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381. Comparative Effectiveness of Strategies to De-escalate Aggressive Behavior in Psychiatric Patients in Acute Care Settings | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/aggression/research-protocol
     January 01, 2020 - We will take the limitations of certain study designs into consideration when we grade the strength of … selection modeling. 71 Grading the Strength of Evidence for Major Comparisons and Outcomes We will grade … the strength of evidence based on the guidance established for the EPC Program. 69 Developed to grade … not assess the risk of bias of noncontrolled or single-group pre/post studies, we plan also not to grade … Definition of strength of evidence grades Grade Definition High We are very confident

382. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/preterm-birth-terbutaline-pump_disposition-comments.pdf
     September 01, 2011 - Please read the paper by Owens at al we referenced for the methodology we followed to grade the strength

383. Noninvasive, Nonpharmacological Treatment for Chronic Pain | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/nonpharma-treatment-pain/research-protocol
     December 01, 2019 - determining strength of evidence for each primary clinical outcome by following the principles for adapting GRADE … unmeasured confounders) as described in the AHRQ Methods guides. 18,22 A final strength of evidence grade … The strength of evidence will be assigned an overall grade of high, moderate, low, or insufficient according

384. Disposition of Comments Report for Pressure Ulcer Risk Assessment and Prevention (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/pressure-ulcer-prevention_disposition-comments.pdf
     May 08, 2013 - Peer Reviewer #6 Introduction Introduction: Page 33: the word grade has been dropped, use stage or … The NPUAP has now adopted the term "Stage" rather than "Grade". … For further details about modification to GRADE and rationale please see the EPC Methods Guide at http … Also there is no grade V. … a more advanced static support surface (an air suspension bed) associated with decreased risk of grade

385. Local Therapies for the Treatment of Stage I Non-Small Cell Lung Cancer and Endobronchial Obstruction Due to Advanced Lung Tumors | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/lung-cancer-nonsurgical-therapies/research-protocol
     December 01, 2019 - the primary authors concur that, if obtained, evidence could impact results meaningfully (i.e., alter GRADE … overall body of evidence is outlined in the Methods Guide 27 and is based on a system developed by the GRADE … The grade of evidence strength is classified into the following four categories: High. … The grade rating will be made by independent reviewers, and disagreements will be resolved by consensus

386. The Effect of Dietary Digestible Carbohydrate Intake on Risk of Type 2 Diabetes, Growth, Size, and Body Composition | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/effect-dietary-digestible/protocol
     December 01, 2023 - Grading the Strength of Evidence (SOE) for Major Comparisons and Outcomes We will grade the strength … of the body of evidence (SOE) per the EPC methods guide on assessing SOE. 18 We will grade SOE for selected

387. Total Worker Health® (TWH) (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/worker-health_executive.pdf
     April 01, 2016 - A grade of high SOE indicates that we have high confidence that the evidence reflects the true effect … Two reviewers assessed each domain independently and also assigned an overall grade for comparisons … cessation and healthy eating outcomes, and two studies enrolling office workers contributed to our SOE grade … concurrent control group, but limiting by study design is unlikely to have had a major effect on our SOE grade

388. Evidence Report on the (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/labor-nitrous-oxide_research-protocol.pdf
     August 24, 2011 - Each key outcome on each comparison of interest will be given an overall evidence grade based on the … Two senior staff will independently grade the body of evidence, with disagreements resolved through

389. Psychosocial and Pharmacologic Interventions for Disruptive Behavior Disorder | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/disruptive-behavior-disorder/research-protocol
     December 01, 2019 - “domains” and then combine domain scores into an overall grade. … Two senior staff will independently grade the body of evidence; disagreements will be resolved as needed … Individual comparisons and outcomes We will give an overall evidence grade based on the ratings for … When no studies are available for an outcome or comparison of interest, we will grade the evidence as … Strength of evidence grades and definitions Grade Definition High We are very confident

390. Diagnosis and Treatment of Clinical Alzheimer's-type Dementia (CATD) (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/catd-protocol-draft_0.pdf
     November 02, 2018 - investigators will independently assess five required domains (listed below) and other possible factors to grade … For treatment comparisons, the starting SOE grade for an evidence base derived from RCTs will be high … , while the starting SOE grade for an evidence based derived from observational studies will be low. … For diagnostic tests, the starting SOE grade for an evidence base will be high.28 The final SOE grades

391. Maternal and Fetal Effects of Mental Health Treatments in Pregnant and Breastfeeding Women: A Systematic Review of Pharmacological Interventions (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/protocol-pharm-pregnant-women_0.pdf
     December 05, 2018 - Grading the Strength of Evidence for Major Comparisons and Outcomes We will grade the SOE based on … the guidance established for the Evidence-based Practice Center (EPC) Program.45 Developed to grade … Definitions of the grades of overall SOE46 Grade Definition High High confidence that the evidence

392. Allergy-Seasonal Executive (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/allergy-seasonal_executive.pdf
     July 01, 2013 - evaluated separately for each treatment comparison and each outcome of interest to derive a single GRADE … • A high GRADE indicates high confidence that the evidence reflects the true effect. … • A moderate GRADE indicates moderate confidence that the evidence reflects the true effect. … • A low GRADE indicates low confidence that the evidence reflects the true effect. … Decision rules used to assess each GRADE domain are provided in the full report.

393. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/cancer-anemia-update_research-protocol.pdf
     June 16, 2010 - The National Cancer Institute and others classify anemia based on hemoglobin (Hb) values: 6 • Grade … normal limits, hemoglobin values are 12.0 to 16.0 g/dL for women and 14.0 to 18.0 g/dL for men • Grade … 1, mild (Hb 10 g/dL to normal limits) • Grade 2, moderate (Hb 8.0 to 10.0 g/dL) • Grade 3, serious … /severe (Hb 6.5 to 7.9 g/dL) • Grade 4, life threatening (Hb less than 6.5 g/dL). … Working Group.57 The GRADE system explicitly addresses the following domains: risk of bias, consistency

394. VU EPC DBD Protocol_AHRQ comments_revised_clean (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/disruptive-behavior-disorder_research-protocol.pdf
     January 30, 2014 - “domains” and then combine domain scores into an overall grade. … Two senior staff will independently grade the body of evidence; disagreements will be resolved as needed … Individual comparisons and outcomes We will give an overall evidence grade based on the ratings for … When no studies are available for an outcome or comparison of interest, we will grade the evidence as … Strength of evidence grades and definitions Grade Definition High We are very confident that the estimate

395. Treatment of Depression in Children and Adolescents: A Systematic Review - Evidence Summary (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/Evidence%20Summary_0_0.pdf
     April 01, 2020 - For bodies of evidence for which we could conduct sensitivity analyses, we based the final SOE grade … We appended a footnote to SOE tables to indicate when sensitivity analyses changed the SOE grade. … baseline or followup control arms ranges from 4.031 to 5.7.29 b Without high risk-of-bias studies, the grade

396. Major-Depressive-Disorder Executive (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/major-depressive-disorder_executive.pdf
     December 01, 2015 - the Key Informants to rank the relative importance of outcomes following a process proposed by the GRADE … GRADE guidelines: 2. Framing the question and deciding on important outcomes.

397. Disposition of Comments Report for Procalcitonin-Guides Antibiotic Therapy (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cer78_procalcitonin_disposition_20121210.pdf
     October 05, 2012 - helpful to refer to Table ES-2 in the ES (page ES-6, line 37) where the ES describes the elements of GRADE … Affiliation Section Comment Response PR (#3) Results Critically III/Ventilator-Associated Pneumonia The grade

398. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/cad-women-treatment_research-protocol.pdf
     September 29, 2011 - The strength of evidence will also be assigned an overall grade of high, moderate, low, or insufficient

399. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/ptsd-adult-treatment_research-protocol.pdf
     December 20, 2011 - We will grade the strength of evidence based on the guidance established for the Evidence-based Practice … Center Program. 26 Developed to grade the overall strength of a body of evidence, this approach … We will grade the strength of evidence for the outcomes deemed to be of greatest importance to decisionmakers … Definitions of the grades of overall strength of evidence 26 Grade Definition High High confidence

400. Closing the Quality Gap Series: The Effects of Bundled Payment Strategies on Health Care Spending and Quality of Care | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/bundled-payments-quality-effects/research-protocol
     December 01, 2020 - guidance outlined in the Methods Guide . 10 This method is based loosely on one developed by the Grade … Working Group and classifies the grade of evidence according to the following criteria: High = High … The evidence grade is based on four primary domains (required) and two optional domains.