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141. Pharmacologic Management of Acute Pain by EMS in the Prehospital Setting Protocol Amendment (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/acute-pain-ems-protocol-amendment.pdf
     January 28, 2019 - Grading the Strength of Evidence (SOE) for Major Comparisons and Outcomes - We will grade the SOE … based on the guidance established for the EPC program.31 We plan to grade the comparisons of opioids … At the completion of the review, two reviewers will independently grade the SOE.

142. Pharmacologic Management of Acute Pain by EMS in the Prehospital Setting | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/acute-pain-ems/protocol
     February 01, 2019 - Grading the Strength of Evidence (SOE) for Major Comparisons and Outcomes— We will grade the SOE based … on the guidance established for the EPC program. 31 We plan to grade the comparisons of opioids (fentanyl … At the completion of the review, two reviewers will independently grade the SOE.

143. Treatment of Depression During Pregnancy and the Postpartum Period | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/depression-pregnancy-postpartum/research-protocol
     December 01, 2019 - skills) and educational achievement Kindergarten readiness Age at Kindergarten entry Third grade … testing outcomes Other standard testing outcomes (Eighth grade, etc) Intelligence tests (any) … edited version of the chapter has also been published in the Journal of Clinical Epidemiology 23 ) to grade … Based on this assessment, the body of evidence will be assigned a strength-of-evidence grade of high, … In cases where evidence does not exist, is sparse, or contains irreconcilable inconsistency, a grade

144. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/weight-gain-prevention_research-protocol.pdf
     January 01, 2020 - Grading the Evidence for Each Key Question At the completion of our review, we will grade the quantity … We will classify evidence pertaining to Key Questions 1 – 6 into four basic categories: (1) “high” grade … research is very unlikely to change our confidence in the estimate of the effect); (2) “moderate” grade … confidence in the estimate of the effect and is likely to change the estimate); and (4) “insufficient” grade … The grade of evidence for each key question will be based on consensus. G.

145. Comparative Effectiveness of Approaches to Weight Maintenance in Adults | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/weight-gain-prevention/research-protocol
     December 01, 2019 - Grading the Evidence for Each Key Question At the completion of our review, we will grade the quantity … We will classify evidence pertaining to Key Questions 1–6 into four basic categories: (1) “high” grade … research may change our confidence in the estimate of the effect and may change the estimate); (3) “low” grade … confidence in the estimate of the effect and is likely to change the estimate); and (4) “insufficient” grade … The grade of evidence for each key question will be based on consensus. G.

146. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/treatment-resistant-depression_research-protocol.pdf
     December 09, 2009 - based on the standard methods of the EPCs, which use a revised version of the approach devised by the GRADE … working group.4 Developed to grade the quality of evidence and the strength of recommendations, this … Atkins D, Eccles M, Flottorp S, et al, for the GRADE Working Group.

147. Telehealth During COVID-19 | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/virtual-health-covid/protocol
     January 01, 2023 - Grading the Strength of Evidence (SoE) We will grade the body of evidence separately for quantitative … Applying GRADE-CERQual to qualitative evidence synthesis findings: introduction to the series. … Applying GRADE-CERQual to qualitative evidence synthesis findings-paper 4: how to assess coherence. … Applying GRADE-CERQual to qualitative evidence synthesis findings-paper 6: how to assess relevance of … Applying GRADE-CERQual to qualitative evidence synthesis findings-paper 5: how to assess adequacy of

148. Diabetes Medications for Adults with Type 2 Diabetes: An Update Focused on Monotherapy and Add-on Therapy to Metformin | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/diabetes-update-2015/research-protocol
     December 01, 2019 - KQ1 will be: Hemoglobin A1c (will not evaluate metformin vs. sulfonylureas, evidence is high grade … not evaluate for metformin vs. thiazolidinediones or metformin vs. sulfonylureas; evidence is high grade … be (will not evaluate any of these for metformin vs. sulfonylureas except cancer; evidence is high grade … Additionally, we will grade the strength of evidence for adverse events that are most relevant for a … We will classify evidence pertaining to the Key Questions into four categories: (1) “high” grade (indicating

149. Emerging Approaches to Diagnosis and Treatment of Non–Muscle-Invasive Bladder Cancer | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/bladder-cancer-non-muscle-invasive/research
     December 01, 2019 - Sensitivity increased for higher stage and grade tumors. … Intravesical therapy appeared to be effective across subgroups defined by tumor stage, grade, multiplicity

150. Diagnosis and Treatment of Non-muscle Invasive Bladder Cancer | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/diagnosis-and-treatment-of-non-muscle-invasive-bladder-cancer
     November 01, 2020 - How do tumor characteristics (stage, grade, multiplicity, size, molecular and genetic alterations) predict … consistently worse for African Americans than for any other ethnicity, even when stratified by stage and grade … excess hazard of death from bladder cancer among African Americans despite adjustment of age, stage and grade … Soloway 2003, Donat 2004, Gofrit 2006) However, only those patients with a well-documented history of low grade … heterogeneous and includes tumors that are papillary in nature and limited to the mucosa (Ta), high-grade

151. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/asthma-provider-adherence_research-protocol.pdf
     March 02, 2012 - Grading the Strength of Evidence for Each Key Question Two reviewers independently will grade the … Source: www.effectivehealthcare.ahrq.gov Published Online: March 2, 2012 categories: 1) “high” grade … further research is very unlikely to change our confidence in the estimate of the effect); 2) “moderate” grade … research may change our confidence in the estimate of the effect and may change the estimate); 3) “low” grade … confidence in the estimate of the effect and is likely to change the estimate); and 4) “insufficient” grade

152. Evidence Report on the (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/osteoarthritis-pain_research-protocol.pdf
     August 05, 2010 - No pharmaceutical grade formulation is approved by the FDA. … Accordingly, this report will focus on studies of nonpharmaceutical grade preparations available in … Studies of pharmaceutical-grade glucosamine and chondroitin will also be included, however; they will … evidence for each key question using the four categories recommended by Owens, et al.13: (1) “high” grade … the confidence in the estimate of effect and is likely to change the estimate; (4) “insufficient” grade

153. Oral Contraceptive Use for the Primary Prevention of Ovarian Cancer | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/cancer-ovarian-contraceptives/research-protocol
     December 01, 2019 - The strength of evidence will also be assigned an overall grade of high, moderate, low, or insufficient … The final choice of which outcomes to grade will be based on rankings of the potential impact of OC use

154. Disposition of Comments for CER 222: Achieving Health Equity in Preventive Services (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cer-222-health-equity-preventive-services-comments.pdf
     December 03, 2019 - The grading system for the evidence appeared to lack clarity-the specific tool used to determine the grade

155. Radiotherapy Treatments for Head and Neck Cancer (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/head-neck-cancer-update_clinician.pdf
     August 01, 2015 - PBT Tumor control and survival ��� ��� ��� Grade ≥2 late xerostomia* Significantly reduced incidence … � Quality of life related to late xerostomia Improved with IMRT (���) ��� ��� Other RT-associated grade

156. Layout 1 (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/prostate-cancer_executive.pdf
     February 01, 2008 - Histologic grade was associated with overall and prostate-cancer-specific survival. … Men with low-grade prostate cancers had a minimal risk of dying from prostate cancer (7 percent with … Differences remained significant for late Grade 2 GI morbidity. … Acute urinary toxicity, Grade 1, was detected in 37%-46% after different doses of IMRT. … Percentages were 28%-31% for GU toxicity Grade 2. Absolute risk of late toxicity was <20%.

157. Evidence Report on the (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/rheumatoid-arthritis-medicine_research-protocol.pdf
     December 06, 2010 - the Evidence-based Practice Centers, which use a revised version of the approach devised by the GRADE … Working Group.6 Developed to grade the quality of evidence and the strength of recommendations, this … Atkins D, Eccles M, Flottorp S, et al, for the GRADE Working Group. … of evidence and the strength of recommendations I: critical appraisal of existing approaches: the GRADE

158. Nonpharmacological Versus Pharmacological Treatments for Adult Patients With Major Depressive Disorder | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/major-depressive-disorder/research
     December 01, 2019 - Skip to main content An official website of the Department of Health & Human Services Careers Contact Us Español FAQs Effective Health Care Program Powered by the Evidence-based Practice Centers …

159. Improving the Management of Menopausal Symptoms in Perimenopausal and Early Postmenopausal Women: A Systematic Review | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/menopausal-symptoms/protocol
     February 01, 2025 - Preventive Services Task Force recommends against use of HT to prevent chronic conditions (Grade D). … If no studies are identified that report an outcome selected for SOE grading, we will grade the outcome … Otherwise, we will assign an overall SOE grade for each comparison and outcome as high, moderate, low … To grade the SOE, we will consider the domains of consistency, precision, directness, study limitations … GRADE Guidance 34: update on rating imprecision using a minimally contextualized approach.

160. Telehealth During COVID-19 (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/product/pdf/telehealth-during-COVID-19-amendments.pdf
     April 28, 2022 - Grading the Strength of Evidence (SoE) We will grade the body of evidence separately for quantitative … Applying GRADE-CERQual to qualitative evidence synthesis findings: introduction to the series. … Applying GRADE-CERQual to qualitative evidence synthesis findings-paper 4: how to assess coherence. … Applying GRADE-CERQual to qualitative evidence synthesis findings-paper 6: how to assess relevance of … Applying GRADE-CERQual to qualitative evidence synthesis findings-paper 5: how to assess adequacy of