual study’s quality (using the … We did not grade Pulmonary function test because it is an intermediate outcome.

30. Data Points 15: Breast Cancer Diagnostic Workup: Prognostic factor testing among older women with ductal carcinoma in situ and early invasive breast cancer (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/dcis-prognostic-tests_research.pdf
    August 22, 2012 - recurrence include com- edo histology, younger age, larger tumor size, high pathologic or nuclear grade … We analyzed how testing varied by patient age, tumor size, and tumor grade—all factors known to increase … Grade: We defined grade using the data fields provided by SEER: well differenti- ated, moderately/intermediately … Women with DCIS also had a higher incidence of un- known tumor size and grade (Table 1). … , women with DCIS were more likely to have smaller tumors and higher grade tumors.

31. The Performance of Fusion Procedures for Degenerative Disease of teh Lumbar Spine (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/lumbar-fusion-protocol.pdf
    June 20, 2024 - I (0%−25%), Grade II (25%−50%), Grade III (50%−75%), Grade IV (75%−100%) and Grade V (>100%). … Grades I and II are considered low-grade slip, are most common, and are least likely to progress.3,4,11 … Grades III-V are considered a high-grade slip. 2 Management of Degenerative Lumbar Spine … DLS is controversial.6,12,20 Low-grade DLS is the most common6 and may be an incidental radiographic … Management of symptomatic degenerative low-grade lumbar spondylolisthesis.

32. Transparency of Reporting Requirements: Effectiveness of Treatments Options for the Prevention of Complications and Treatment of Symptoms of Diabetic Peripheral Neuropathy (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/transparency-neuropathy_research-protocol.pdf
    September 01, 2016 - qualitative dis- cordance (preliminarily defined as change in direction of conclusion and/or level of grade … We will conduct the following for each outcome by drug comparison: • We will grade the level evidence

33. Bladder-Cancer-Non-Muscle-Invasive Executive (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/bladder-cancer-non-muscle-invasive_executive.pdf
    October 01, 2015 - These include the stage of the cancer, tumor grade (higher grade tumors are more likely to recur and … Does the comparative effectiveness differ according to tumor characteristics, such as stage, grade, … • Effects of tumor grade: Across urinary biomarkers, sensitivity increased with higher tumor grade … with higher tumor grade. … Stage, grade, tumor multiplicity, primary vs.

34. Prostate-Cancer-Therapies-Update Executive (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/prostate-cancer-therapies-update_executive.pdf
    December 01, 2014 - cancer in healthy men of all ages, concluding that the harms of screening outweigh the benefits (Grade … Current practice is to use tumor grade as the primary prognostic variable in patients with clinically … by Owens and colleagues.21 Briefly, a high grade reflects high confidence that the effect estimate … lies close to the true effect; a moderate grade reflects moderate confidence; a 6 low grade reflects … The decision to grade an evidence base as insufficient rather than low often reflected an imprecise

35. Appendix K Rapid Evidence Review Treatments for Clostridium difficile Colitis (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/clinical-pathway-methods-report-appendix-k.pdf
    February 01, 2018 - Grade of Recommendation: Weak recommendation based on low-quality evidence, 2C. … Grade of Recommendation: Strong recommendation based on low-quality evidence, 1C. … ) system Recommendation rating: GRADE system 2. … and ‘we suggest’ for a weak recommendation grade.” 4. … rating: GRADE system 5.

36. Evidence-based Practice Center Systematic Review Protocol (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/screening-counseling-interventions-protocol-amendment.pdf
    February 05, 2025 - Depression and Suicide Risk (B and I Grades) − Screening for Eating Disorders (adolescents only; I Grade … unhealthy Drug Use (adolescent only; B and I Grades) − Counseling regarding Illicit Drug Use (I Grade … the guidance established by the Grading of Recommendations Assessment, Development and Evaluation (GRADE … We will grade the seven outcomes, rated as most important for decision making. … GRADE guidelines: 3. Rating the quality of evidence.

37. Assessing Applicability: Interactive Case Study Quiz (ppt file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/assessing-applicability-quiz.ppt
    May 29, 2025 - Assessing Applicability: Interactive Case Study Quiz Assessing Applicability Interactive Quiz Prepared for: The Agency for Healthcare Research and Quality (AHRQ) Training Modules for Systematic Reviews Methods Guide www.ahrq.gov Assessing Applicability Interactive Quiz Why might trials with run-in periods and …

38. Assessing Applicability: Interactive Case Study Quiz (ppt file)
    effectivehealthcare.ahrq.gov/sites/default/files/assessing-applicability-quiz.ppt
    May 29, 2025 - Assessing Applicability: Interactive Case Study Quiz Assessing Applicability Interactive Quiz Prepared for: The Agency for Healthcare Research and Quality (AHRQ) Training Modules for Systematic Reviews Methods Guide www.ahrq.gov Assessing Applicability Interactive Quiz Why might trials with run-in periods and …

39. Comparative Effectiveness of Strategies to De-escalate Aggressive Behavior in Psychiatric Patients in Acute Care Settings (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/aggression_executive.pdf
    October 01, 2016 - Mirroring our decision not to assess the risk of bias of pre/post studies, we did not grade the SOE … We report below only on findings from trials or studies for which we could grade SOE. … in this report did not control for clustering in their statistical analyses, which weakened the SOE grade … Their inherent high risk of bias precludes drawing inferences of causality, so we did not grade SOE … No KQs had comparative data supporting an SOE grade that exceeded low strength of evidence.

40. Surveillance & Identification of Triggers for Updating Systematic Reviews for the EHC Program (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/head-neck-cancer_surveillance.pdf
    August 01, 2012 - CRT (2DRT) Grade 3 dysphagia 57% vs. 58% Time of onset of grade 3 dysphagia 6.4 vs. 4.8 weeks … ; p = 0.05 Duration grade 3 dysphagia toxicity 4.9 vs. 7.5 weeks; p = 0.03 … CRT (n=14; dose: NR) 2008- 2010 Or Minimum (12 months) Grade 3 dysphagia IMRT vs. … Conventional RT(2DRT) Grade 3 dysphagia 57% vs. 58% Time of onset of grade 3 dysphagia 6.4 … ) Dermatitis (RTOG Grade 3–4) 44 (45) vs. 92 (65); p=0.02 Mucositis (RTOG Grade 3–4) 73 (75%)