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161. high-cholesterol-medicines-update-protocol-130516 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/high-cholestorol-medicines-update_research-protocol.pdf
     December 31, 2013 - We will grade evidence for each outcome identified in the KQs. … We will classify evidence pertaining to KQs 1, 2, and 3 into four categories: (1) “high” grade (indicating … research is very unlikely to change our confidence in the estimate of the effect); (2) “moderate” grade … confidence in the estimate of the effect and is likely to change the estimate); and (4) “insufficient” grade … The grade of evidence for each KQ will be based on consensus.

162. Evaluation of Effectiveness and Safety of Antiepileptic Medications in Patients With Epilepsy (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/epilepsy-medicine_research-protocol.pdf
     February 01, 2008 - Grading the Strength of Evidence We will use EPC methodology based on the criteria and methods of GRADE … The GRADE system uses four required domains – risk of bias, consistency, directness, and precision.45 … Definitions for grading the strength of evidence Grade Definition High There is high confidence that … GRADE handbook for grading quality of evidence and strength of recommendation. … The GRADE Working Group; 2008. 46. Gartlehner G, Hansen RA, Nissman D, et al.

163. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/medication-adherence-interventions_research-protocol.pdf
     August 18, 2011 - We will grade the strength of evidence based on the guidance established by the Evidence-based Practice … Center (EPC) program. 49 Developed to grade the overall strength of a body of evidence, this approach … We will grade the strength of evidence for the outcomes deemed to be of greatest importance to decisionmakers … Definitions of the grades of overall strength of evidence 49 Grade Definition High High confidence

164. Effect-Dietary-Digestible (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/effect-dietary-digestible.pdf
     January 01, 2021 - Grading the Strength of Evidence (SOE) for Major Comparisons and Outcomes We will grade the strength … of the body of evidence (SOE) per the EPC methods guide on assessing SOE.18 We will grade SOE for selected

165. labor-dystocia-protocol-amended-160728 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/labor-dystocia_research-protocol.pdf
     July 28, 2016 - outcome well but did an incomplete analysis of a secondary outcome would be assigned a different quality grade … Brown EPC.25 Grading the Strength of Evidence (SOE) for Major Comparisons and Outcomes We will grade … the body of evidence for a particular outcome includes both RCTs and observational studies, we will grade … In these situations, a grade of “insufficient” will be assigned.

166. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/chronic-cough_research-protocol.pdf
     October 22, 2012 - outcome well but did an incomplete analysis of a secondary outcome would be assigned a different quality grade … Grading the Evidence for Each Key Question We will grade the strength of evidence for each outcome … In these situations, a grade of insufficient will be assigned. … Center Systematic Review Protocol Project Title: Assessment and Management of Chronic Cough We will grade

167. Methods Guide for Comparative Effectiveness Reviews_Inclusion of Nonrandomized Studies of Interventions in Systematic Reviews of Intervention Effectiveness: An Update (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/pdf/methods-guide-inclusion-nonrandomized-studies.pdf
     September 01, 2022 - The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system is widely … of a Body of Evidence That Includes NRSIs The AHRQ EPC Program adopted a modified version of the GRADE … to the lack of randomization and higher potential for confounding.97 Thus, an initial provisional grade … Grade strength of evidence for NRSIs using established guidance. … GRADE guidelines: 3. Rating the quality of evidence.

168. Methods Guide for Comparative Effectiveness Reviews_Inclusion of Nonrandomized Studies of Interventions in Systematic Reviews of Intervention Effectiveness: An Update (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/methods-guide-inclusion-nonrandomized-studies.pdf
     September 01, 2022 - The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system is widely … of a Body of Evidence That Includes NRSIs The AHRQ EPC Program adopted a modified version of the GRADE … to the lack of randomization and higher potential for confounding.97 Thus, an initial provisional grade … Grade strength of evidence for NRSIs using established guidance. … GRADE guidelines: 3. Rating the quality of evidence.

169. Evidence-based Practice Center Technical Brief Protocol: Disparities and Barriers for Pediatric Cancer Survivorship Care (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/pediatric-cancer-survivorship-protocol.pdf
     June 01, 2020 - OR “youngster“ OR “youngsters“ OR “girl“ OR “girls“ OR “boy“ OR “boys“ OR “elementary school*” OR “grade … OR “youngster“ OR “youngsters“ OR “girl“ OR “girls“ OR “boy“ OR “boys“ OR “elementary school*” OR “grade … OR “youngster“ OR “youngsters“ OR “girl“ OR “girls“ OR “boy“ OR “boys“ OR “elementary school*” OR “grade … youngster OR youngsters OR girl OR girls OR boy OR boys OR elementary school OR elementary schools OR grade … school OR grade schools OR preadolescent OR preadolescents OR preadolescence OR pre adolescent OR pre

170. pneumonia-antibiotic-treatment-protocol-130718 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/pneumonia-antibiotic-treatment_research-protocol.pdf
     July 19, 2013 - Abdul-Aziz and colleagues26 did not appraise the quality of individual studies or grade the quality … Grading the Strength of Evidence (SOE) for Individual Comparisons and Outcomes We will grade the … on the guidance established for the Evidence- based Practice Center (EPC) Program.33 Developed to grade … Definitions of the grades of overall strength of evidence Grade Definition High High confidence that … Source: Owens et al.33 We will grade the strength of evidence for the outcomes deemed to be of greatest

171. heart-failure-readmission-protocol-130611 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/heart-failure-transition-care_research-protocol.pdf
     June 10, 2013 - Grading the Strength of Evidence for Individual Comparisons and Outcomes We will grade the strength … based on the guidance established for the Evidence- based Practice Center (EPC) Program.47 Developed to grade … Definitions of the grades of overall strength of evidence Grade Definition High High confidence that … Source: Owens et al., 201047 We will grade the strength of evidence for all outcomes related to … We will not grade the evidence for KQ 3; this question is a descriptive question. G.

172. Alcohol-misuse-drug-therapy-140326 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/alcohol-misuse-drug-therapy_research-protocol.pdf
     January 27, 2012 - Grading the Strength of Evidence (SOE) for Individual Comparisons and Outcomes—We will grade the strength … based on the guidance established for the Evidence-based Practice Center Program.45 Developed to grade … We will grade the strength of evidence for alcohol-consumption measures, accidents, injuries, quality … Definitions of the grades of overall strength of evidence45 Grade Definition High High confidence

173. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/disparities-quality-improvement_research-protocol.pdf
     February 23, 2012 - Studies will be given a quality grade of good, fair, or poor per the Methods Guide for Effectiveness … www.effectivehealthcare.ahrq.gov Published Online: February 23, 2012 12 interest will be given an overall evidence grade … Two senior staff will independently grade the body of evidence; disagreements will be resolved as needed

174. Layout 1 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/renal-artery-stenosis_executive.pdf
     October 01, 2006 - mortality rates, over 40 percent within 6 years, occurred mostly in studies of patients with either high-grade … Among the studies, worse kidney function, higher grade stenosis, various markers of cardiac disease, … The other trial included patients with lower grade stenosis (>50 percent) but did not exclude patients … association with either kidney function or diastolic blood pressure. 1 found that patients with higher grade … Baseline Weak • 2 studies found that higher grade stenosis was independently RAS severity associated

175. Topic 0502 Non-Muscle Invasive Bladder Cancer NSD FINAL_SJ (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND-0587-131115.pdf
     March 06, 2013 - How do tumor characteristics (stage, grade, multiplicity, size, molecular and genetic alterations)

176. CER 174 Executive Summary: Imaging for the Pretreatment of Small Cell Lung Cancer (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/lung-cancer-staging_executive.pdf
     April 01, 2016 - The output is a grade for the strength of evidence: high, moderate, low, or insufficient. … This grade is provided separately for each outcome of each comparison of each KQ. … A grade was determined separately for each modality comparison (e.g., CT vs. PET/CT). … If the evidence was sufficient to permit a conclusion, the grade was deemed high, moderate, or low. … The grade was provided by three independent raters, with discrepancies resolved by consensus.

177. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/colorectal-cancer-liver-metastases-therapies_research-protocol.pdf
     September 27, 2012 - the EPC staff believes that such evidence could impact results meaningfully (i.e., alter evidence GRADE … 27, 2012 evidence is outlined in the Methods Guide25 and is based on a system developed by the GRADE … The grade of evidence strength is classified into the following four categories: • High. … The grade rating will be made by independent reviewers, and disagreements will be resolved by consensus

178. Title (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/obesity-child_research-protocol.pdf
     March 31, 2010 - Grading the Evidence for Each Key Question At the completion of the review, we will grade the quantity … We will classify evidence pertaining to Key Questions 1- 7 into four basic categories: (1) “high” grade … research is very unlikely to change our confidence in the estimate of the effect); (2) “moderate” grade … research may change our confidence in the estimate of the effect and may change the estimate); (3) “low” grade … confidence in the estimate of the effect and is likely to change the estimate); and (4) “insufficient” grade

179. Medical-Evidence-Communication Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/medical-evidence-communication_research-protocol.pdf
     July 31, 2012 - The overall strength of evidence grade is made up of judgments about four required domains. … specific determinations of net benefit and also includes applicability in their judgments about evidence grade … Grading the Strength of Evidence for Individual Outcomes We will grade the strength of evidence on … the basis of guidance established for the EPC Program.38,41 Developed to grade the overall strength … Definitions of the grades of overall strength of evidence Grade Definition High High confidence that

180. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/hepatitis-c_research-protocol.pdf
     November 30, 2011 - Key Question We will use the methods outlined in Chapter 10 of the AHRQ Methods Guide 18 to grade … Based on this assessment, the body of evidence will be assigned a strength-of-evidence grade of high … November 30, 2011 9 evidence does not exist, is sparse, or contains irreconcilable inconsistency, a grade