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221. Labor Dystocia | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/labor-dystocia/research-protocol
     August 01, 2020 - outcome well but did an incomplete analysis of a secondary outcome would be assigned a different quality grade … Brown EPC. 25 Grading the Strength of Evidence (SOE) for Major Comparisons and Outcomes We will grade … the body of evidence for a particular outcome includes both RCTs and observational studies, we will grade … In these situations, a grade of "insufficient" will be assigned.

222. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/gestational-diabetes-screening-diagnosis_research-protocol.pdf
     December 16, 2011 - Grading the Evidence for Each Key Question Two independent reviewers will grade the strength of the … evidence for major outcomes and comparisons using the Evidence-based Practice Center (EPC) GRADE approach … We will grade the following key outcomes: birth injury, preeclampsia, neonatal hypoglycemia, maternal … We will not grade the evidence on the test properties of the screening and diagnostic tests (KQ1). … Low-quality cohort studies will receive an initial grade of “low” strength of evidence.

223. Management of Suicidal Thoughts and Behaviors in Youth | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/suicidal-thoughts-youth/protocol
     February 01, 2025 - Grading the Strength of Evidence (SOE) for Major Comparisons and Outcomes We will grade the strength … Comparative Effectiveness Reviews on assessing SOE. 31 RCTs will start with a provisional high SOE grade … , while observational studies will start with a provisional low SOE grade. 31 The domains to be used … for determining final SOE grade will be: the methodological limitations of the studies (i.e., risk of

224. Diagnosis and Treatment of Tethered Spinal Cord | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/tethered-spinal-cord/protocol
     August 01, 2023 - determining strength of evidence for each primary clinical outcome by following the principles for adapting GRADE … unmeasured confounders) as described in the AHRQ Methods guides. 15 A final strength of evidence grade … The strength of evidence will be assigned an overall grade of high, moderate, low, or insufficient according

225. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/tethered-spinal-cord-protocol.pdf
     July 19, 2023 - determining strength of evidence for each primary clinical outcome by following the principles for adapting GRADE … unmeasured confounders) as described in the AHRQ Methods guides.15 A final strength of evidence grade … The strength of evidence will be assigned an overall grade of high, moderate, low, or insufficient

226. Methods Guide for Effectiveness and Comparative Effectiveness Reviews | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/collections/cer-methods-guide
     October 01, 2022 - Skip to main content An official website of the Department of Health & Human Services Careers Contact Us Español FAQs Effective Health Care Program Powered by the Evidence-based Practice Centers …

227. Using the Principles of Randomized Controlled Trial Design to Guide Test Evaluation | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/rtc-design-principles/research
     January 01, 2019 - have reported LBC has similar sensitivity and specificity to the Pap test for the detection of high-grade … cytology tests being compared might have the same sensitivity when using the total number of true low-grade … and high-grade lesions detected, but one test might detect a higher proportion of high-grade cytological … abnormalities and a lower proportion of low-grade cytological abnormalities than the other test. … The GRADE (Grading of Recommendations, Assessment, Development and Evaluation) Working Group has recently

228. Comparative Effectiveness of Pharmacologic Therapies for the Management of Crohn’s Disease | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/crohns-disease/research-protocol
     December 01, 2019 - Grading the Evidence for Each Key Question At the completion of our review, we will grade the quantity … We will classify evidence pertaining to Key Questions 1 – 4 into four basic categories: (1) “high” grade … further research is very unlikely to change our confidence in the estimate of the effect); (2) “moderate” grade … research may change our confidence in the estimate of the effect and may change the estimate); (3) “low” grade … confidence in the estimate of the effect and is likely to change the estimate); and (4) “insufficient” grade

229. Disposition of Comments for CER 202 Effectiveness and Safety of Bronchial Thermoplasty in the Management of Asthma (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cer-202-thermoplasty-comments.pdf
     December 14, 2017 - Peer Reviewer 2 Methods Please explicitly define the GRADE criteria approach. … Classically, RCTs are usually reported as "the highest grade of evidence". furthermore, Air 2 used a … We would encourage consideration of a greater grade of ‘High’ be used to communicate the strength of … Given the ‘Low’ result describing pulmonary physiology, we would recommend AHRQ consider a ‘High’ grade … Each of the outcomes we deemed critical has its own strength of evidence grade for each intervention

230. Nephropathy-Contrast-Induced Executive (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/nephropathy-contrast-induced_executive.pdf
     October 01, 2015 - consistency, precision, reporting bias, and magnitude of effect.8 Following the guidance of the GRADE … The body of evidence was considered high grade if study limitations were low and there were no problems … GRADE guidelines 6. Rating the quality of evidence--imprecision.

231. Imaging for the Pretreatment Staging of Small Cell Lung Cancer | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/lung-cancer-staging/research
     December 01, 2019 - We assigned a grade of low to the strength of evidence for these conclusions, mostly due to risk of bias

232. Fractional Exhaled Nitric Oxide Clinical Utility in Asthma Management | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/asthma-nitric-oxide/research-protocol
     June 01, 2021 - Grading the Strength of Evidence (SOE) for Major Comparisons and Outcomes We will grade the strength … We will grade the strength of evidence for the outcomes we classified as most important or critical such … Independent reviewers, working in pairs, will grade the SOE and resolve the conflicts by discussion and

233. Closing the Quality Gap Series: Quality Improvement Interventions to Address Health Disparities | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/disparities-quality-improvement/research-protocol
     December 01, 2019 - Studies will be given a quality grade of good, fair, or poor per the Methods Guide for Effectiveness … Each key outcome on each comparison of interest will be given an overall evidence grade based on the … Two senior staff will independently grade the body of evidence; disagreements will be resolved as needed

234. Comparative Effectiveness of Bariatric Surgery and Nonsurgical Therapy in Adults With Metabolic Conditions and a Body Mass Index of 30.0 to 34.9 kg/m² | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/weight-loss-surgery/research-protocol
     December 01, 2019 - for its Effective Health Care Program. 19,20 This method is based loosely on one developed by the Grade … Working Group, 21 and classifies the grade of evidence according to the following criteria: High … The evidence grade is based on four primary (required) domains and four optional domains. … Atkins D, Best D, Briss PA, et al, for the GRADE Working Group.

235. Disposition of Comments CER 219 Antipsychotics for the Prevention and Treatment of Delirium (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/delirium-disposition-comments.pdf
     September 03, 2019 - Using positive results to determine which outcomes to grade could potentially introduce some bias into … We reviewed the outcomes where we did not grade the body of evidence (did not do SOE) to ensure that … outlined in the AHRQ Methods Guidance, which is very similar to the approach developed by others such as GRADE … For those that aren’t familiar with AHRQ reports or GRADE methodology, the phrase "strength of evidence … We added a footnote to Figures A and B of the Executive Summary defining each evidence grade.

236. Update of Comparative Effectiveness of Lipid-Modifying Agents | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/high-cholestorol-medicines-update/research-protocol
     December 01, 2019 - We will grade evidence for each outcome identified in the KQs. … “Moderate” grade (indicating moderate confidence that the evidence reflects the true effect, and further … “Low” grade (indicating low confidence that the evidence reflects the true effect, and further research … “Insufficient” grade (evidence is unavailable). … The grade of evidence for each KQ will be based on consensus.

237. Comparative Effectiveness of Venous Thromboembolism (VTE) Prophylaxis in Orthopedic Surgery | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/blood-clots-hip-knee-surgery/research-protocol
     December 01, 2019 - Grading the Strength of Evidence We will use EPC GRADE (Grading of Recommendations Assessment, Development … to each KQ will be classified into three broad categories: (1) “high”, (2) “moderate”, or (3) “low” grade … Definitions for grading the strength of evidence Grade Definition High There is high … GRADE handbook for grading quality of evidence and strength of recommendation. … The GRADE Working Group; 2008. Gartlehner G, Hansen RA, Nissman D, Lohr KN, Carey TS.

238. Radiotherapy Treatments for Head and Neck Cancer | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/head-neck-cancer-update/clinician
     December 01, 2019 - control and survival [evidence insufficient] [evidence insufficient] [evidence insufficient] Grade … IMRT [evidence medium] [evidence insufficient] [evidence insufficient] Other RT-associated grade

239. AHRQ Slide Template 2009 (ppt file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/reporting.ppt
     September 01, 2009 - to be limited to men under 65 years of age but is not dependent on baseline PSA level or histologic grade

240. Executive Summary_Comparative Effectiveness Review No. 259: Partial Breast Irradiation for Breast Cancer (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cer-259-partial-breast-irradiation-executive-summary.pdf
     January 01, 2023 - There were significantly fewer acute AEs and late AEs Grade ≥2 with IORT. … in clinical trials, for example, postmenopausal age range, estrogen receptor (ER) positive status, grade … patients who participated, for example age <50 years, invasive lobular carcinoma, tumor size 2.1-3 cm, grade