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321. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/progestogens-preterm-birth_research-protocol.pdf
     June 01, 2010 - Evidence-based Practice Center Systematic Review Protocol Source: www.effectivehealthcare.ahrq.gov Published Online: April 15, 2010 1 Evidence-based Practice Center Systematic Review Protocol Project Title: Comparative Effectiveness of Progestogens for the Prevention of Preterm B…

322. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/depression-postpartum-screening_research-protocol.pdf
     May 01, 2013 - Grade B recommendation for screening “when staff-assisted depression care supports are in place to … assure accurate diagnosis, effective treatment, and follow-up;” Grade C recommendation against screening … Grading the Evidence for Each Key Question We will grade the strength of evidence for each outcome … In these situations, a grade of insufficient will be assigned. … Review Protocol Project Title: Efficacy and Safety of Screening for Postpartum Depression We will grade

323. Combination Therapy Versus Intensification of Statin Monotherapy: An Update | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/high-cholestorol-medicines-update/research
     December 01, 2019 - Skip to main content An official website of the Department of Health & Human Services Careers Contact Us Español FAQs Effective Health Care Program Powered by the Evidence-based Practice Centers …

324. Strategies to Improve Mental Health Care for Children and Adolescents | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/mental-health-children/research
     March 01, 2020 - Skip to main content An official website of the Department of Health & Human Services Careers Contact Us Español FAQs Effective Health Care Program Powered by the Evidence-based Practice Centers …

325. ASSESSING THE QUALITY OF INCLUDED STUDIES (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/assessing-the-risk-of-bias_draft-report.pdf
     June 02, 2011 - At that stage, EPCs generally give evidence derived from observational studies a low starting grade … and evidence from randomized controlled trials a high grade. … GRADE guidelines: 3. Rating the quality of evidence. Journal of Clinical Epidemiology. … GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. … GRADE guidelines: 4.

326. Pharmacotherapy for Adults With Alcohol-Use Disorders in Outpatient Settings | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/alcohol-misuse-drug-therapy/research-protocol
     January 01, 2021 - Grading the Strength of Evidence (SOE) for Individual Comparisons and Outcomes We will grade the strength … based on the guidance established for the Evidence-based Practice Center Program. 45 Developed to grade … We will grade the strength of evidence for alcohol-consumption measures, accidents, injuries, quality … Definitions of the grades of overall strength of evidence 45 Grade Definition High

327. rheumatoid-arthritis-medicine-update-protocol-170515 (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/rheumatoid-arthritis-medicine-update_research-protocol.pdf
     May 15, 2017 - Grading the SOE for Major Comparisons and Outcomes We will grade SOE based on the guidance established … for the Evidence-based Practice Center (EPC) Program.33 Developed to grade the overall strength of … Definitions of the Grades of Overall Strength of Evidence Grade Definition High We are very confident … Source: www.effectivehealthcare.ahrq.gov Published online: May 15, 2017 12 We will grade

328. Psoriasis-Chronic Executive (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/psoriasis-chronic_executive.pdf
     November 01, 2012 - The overall grade for strength of evidence for each comparison and outcome evaluated was rated and … There was insufficient evidence to grade death, and no other final health outcomes were reported. … There was insufficient evidence to grade BSA, and no other intermediate outcomes were reported. … When comparing ustekinumab with methotrexate, there was insufficient evidence to grade HRQoL, and no … However, there was insufficient evidence to grade HRQoL, BSA, PASI, PGA, psoriatic arthritis (PsA)

329. Ptsd-Adults-Trauma-Interventions Executive (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/ptsd-adults-trauma-interventions_executive.pdf
     April 01, 2013 - based on the guidance established for the Evidence-based Practice Center program.10 Developed to grade … Two reviewers assessed each domain for each key outcome and determined an overall SOE grade based on … In the event of disagreements on the domain or overall grade, they resolved differences by consensus

330. Comparative Effectiveness of Non-Invasive Diagnostic Tests for Breast Abnormalities – An Update of a 2006 Report | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/breast-abnormalities-tests-update/research-protocol
     December 01, 2019 - Quality of Individual Studies We will use an internal validity rating scale for diagnostic studies to grade … The grade will be developed by considering four important domains: the risk of bias in the evidence base

331. Comparative Effectiveness of Breathing Exercises and/or Retraining Techniques in the Treatment of Asthma | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/asthma-treatment/research-protocol
     December 01, 2020 - F.Grading the Evidence for Each Key Question We will grade the strength of evidence for primary outcomes … outlined in the Methods Guide for Effectiveness and Comparative Effectiveness Reviews . 20 , 21 The grade … Strength of evidence grades and definitions Grade Definition High High confidence

332. Progestogens for the Prevention of Preterm Birth | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/progestogens-preterm-birth/research-protocol
     December 01, 2019 - Skip to main content An official website of the Department of Health & Human Services Careers Contact Us Español FAQs Effective Health Care Program Powered by the Evidence-based Practice Centers …

333. Effective Health Care (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/TND_0251_05-20-2010.pdf
     January 01, 2010 - Wound care dressings with a cytolytic agent or antibiotics (e.g., silver, cadexomer iodine, medical-grade

334. Mrsa-Screening-2010 Research-Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/mrsa-screening-2010_research-protocol.pdf
     January 01, 2010 - for Healthcare Research and Quality for its Methods Guide,33,38 based on a system developed by the GRADE … The grade of evidence strength is classified into the following four categories:  High. … Atkins D, Eccles M, Flottorp S, et al, for the GRADE Working Group.

335. Management of Uterine Fibroids | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/uterine-fibroids/research-protocol
     May 01, 2019 - Intervention-outcomes pairs will be given an overall evidence grade based on the ratings for the individual … We assign an overall grade (high, moderate, low or insufficient) for the strength of evidence for each … Strength of evidence grades and definitions Grade Definition High We are very confident … Two senior staff will independently grade the body of evidence; disagreements will be resolved as needed … When no studies are available for an outcome or comparison of interest, we will grade the evidence as

336. Assessing the Applicability of Studies When Comparing Medical Interventions | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/methods-guidance-applicability/methods
     May 01, 2020 - treatments and outcomes.” 3 The Grading of Recommendations Assessment, Development and Evaluation (GRADE … Applicability Is Best Reported Separately From the Strength of a Body of Evidence GRADE incorporates … Epidemiologic studies indicate that prostate cancer prognosis is tied to grade and, to a lesser extent … Results may not be applicable to current practices due to the evolving techniques in both stage and grade … to be limited to men under 65 years of age but is not dependent on baseline PSA level or histologic grade

337. Diagnosis and Treatment of Clinical Alzheimer's-type Dementia (CATD) | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/alzheimers-type-dementia/protocol
     August 01, 2020 - investigators will independently assess five required domains (listed below) and other possible factors to grade … For treatment comparisons, the starting SOE grade for an evidence base derived from RCTs will be high … , while the starting SOE grade for an evidence based derived from observational studies will be low. … For diagnostic tests, the starting SOE grade for an evidence base will be high. 28 The final SOE grades

338. Partial Breast Irradiation for Breast Cancer | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/accelerated-partial-breast-irradiation/protocol
     October 01, 2021 - features that were included in clinical trials of PBI, such as larger tumor size (2-3 cm), high tumor grade … nodes) Nodal assessment (i.e., sentinel lymph node biopsy, axillary lymph node dissection, none) Tumor grade … Grading the Strength of Evidence (SOE) for Major Comparisons and Outcomes We will grade the strength … RCTs start with a provisional high SOE grade, while observational studies start with a provisional low … SOE grade. 28 The domains to be used for determining final SOE grade will be: the methodological limitations

339. CER 210: Disposition of Comments for Breastfeeding Programs and Policies, Breastfeeding Uptake, and Maternal Health Outcomes in Developed Countries (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cer-210-breastfeeding-disposition-comments.pdf
     January 01, 2020 - This is one example of why a SOE grade might be “low” rather than “insufficient” when only one study … Yes, this evidence was considered in the SOE grade. … We have clarified when the grade refers to no association (for fracture). … We have reviewed this SOE grade. … Information on magnitude helps us interpret the strength of association and the final grade.

340. Medication Therapy Management | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/medication-therapy-management/research-protocol
     December 01, 2019 - Grading the Strength of Evidence for Individual Comparisons and Outcomes We will grade the strength … based on the guidance established for the Evidence-based Practice Center Program. 17 Developed to grade … We will grade the strength of evidence for the outcomes deemed to be of greatest importance to decisionmakers … Definitions of the grades of overall strength of evidence 15 Grade Definition High