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41. Standardized Library of Lung Cancer Outcome Measures (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/wysiwyg/white-paper-lung-cancer.pdf
    August 01, 2021 - Regarding toxicity, over 750 Grade 3 or Grade 4 complications are listed in CTCAE v5 for radiation therapy … Rather than model each complication, observations were created for “CTCAE grade 3” and “CTCAE grade … This approach also allows the definition to capture Grade 3 or Grade 4 complications, regardless of … infarction Unexpected return to operating room (any cause) Radiation therapy complications CTCAE grade … 3 or 4 complications due to radiotherapy Systemic therapy complications CTCAE grade 3 or 4 complications

42. Transparency of Reporting Requirements: Effectiveness of Treatments Options for the Prevention of Complications and Treatment of Symptoms of Diabetic Peripheral Neuropathy (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/transparency-neuropathy_research-protocol.pdf
    September 01, 2016 - qualitative dis- cordance (preliminarily defined as change in direction of conclusion and/or level of grade … We will conduct the following for each outcome by drug comparison: • We will grade the level evidence

43. Grading the Strength of a Body of Evidence When Assessing Health Care Interventions: An Update | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/methods-guidance-grading-evidence
    March 01, 2021 - Skip to main content An official website of the Department of Health & Human Services Careers Contact Us Español FAQs Effective Health Care Program Powered by the Evidence-based Practice Centers …

44. Transparency of Reporting Requirements: Effectiveness of Treatments Options for the Prevention of Complications and Treatment of Symptoms of Diabetic Peripheral Neuropathy | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/transparency-neuropathy/research-protocol
    June 01, 2021 - qualitative discordance (preliminarily defined as change in direction of conclusion and/or level of grade … We will conduct the following for each outcome by drug comparison: We will grade the level evidence

45. The Performance of Fusion Procedures for Degenerative Disease of the Lumbar Spine | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/lumbar-spinal-fusion/protocol
    December 01, 2024 - , 9 The Meyerding classification 10 is commonly used to describe the percent of vertebral slip as Grade … I (0%−25%), Grade II (25%−50%), Grade III (50%−75%), Grade IV (75%−100%) and Grade V (>100%). … Grades I and II are considered low-grade slip, are most common, and are least likely to progress. 3 , … 4 , 11 Grades III-V are considered a high-grade slip. … Management of symptomatic degenerative low-grade lumbar spondylolisthesis.

46. Prostate-Cancer-Therapies-Update Executive (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/prostate-cancer-therapies-update_executive.pdf
    December 01, 2014 - cancer in healthy men of all ages, concluding that the harms of screening outweigh the benefits (Grade … Current practice is to use tumor grade as the primary prognostic variable in patients with clinically … by Owens and colleagues.21 Briefly, a high grade reflects high confidence that the effect estimate … lies close to the true effect; a moderate grade reflects moderate confidence; a 6 low grade reflects … The decision to grade an evidence base as insufficient rather than low often reflected an imprecise

47. Data Points 15: Breast Cancer Diagnostic Workup: Prognostic factor testing among older women with ductal carcinoma in situ and early invasive breast cancer (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/dcis-prognostic-tests_research.pdf
    August 22, 2012 - recurrence include com- edo histology, younger age, larger tumor size, high pathologic or nuclear grade … We analyzed how testing varied by patient age, tumor size, and tumor grade—all factors known to increase … Grade: We defined grade using the data fields provided by SEER: well differenti- ated, moderately/intermediately … Women with DCIS also had a higher incidence of un- known tumor size and grade (Table 1). … , women with DCIS were more likely to have smaller tumors and higher grade tumors.

48. Strength of Evidence | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/methods-guidance-grading-evidence/slides
    January 01, 2020 - Skip to main content An official website of the Department of Health & Human Services Careers Contact Us Español FAQs Effective Health Care Program Powered by the Evidence-based Practice Centers …

49. Frameworks for Determining Research Gaps During Systematic Reviews | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/methods-future-research-steps-framework/research
    December 01, 2019 - used evidence grading systems: the Grading of Recommendations Assessment, Development and Evaluation (GRADE

50. Comparative Effectiveness of Strategies to De-escalate Aggressive Behavior in Psychiatric Patients in Acute Care Settings (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/aggression_executive.pdf
    October 01, 2016 - Mirroring our decision not to assess the risk of bias of pre/post studies, we did not grade the SOE … We report below only on findings from trials or studies for which we could grade SOE. … in this report did not control for clustering in their statistical analyses, which weakened the SOE grade … Their inherent high risk of bias precludes drawing inferences of causality, so we did not grade SOE … No KQs had comparative data supporting an SOE grade that exceeded low strength of evidence.

51. Effective Health Care (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/TND_0210_12-07-2009.pdf
    January 01, 2009 - adolescents, and adults with sustained cognitive, physical, and/or psychological impairments from a grade … Staff-Generated PICO Population(s): Children, adolescents, and adults six months post an initial grade

52. The Performance of Fusion Procedures for Degenerative Disease of teh Lumbar Spine (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/lumbar-fusion-protocol.pdf
    June 20, 2024 - I (0%−25%), Grade II (25%−50%), Grade III (50%−75%), Grade IV (75%−100%) and Grade V (>100%). … Grades I and II are considered low-grade slip, are most common, and are least likely to progress.3,4,11 … Grades III-V are considered a high-grade slip. 2 Management of Degenerative Lumbar Spine … DLS is controversial.6,12,20 Low-grade DLS is the most common6 and may be an incidental radiographic … Management of symptomatic degenerative low-grade lumbar spondylolisthesis.

53. Implementation of Recommended Screening and Counseling Interventions to Prevent Mental Health Disorders in Children and Adolescents | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/behavioral-health-screening/protocol
    February 01, 2025 - for Depression and Suicide Risk (B and I Grades) Screening for Eating Disorders (adolescents only; I Grade … Grading the Strength of Evidence for Major Comparisons and Outcomes We will grade the strength of evidence … the guidance established by the Grading of Recommendations Assessment, Development and Evaluation (GRADE … We will grade the seven outcomes, rated as most important for decision making. … GRADE guidelines: 3. Rating the quality of evidence.

54. Evidence-based Practice Center Systematic Review Protocol (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/screening-counseling-interventions-protocol-amendment.pdf
    February 05, 2025 - Depression and Suicide Risk (B and I Grades) − Screening for Eating Disorders (adolescents only; I Grade … unhealthy Drug Use (adolescent only; B and I Grades) − Counseling regarding Illicit Drug Use (I Grade … the guidance established by the Grading of Recommendations Assessment, Development and Evaluation (GRADE … We will grade the seven outcomes, rated as most important for decision making. … GRADE guidelines: 3. Rating the quality of evidence.

55. Bladder-Cancer-Non-Muscle-Invasive Executive (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/bladder-cancer-non-muscle-invasive_executive.pdf
    October 01, 2015 - These include the stage of the cancer, tumor grade (higher grade tumors are more likely to recur and … Does the comparative effectiveness differ according to tumor characteristics, such as stage, grade, … • Effects of tumor grade: Across urinary biomarkers, sensitivity increased with higher tumor grade … with higher tumor grade. … Stage, grade, tumor multiplicity, primary vs.

56. Implementation of Recommended Screening and Counseling Interventions to Prevent Mental Health Disorders in Children and Adolescents (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/screening-counseling-interventions-protocol.pdf
    October 01, 2023 - Depression and Suicide Risk (B and I Grades) − Screening for Eating Disorders (adolescents only; I Grade … Grading the Strength of Evidence for Major Comparisons and Outcomes We will grade the strength of evidence … the guidance established by the Grading of Recommendations Assessment, Development and Evaluation (GRADE … We will grade the seven outcomes, rated as most important for decision making. … GRADE guidelines: 3. Rating the quality of evidence.

57. Assessing Applicability: Interactive Case Study Quiz (ppt file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/assessing-applicability-quiz.ppt
    September 02, 2013 - Assessing Applicability: Interactive Case Study Quiz Assessing Applicability Interactive Quiz Prepared for: The Agency for Healthcare Research and Quality (AHRQ) Training Modules for Systematic Reviews Methods Guide www.ahrq.gov Assessing Applicability Interactive Quiz Why might trials with run-in periods and …

58. Assessing Applicability: Interactive Case Study Quiz (ppt file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/assessing-applicability-quiz.ppt
    September 02, 2013 - Assessing Applicability: Interactive Case Study Quiz Assessing Applicability Interactive Quiz Prepared for: The Agency for Healthcare Research and Quality (AHRQ) Training Modules for Systematic Reviews Methods Guide www.ahrq.gov Assessing Applicability Interactive Quiz Why might trials with run-in periods and …

59. Supplemental Project To Assess the Transparency of Reporting Requirements for Studies Evaluating the Effectiveness of Treatment Options for Symptoms of Diabetic Peripheral Neuropathy (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/transparency-neuropathy_research.pdf
    March 01, 2018 - grade remained “Insufficient.” … No effect Although we now have a body of evidence to grade, the overall evidence grade remained “ … , the overall evidence grade remained “Insufficient.” … No effect Although we now have a body of evidence to grade, the overall evidence grade remained “ … The overall evidence grade would remain “Insufficient.”

60. Management of Renal Masses and Localized Renal Cancer | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/renal-cancer/research-protocol
    December 01, 2019 - Major Comparisons and Outcomes At the completion of our review, two reviewers will independently grade … We will grade the strength of evidence addressing management studies using the evidence grading scheme … The evidence pertaining to the KQs classify into four basic categories: 1) “high” grade; 2) “moderate … ” grade; 3) “low” grade; and 4) “insufficient” grade. … Table 6 defines each strength of evidence grade. Table 6.