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61. Appendix K Rapid Evidence Review Treatments for Clostridium difficile Colitis (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/clinical-pathway-methods-report-appendix-k.pdf
    February 01, 2018 - Grade of Recommendation: Weak recommendation based on low-quality evidence, 2C. … Grade of Recommendation: Strong recommendation based on low-quality evidence, 1C. … ) system Recommendation rating: GRADE system 2. … and ‘we suggest’ for a weak recommendation grade.” 4. … rating: GRADE system 5.

62. Surveillance & Identification of Triggers for Updating Systematic Reviews for the EHC Program (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/head-neck-cancer_surveillance.pdf
    August 01, 2012 - CRT (2DRT) Grade 3 dysphagia 57% vs. 58% Time of onset of grade 3 dysphagia 6.4 vs. 4.8 weeks … ; p = 0.05 Duration grade 3 dysphagia toxicity 4.9 vs. 7.5 weeks; p = 0.03 … CRT (n=14; dose: NR) 2008- 2010 Or Minimum (12 months) Grade 3 dysphagia IMRT vs. … Conventional RT(2DRT) Grade 3 dysphagia 57% vs. 58% Time of onset of grade 3 dysphagia 6.4 … ) Dermatitis (RTOG Grade 3–4) 44 (45) vs. 92 (65); p=0.02 Mucositis (RTOG Grade 3–4) 73 (75%)

63. head-neck-cancer-update-140204 (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/head-neck-cancer-update_research-protocol.pdf
    February 04, 2014 - The EPC should specify the comparison and outcome for which the SOE grade applies. … In the EPC grading system, a body of evidence including RCTs is assigned a provisional SOE grade of … This type of evidence is generally assigned a provisional initial SOE grade of “low”. … The overall SOE grade is classified into four categories as shown in Table 2. … The overall SOE grade for each outcome will be specifically reported in this table. Table 2.

64. Radiation Therapy for Metastatic Bone Disease: Effectiveness and Harms | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/radiation-therapy-bone-metastases/research
    December 01, 2023 - time None N=137, 47.4% vs. 61.2%, RR 0.77, 95% CI 0.56 to 1.07 low SOE Harms/AEs — Toxicity, Acute Grade … low SOE Harms/AEs — Pathological Fracture Not Reported No evidence     Harms/AEs — Toxicity, Acute Grade … None 1 RCT, N=431, 3.3% vs. 5.6%, RR 0.58, 95% CI 0.23 to 1.45 low SOE Harms/AEs — Toxicity, Acute Grade … ≥3 Bone Pain Not Reported No evidence     Harms/AEs — Toxicity, Acute Grade 3, 4 Other Not Reported … ≥3 Bone Pain Acute, Not Reported Moderate 1 RCT, N=298 low SOE Harms/AEs — Toxicity, Grade 3, 4 Acute

65. Supplemental Project To Assess the Transparency of Reporting Requirements for Studies Evaluating the Effectiveness of Treatment Options for Symptoms of Diabetic Peripheral Neuropathy | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/transparency-neuropathy/research
    December 01, 2019 - We compared conclusions and SOE grade with and without ClinicalTrials.gov records for pain and quality

66. Radiotherapy Treatments for Head and Neck Cancer: Update | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/head-neck-cancer-update/research-protocol
    December 01, 2019 - The EPC should specify the comparison and outcome for which the SOE grade applies. … In the EPC grading system, a body of evidence including RCTs is assigned a provisional SOE grade of “ … This type of evidence is generally assigned a provisional initial SOE grade of “low”. … The overall SOE grade is classified into four categories as shown in Table 2. … The overall SOE grade for each outcome will be specifically reported in this table. Table 2.

67. Dietary-Supplements Executive (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/dietary-supplements_executive.pdf
    April 01, 2012 - Objectives The objective of this Comparative Effectiveness Review was to systematically synthesize and grade … Overall, no significant differences (grade: insufficient; results inconclusive) were seen between the … The mean SBP was significantly lowered in the supplement-statin combination group (grade: low) in 22 … : low), and triglycerides (grade: low), but not HDL-C (inconclusive, grade: insufficient) or SBP (inconclusive … Likewise, there was no significant difference in blood pressure (inconclusive; grade: insufficient)

68. Data Points 13: Use of Preoperative Breast MRI among older women with ductal carcinoma in situ and locally invasive breast cancer (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/dcis-mri-utilization_research.pdf
    August 01, 2012 - Grade: We defined grade using the field provided by SEER: well dif- ferentiated, moderately/intermediately … Increasing size and higher grade are related to higher rates of MRI use for women with DCIS but not … Among women with invasive cancer, rates of MRI use de- creased with higher grade disease. … Use was higher for women with larger or higher grade tumors. … Size <1 cm (incl micro) 438 13.9 1,801 19.0 <2 cm 274 17.5 2,643 19.4 ≥2 cm 240 22.5 1,669 17.7 Grade

69. Assessing the Risk of Bias of Individual Studies in Systematic Reviews of Health Care Interventions | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/methods-guidance-bias-individual-studies/methods
    October 01, 2019 - and evidence from randomized controlled trials a high grade. … GRADE guidelines 6. Rating the quality of evidence-imprecision. … GRADE guidelines: 8. Rating the quality of evidence-indirectness. … GRADE guidelines: 7. Rating the quality of evidence-inconsistency. … GRADE guidelines: 5. Rating the quality of evidence-publication bias.

70. 04-E029-1 Summary (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/prostate-cancer-surveillance_executive.pdf
    December 01, 2011 - The quality grade was confirmed by at least one other team member. … tumor grade (level of tumor differentiation or Gleason score). … Tumor grade Three studies reported information on prostate cancer mortality stratified by tumor grade … One required that less than 25 percent of the tumor was Gleason grade 4 and less than 5 percent grade … grade (≥7) tumors, and a concomitant increase in intermediate grade tumors (Gleason 5–6).

71. Disposition of Comments for Treatments for Seasonal Allergic Rhinitis (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/allergy-seasonal_disposition-comments.pdf
    July 17, 2013 - of “insufficient evidence” is not included in the GRADE approach and it might be reasonable to admit … that the grading used here was a modification of the GRADE approach. … The reference cited in the report states, “Strength of evidence receives a single grade: high, moderate … AHRQ Methods Guide states:5 “EPCs should grade strength of evidence separately for each major outcome … The translation of USPSTF quality ratings of individual trials to GRADE risk of bias assessments is

72. EHC Protocol: Recurrent Nephrolithiasis in Adults and Children: Comparative Effectiveness of Preventive Medical Strategies (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/kidney-stones-protocol.pdf
    September 24, 2024 - (Grading of Recommendations Assessment, Development and Evaluation) working group.21 We will grade … We will grade SOE for the outcomes detailed in Table 2 as they are critical or important to decision … Otherwise, we will assign an overall SOE grade for each comparison and outcome as high, moderate, low … GRADE Working Group. Welcome to the GRADE working group. 2024. https://www.gradeworkinggroup.org/. … GRADE Guidance 34: update on rating imprecision using a minimally contextualized approach.

73. Imaging for Pretreatment Staging of Small Cell Lung Cancer | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/lung-cancer-staging/research-protocol
    December 01, 2019 - The reason that we will consider sensitivity and specificity together for a single grade is that the … The output is a grade for the strength of evidence: High, Moderate, Low, or Insufficient. … This grade is provided separately for each outcome of each comparison of each Key Question. … This domain will generally increase the strength of evidence grade. Strength of association . … If true, this domain will generally increase the strength of evidence grade.

74. NIH State-of-the-Science Conference: Role of Active Surveillance in the Management of Men With Localized Prostate Cancer | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/prostate-cancer-surveillance/research-protocol
    December 01, 2019 - ) either regional lymph node involvement (N0–X) or metastases (M0–X), regardless of age, histologic grade … Grading the Strength of Evidence When it is appropriate to do so, we will grade the strength of evidence

75. Disposition of Comments for CER 153 Non-Muscle-Invasive Bladder Cancer (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/bladder-cancer-non-muscle-invasive_disposition-comments.pdf
    October 27, 2015 - On one end of the spectrum are patients with low grade noninvasive tumors that rarely develop tumors … Suggest deleting this retaining the description as a flat high grade cancer confined to the inside … As noted by the reviewer, accuracy increased with higher tumor stage and grade. … I assume that these (low and high grade) were lumped together. … As noted by the reviewer, accuracy increased with higher tumor stage and grade.

76. Layout 1 (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/antidepressants-update_executive.pdf
    December 01, 2011 - Some results are now supported by better evidence than in 2007, which is reflected in a higher grade … Some results are now supported by better evidence than in 2007, which is reflected in a higher grade

77. Frameworks for Determining Research Gaps During Systematic Reviews (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/methods-future-research-steps-framework_research.pdf
    June 01, 2011 - • GRADE: The GRADE Working Group advises decreasing the grade of the quality of the evidence if … • GRADE: Consistency is a key element. … o GRADE: The GRADE Working Group advises decreasing the grade of the quality of the evidence if the … o GRADE: Consistency is a key element. … o GRADE: Directness is a key element.

78. Renal-Cancer Research-Protocol (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/renal-cancer_research-protocol.pdf
    April 20, 2015 - with cytopathology or surgical pathology) in establishing a diagnosis (malignancy, histology and grade … Major Comparisons and Outcomes: At the completion of our review, two reviewers will independently grade … We will grade the strength of evidence addressing management studies using the evidence grading scheme … ; 2) “moderate” grade; 3) “low” grade; and 4) “insufficient” grade. … Table 7 defines each strength of evidence grade. Table 7.

79. Cancer-Pancreas Executive (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cancer-pancreas_executive.pdf
    September 01, 2014 - The output is a grade of the strength of evidence: high, moderate, low, or insufficient. … This grade is made separately for each outcome of each comparison of each KQ. … The grade was provided by two independent raters, and discrepancies were resolved by consensus. … We did not grade the strength of the evidence from systematic reviews. … We did not grade the strength of evidence for harms.

80. Evidence-based Practice Center Review Protocol (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/prostate-cancer-surveillance_research-protocol.pdf
    May 19, 2011 - either regional lymph node involvement (N0–X) or metastases (M0–X), regardless of age, histologic grade … Grading the Strength of Evidence When it is appropriate to do so, we will grade the strength of