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161. Speech and Communication Disorders | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/health-topics/speech-and-communication-disorders
     April 04, 2011 - By first grade, about 5 percent of children have noticeable speech disorders.

162. Colorectal-Cancer-Staging Executive (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/colorectal-cancer-staging_executive.pdf
     September 01, 2014 - Disease characteristics (e.g., tumor grade)? iii. … Disease characteristics (e.g., tumor grade)? iii. … The grade was developed by considering four important domains: study limitations (based on the risk … Disease characteristics (e.g., tumor grade)? iii. … Disease characteristics (e.g., tumor grade)? iii.

163. worker-health-protocol-150526 (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/worker-health_research-protocol.pdf
     May 26, 2015 - Grading the Strength of Evidence for Major Comparisons and Outcomes: We will grade the strength of evidence … based on the guidance established for the Evidence-based Practice Center Program.23 Developed to grade … We will grade the strength of evidence related to all outcomes relevant to KQ 2. … Definitions of the grades of overall strength of evidence Grade Definition High We are very confident

164. Comparative Effectiveness of Fecal DNA Testing in Screening for Colorectal Cancer in Average-Risk Adults | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/colorectal-cancer-screening/research-protocol
     December 01, 2019 - villous histology) Composite outcome, that is, advanced neoplasia (adenocarcinoma, adenomas with high-grade … Grading the Evidence for Each Key Question We will grade the strength of evidence for primary outcomes … as outlined in the Methods Guide for Effectiveness and Comparative Effectiveness Reviews . 17 The grade … Strength of evidence grades and definitions Grade Definition High High confidence

165. CER 215 Executive Summary: Adverse Effects of Pharmacologic Treatments of Major Depression in Older Adults (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cer-215-depression-older-adults-executive-summary.pdf
     March 01, 2019 - variety of potential outcomes on which to focus, and after Technical Expert Panel input, we decided to grade … adverse event profiles, particularly when SOE ratings are low or for outcomes that do not have a SOE grade

166. Non-Pharmacologic Interventions for Treatment-resistant Depression in Adults — Research Protocol Document | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/treatment-resistant-depression/research-protocol
     March 01, 2020 - based on the standard methods of the EPCs, which use a revised version of the approach devised by the GRADE … Developed to grade the quality of evidence and the strength of recommendations, this approach incorporates … quality of evidence and the strength of recommendations I: Critical appraisal of existing approaches: The GRADE

167. Maternal, Fetal, and Child Outcomes of Mental Health Treatments in Women: A Systematic Review of Perinatal Pharmacological Interventions (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/cer-236-maternal-fetal-child-outcomes-disposition-comments.pdf
     April 15, 2021 - Readers that are unfamiliar with the AHRQ or GRADE review methodologies may be confused by phrases … We revised the paragraphs to insert the grade parenthetically when not otherwise stated. … Throughout the document, it would be helpful to minimize use of GRADE related or statistical jargon … The GRADE terminology is confusing enough to the average reader as are the concepts of upgrading and … of the GRADE related terms and jargon.

168. Interventions to Improve Care of Bereaved Persons (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/bereaved-persons-protocol.pdf
     June 01, 2023 - We will apply the EPC strength of evidence criteria to evaluate the body of evidence, informed by GRADE … determining strength of evidence for each primary clinical outcome by following the principles for adapting GRADE … unmeasured confounders) as described in the AHRQ Methods guides.45 A final strength of evidence grade … The strength of evidence will be assigned an overall grade of high, moderate, low, or insufficient … Judging the quality of evidence in reviews of prognostic factor research: adapting the GRADE framework

169. Comparative Effectiveness of Therapies for Clinically Localized Prostate Cancer: An Update of a 2008 Comparative Effectiveness Review | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/prostate-cancer-therapies-update/research-protocol
     December 01, 2019 - Current practice is to use tumor grade as the primary prognostic variable in patients with clinically … of active surveillance and other observational management strategies for PSA-screening–detected, low-grade … have clinically localized prostate cancer (T1 to T2, N0 to X, M0 to X) regardless of age, histologic grade … Strength-of-evidence grade for the body of evidence Grade Evidence-based Practice Center Program … We will consider the primary biology and epidemiology (grade and stage of the prostate cancer) and the

170. Management of Suicidal Thoughts and Behaviors in Youth (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/suicidal-thoughts-young-people-draft-protocol.pdf
     March 14, 2024 - Grading the Strength of Evidence (SOE) for Major Comparisons and Outcomes We will grade the strength … Comparative Effectiveness Reviews on assessing SOE.31 RCTs will start with a provisional high SOE grade … , while observational studies will start with a provisional low SOE grade.31 The domains to be used … for determining final SOE grade will be: the methodological limitations of the studies (i.e., risk of

171. Management of Suicidal Thoughts and Behaviors in Youth (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/suicidal-thoughts-young-people-amendement.pdf
     February 05, 2025 - Grading the Strength of Evidence (SOE) for Major Comparisons and Outcomes We will grade the strength … Comparative Effectiveness Reviews on assessing SOE.31 RCTs will start with a provisional high SOE grade … , while observational studies will start with a provisional low SOE grade.31 The domains to be used … for determining final SOE grade will be: the methodological limitations of the studies (i.e., risk of

172. Screening, Behavioral Counseling, and Referral in Primary Care to Reduce Alcohol Misuse | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/alcohol-misuse/research-protocol
     December 01, 2019 - Grade: B Recommendation Evidence is insufficient to recommend for or against screening and behavioral … Grade: I Statement The original systematic review conducted by the Oregon Evidence-based Practice … Grading the Evidence for Each Key Question We will grade the strength of evidence based on the guidance … established for the Evidence-based Practice Center Program. 41 Developed to grade the overall strength … Definitions of the grades of overall strength of evidence 41 Grade Definition High

173. Comparative Effectiveness of Hematopoietic Stem-cell Transplantation in the Pediatric Population | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/stem-cell-children/research-protocol
     December 01, 2019 - of evidence was developed by AHRQ 8 for the EPC Methods Guide, based on a system developed by the GRADE … Grade of evidence strength is classified into the following four categories: High quality: Further … GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. … captured in overall survival we decided to use overall survival as the basis for our synthesis and GRADE … minimizing the available evidence on the basis of individual study quality, and instead focus on the GRADE

174. AHRQ’s Evidence-based Practice Center Program: Synthesizing evidence to improve health care practice and delivery (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/epc-health-care-practice-delivery.pdf
     November 01, 2022 - They grade and assess the strength of the evidence base.

175. Prostate-Cancer-Therapies-Update Research-Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/prostate-cancer-therapies-update_research-protocol.pdf
     April 01, 2013 - Current practice is to use tumor grade as the primary prognostic variable in patients with clinically … localized prostate cancer.2 After biopsy confirms the presence of the cancer, pathologists report tumor grade … active surveillance and other observational management strategies for PSA-screening–detected, low-grade … Strength-of-evidence grade for the body of evidence Grade Evidence-based Practice Center Program Definition … We will consider the primary biology and epidemiology (grade and stage of the prostate cancer) and the

176. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/type-2-diabetes-medications-update_research-protocol.pdf
     April 06, 2010 - Grading the Evidence for Each Key Question At the completion of our review, we will grade the quantity … will classify evidence pertaining to Key Questions 1, 2 and 3, into four basic categories: (1) “high” grade … research is very unlikely to change our confidence in the estimate of the effect); (2) “moderate” grade … research may change our confidence in the estimate of the effect and may change the estimate); (3) “low” grade … confidence in the estimate of the effect and is likely to change the estimate); and (4) “insufficient” grade

177. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/colorectal-cancer-screening_research-protocol.pdf
     May 18, 2011 - histology) c) Composite outcome, that is, advanced neoplasia (adenocarcinoma, adenomas with high-grade … Grading the Evidence for Each Key Question We will grade the strength of evidence for primary outcomes … as outlined in the Methods Guide for Effectiveness and Comparative Effectiveness Reviews. 17 The grade … Strength of evidence grades and definitions Grade Definition High High confidence that the evidence

178. Screening and Diagnosis of Gestational Diabetes Mellitus | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/gestational-diabetes-screening-diagnosis/research-protocol
     December 01, 2019 - Grading the Evidence for Each Key Question Two independent reviewers will grade the strength of the … evidence for major outcomes and comparisons using the Evidence-based Practice Center (EPC) GRADE approach30 … We will grade the following key outcomes: birth injury, preeclampsia, neonatal hypoglycemia, maternal … We will not grade the evidence on the test properties of the screening and diagnostic tests (KQ1). … Low-quality cohort studies will receive an initial grade of “low” strength of evidence.

179. Diagnostic Errors in the Emergency Department: A Systematic Review | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/diagnostic-errors-emergency/protocol
     February 01, 2021 - Strength of Evidence (SOE) for Major Comparisons and Outcomes— At the completion of our review, we will grade … We will classify evidence pertaining to the Key Questions into four categories: (1) "high" grade (indicating … further research is very unlikely to change our confidence in the estimate of the effect); (2) "moderate" grade … research could change our confidence in the estimate of the effect and may change the estimate); (3) "low" grade … confidence in the estimate of the effect and is likely to change the estimate); and (4) "insufficient" grade

180. depression-pregnancy-postpartum-protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/depression-pregnancy-postpartum_research-protocol.pdf
     March 29, 2013 - skills) and educational achievement o Kindergarten readiness o Age at Kindergarten entry o Third grade … testing outcomes o Other standard testing outcomes (Eighth grade, etc) o Intelligence tests (any … edited version of the chapter has also been published in the Journal of Clinical Epidemiology23) to grade … Based on this assessment, the body of evidence will be assigned a strength-of-evidence grade of high … In cases where evidence does not exist, is sparse, or contains irreconcilable inconsistency, a grade