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141. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/wireless-motility-capsule_research-protocol.pdf
     March 14, 2012 - Grading the Evidence for Each Key Question – At the completion of our review, we will grade the strength … Effectiveness and Comparative Effectiveness Reviews.24,25 Both of these evidence grading schemes are based on GRADE … Source: www.effectivehealthcare.ahrq.gov Published Online: March 14, 2012 the estimate); 3) “low” grade … GRADE: an emerging consensus on rating quality of evidence and strength of recommendations.

142. Amended Protocol: Management of Infantile Epilepsy (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/infantile-epilepsy-amended-protocol.pdf
     March 07, 2021 - We will grade the SOE based on the EPC Methods Guide recommendations.4 The primary domains assessed

143. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/gestational-diabetes-screening-diagnosis_research-protocol.pdf
     December 16, 2011 - Grading the Evidence for Each Key Question Two independent reviewers will grade the strength of the … evidence for major outcomes and comparisons using the Evidence-based Practice Center (EPC) GRADE approach … We will grade the following key outcomes: birth injury, preeclampsia, neonatal hypoglycemia, maternal … We will not grade the evidence on the test properties of the screening and diagnostic tests (KQ1). … Low-quality cohort studies will receive an initial grade of “low” strength of evidence.

144. Executive Summary_Comparative Effectiveness Review No. 259: Partial Breast Irradiation for Breast Cancer (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-259-partial-breast-irradiation-executive-summary.pdf
     January 01, 2023 - There were significantly fewer acute AEs and late AEs Grade ≥2 with IORT. … in clinical trials, for example, postmenopausal age range, estrogen receptor (ER) positive status, grade … patients who participated, for example age <50 years, invasive lobular carcinoma, tumor size 2.1-3 cm, grade

145. Nephropathy-Contrast-Induced Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/nephropathy-contrast-induced_executive.pdf
     October 01, 2015 - consistency, precision, reporting bias, and magnitude of effect.8 Following the guidance of the GRADE … The body of evidence was considered high grade if study limitations were low and there were no problems … GRADE guidelines 6. Rating the quality of evidence--imprecision.

146. Disposition of Comments CER 219 Antipsychotics for the Prevention and Treatment of Delirium (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/delirium-disposition-comments.pdf
     September 03, 2019 - Using positive results to determine which outcomes to grade could potentially introduce some bias into … We reviewed the outcomes where we did not grade the body of evidence (did not do SOE) to ensure that … outlined in the AHRQ Methods Guidance, which is very similar to the approach developed by others such as GRADE … For those that aren’t familiar with AHRQ reports or GRADE methodology, the phrase "strength of evidence … We added a footnote to Figures A and B of the Executive Summary defining each evidence grade.

147. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/tethered-spinal-cord-protocol.pdf
     July 19, 2023 - determining strength of evidence for each primary clinical outcome by following the principles for adapting GRADE … unmeasured confounders) as described in the AHRQ Methods guides.15 A final strength of evidence grade … The strength of evidence will be assigned an overall grade of high, moderate, low, or insufficient

148. Disposition of Comments for CER 202 Effectiveness and Safety of Bronchial Thermoplasty in the Management of Asthma (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-202-thermoplasty-comments.pdf
     December 14, 2017 - Peer Reviewer 2 Methods Please explicitly define the GRADE criteria approach. … Classically, RCTs are usually reported as "the highest grade of evidence". furthermore, Air 2 used a … We would encourage consideration of a greater grade of ‘High’ be used to communicate the strength of … Given the ‘Low’ result describing pulmonary physiology, we would recommend AHRQ consider a ‘High’ grade … Each of the outcomes we deemed critical has its own strength of evidence grade for each intervention

149. Layout 1 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/osteoarthritis-pain_executive.pdf
     October 01, 2011 - evidence for each Key Question using the four categories recommended in the AHRQ guide:19 A “high” grade … further research is very unlikely to change our confidence in the estimate of effect; a “moderate” grade … A recent large, good-quality NIH-funded trial found the combination of pharmaceutical grade glucosamine … product (no pharmaceutical-grade glucosamine available in the United States). 13 Table A. … • Most trials showing therapeutic benefits from glucosamine were conducted using pharmaceutical-grade

150. Dietary Intake of Polyunsaturated Fatty Acids and Plasma Lipid and Cardiovascular Events (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/polyunsaturated-fatty-protocol.pdf
     January 01, 2024 - low-quality evidence per the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE … GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. … Healthcare Research and Quality DRI Dietary reference intake EPC Evidence-based Practice Center GRADE

151. Dietary Saturated Fat Replacement and Plasma Lipid and Cardiovascular Events (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/saturated-fat-replacement-protocol.pdf
     January 01, 2024 - low-quality evidence per the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE … GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. … Healthcare Research and Quality DRI Dietary reference intake EPC Evidence-based Practice Center GRADE

152. The Effectiveness and Risks of Long-Term Opioid Treatment of Chronic Pain (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/chronic-pain-opioid-treatment_executive.pdf
     September 19, 2014 - Summary of evidence Key Question Outcome Strength of Evidence Grade Conclusion 1. … Summary of evidence (continued) 12 Key Question Outcome Strength of Evidence Grade Conclusion … Summary of evidence (continued) 13 Key Question Outcome Strength of Evidence Grade Conclusion … Summary of evidence (continued) 14 Key Question Outcome Strength of Evidence Grade Conclusion … Summary of evidence (continued) 15 Key Question Outcome Strength of Evidence Grade Conclusion

153. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/venous-ulcers-treatment_research-protocol.pdf
     September 13, 2012 - clinical severity, etiology, anatomy, and pathophysiology.5 In this classification scheme, the highest grade … We will grade the strength of evidence based on the quantity, quality, and consistency of the best available … further research is very unlikely to change our confidence in the estimate of the effect); 2) “moderate” grade … confidence in the estimate of the effect and is likely to change the estimate); and 4) “insufficient” grade … dressing, wound filler Foams • Sterile, nonlinting, absorptive dressing made of open cell, medical grade

154. AHRQ Slide Template 2009 (ppt file)
     effectivehealthcare.ahrq.gov/sites/default/files/reporting.ppt
     September 01, 2009 - to be limited to men under 65 years of age but is not dependent on baseline PSA level or histologic grade

155. Han (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/han.pdf
     December 26, 2012 - represented by quality ratings   o Non-­‐quantitative (verbal) o Emerging formal rating systems (USPSTF, GRADE … Slide 24: Representing  ambiguity in clinical evidence: USPSTF A page of grade definitions from  

156. Assessing the Predictive Validity of Strength of Evidence Grades: A Meta-Epidemiological Study | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/grades-predictive-values/white-paper

157. Evaluation of Effectiveness and Safety of Antiepileptic Medications in Patients With Epilepsy (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/epilepsy-medicine_research-protocol.pdf
     February 01, 2008 - Grading the Strength of Evidence We will use EPC methodology based on the criteria and methods of GRADE … The GRADE system uses four required domains – risk of bias, consistency, directness, and precision.45 … Definitions for grading the strength of evidence Grade Definition High There is high confidence that … GRADE handbook for grading quality of evidence and strength of recommendation. … The GRADE Working Group; 2008. 46. Gartlehner G, Hansen RA, Nissman D, et al.

158. Mental-Illness-Adults-Prisons Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/mental-illness-adults-prisons_executive.pdf
     August 01, 2013 - of the 16 included trials received a medium risk-of-bias rating and 1 received a low risk-of-bias grade … The various domains were considered together, along with the size of the evidence base, to grade the … To receive a grade of low or better, at least two studies must have reported consistent results for … We assigned a low strength-of-evidence grade for the following findings. … interventions (continued) Comparison Outcome Risk of Bias Consistency Precision Directness SOE Grade

159. high-cholesterol-medicines-update-protocol-130516 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/high-cholestorol-medicines-update_research-protocol.pdf
     December 31, 2013 - We will grade evidence for each outcome identified in the KQs. … We will classify evidence pertaining to KQs 1, 2, and 3 into four categories: (1) “high” grade (indicating … research is very unlikely to change our confidence in the estimate of the effect); (2) “moderate” grade … confidence in the estimate of the effect and is likely to change the estimate); and (4) “insufficient” grade … The grade of evidence for each KQ will be based on consensus.

160. Effect-Dietary-Digestible (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/effect-dietary-digestible.pdf
     January 01, 2021 - Grading the Strength of Evidence (SOE) for Major Comparisons and Outcomes We will grade the strength … of the body of evidence (SOE) per the EPC methods guide on assessing SOE.18 We will grade SOE for selected