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341. Local Therapies for Unresectable Primary Hepatocellular Carcinoma: Comparative Effectiveness Review | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/liver-cancer-therapy/research-protocol
     December 01, 2019 - primary authors concur that if obtained, evidence could impact results meaningfully (i.e., alter evidence GRADE … EPC approach, which is outlined in the Methods Guide 43 and is based on a system developed by the GRADE … The grade of evidence strength is classified into the following four categories: High. … The grade rating will be made by independent reviewers, and disagreements will be resolved by consensus

342. Safety of Vaccines Used for Routine Immunization in the United States (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/vaccine-safety_executive.pdf
     January 01, 2020 - For each AE associated with a particular vaccine, what is the average severity (grade 1/mild; grade 2 … For each AE associated with a particular vaccine, what is the average severity (grade 1/mild; grade 2 … For each AE associated with a particular vaccine, what is the average severity (grade 1/mild; grade 2 … For each AE associated with a particular vaccine, what is the average severity (grade 1/mild; grade 2 … The evidence grade is based on four primary (required) domains and four optional domains.

343. Assessment and Management of Chronic Cough | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/chronic-cough/research-protocol
     December 01, 2020 - outcome well but did an incomplete analysis of a secondary outcome would be assigned a different quality grade … Grading the Evidence for Each Key Question We will grade the strength of evidence for each outcome … In these situations, a grade of insufficient will be assigned.

344. Management of Infertility | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/infertility/research-protocol
     October 01, 2019 - outcome well but did an incomplete analysis of a secondary outcome would be assigned a different quality grade … Brown EPC. 62 Grading the Strength of Evidence (SOE) for Major Comparisons and Outcomes We will grade … the body of evidence for a particular outcome includes both RCTs and observational studies, we will grade … In these situations, a grade of "insufficient" will be assigned. … reproductive technology BMI = body mass index GI = gastrointestinal GnRH = gonadotropin-releasing hormone GRADE

345. Efficacy and Safety of Screening for Postpartum Depression | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/depression-postpartum-screening/research-protocol
     December 01, 2019 - Grade B recommendation for screening “when staff-assisted depression care supports are in place to … assure accurate diagnosis, effective treatment, and follow-up;” Grade C recommendation against screening … outcome well but did an incomplete analysis of a secondary outcome would be assigned a different quality grade … Grading the Evidence for Each Key Question We will grade the strength of evidence for each outcome … In these situations, a grade of insufficient will be assigned.

346. High-Cholestorol-Medicines-Update Executive (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/high-cholestorol-medicines-update_executive.pdf
     February 01, 2014 - We used four domains to yield a final evidence grade: risk of bias, consistency, directness and precision … The final strength-of-evidence (SOE) grades were: (1) “high” grade (indicating high confidence that … final.cfm. 6 very unlikely to change our confidence in the estimate of the effect); (2) “moderate” grade … research may change our confidence in the estimate of the effect and may change the estimate); (3) “low” grade … confidence in the estimate of the effect and is likely to change the estimate); and (4) “insufficient” grade

347. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/vte-prophyalaxis_research-protocol.pdf
     March 01, 2011 - that anticoagulant medications that bioaccumulate should be avoided, dose adjusted, or monitored (Grade … Grading the Evidence for Each Key Question At the completion of our review, we will grade the quantity … We will classify evidence pertaining to KQs 1–8 into four basic categories: 1) “high” grade (indicating … research may change our confidence in the estimate of the effect and may change the estimate); 3) “low” grade … confidence in the estimate of the effect and is likely to change the estimate); and 4) “insufficient” grade

348. Diagnosis and Treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/chronic-fatigue_executive.pdf
     July 01, 2016 - Diagnosis and Treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Evidence-Based Practice Evidence-based Practice Program The Agency for Healthcare Research and Quality (AHRQ), through its Evidence- based Practice Centers (EPCs), sponsors the development of evidence reports and technology assessme…

349. uterine-fibroids-protocol-160301 (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/uterine-fibroids_research-protocol.pdf
     March 01, 2016 - Intervention-outcomes pairs will be given an overall evidence grade based on the ratings for the individual … We assign an overall grade (high, moderate, low or insufficient) for the strength of evidence for each … Strength of evidence grades and definitions Grade   Definition     High     We  are  very  confident … Two senior staff will independently grade the body of evidence; disagreements will be resolved as needed … When no studies are available for an outcome or comparison of interest, we will grade the evidence

350. Fiber Intake and Laxation Outcomes (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/fiber-intake-protocol.pdf
     August 15, 2023 - low-quality evidence per the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE … Healthcare Research and Quality DRI Dietary reference intake EPC Evidence-based Practice Center GRADE

351. Evidence-based Practice Center Systematic Review Protocol: Malnutrition in Hospitalized Adults (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/malnutrition-hospitalized-adults-protocol.pdf
     October 19, 2020 - Evidence-based Practice Center Systematic Review Protocol: Malnutrition in Hospitalized Adults Evidence-based Practice Center Systematic Review Protocol Project Title: Malnutrition in Hospitalized Adults I. Background and Objectives for the Systematic Review Malnutrition among hospitalized patients remain…

352. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/stroke-atrial-fibrillation_research-protocol.pdf
     January 30, 2012 - Grading the Evidence for Each Key Question We will grade the strength of evidence for each outcome … In these situations, a grade of “insufficient” will be assigned.

353. Executive Summary: Radiation Therapy for Metastatic Bone Disease: Effectiveness and Harms (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cer-265-radiation-bone-disease-summary.pdf
     August 01, 2023 - (Effect Size/SOE)a Any time No evidence No difference + No evidence Harms/AEs – Toxicity, Acute Grade … Use of dexamethasone with EBRT may improve pain and quality of life and reduce pain flare and acute Grade

354. Maternal and Fetal Effects of Mental Health Treatments in Pregnant and Breastfeeding Women: A Systematic Review of Pharmacological Interventions | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/mental-health-pregnancy/protocol
     January 01, 2020 - Grading the Strength of Evidence for Major Comparisons and Outcomes We will grade the SOE based on … the guidance established for the Evidence-based Practice Center (EPC) Program. 45 Developed to grade … Definitions of the grades of overall SOE 46 Grade Definition High

355. Closing the Quality Gap Series: Comparative Effectiveness of Medication Adherence Interventions | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/medication-adherence-interventions/research-protocol
     December 01, 2019 - We will grade the strength of evidence based on the guidance established by the Evidence-based Practice … Center (EPC) program. 49 Developed to grade the overall strength of a body of evidence, this approach … We will grade the strength of evidence for the outcomes deemed to be of greatest importance to decisionmakers

356. Renal-Function Research-Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/renal-function_research-protocol.pdf
     June 13, 2013 - We will grade the strength of evidence based on the quantity, quality, and consistency of the best available … We will classify evidence pertaining to the KQs into four basic categories: 1) “high” grade (indicating … research is very unlikely to change our confidence in the estimate of the effect); 2) “moderate” grade … research may change our confidence in the estimate of the effect and may change the estimate); 3) “low” grade … confidence in the estimate of the effect and is likely to change the estimate); and 4) “insufficient” grade

357. Comparative Effectiveness and Safety of Insulin Delivery and Glucose Monitoring Methods for Diabetes Mellitus | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/insulin-blood-sugar-2010/research-protocol
     December 01, 2019 - Grading the Evidence for Each Key Question At the completion of our review, we will grade the strength … We will classify evidence pertaining to KQs 1 and 2 into four basic categories: 1) “high” grade (indicating … further research is very unlikely to change our confidence in the estimate of the effect); 2) “moderate” grade … research may change our confidence in the estimate of the effect and may change the estimate); 3) “low” grade … confidence in the estimate of the effect and is likely to change the estimate); and 4) “insufficient” grade

358. Comparative Effectiveness of Epoetin and Darbepoetin for Managing Anemia in Patients Undergoing Cancer Treatment–An Update to the 2006 Report | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/cancer-anemia-update/research-protocol
     December 01, 2019 - The National Cancer Institute and others classify anemia based on hemoglobin (Hb) values: 6 Grade … within normal limits, hemoglobin values are 12.0 to 16.0 g/dL for women and 14.0 to 18.0 g/dL for men Grade … 1, mild (Hb 10 g/dL to normal limits) Grade 2, moderate (Hb 8.0 to 10.0 g/dL) Grade 3, serious/severe … (Hb 6.5 to 7.9 g/dL) Grade 4, life threatening (Hb less than 6.5 g/dL). … Working Group. 57 The GRADE system explicitly addresses the following domains: risk of bias, consistency

359. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/autism_research-protocol.pdf
     December 09, 2009 - Evidence-based Practice Center Systematic Review Protocol Source: www.effectivehealthcare.ahrq.gov Published Online: December 7, 2009 1 Evidence-based Practice Center Systematic Review Protocol Project Title: Therapies for Children with Autism Spectrum Disorders I. Backgrou…

360. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/therapies-for-autism-spectrum-disorder-2-9-2010.pdf
     January 01, 2010 - Evidence-based Practice Center Systematic Review Protocol Source: www.effectivehealthcare.ahrq.gov Published Online: December 7, 2009 1 Evidence-based Practice Center Systematic Review Protocol Project Title: Therapies for Children with Autism Spectrum Disorders I. Backgrou…