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241. Dietary Intake of Polyunsaturated Fatty Acids and Plasma Lipid and Cardiovascular Events (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/polyunsaturated-fatty-protocol.pdf
     January 01, 2024 - low-quality evidence per the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE … GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. … Healthcare Research and Quality DRI Dietary reference intake EPC Evidence-based Practice Center GRADE

242. Dietary Saturated Fat Replacement and Plasma Lipid and Cardiovascular Events (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/saturated-fat-replacement-protocol.pdf
     January 01, 2024 - low-quality evidence per the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE … GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. … Healthcare Research and Quality DRI Dietary reference intake EPC Evidence-based Practice Center GRADE

243. Topic 0523 Muscle Invasive Bladder Cancer NSD FINAL_SJ (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/TND_0620_131115.pdf
     March 13, 2013 - How do tumor characteristics (i.e. stage, grade, multiplicity, size, molecular and genetic alterations

244. The Effectiveness and Risks of Long-Term Opioid Treatment of Chronic Pain (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/chronic-pain-opioid-treatment_executive.pdf
     September 19, 2014 - Summary of evidence Key Question Outcome Strength of Evidence Grade Conclusion 1. … Summary of evidence (continued) 12 Key Question Outcome Strength of Evidence Grade Conclusion … Summary of evidence (continued) 13 Key Question Outcome Strength of Evidence Grade Conclusion … Summary of evidence (continued) 14 Key Question Outcome Strength of Evidence Grade Conclusion … Summary of evidence (continued) 15 Key Question Outcome Strength of Evidence Grade Conclusion

245. Prevention of Contrast Media Induced Nephropathy | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/nephropathy-contrast-induced/research-protocol
     December 01, 2019 - Individual Comparisons and Outcomes At the completion of this review, two reviewers will independently grade … effect). 42 We will classify the evidence pertaining to the key questions into four categories: high grade … and further research is very unlikely to change our confidence in the estimate of effect); moderate grade … reflects the true effect, and further research may change our confidence in the estimate of effect); low grade … confidence in the estimate of the effect and is likely to change the effect estimate); and insufficient grade

246. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/venous-ulcers-treatment_research-protocol.pdf
     September 13, 2012 - clinical severity, etiology, anatomy, and pathophysiology.5 In this classification scheme, the highest grade … We will grade the strength of evidence based on the quantity, quality, and consistency of the best available … further research is very unlikely to change our confidence in the estimate of the effect); 2) “moderate” grade … confidence in the estimate of the effect and is likely to change the estimate); and 4) “insufficient” grade … dressing, wound filler Foams • Sterile, nonlinting, absorptive dressing made of open cell, medical grade

247. Effect-Dietary-Digestible (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/effect-dietary-digestible.pdf
     January 01, 2021 - Grading the Strength of Evidence (SOE) for Major Comparisons and Outcomes We will grade the strength … of the body of evidence (SOE) per the EPC methods guide on assessing SOE.18 We will grade SOE for selected

248. labor-dystocia-protocol-amended-160728 (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/labor-dystocia_research-protocol.pdf
     July 28, 2016 - outcome well but did an incomplete analysis of a secondary outcome would be assigned a different quality grade … Brown EPC.25 Grading the Strength of Evidence (SOE) for Major Comparisons and Outcomes We will grade … the body of evidence for a particular outcome includes both RCTs and observational studies, we will grade … In these situations, a grade of “insufficient” will be assigned.

249. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/chronic-cough_research-protocol.pdf
     October 22, 2012 - outcome well but did an incomplete analysis of a secondary outcome would be assigned a different quality grade … Grading the Evidence for Each Key Question We will grade the strength of evidence for each outcome … In these situations, a grade of insufficient will be assigned. … Center Systematic Review Protocol Project Title: Assessment and Management of Chronic Cough We will grade

250. Communication and Dissemination Strategies To Facilitate the Use of Health-Related Evidence | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/medical-evidence-communication/research-protocol
     December 01, 2019 - The overall strength of evidence grade is made up of judgments about four required domains. … specific determinations of net benefit and also includes applicability in their judgments about evidence grade … Grading the Strength of Evidence for Individual Outcomes We will grade the strength of evidence on … the basis of guidance established for the EPC Program. 38,41 Developed to grade the overall strength … Definitions of the grades of overall strength of evidence Grade Definition Source:

251. Comparative Effectiveness of Treatment for Hepatitis C in Adults | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/hepatitis-c/research-protocol
     December 01, 2019 - Each Key Question We will use the methods outlined in Chapter 10 of the AHRQ Methods Guide 18 to grade … Based on this assessment, the body of evidence will be assigned a strength-of-evidence grade of high, … In cases where evidence does not exist, is sparse, or contains irreconcilable inconsistency, a grade

252. high-cholesterol-medicines-update-protocol-130516 (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/high-cholestorol-medicines-update_research-protocol.pdf
     December 31, 2013 - We will grade evidence for each outcome identified in the KQs. … We will classify evidence pertaining to KQs 1, 2, and 3 into four categories: (1) “high” grade (indicating … research is very unlikely to change our confidence in the estimate of the effect); (2) “moderate” grade … confidence in the estimate of the effect and is likely to change the estimate); and (4) “insufficient” grade … The grade of evidence for each KQ will be based on consensus.

253. Mental-Illness-Adults-Prisons Executive (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/mental-illness-adults-prisons_executive.pdf
     August 01, 2013 - of the 16 included trials received a medium risk-of-bias rating and 1 received a low risk-of-bias grade … The various domains were considered together, along with the size of the evidence base, to grade the … To receive a grade of low or better, at least two studies must have reported consistent results for … We assigned a low strength-of-evidence grade for the following findings. … interventions (continued) Comparison Outcome Risk of Bias Consistency Precision Directness SOE Grade

254. Evaluation of Effectiveness and Safety of Antiepileptic Medications in Patients With Epilepsy (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/epilepsy-medicine_research-protocol.pdf
     February 01, 2008 - Grading the Strength of Evidence We will use EPC methodology based on the criteria and methods of GRADE … The GRADE system uses four required domains – risk of bias, consistency, directness, and precision.45 … Definitions for grading the strength of evidence Grade Definition High There is high confidence that … GRADE handbook for grading quality of evidence and strength of recommendation. … The GRADE Working Group; 2008. 46. Gartlehner G, Hansen RA, Nissman D, et al.

255. Antinuclear Antibody, Rheumatoid Factor, and Cyclic-Citrullinated Peptide Testing for the Evaluation of Musculoskeletal Complaints in Pediatric Populations | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/musculoskeletal-complaints-tests-children/research-protocol
     December 01, 2019 - reviews of treatment interventions, where appropriate the grading system will be modified following the GRADE … GRADE: Grading the quality of evidence and strength of recommendations for diagnostic tests and strategies

256. Han (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/han.pdf
     December 26, 2012 - represented by quality ratings   o Non-­‐quantitative (verbal) o Emerging formal rating systems (USPSTF, GRADE … Slide 24: Representing  ambiguity in clinical evidence: USPSTF A page of grade definitions from  

257. Effectiveness of Practice-based Interventions Addressing Concomitant Mental Health and Chronic Medical Conditions in the Primary Care Setting | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/depression-chronic-conditions-interventions/research-protocol
     December 01, 2019 - Grading the Evidence for Each Key Question We will grade the strength of evidence based on the guidance … established for the Evidence-based Practice Center (EPC) Program. 35 Developed to grade the overall … Definitions of the grades of overall strength of evidence Grade Definition Source … We will grade the strength of evidence for the outcomes deemed to be of greatest importance to decisionmakers

258. Comparative Effectiveness of Intravascular Diagnostic Procedures and Imaging Techniques versus Angiography Alone | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/coronary-artery-stenting/research-protocol
     December 01, 2019 - outcome well but did an incomplete analysis of a secondary outcome would be assigned a different quality grade … Grading the Evidence for Each Key Question We will follow the AHRQ Methods Guide to grade the strength

259. Alcohol-misuse-drug-therapy-140326 (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/alcohol-misuse-drug-therapy_research-protocol.pdf
     January 27, 2012 - Grading the Strength of Evidence (SOE) for Individual Comparisons and Outcomes—We will grade the strength … based on the guidance established for the Evidence-based Practice Center Program.45 Developed to grade … We will grade the strength of evidence for alcohol-consumption measures, accidents, injuries, quality … Definitions of the grades of overall strength of evidence45 Grade Definition High High confidence

260. heart-failure-readmission-protocol-130611 (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/heart-failure-transition-care_research-protocol.pdf
     June 10, 2013 - Grading the Strength of Evidence for Individual Comparisons and Outcomes We will grade the strength … based on the guidance established for the Evidence- based Practice Center (EPC) Program.47 Developed to grade … Definitions of the grades of overall strength of evidence Grade Definition High High confidence that … Source: Owens et al., 201047 We will grade the strength of evidence for all outcomes related to … We will not grade the evidence for KQ 3; this question is a descriptive question. G.