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361. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/autism_research-protocol.pdf
     December 09, 2009 - Evidence-based Practice Center Systematic Review Protocol Source: www.effectivehealthcare.ahrq.gov Published Online: December 7, 2009 1 Evidence-based Practice Center Systematic Review Protocol Project Title: Therapies for Children with Autism Spectrum Disorders I. Backgrou…

362. Emerging Approaches to Diagnosis and Treatment of Non-Muscle-Invasive Bladder Cancer | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/bladder-cancer-non-muscle-invasive/research-protocol
     December 01, 2020 - These include the stage of the cancer, tumor grade, whether the tumor is an initial tumor or a recurrence … risk-adapted approach to treatment decision-making, based on available prognostic factors including grade … the comparative effectiveness differ according to tumor characteristics, such as histology, stage, grade … the comparative effectiveness differ according to tumor characteristics, such as histology, stage, grade … The strength of evidence will be assigned an overall grade of high, moderate, low, or insufficient according

363. Misuse of Prescription Stimulants in Adults (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/misuse-prescription-protocol.pdf
     September 13, 2024 - For the Key Questions on consequences of misuse, we will use the GRADE (Grading of Recommendations, … Judging the quality of evidence in reviews of prognostic factor research: adapting the GRADE framework

364. Lung-Cancer-Nonsurgical-Therapies Executive (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/lung-cancer-nonsurgical-therapies_executive.pdf
     June 01, 2013 - by consensus discussion; the same reviewers also used the domain scores to assign an overall SOE grade … Further, based on GRADE guidelines on assessing the risk of bias,34 when the evidence was generated … The grade of evidence strength was classified into the following four categories: • High. … program and referenced in the Methods Guide.29 This approach is based on a system developed by the GRADE … GRADE guidelines: 4. Rating the quality of evidence—study limitations (risk of bias).

365. Breast-Abnormalities-Tests-Update Research-Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/breast-abnormalities-tests-update_research-protocol.pdf
     July 01, 2010 - Quality of Individual Studies We will use an internal validity rating scale for diagnostic studies to grade … The grade will be developed by considering four important domains: the risk of bias in the evidence

366. Depression SSRI Surveillance Assessment_CER 62_Low-1 (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/depression-treatment-ssri_surveillance.pdf
     January 01, 2013 - therapies relative to other combined therapies were grouped as one category for grading SOE; the overall grade … therapies relative to other combined therapies were grouped as one category for grading SOE; the overall grade

367. Treatment of Non-metastatic Muscle-invasive Bladder Cancer | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/bladder-cancer-muscle-invasive/research-protocol
     July 21, 2014 - These include the stage of the cancer, tumor grade, whether the tumor is an initial tumor or a recurrence … the comparative effectiveness differ according to tumor characteristics, such as histology, stage, grade … the comparative effectiveness differ according to tumor characteristics, such as histology, stage, grade … neo-adjuvant or adjuvant chemotherapy differ according to tumor characteristics, such as histology, stage, grade … The strength of evidence will be assigned an overall grade of high, moderate, low, or insufficient according

368. Bladder-Cancer-Muscle-Invasive Research-Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/bladder-cancer-muscle-invasive_research-protocol.pdf
     July 21, 2014 - These include the stage of the cancer, tumor grade, whether the tumor is an initial tumor or a recurrence … the comparative effectiveness differ according to tumor characteristics, such as histology, stage, grade … the comparative effectiveness differ according to tumor characteristics, such as histology, stage, grade … neo-adjuvant or adjuvant chemotherapy differ according to tumor characteristics, such as histology, stage, grade … The strength of evidence will be assigned an overall grade of high, moderate, low, or insufficient according

369. Diagnosis of Gout | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/gout/research-protocol-2014
     March 01, 2020 - AHRQ for its Effective Health Care Program. 16 This method is based loosely on one developed by the GRADE … Working Group and classifies the grade of evidence as High, Moderate, Low, or Insufficient. … The evidence grade is based on five required domains: study limitations, consistency, directness, precision

370. Antidepressant Treatment of Depression During Pregnancy and the Postpartum Period (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/depression-pregnancy-postpartum_executive.pdf
     July 01, 2014 - emotional skills) and educational achievement; kindergarten readiness; age at kindergarten entry; third grade … testing outcomes; other standard testing outcomes (eighth grade, etc … Chapter 10 of the AHRQ “Methods Guide for Effectiveness and Comparative Effectiveness Reviews”20,28 to grade … Based on this assessment, reviewers assigned the body of evidence a strength-of-evidence grade of high … which evidence did not exist, was sparse, or contained irreconcilable inconsistency, we assigned a grade

371. Treatments for Fecal Incontinence | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/fecal-incontinence/research-protocol
     December 01, 2019 - strength of evidence methods must meet accepted AHRQ EPC standards (such as Cochrane review methods or GRADE … Deficiencies in the five domains will lower the strength of evidence grade. 43 We will require the existence … For published systematic reviews that did not provide a strength of evidence assessment based on a GRADE … or GRADE-equivalent method, we will assess strength of evidence by replacing de novo review processes

372. Psychological Treatments and Pharmacological Treatments for Adults with Post-traumatic Stress Disorder (PTSD) | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/ptsd-adult-treatment/research-protocol
     December 01, 2020 - Grading the Evidence for Each Key Question We will grade the strength of evidence based on the guidance … established for the Evidence-based Practice Center Program. 26 Developed to grade the overall strength … We will grade the strength of evidence for the outcomes deemed to be of greatest importance to decisionmakers … Definitions of the grades of overall strength of evidence 26 Grade Definition High

373. Therapies for Children with Autism Spectrum Disorders—Research Protocol Document | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/autism/research-protocol
     December 01, 2019 - Skip to main content An official website of the Department of Health & Human Services Careers Contact Us Español FAQs Effective Health Care Program Powered by the Evidence-based Practice Centers …

374. Medication-Therapy-Management Research-Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/medication-therapy-management_research-protocol.pdf
     January 01, 2014 - Grading the Strength of Evidence for Individual Comparisons and Outcomes We will grade the strength … based on the guidance established for the Evidence- based Practice Center Program.17 Developed to grade … We will grade the strength of evidence for the outcomes deemed to be of greatest importance to decisionmakers … Definitions of the grades of overall strength of evidence15 Grade Definition 19 Source: www.effectivehealthcare.ahrq.gov

375. Liver-Cancer-Therapy Research-Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/liver-cancer-therapy_research-protocol.pdf
     November 28, 2012 - authors concur that if obtained, evidence could impact results meaningfully (i.e., alter evidence GRADE … EPC approach, which is outlined in the Methods Guide43 and is based on a system developed by the GRADE … The grade of evidence strength is classified into the following four categories: • High. … The grade rating will be made by independent reviewers, and disagreements will be resolved by consensus

376. Untitled (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/autism-medical-update_research-protocol.pdf
     February 16, 2016 - We assign an overall grade (high, moderate, low or insufficient) for the strength of evidence for each … Strength of evidence grades and definitions Grade   Definition     High     Very  confident  that  the … Two senior staff will independently grade the body of evidence; disagreements will be resolved as needed … When no studies are available for an outcome or comparison of interest, we will grade the evidence … When no studies are available for an outcome or comparison of interest, we will grade the evidence as

377. Nephropathy-Contrast-Induced Research-Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/nephropathy-contrast-induced_research-protocol.pdf
     October 01, 2013 - Individual Comparisons and Outcomes – At the completion of this review, two reviewers will independently grade … effect).42 We will classify the evidence pertaining to the key questions into four categories: high grade … and further research is very unlikely to change our confidence in the estimate of effect); moderate grade … reflects the true effect, and further research may change our confidence in the estimate of effect); low grade … confidence in the estimate of the effect and is likely to change the effect estimate); and insufficient grade

378. Comparative Effectiveness of Treatment Strategies for Women With Coronary Artery Disease | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/cad-women-treatment/research-protocol
     December 01, 2019 - The strength of evidence will also be assigned an overall grade of high, moderate, low, or insufficient

379. Interventions for Substance Use Disorders in Adolescents: A Systematic Review | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/substance-use-disorders-adolescents/protocol
     October 01, 2019 - Grading the Strength of Evidence for Major Comparisons and Outcomes We will grade the strength of the … evidence "any estimate of effect is very uncertain," the definition of Very Low quality evidence per GRADE … GRADE: an emerging consensus on rating quality of evidence and strength of recommendations.

380. Research Protocol for Interventions for Substance Use Disorders in Adolescents: A Systematic Review (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/suda-final-protocol.pdf
     October 02, 2018 - Grading the Strength of Evidence for Major Comparisons and Outcomes We will grade the strength of … evidence “any estimate of effect is very uncertain,” the definition of Very Low quality evidence per GRADE … GRADE: an emerging consensus on rating quality of evidence and strength of recommendations.