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181. Evidence-based Practice Center Systematic Review Protocol: Therapies for Clinically Localized Prostate Cancer (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/prostate-cancer-therapies-protocol_amended110619.pdf
     November 02, 2019 - characteristics (e.g., age, ethnicity, comorbidities, preferences), tumor characteristics (e.g., PSA, histologic grade … Comparisons and Outcomes: We will use the Grading of Recommendations Assessment, Development and Evaluation (GRADE … We will present the overall quality or certainty of the evidence for key outcomes according to the GRADE … GRADE guidelines: 11. … localized prostate cancer EAU= European Association of Urology EBRT= external beam radiotherapy GRADE

182. Therapies for Clinically Localized Prostate Cancer | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/prostate-cancer-therapies/protocol
     March 01, 2020 - characteristics (e.g., age, ethnicity, comorbidities, preferences), tumor characteristics (e.g., PSA, histologic grade … Comparisons and Outcomes: We will use the Grading of Recommendations Assessment, Development and Evaluation (GRADE … We will present the overall quality or certainty of the evidence for key outcomes according to the GRADE … GRADE guidelines: 11. … localized prostate cancer EAU= European Association of Urology EBRT= external beam radiotherapy GRADE

183. Research Protocol: Diabetes Medications for Adults With Type 2 Diabetes: An Update Focused on Monotherapy and Add-On Therapy to Metformin (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/diabetes-update-2015_research-protocol.pdf
     January 01, 2015 - § Hemoglobin A1c (will not evaluate metformin vs. sulfonylureas, evidence is high grade … not evaluate for metformin vs. thiazolidinediones or metformin vs. sulfonylureas; evidence is high grade … be (will not evaluate any of these for metformin vs. sulfonylureas except cancer; evidence is high grade … Additionally, we will grade the strength of evidence for adverse events that are most relevant for a … could change our confidence in the estimate of the effect and may change the estimate); (3) “low” grade

184. Evidence Report on the (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/vte-protocol-8-4-10.pdf
     February 01, 2008 - to each KQ will be classified into three broad categories: (1) “high”, (2) “moderate”, or (3) “low” grade … Definitions for grading the strength of evidence Grade Definition High There is high confidence that … GRADE handbook for grading quality of evidence and strength of recommendation. … The GRADE Working Group; 2008. 12. Gartlehner G, Hansen RA, Nissman D, Lohr KN, Carey TS. … DVT Deep vein thrombosis EPC Evidence based practice center GCS Graduated compression stocking GRADE

185. Evidence Report on the (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/blood-clots-hip-knee-surgery_research-protocol.pdf
     February 01, 2008 - to each KQ will be classified into three broad categories: (1) “high”, (2) “moderate”, or (3) “low” grade … Definitions for grading the strength of evidence Grade Definition High There is high confidence that … GRADE handbook for grading quality of evidence and strength of recommendation. … The GRADE Working Group; 2008. 12. Gartlehner G, Hansen RA, Nissman D, Lohr KN, Carey TS. … DVT Deep vein thrombosis EPC Evidence based practice center GCS Graduated compression stocking GRADE

186. Healthcare Delivery of Clinical Preventive Services for People with Disabilities (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/people-with-disabilities-protocol.pdf
     January 16, 2024 - A and Grade B recommendations: - Screening (anxiety disorders, breast cancer, cervical cancer, colorectal … Each included preventive service has a Grade A or Grade B recommendation from the United States Preventive … For each population (adults; children and adolescents), screening for depression is Grade B, and screening … for suicide risk is Grade I (insufficient). … Because having a USPSTF Grade A or Grade B recommendation is an inclusion criterion for the systematic

187. Serum-Free Light Chain Analysis for the Diagnosis, Management, and Prognosis of Plasma Cell Dyscrasias | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/plasma-cell-dyscrasias-sflc-assay/research-protocol
     December 01, 2019 - Grading the Evidence for Each Key Question We will follow the Methods Guide 11 to grade the strength … Atkins D, Eccles M, Flottorp S, et al, for the GRADE Working Group.

188. Executive summary_Comparative Effectiveness Review No. 276: Diagnosis and Management of Obsessive Compulsive Disorders in Children (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cer-276-ocd-executive-summary.pdf
     December 01, 2024 - Executive summary_Comparative Effectiveness Review No. 276: Diagnosis and Management of Obsessive Compulsive Disorders in Children Comparative Effectiveness Review Number 276 Diagnosis and Management of Obsessive Compulsive Disorders in Children Executive Summary Main Points • Diagnosis of O…

189. Strategies To Reduce Cesarean | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/cesarean-birth-2010/research-protocol
     December 01, 2019 - Studies will be given a quality grade of good, fair, or poor per the Methods Guide for Effectiveness … Each key outcome on each comparison of interest will be given an overall evidence grade based on the … Two senior staff will independently grade the body of evidence; disagreements will be resolved as needed

190. Local Therapies for Unresectable Primary Hepatocellular Carcinoma | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/liver-cancer-therapy/research
     December 01, 2019 - survival when treated with RFA was superior to that for PEI/PAI for unresectable HCC, with a moderate grade

191. Healthcare Delivery of Clinical Preventive Services for People with Disabilities | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/people-with-disabilities/protocol
     February 01, 2024 - A and Grade B recommendations: Screening (anxiety disorders, breast cancer, cervical cancer, colorectal … Each included preventive service has a Grade A or Grade B recommendation from the United States Preventive … Directness (direct or indirect) Precision (precise or imprecise) The SOE will be assigned an overall grade … for suicide risk is Grade I (insufficient). … Because having a USPSTF Grade A or Grade B recommendation is an inclusion criterion for the systematic

192. Procalcitonin for Diagnosis and Management of Sepsis | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/procalcitonin/research-protocol
     December 01, 2019 - overall body of evidence is outlined in the Methods Guide 10 and is based on a system developed by the GRADE … The grade of evidence strength is classified into the following four categories: High. … The grade rating will be made by independent reviewers, and disagreements will be resolved by consensus

193. RENAL MASS AND LOCALIZED RENAL CANCER *the following questions are recommended to address the healthcare tests and/or treatments this program should consider: • What indicators can be used to predict malignancy and/or aggressiveness of… | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/renal-mass-and-localized-renal-cancer-the-following-questions-are-recommended-to-address-the-healthcare-tests-andor-treatments-this-program-should-consider-what-indicators-can-be-used-to-predict-malignancy-andor-aggressivene
     November 01, 2017 - in patients with a localized renal mass, including demographic information, biopsy data (histology, grade … What impact do tumor characteristics (size, stage, grade, histologic subtype and other histologic features … What impact do tumor characteristics (size, stage, grade, histologic subtype and other histologic features … strategies: Prognostic Markers: Tumor characteristics Standard histological findings (cell-type, grade

194. Wireless Motility Capsule Versus Other Diagnostic Technologies for Evaluating Gastroparesis and Constipation: A Comparative Effectiveness Review | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/wireless-motility-capsule/research-protocol
     December 01, 2019 - Grading the Evidence for Each Key Question At the completion of our review, we will grade the strength … and Comparative Effectiveness Reviews . 24,25 Both of these evidence grading schemes are based on GRADE … research may change our confidence in the estimate of the effect and may change the estimate); 3) “low” grade … GRADE: an emerging consensus on rating quality of evidence and strength of recommendations.

195. Interventions to Improve Care of Bereaved Persons | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/bereaved-persons/protocol
     December 01, 2023 - We will apply the EPC strength of evidence criteria to evaluate the body of evidence, informed by GRADE … determining strength of evidence for each primary clinical outcome by following the principles for adapting GRADE … unmeasured confounders) as described in the AHRQ Methods guides. 45 A final strength of evidence grade … The strength of evidence will be assigned an overall grade of high, moderate, low, or insufficient according … Judging the quality of evidence in reviews of prognostic factor research: adapting the GRADE framework

196. Disposition of Comments for CER 196 The Role of Immunotherapy in the Treatment of Asthma (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cer-196-disposition-comments-immunotherapy-asthma.pdf
     March 23, 2018 - here) Peer Reviewer #2 Introduction Also some background on the GINA classification/severity grade … Anaphylaxis was pre-specified in our protocol as a critical outcome, that is, an outcome for which we would grade … One case series reported of one participant out of 18 presenting “Bronchospasm grade 2”, after receiving … on the 2010 grading system, local reactions with SLIT such as lip pruritus would be considered a grade … We added following text to our limitations section in Discussion: "We tried to grade all adverse events

197. Blood-based Tests for Multiple Cancer Screening: A Systematic Review (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cell-free-dna-protocol.pdf
     June 05, 2024 - Based on input from our review’s Key Informants and Technical Expert Panel, we will grade SOE for the … GRADE guidelines: 21 part 1. … GRADE guidelines: 22. … GRADE Working Group. Welcome to the GRADE working group. 2024. … GRADE Guidance 34: update on rating imprecision using a minimally contextualized approach.

198. Blood-based Tests for Multiple Cancer Screening: A Systematic Review | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/cell-free-dna/protocol
     July 01, 2024 - working group. 22 We will grade outcomes from RCT bodies of evidence separately from outcomes from … GRADE guidelines: 21 part 1. … GRADE guidelines: 22. … GRADE Working Group. Welcome to the GRADE working group. 2024 . Accessed on May 29, 2024. … GRADE Guidance 34: update on rating imprecision using a minimally contextualized approach.

199. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/cancer-ovarian-contraceptives_research-protocol.pdf
     March 13, 2012 - The strength of evidence will also be assigned an overall grade of high, moderate, low, or insufficient … The final choice of which outcomes to grade will be based on rankings of the potential impact of OC

200. Chronic Venous Ulcers: A Comparative Effectiveness Review of Treatment Modalities | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/venous-ulcers-treatment/research-protocol
     December 01, 2019 - clinical severity, etiology, anatomy, and pathophysiology.5 In this classification scheme, the highest grade … We will grade the strength of evidence based on the quantity, quality, and consistency of the best available … We will classify evidence pertaining to the KQs into four basic categories: 1) “high” grade (indicating … confidence in the estimate of the effect and is likely to change the estimate); and 4) “insufficient” grade … wound filler Foams Sterile, nonlinting, absorptive dressing made of open cell, medical grade