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21. Comparative Effectiveness of Adjunctive Devices to Remove Thrombi or Protect Against Distal Embolization in Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention of Native Vessels (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/acs-pci-adjunctive-devices_disposition-comments.pdf
    March 01, 2012 - But perhaps, investigators would still want to grade them so I agree to disagree. … (current usage is that of GRADE working group)  Only one body of evidence should be rated per outcome … of evidence is rated as low risk of bias; there is no inconsistency; imprecision – I would still grade … What we can conclude about the grade is that evidence is insufficient (insufficient in power) even when … In the methods section, we specify that the GRADE system was used for the grading of the strength of

22. Interventions To Modify Health Care Provider Adherence to Asthma Guidelines | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/asthma-provider-adherence/research
    December 01, 2019 - medications using decision support, feedback and audit, and clinical pharmacy support interventions and low grade … interventions to increase provision of patient self-education/asthma action plans; for the same outcome, low grade … Moderate grade evidence supports use of decision support tools to reduce ED visits/hospitalizations while … low grade evidence suggests there is no benefit associated with organizational change, education only

23. Integrating Bodies of Evidence: Existing Systematic Reviews and Primary Studies | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/integrating-evidence/methods
    December 01, 2019 - Robust quality assessments for existing systematic reviews (beyond AMSTAR 5 ), and; Methods to grade … Assessments that are compatible include the EPC SOE, GRADE, and USPTF tools. 16-18 However, no matter … However, the process for how to determine if there is sufficient evidence to change a prior grade is … What is enough, in terms of studies/type of evidence, to prompt a change in grade? … What is enough, in terms of studies/type of evidence, to prompt a change in grade?

24. Evidence-based Practice Center Systematic Review Protocol (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/vaccine-safety_research-protocol.pdf
    September 18, 2012 - For each AE associated with a particular vaccine, what is the average severity (grade 1/mild; grade … For each AE associated with a particular vaccine, what is the average severity (grade 1/mild; grade … For each AE associated with a particular vaccine, what is the average severity (grade 1/mild; grade … For each AE associated with a particular vaccine, what is the average severity (grade 1/mild; grade … The evidence grade is based on four primary (required) domains and four optional domains.

25. Integrating Bodies of Evidence: Existing Systematic Reviews and Primary Studies (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/integrating-evidence_methods.pdf
    February 01, 2015 - assessment of bodies of evidence again using their own criteria and judgment, while others do not grade … Assessments that are compatible include the EPC SOE, GRADE, and USPTF tools.16-18 However, no matter … However, the process for how to determine if there is sufficient evidence to change a prior grade is … What is enough, in terms of studies/type of evidence, to prompt a change in grade? 4. … What is enough, in terms of studies/type of evidence, to prompt a change in grade? 5.

26. Prioritization and Selection of Harms for Inclusion in Systematic Reviews (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/ehc-presentation-selection-harms-systematic-reviews.pdf
    February 01, 2018 - Assessment, Development and Evaluation (GRADE) group recommends that guideline developers prioritize … GRADE guidelines: 2. Framing the question and deciding on important outcomes. … GRADE guidelines: 12. Preparing Summary of Findings tables—binary outcomes. … GRADE guidelines: 2. Framing the question and deciding on important outcomes. … GRADE guidelines: 12. Preparing Summary of Findings tables—binary outcomes.

27. Protocol Amendment - Safety of Vaccines 030413 (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/vaccines-safety-protocol-130325.pdf
    September 18, 2012 - For each AE associated with a particular vaccine, what is the average severity (grade 1/mild; grade … For each AE associated with a particular vaccine, what is the average severity (grade 1/mild; grade … For each AE associated with a particular vaccine, what is the average severity (grade 1/mild; grade … For each AE associated with a particular vaccine, what is the average severity (grade 1/mild; grade … The evidence grade is based on four primary (required) domains and four optional domains.

28. Treatment of Stage I-III Squamous Cell Anal Cancer (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/anal-cancer-protocol.pdf
    September 26, 2023 - Guyatt GH OA, Kunz R, Vist GE, Falck-Ytter Y, Schünemann HJ; GRADE Working Group. … GRADE guidelines: 11. … Reference 21: Guyatt GH OA, Kunz R, Vist GE, Falck-Ytter Y, Schünemann HJ; GRADE Working Group. … GRADE guidelines: 11. … r) adj2 (assess* or burden or grade or grading or invasive* or metastas?

29. Meditation Programs for Stress and Well-Being | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/meditation/research-protocol
    December 01, 2019 - Grading the Evidence for Each Key Question At the completion of our review, we will grade the quantity … We will classify evidence pertaining to the KQs into four basic categories: 1) “high” grade (indicating … confidence in the estimate of the effect and is likely to change the estimate); and 4) “insufficient” grade … Grading the Evidence for Each Key Question At the completion of our review, we will grade the quantity … there are more direct measures of those domains. 3) To specify the details of how we will grade

30. Bladder-Cancer-Muscle-Invasive Executive (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/bladder-cancer-muscle-invasive_executive.pdf
    June 01, 2015 - A moderate grade indicates moderate confidence that the evidence reflects the true effect; further … Summary of evidence Key Question Outcome Strength- of-Evidence Grade Conclusion 1. … Summary of evidence (continued) Key Question Outcome Strength- of-Evidence Grade Conclusion 3. … Summary of evidence (continued) Key Question Outcome Strength- of-Evidence Grade Conclusion 4. … with grade 3 or 4 hematological adverse events.

31. Layout 1 (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/gerd-2005_executive.pdf
    January 01, 2005 - followup was 8 months, and all three studies had significant bias that may invalidate the results (Grade … These analyses had minimal bias and their results are considered valid (Grade A). … (Grade C) nonrandomized study. … This one study on Stretta™ versus sham had a small number of patients and short duration of followup (Grade … antireflux medications compared to medical patients; less bodily pain; no difference in esophagitis grade

32. Treatment of Stage I-III Squamous Cell Anal Cancer | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/anal-cancer-treatment/protocol
    October 01, 2023 - Guyatt GH OA, Kunz R, Vist GE, Falck-Ytter Y, Schünemann HJ; GRADE Working Group. … GRADE guidelines: 11. … Reference 21: Guyatt GH OA, Kunz R, Vist GE, Falck-Ytter Y, Schünemann HJ; GRADE Working Group. … GRADE guidelines: 11. … r) adj2 (assess* or burden or grade or grading or invasive* or metastas?

33. White Paper: Narratively Describing Effects of Interventions in Systematic Reviews (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/white-paper-roadmap-interventions.pdf
    November 01, 2020 - Informative Statements To Communicate Results of Systematic Reviews From GRADE Appendix C. … The GRADE Working Group developed in 2004 an approach for rating the certainty in evidence that has … Recently, the GRADE Working Group has proposed an approach for making narrative statements. … Using EPOC and GRADE suggestions, we developed a framework (Figure 1) for key overlapping constructs … Informative Statements To Communicate Results of Systematic Reviews From GRADE Appendix C.

34. Safety of Vaccines Used for Routine Immunization of Adults (Including Pregnant Women) and Children | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/vaccine-safety/research-protocol
    December 01, 2020 - For each AE associated with a particular vaccine, what is the average severity (grade 1/mild; grade 2 … For each AE associated with a particular vaccine, what is the average severity (grade 1/mild; grade 2 … For each AE associated with a particular vaccine, what is the average severity (grade 1/mild; grade 2 … For each AE associated with a particular vaccine, what is the average severity (grade 1/mild; grade 2 … The evidence grade is based on four primary (required) domains and four optional domains.

35. Methods Research Report - Framework for Determining Research Gaps During Systematic Review: Evaluation (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/research-gaps_research.pdf
    February 01, 2013 - • GRADE: The GRADE Working Group advises decreasing the grade of the quality of the evidence if … • GRADE: Consistency is a key element. … • GRADE: Directness is a key element. … • GRADE: The GRADE Working Group advises decreasing the grade of the quality of the evidence if … • GRADE: The GRADE Working Group advises decreasing the grade of the quality of the evidence if

36. Executive Summary_Comparative Effectiveness Review No. 273_Treatment of Stages I-III Squamous Cell Anal Cancer: A Systematic Review (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cer-273-anal-cancer-executive-summary.pdf
    August 01, 2024 - RT alone, frequency: 1 vs.0 grade 4 events (n=110); or 20 vs.0 overall events (n=585). … cisplatin, with grade 3+ toxicity frequency of 61% vs. 42% (p<0.001, n=682) and 26% vs. 16% (p<0.001 … Low Neutropenia (grade 3 or 4) 1; RCT; n=144 No significant difference, imprecise estimates. … Low Note: Remaining comparisons not mentioned in the table received an insufficient grade. … All harms are grade 3 or 4 unless specified otherwise.

37. Grading the Strength of a Body of Evidence When Assessing Health Care Interventions for the Effective Health Care Program of the Agency for Healthcare Research and Quality: An Update | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/methods-guidance-grading-evidence/methods
    November 01, 2017 - Skip to main content An official website of the Department of Health & Human Services Careers Contact Us Español FAQs Effective Health Care Program Powered by the Evidence-based Practice Centers …

38. Meditation Research-Protocol (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/meditation_research-protocol.pdf
    October 17, 2012 - research is very unlikely to change our confidence in the estimate of the effect); (2) “moderate” grade … We will classify evidence pertaining to Key Questions into four basic categories: (1) “high” grade … research is very unlikely to change our confidence in the estimate of the effect); (2) “moderate” grade … but there are more direct measures of those domains. 3) To specify the details of how we will grade … Protocol Revised Protocol Rationale and is likely to change the estimate); and (4) “insufficient” grade

39. Grading the Strength of a Body of Evidence when Comparing Medical Interventions | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/methods-guidance-grading-strength
    March 01, 2021 - Skip to main content An official website of the Department of Health & Human Services Careers Contact Us Español FAQs Effective Health Care Program Powered by the Evidence-based Practice Centers …

40. Disposition of Comments Report for Allergen-Specific Immunotherapy for the Treatment of Allergic Rhinoconjunctivitis and/or Asthma (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/asthma-immunotherapy-2010_disposition-comments.pdf
    January 01, 2010 - Our group did not use statistical significance/precision to grade articles. … Instead, as described in our methods section, In our grade assignments, we considered the limitations … We used the GRADE tool, as a recognized method when performing effectiveness reviews. … In our grade assignments, we considered the limitations of each individual study’s quality (using the … We did not grade Pulmonary function test because it is an intermediate outcome.