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101. Evidence Report on the (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/osteoarthritis-pain_research-protocol.pdf
     August 05, 2010 - No pharmaceutical grade formulation is approved by the FDA. … Accordingly, this report will focus on studies of nonpharmaceutical grade preparations available in … Studies of pharmaceutical-grade glucosamine and chondroitin will also be included, however; they will … evidence for each key question using the four categories recommended by Owens, et al.13: (1) “high” grade … the confidence in the estimate of effect and is likely to change the estimate; (4) “insufficient” grade

102. Radiotherapy Treatments for Head and Neck Cancer (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/head-neck-cancer-update_clinician.pdf
     August 01, 2015 - PBT Tumor control and survival ��� ��� ��� Grade ≥2 late xerostomia* Significantly reduced incidence … � Quality of life related to late xerostomia Improved with IMRT (���) ��� ��� Other RT-associated grade

103. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/treatment-resistant-depression_research-protocol.pdf
     December 09, 2009 - based on the standard methods of the EPCs, which use a revised version of the approach devised by the GRADE … working group.4 Developed to grade the quality of evidence and the strength of recommendations, this … Atkins D, Eccles M, Flottorp S, et al, for the GRADE Working Group.

104. CER 215 Executive Summary: Adverse Effects of Pharmacologic Treatments of Major Depression in Older Adults (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-215-depression-older-adults-executive-summary.pdf
     March 01, 2019 - variety of potential outcomes on which to focus, and after Technical Expert Panel input, we decided to grade … adverse event profiles, particularly when SOE ratings are low or for outcomes that do not have a SOE grade

105. Telehealth During COVID-19 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/telehealth-during-COVID-19-amendments.pdf
     April 28, 2022 - Grading the Strength of Evidence (SoE) We will grade the body of evidence separately for quantitative … Applying GRADE-CERQual to qualitative evidence synthesis findings: introduction to the series. … Applying GRADE-CERQual to qualitative evidence synthesis findings-paper 4: how to assess coherence. … Applying GRADE-CERQual to qualitative evidence synthesis findings-paper 6: how to assess relevance of … Applying GRADE-CERQual to qualitative evidence synthesis findings-paper 5: how to assess adequacy of

106. Disposition of Comments for CER 222: Achieving Health Equity in Preventive Services (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-222-health-equity-preventive-services-comments.pdf
     December 03, 2019 - The grading system for the evidence appeared to lack clarity-the specific tool used to determine the grade

107. Evidence Report on the (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/rheumatoid-arthritis-medicine_research-protocol.pdf
     December 06, 2010 - the Evidence-based Practice Centers, which use a revised version of the approach devised by the GRADE … Working Group.6 Developed to grade the quality of evidence and the strength of recommendations, this … Atkins D, Eccles M, Flottorp S, et al, for the GRADE Working Group. … of evidence and the strength of recommendations I: critical appraisal of existing approaches: the GRADE

108. Prostate-Cancer-Therapies-Update Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/prostate-cancer-therapies-update_research-protocol.pdf
     April 01, 2013 - Current practice is to use tumor grade as the primary prognostic variable in patients with clinically … localized prostate cancer.2 After biopsy confirms the presence of the cancer, pathologists report tumor grade … active surveillance and other observational management strategies for PSA-screening–detected, low-grade … Strength-of-evidence grade for the body of evidence Grade Evidence-based Practice Center Program Definition … We will consider the primary biology and epidemiology (grade and stage of the prostate cancer) and the

109. Colorectal-Cancer-Staging Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/colorectal-cancer-staging_executive.pdf
     September 01, 2014 - Disease characteristics (e.g., tumor grade)? iii. … Disease characteristics (e.g., tumor grade)? iii. … The grade was developed by considering four important domains: study limitations (based on the risk … Disease characteristics (e.g., tumor grade)? iii. … Disease characteristics (e.g., tumor grade)? iii.

110. Maternal, Fetal, and Child Outcomes of Mental Health Treatments in Women: A Systematic Review of Perinatal Pharmacological Interventions (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/cer-236-maternal-fetal-child-outcomes-disposition-comments.pdf
     April 15, 2021 - Readers that are unfamiliar with the AHRQ or GRADE review methodologies may be confused by phrases … We revised the paragraphs to insert the grade parenthetically when not otherwise stated. … Throughout the document, it would be helpful to minimize use of GRADE related or statistical jargon … The GRADE terminology is confusing enough to the average reader as are the concepts of upgrading and … of the GRADE related terms and jargon.

111. worker-health-protocol-150526 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/worker-health_research-protocol.pdf
     May 26, 2015 - Grading the Strength of Evidence for Major Comparisons and Outcomes: We will grade the strength of evidence … based on the guidance established for the Evidence-based Practice Center Program.23 Developed to grade … We will grade the strength of evidence related to all outcomes relevant to KQ 2. … Definitions of the grades of overall strength of evidence Grade Definition High We are very confident

112. Suicidal-Thoughts-Young-People-Amendement-May-2025 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/suicidal-thoughts-young-people-amendement-may-2025.pdf
     January 01, 2025 - Grading the Strength of Evidence (SOE) for Major Comparisons and Outcomes We will grade the strength … Comparative Effectiveness Reviews on assessing SOE.31 RCTs will start with a provisional high SOE grade … , while observational studies will start with a provisional low SOE grade.31 The domains to be used … for determining final SOE grade will be: the methodological limitations of the studies (i.e., risk of

113. Management of Suicidal Thoughts and Behaviors in Youth (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/suicidal-thoughts-young-people-amendement.pdf
     February 05, 2025 - Grading the Strength of Evidence (SOE) for Major Comparisons and Outcomes We will grade the strength … Comparative Effectiveness Reviews on assessing SOE.31 RCTs will start with a provisional high SOE grade … , while observational studies will start with a provisional low SOE grade.31 The domains to be used … for determining final SOE grade will be: the methodological limitations of the studies (i.e., risk of

114. Interventions to Improve Care of Bereaved Persons (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/bereaved-persons-protocol.pdf
     June 01, 2023 - We will apply the EPC strength of evidence criteria to evaluate the body of evidence, informed by GRADE … determining strength of evidence for each primary clinical outcome by following the principles for adapting GRADE … unmeasured confounders) as described in the AHRQ Methods guides.45 A final strength of evidence grade … The strength of evidence will be assigned an overall grade of high, moderate, low, or insufficient … Judging the quality of evidence in reviews of prognostic factor research: adapting the GRADE framework

115. Management of Suicidal Thoughts and Behaviors in Youth (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/suicidal-thoughts-young-people-draft-protocol.pdf
     March 14, 2024 - Grading the Strength of Evidence (SOE) for Major Comparisons and Outcomes We will grade the strength … Comparative Effectiveness Reviews on assessing SOE.31 RCTs will start with a provisional high SOE grade … , while observational studies will start with a provisional low SOE grade.31 The domains to be used … for determining final SOE grade will be: the methodological limitations of the studies (i.e., risk of

116. Evidence-based Practice Center Systematic Review Protocol: Therapies for Clinically Localized Prostate Cancer (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/prostate-cancer-therapies-protocol_amended110619.pdf
     November 02, 2019 - characteristics (e.g., age, ethnicity, comorbidities, preferences), tumor characteristics (e.g., PSA, histologic grade … Comparisons and Outcomes: We will use the Grading of Recommendations Assessment, Development and Evaluation (GRADE … We will present the overall quality or certainty of the evidence for key outcomes according to the GRADE … GRADE guidelines: 11. … localized prostate cancer EAU= European Association of Urology EBRT= external beam radiotherapy GRADE

117. Dietary-Supplements Surveillance (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/dietary-supplements_surveillance.pdf
     January 01, 2013 - identified on the interaction between omega-3 fatty acids, both over-the- counter and prescription-grade … plus warfarin vs. warfarin alone: no significant difference in post-treatment INR (inconclusive; grade … studies were identified by the search and/or experts. 3 of the studies reported on prescription-grade … The mean SBP was significantly lowered in the supplement- statin combination group (grade: low) in … The mean SBP was significantly lowered in the supplement-statin combination group (grade: low) in 22

118. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/type-2-diabetes-medications-update_research-protocol.pdf
     April 06, 2010 - Grading the Evidence for Each Key Question At the completion of our review, we will grade the quantity … will classify evidence pertaining to Key Questions 1, 2 and 3, into four basic categories: (1) “high” grade … research is very unlikely to change our confidence in the estimate of the effect); (2) “moderate” grade … research may change our confidence in the estimate of the effect and may change the estimate); (3) “low” grade … confidence in the estimate of the effect and is likely to change the estimate); and (4) “insufficient” grade

119. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/colorectal-cancer-screening_research-protocol.pdf
     May 18, 2011 - histology) c) Composite outcome, that is, advanced neoplasia (adenocarcinoma, adenomas with high-grade … Grading the Evidence for Each Key Question We will grade the strength of evidence for primary outcomes … as outlined in the Methods Guide for Effectiveness and Comparative Effectiveness Reviews. 17 The grade … Strength of evidence grades and definitions Grade Definition High High confidence that the evidence

120. Pharmacologic Management of Acute Pain by EMS in the Prehospital Setting Protocol Amendment (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/acute-pain-ems-protocol-amendment.pdf
     January 28, 2019 - Grading the Strength of Evidence (SOE) for Major Comparisons and Outcomes - We will grade the SOE … based on the guidance established for the EPC program.31 We plan to grade the comparisons of opioids … At the completion of the review, two reviewers will independently grade the SOE.