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81. What is the comparative effectiveness and harms of treatments for traumatic brain injury? Preliminary Key Questions 1. What is the comparative effectiveness of the treatments for TBI for grades I-IV? 2. For patients, what are the potential… | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/what-is-the-comparative-effectiveness-and-harms-of-treatments-for-traumatic-brain-injury-preliminary-key-questions-1-what-is-the-comparative-effectiveness-of-the-treatments-for-tbi-for-grades-i-iv-2-for-patients-what-are-the
    November 01, 2017 - Skip to main content An official website of the Department of Health & Human Services Careers Contact Us Español FAQs Effective Health Care Program Powered by the Evidence-based Practice Centers …

82. Comparative Effectiveness of Screening for Glaucoma | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/glaucoma-screening/research-protocol
    December 01, 2019 - We will use an evidence-grading scheme recommended by the GRADE Working Group, 14 adapted by AHRQ in … is evaluated by at least one randomized controlled trial and by observational studies, our evidence grade … If an outcome is evaluated by one or no randomized controlled trials, our evidence grade will be based … Effectiveness Reviews 15 and by Owens and colleagues. 16 For each outcome of interest, two reviewers will grade … Atkins D, Best D, Briss PA, et al, for the GRADE Working Group.

83. Research to Improve the Delivery of Clinical Preventive Services to People with Disabilities (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/wysiwyg/stakeholder-report_0824.pdf
    August 01, 2024 - It focused on 20 high-priority clinical preventive services with Grade A or B recommendations from the … Grade Definition A The USPSTF recommends the service. … available at https://www.uspreventiveservicestaskforce.org/uspstf/about-uspstf/methods-and- processes/grade-definitions … https://www.uspreventiveservicestaskforce.org/uspstf/about-uspstf/methods-and-processes/grade-definitions … https://www.uspreventiveservicestaskforce.org/uspstf/about-uspstf/methods-and-processes/grade-definitions

84. Comparative Effectiveness of Adjunctive Devices to Remove Thrombi or Protect Against Distal Embolization in Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention of Native Vessels | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/acs-pci-adjunctive-devices/research-protocol
    December 01, 2019 - despite patent coronary vessels—often defined as (1) a thrombolysis in myocardial infarction (TIMI) flow grade … vessel patency and the absence of dissection, spasm or distal macroembolus, or (2) a myocardial blush grade … pertaining to each key question will be classified into three broad categories: high, moderate, or low grade … Definitions for grading the strength of evidence Grade Definition High There is … Practice Center MACE major adverse cardiac event MBG myocardial blush grade

85. Diabetes Medications for Adults with Type 2 Diabetes: An Update | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/diabetes-update-2015/research
    December 01, 2019 - using a protocol adapted from the Grading of Recommendations Assessment, Development, and Evaluation (GRADE

86. Effectiveness of Recombinant Human Growth Hormone in the Treatment of Cystic Fibrosis — Research Protocol Document | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/cystic-fibrosis-hgh/research-protocol
    December 01, 2019 - A separate grade will be given for all major outcomes, including benefits and harms. … We will then use the subsequent domains to modify the overall grade. … The evidence report will also include the definitions used, and the final grade of high, moderate, low … GRADE handbook for grading quality of evidence and strength of recommendation. … The GRADE Working Group, 2008. Available at: http://www.cc-ims.net/gradepro.

87. Data Points 14: Use of Endocrine Therapy (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/dcis-endocrine-therapy_research.pdf
    August 01, 2012 - With early inva- sive disease, use increased with increasing tumor size and declined with higher grade … Grade: We defined grade using the fields provided by SEER: well differentiated, moderately/intermediately … Use did not vary greatly across tumor size or grade. … Tumor Grade DCIS Early Invasive 0 25 50 75 100 Not Done Positive Negative Unknown Pa tie nt … With early invasive dis- ease, use increased with increasing tumor size and declined with higher grade

88. Menopausal Symptoms: Comparative Effectiveness Review of Therapies | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/menopause/research-protocol
    December 01, 2019 - primary evidence base 34 (supplemented by any more recent RCTs and observational studies when the GRADE … or ovarian cancer Criteria Inclusion/Exclusion a If evidence is sufficient to grade … Moreover, all observational data are considered lesser (low) GRADE strength. 45 The perspective here … The GRADE definitions are as follows: High : High confidence that the evidence reflects the true … GRADE guidelines: 3. Rating the quality of evidence. J Clin Epidemiol 2011;64(4):401-6.

89. Assessing the Quality of Individual Studies (ppt file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/assessing-quality.ppt
    January 01, 2010 - Assessing the Quality of Individual Studies Assessing the Quality of Individual Studies Agency for Healthcare Research and Quality (AHRQ) Training Modules for Methods Guide on Effectiveness and Comparative Effectiveness Reviews Assessing the Quality of Individual Studies Systematic Review Process Overview * …

90. Recurrent Nephrolithiasis in Adults and Children: Comparative Effectiveness of Preventive Medical Strategies | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/kidney-stones/protocol
    December 01, 2024 - (Grading of Recommendations Assessment, Development and Evaluation) working group. 21 We will grade … We will grade SOE for the outcomes detailed in Table 2 as they are critical or important to decision … Otherwise, we will assign an overall SOE grade for each comparison and outcome as high, moderate, low … GRADE Working Group. Welcome to the GRADE working group . 2024. Accessed on September 24, 2024. … GRADE Guidance 34: update on rating imprecision using a minimally contextualized approach.

91. Evidence-based Practice Center Systematic Review Protocol (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/genitourinary-symptoms-protocol_0.pdf
    July 10, 2023 - )28 for rating evidence certainty, we will use the GRADE approach to assess the overall quality of … We will GRADE the 8 consensus outcomes identified in the Core Outcomes in Menopause (COMMA) review.29 … The GRADE approach assesses five criteria which measure either internal validity (risk of bias, … Guyatt GH OA, Kunz R, Vist GE, Falck-Ytter Y, Schünemann HJ; GRADE Working Group. … GRADE guidelines: 11.

92. Evidence-based Practice Center Systematic Review Protocol (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/cystic-fibrosis-hgh_research-protocol.pdf
    August 22, 2008 - A separate grade will be given for all major outcomes, including benefits and harms. … We will then use the subsequent domains to modify the overall grade. … The evidence report will also include the definitions used, and the final grade of high, moderate, low … GRADE handbook for grading quality of evidence and strength of recommendation. … The GRADE Working Group, 2008.

93. Assessing the Risk of Bias of Individual Studies in Systematic Reviews of Health Care Interventions (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/methods-guidance-bias-individual-studies_methods.pdf
    March 01, 2012 - and evidence from randomized controlled trials a high grade. … GRADE guidelines 6. Rating the quality of evidence-imprecision. … GRADE guidelines: 8. Rating the quality of evidence-indirectness. … GRADE guidelines: 7. Rating the quality of evidence-inconsistency. … GRADE guidelines: 5. Rating the quality of evidence-publication bias.

94. Obesity-Child Executive (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/obesity-child_executive.pdf
    March 31, 2010 - Within this hierarchy, each study contributed only one weight-related measure to the grade. … We did not grade adverse events or clinical outcomes. … We classified evidence pertaining to the KQs into four categories: (1) “high” grade, indicating high … research is very unlikely to change our confidence in the estimate of the effect; (2) “moderate” grade … We caution that a high strength-of-evidence grade is not necessarily an indicator of effectiveness;

95. Slide 1 (ppt file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/marketing_evidence_evans.ppt
    September 13, 2006 - 0.564 _Idma* All Grades Trend in actual smoking Predicted trend if truth did not exist 8th Grade … medumiss 0.6458029 0.000 pctotfund2 1.020214 0.180 rprice 1.006923 0.956 _Idma* 8th Grade … 0.1908482923 0.1745698 0.1745557681 0.1464191 0.1629967384 0.1218577 0.1427140374 0.106999 0.1233924489 10th Grade … 0.8132422 0.000 pctotfund2 0.973652 0.033 rprice 0.9999468 1.000 _Idma* 10th Grade … medumiss 0.9907165 0.883 pctotfund2 1.004672 0.752 rprice 1.00859 0.92 _Idma* 12th Grade

96. Comparative Effectiveness of Drug Therapy for Rheumatoid Arthritis in Adults – An Update to the 2007 Report | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/rheumatoid-arthritis-medicine/research-protocol
    December 01, 2019 - of the Evidence-based Practice Centers, which use a revised version of the approach devised by the GRADE … Working Group. 6 Developed to grade the quality of evidence and the strength of recommendations, this … Atkins D, Eccles M, Flottorp S, et al, for the GRADE Working Group. … quality of evidence and the strength of recommendations I: critical appraisal of existing approaches: the GRADE

97. Attention Deficit Hyperactivity Disorder: Effectiveness of Treatment in At-risk Preschoolers; Long-term Effectiveness in All Ages; and Variability in Prevalence, Diagnosis, and Treatment | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/adhd/research-protocol
    December 01, 2019 - Preschoolers with ADHD may continue to have difficulties with attention, learning and behavior in grade … Evidence for Each Key Question We will assess the overall strength of the body of the evidence using the GRADE … certainty surrounding an effect estimate for a specific outcome) There are factors recommended by the GRADE … therapy, importance of the outcome being evaluated) that may be taken into consideration when assigning a GRADE … Cochrane Handbook for Systematic Reviews of Interventions: The Cochrane Collaboration, 2008. 21 Grade

98. Evidence Report on the (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/glaucoma-screening_research-protocol.pdf
    November 16, 2010 - We will use an evidence-grading scheme recommended by the GRADE Working http://www.effectivehealthcare.ahrq.gov … evaluated by at least one randomized controlled trial and by observational studies, our evidence grade … If an outcome is evaluated by one or no randomized controlled trials, our evidence grade will be based … Effectiveness Reviews15 and by Owens and colleagues.16 For each outcome of interest, two reviewers will grade … Atkins D, Best D, Briss PA, et al, for the GRADE Working Group.

99. The Role of Immunotherapy and the Management of Asthma: Systematic Review | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/asthma-immunotherapy/research-protocol
    April 01, 2021 - Grading the Evidence for Each Key Question For key questions 1 and 3 we will grade asthma control composite … For key questions 2 and 4 we will grade harms: anaphylaxis, hypersensitivity adverse effects and death … tables. 40 We will classify evidence pertaining to the Key Questions into four categories: (1) "High" grade … further research is very unlikely to change our confidence in the estimate of the effect); (2) "Moderate" grade … confidence in the estimate of the effect and is likely to change the estimate); and (4) "Insufficient" grade

100. Assessing the Impact of Economic Evidence on Policymakers in Health Care — A Systematic Review | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/economic-evidence/research
     November 01, 2017 - evidence using an adaptation of the grading of recommendations assessment development and evaluation (GRADE