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221. Methods Guide for Effectiveness and Comparative Effectiveness Reviews | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/collections/cer-methods-guide
     October 01, 2022 - Skip to main content An official website of the Department of Health & Human Services Careers Contact Us Español FAQs Effective Health Care Program Powered by the Evidence-based Practice Centers …

222. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/gestational-diabetes-screening-diagnosis_research-protocol.pdf
     December 16, 2011 - Grading the Evidence for Each Key Question Two independent reviewers will grade the strength of the … evidence for major outcomes and comparisons using the Evidence-based Practice Center (EPC) GRADE approach … We will grade the following key outcomes: birth injury, preeclampsia, neonatal hypoglycemia, maternal … We will not grade the evidence on the test properties of the screening and diagnostic tests (KQ1). … Low-quality cohort studies will receive an initial grade of “low” strength of evidence.

223. Management of Suicidal Thoughts and Behaviors in Youth | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/suicidal-thoughts-youth/protocol
     February 01, 2025 - Grading the Strength of Evidence (SOE) for Major Comparisons and Outcomes We will grade the strength … Comparative Effectiveness Reviews on assessing SOE. 31 RCTs will start with a provisional high SOE grade … , while observational studies will start with a provisional low SOE grade. 31 The domains to be used … for determining final SOE grade will be: the methodological limitations of the studies (i.e., risk of

224. Disposition of Comments for CER 202 Effectiveness and Safety of Bronchial Thermoplasty in the Management of Asthma (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cer-202-thermoplasty-comments.pdf
     December 14, 2017 - Peer Reviewer 2 Methods Please explicitly define the GRADE criteria approach. … Classically, RCTs are usually reported as "the highest grade of evidence". furthermore, Air 2 used a … We would encourage consideration of a greater grade of ‘High’ be used to communicate the strength of … Given the ‘Low’ result describing pulmonary physiology, we would recommend AHRQ consider a ‘High’ grade … Each of the outcomes we deemed critical has its own strength of evidence grade for each intervention

225. S123 (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/s123.pdf
     October 01, 2007 - residence from the nearest radiation center, and local area BCSI rate) and controlling for cancer stage, grade … estimated using ordinary least squares as a function of measured confounding variables (cancer stage, grade … 54.3§ 52.6 53.4 IIa 31.2 32.1 25.6‡ 32.5 30.0§ 31.7 30.7 IIb 15.8 17.2 6.9‡ 15.9 15.7 15.6 15.9 Grade … 70–74, 75–79, 80–84, 85�), tumor sizes (�2, 2–5, and 5� cm), positive lymph node involvement, tumor grade … 70–74, 75–79, 80–84, 85�), tumor sizes (�2, 2–5, and 5� cm), positive lymph node involvement, tumor grade

226. Nephropathy-Contrast-Induced Executive (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/nephropathy-contrast-induced_executive.pdf
     October 01, 2015 - consistency, precision, reporting bias, and magnitude of effect.8 Following the guidance of the GRADE … The body of evidence was considered high grade if study limitations were low and there were no problems … GRADE guidelines 6. Rating the quality of evidence--imprecision.

227. Using the Principles of Randomized Controlled Trial Design to Guide Test Evaluation | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/rtc-design-principles/research
     January 01, 2019 - have reported LBC has similar sensitivity and specificity to the Pap test for the detection of high-grade … cytology tests being compared might have the same sensitivity when using the total number of true low-grade … and high-grade lesions detected, but one test might detect a higher proportion of high-grade cytological … abnormalities and a lower proportion of low-grade cytological abnormalities than the other test. … The GRADE (Grading of Recommendations, Assessment, Development and Evaluation) Working Group has recently

228. Comparative Effectiveness of Pharmacologic Therapies for the Management of Crohn’s Disease | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/crohns-disease/research-protocol
     December 01, 2019 - Grading the Evidence for Each Key Question At the completion of our review, we will grade the quantity … We will classify evidence pertaining to Key Questions 1 – 4 into four basic categories: (1) “high” grade … further research is very unlikely to change our confidence in the estimate of the effect); (2) “moderate” grade … research may change our confidence in the estimate of the effect and may change the estimate); (3) “low” grade … confidence in the estimate of the effect and is likely to change the estimate); and (4) “insufficient” grade

229. Imaging for the Pretreatment Staging of Small Cell Lung Cancer | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/lung-cancer-staging/research
     December 01, 2019 - We assigned a grade of low to the strength of evidence for these conclusions, mostly due to risk of bias

230. AHRQ Slide Template 2009 (ppt file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/reporting.ppt
     September 01, 2009 - to be limited to men under 65 years of age but is not dependent on baseline PSA level or histologic grade

231. Topic 0523 Muscle Invasive Bladder Cancer NSD FINAL_SJ (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/TND_0620_131115.pdf
     March 13, 2013 - How do tumor characteristics (i.e. stage, grade, multiplicity, size, molecular and genetic alterations

232. Closing the Quality Gap Series: Quality Improvement Interventions to Address Health Disparities | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/disparities-quality-improvement/research-protocol
     December 01, 2019 - Studies will be given a quality grade of good, fair, or poor per the Methods Guide for Effectiveness … Each key outcome on each comparison of interest will be given an overall evidence grade based on the … Two senior staff will independently grade the body of evidence; disagreements will be resolved as needed

233. Fractional Exhaled Nitric Oxide Clinical Utility in Asthma Management | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/asthma-nitric-oxide/research-protocol
     June 01, 2021 - Grading the Strength of Evidence (SOE) for Major Comparisons and Outcomes We will grade the strength … We will grade the strength of evidence for the outcomes we classified as most important or critical such … Independent reviewers, working in pairs, will grade the SOE and resolve the conflicts by discussion and

234. Comparative Effectiveness of Bariatric Surgery and Nonsurgical Therapy in Adults With Metabolic Conditions and a Body Mass Index of 30.0 to 34.9 kg/m² | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/weight-loss-surgery/research-protocol
     December 01, 2019 - for its Effective Health Care Program. 19,20 This method is based loosely on one developed by the Grade … Working Group, 21 and classifies the grade of evidence according to the following criteria: High … The evidence grade is based on four primary (required) domains and four optional domains. … Atkins D, Best D, Briss PA, et al, for the GRADE Working Group.

235. Disposition of Comments CER 219 Antipsychotics for the Prevention and Treatment of Delirium (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/delirium-disposition-comments.pdf
     September 03, 2019 - Using positive results to determine which outcomes to grade could potentially introduce some bias into … We reviewed the outcomes where we did not grade the body of evidence (did not do SOE) to ensure that … outlined in the AHRQ Methods Guidance, which is very similar to the approach developed by others such as GRADE … For those that aren’t familiar with AHRQ reports or GRADE methodology, the phrase "strength of evidence … We added a footnote to Figures A and B of the Executive Summary defining each evidence grade.

236. Update of Comparative Effectiveness of Lipid-Modifying Agents | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/high-cholestorol-medicines-update/research-protocol
     December 01, 2019 - We will grade evidence for each outcome identified in the KQs. … “Moderate” grade (indicating moderate confidence that the evidence reflects the true effect, and further … “Low” grade (indicating low confidence that the evidence reflects the true effect, and further research … “Insufficient” grade (evidence is unavailable). … The grade of evidence for each KQ will be based on consensus.

237. Comparative Effectiveness of Venous Thromboembolism (VTE) Prophylaxis in Orthopedic Surgery | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/blood-clots-hip-knee-surgery/research-protocol
     December 01, 2019 - Grading the Strength of Evidence We will use EPC GRADE (Grading of Recommendations Assessment, Development … to each KQ will be classified into three broad categories: (1) “high”, (2) “moderate”, or (3) “low” grade … Definitions for grading the strength of evidence Grade Definition High There is high … GRADE handbook for grading quality of evidence and strength of recommendation. … The GRADE Working Group; 2008. Gartlehner G, Hansen RA, Nissman D, Lohr KN, Carey TS.

238. Radiotherapy Treatments for Head and Neck Cancer | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/head-neck-cancer-update/clinician
     December 01, 2019 - control and survival [evidence insufficient] [evidence insufficient] [evidence insufficient] Grade … IMRT [evidence medium] [evidence insufficient] [evidence insufficient] Other RT-associated grade

239. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/tethered-spinal-cord-protocol.pdf
     July 19, 2023 - determining strength of evidence for each primary clinical outcome by following the principles for adapting GRADE … unmeasured confounders) as described in the AHRQ Methods guides.15 A final strength of evidence grade … The strength of evidence will be assigned an overall grade of high, moderate, low, or insufficient

240. Diagnosis and Treatment of Tethered Spinal Cord | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/tethered-spinal-cord/protocol
     August 01, 2023 - determining strength of evidence for each primary clinical outcome by following the principles for adapting GRADE … unmeasured confounders) as described in the AHRQ Methods guides. 15 A final strength of evidence grade … The strength of evidence will be assigned an overall grade of high, moderate, low, or insufficient according