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201. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/cesarean-birth-2010_research-protocol.pdf
     January 01, 2010 - Studies will be given a quality grade of good, fair, or poor per the Methods Guide for Effectiveness … Each key outcome on each comparison of interest will be given an overall evidence grade based on the … Two senior staff will independently grade the body of evidence; disagreements will be resolved as needed

202. Dietary-Supplements Surveillance (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/dietary-supplements_surveillance.pdf
     January 01, 2013 - identified on the interaction between omega-3 fatty acids, both over-the- counter and prescription-grade … plus warfarin vs. warfarin alone: no significant difference in post-treatment INR (inconclusive; grade … studies were identified by the search and/or experts. 3 of the studies reported on prescription-grade … The mean SBP was significantly lowered in the supplement- statin combination group (grade: low) in … The mean SBP was significantly lowered in the supplement-statin combination group (grade: low) in 22

203. Evidence Report on the (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/arthritis-psoriatric_research-protocol.pdf
     December 06, 2010 - based on the standard methods of the EPCs, which use a revised version of the approach devised by the GRADE … Developed to grade the quality of evidence and the strength of recommendations, this approach incorporates … of evidence and the strength of recommendations I: Critical appraisal of existing approaches: The GRADE

204. Disposition of Comments Report for Comparative Effectiveness Review No. 131 (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/crohns-disease_disposition-comments.pdf
     February 25, 2014 - We relied on our defined approach to grade the strength of evidence. … The Colombel 2010 study was included in our assessment of the evidence grade. … approach to grading the strength of evidence in the methods section, with a definition of what each grade … We used GRADE formula to evaluate the strength of evidence, which included precision. … In summary, the report would greatly improve with standard GRADE style evidence profiles, as finding

205. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/plasma-cell-dyscrasias-sflc-assay_research-protocol.pdf
     May 02, 2011 - Grading the Evidence for Each Key Question We will follow the Methods Guide11 to grade the strength … Atkins D, Eccles M, Flottorp S, et al, for the GRADE Working Group.

206. Health Literacy Interventions and Outcomes: An Updated Systematic Review | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/health-literacy/research
     December 01, 2019 - health literacy directly and updated our approach to evaluate individual study risk of bias and to grade

207. PCA3 Testing for the Diagnosis and Management of Prostate Cancer | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/prostate-cancer-test/research
     December 01, 2019 - low, or insufficient according to Grading of Recommendations Assessment, Development and Evaluation (GRADE

208. Data Points #13: Use of preoperative MRI among older women with ductal carcinoma in situ and locally invasive breast cancer | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/dcis-mri-utilization/research
     December 01, 2019 - In general, women with higher risk DCIS (larger tumor size, higher grade disease, or ER-negative tumors

209. Evaluation of Effectiveness and Safety of Antiepileptic Medications in Patients with Epilepsy | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/epilepsy-medicine/research-protocol
     December 01, 2019 - Grading the Strength of Evidence We will use EPC methodology based on the criteria and methods of GRADE … The GRADE system uses four required domains – risk of bias, consistency, directness, and precision.45 … Definitions for grading the strength of evidence Grade Definition High There … GRADE handbook for grading quality of evidence and strength of recommendation. … The GRADE Working Group; 2008. Gartlehner G, Hansen RA, Nissman D, et al.

210. Transitional Care Interventions to Prevent Heart Failure Readmissions | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/heart-failure-transition-care/research-protocol
     December 01, 2019 - Grading the Strength of Evidence for Individual Comparisons and Outcomes We will grade the strength … on the guidance established for the Evidence-based Practice Center (EPC) Program. 47 Developed to grade … Definitions of the grades of overall strength of evidence Grade Definition Source … We will grade the strength of evidence for all outcomes related to health care utilization and health … We will not grade the evidence for KQ 3; this question is a descriptive question.

211. Pharmacokinetic/Pharmacodynamic Measures for Guiding Antibiotic Treatment for Nosocomial Pneumonia | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/pneumonia-antibiotic-treatment/research-protocol
     December 01, 2019 - Abdul-Aziz and colleagues 26 did not appraise the quality of individual studies or grade the quality … Grading the Strength of Evidence (SOE) for Individual Comparisons and Outcomes We will grade the strength … on the guidance established for the Evidence-based Practice Center (EPC) Program. 33 Developed to grade … Definitions of the grades of overall strength of evidence   Grade Definition … Source: Owens et al. 33 We will grade the strength of evidence for the outcomes deemed to be of greatest

212. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/gerd-disposition-120104.pdf
     April 01, 2011 - The evidence-based tables are appropriate and grade the evidence appropriately. … that the healing rate was only significantly different between PPI treatment groups in patients with grade … Please consider providing additional context as to definition of grade I versus grade C (scales). … , enrolled 4092 patients with endoscopically confirmed EE, 29% of which had moderate-to-severe EE (Grade … the gastric body (n=153) and antrum (n=152), 54% and 55% respectively experienced a reduction in grade

213. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/procalcitonin_research-protocol.pdf
     September 08, 2011 - was developed by the AHRQ EPC Program for the EPC Methods Guide, based on a system developed by the GRADE … Grade of evidence strength is classified into the following four categories: High-High confidence … The grade rating will be made by independent reviewers and disagreements will be resolved by consensus

214. Amended Protocol: Management of Infantile Epilepsy (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/infantile-epilepsy-amended-protocol.pdf
     March 07, 2021 - We will grade the SOE based on the EPC Methods Guide recommendations.4 The primary domains assessed

215. Partial Breast Irradiation for Breast Cancer | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/partial-breast-irradiation/research
     May 01, 2023 - There were significantly fewer acute AEs and late AEs Grade ≥2 with IORT. … In a detailed examination, grade 1 events were not statistically different; however, grade 2 and 3 events … Grade 3 acute toxicity events were very few, but numerically lower for PBI, largely as a result of the … For example, telangiectasia of any grade is reported in as many as 69 percent of patients treated with … on clinical trials, for example, postmenopausal age range, estrogen receptor (ER) positive status, grade

216. Alcohol-Misuse Research-Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/alcohol-misuse_research-protocol.pdf
     April 28, 2010 - Grade: B Recommendation Evidence is insufficient to recommend for or against screening and behavioral … Grade: I Statement The original systematic review conducted by the Oregon Evidence-based Practice … Grading the Evidence for Each Key Question We will grade the strength of evidence based on the guidance … established for the Evidence- based Practice Center Program. 41 Developed to grade the overall strength … Definitions of the grades of overall strength of evidence 41 Grade Definition High High confidence

217. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/wireless-motility-capsule_research-protocol.pdf
     March 14, 2012 - Grading the Evidence for Each Key Question – At the completion of our review, we will grade the strength … Effectiveness and Comparative Effectiveness Reviews.24,25 Both of these evidence grading schemes are based on GRADE … Source: www.effectivehealthcare.ahrq.gov Published Online: March 14, 2012 the estimate); 3) “low” grade … GRADE: an emerging consensus on rating quality of evidence and strength of recommendations.

218. Childhood Obesity Prevention Programs: A Comparative Effectiveness Review and Meta-Analysis | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/obesity-child/research-protocol
     December 01, 2019 - Grading the Evidence for Each Key Question At the completion of the review, we will grade the quantity … We will classify evidence pertaining to Key Questions 1- 7 into four basic categories: (1) “high” grade … further research is very unlikely to change our confidence in the estimate of the effect); (2) “moderate” grade … research may change our confidence in the estimate of the effect and may change the estimate); (3) “low” grade … confidence in the estimate of the effect and is likely to change the estimate); and (4) “insufficient” grade

219. Local Therapies for Unresectable Colorectal Cancer Metastases to the Liver: A Comparative Effectiveness Review | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/colorectal-cancer-liver-metastases-therapies/research-protocol
     December 01, 2019 - if the EPC staff believes that such evidence could impact results meaningfully (i.e., alter evidence GRADE … overall body of evidence is outlined in the Methods Guide 25 and is based on a system developed by the GRADE … The grade of evidence strength is classified into the following four categories: High. … The grade rating will be made by independent reviewers, and disagreements will be resolved by consensus

220. Labor Dystocia | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/labor-dystocia/research-protocol
     August 01, 2020 - outcome well but did an incomplete analysis of a secondary outcome would be assigned a different quality grade … Brown EPC. 25 Grading the Strength of Evidence (SOE) for Major Comparisons and Outcomes We will grade … the body of evidence for a particular outcome includes both RCTs and observational studies, we will grade … In these situations, a grade of "insufficient" will be assigned.