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121. Moyer_ECCS2012 (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/moyer_eccs2012.pdf
     January 01, 2012 - Preventive Services  Task Force Recommendation Grades Grade Definition A The U.S.

122. Self-Measured Blood Pressure Monitoring | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/measuring-blood-pressure/research-protocol
     March 01, 2020 - Each Key Question We will follow the AHRQ Methods Guide for Comparative Effectiveness Reviews to grade … For each outcome (or set of outcomes), we will assign a grade for the strength of evidence: high, moderate

123. The Role of Immunotherapy and the Management of Asthma: Systematic Review (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/asthma-immunotherapy_research-protocol.pdf
     September 14, 2016 - Grading the Evidence for Each Key Question For key questions 1 and 3 we will grade asthma control composite … For key questions 2 and 4 we will grade harms: anaphylaxis, hypersensitivity adverse effects and death … tables.40 We will classify evidence pertaining to the Key Questions into four categories: (1) “High” grade … research is very unlikely to change our confidence in the estimate of the effect); (2) “Moderate” grade … could change our confidence in the estimate of the effect and may change the estimate); (3) “Low” grade

124. Assessing-The-Risk-Of-Bias-In-Systematic-Reviews-Of-Health-Care-Interventions (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/assessing-the-risk-of-bias-in-systematic-reviews-of-health-care-interventions-01_0.pdf
     May 01, 2005 - from randomized controlled trials a high grade. … GRADE guidelines 6. Rating the quality of evidence- imprecision. … GRADE guidelines: 8. Rating the quality of evidence- indirectness. … GRADE guidelines: 7. Rating the quality of evidence- inconsistency. … GRADE guidelines: 5. Rating the quality of evidence-publication bias.

125. Protocol: Imaging for Pretreatment Staging of Small Cell Lung Cancer (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/lung-cancer-staging_research-protocol.pdf
     December 08, 2014 - The reason that we will consider sensitivity and specificity together for a single grade is that the … The output is a grade for the strength of evidence: High, Moderate, Low, or Insufficient. … This grade is provided separately for each outcome of each comparison of each Key Question. … This domain will generally increase the strength of evidence grade. … If true, this domain will generally increase the strength of evidence grade.

126. Menopause-Protocol-130612 (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/menopause-protocol-130612.pdf
     June 12, 2013 - primary evidence base34 (supplemented by any more recent RCTs and observational studies when the GRADE … members concur that if obtained, evidence could impact results meaningfully (i.e., alter evidence GRADE … Moreover, all observational data are considered lesser (low) GRADE strength.35 The perspective here … The GRADE definitions are as follows: • High: High confidence that the evidence reflects the true … GRADE guidelines: 3. Rating the quality of evidence. J Clin Epidemiol. 2011 Apr;64(4):401-6.

127. Liver-Cancer-Therapy Executive (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/liver-cancer-therapy_executive.pdf
     May 01, 2013 - Summary GRADE strength of evidence for KQ1 and KQ2 Key Question, Comparison, and Outcome Strength … Summary GRADE strength of evidence for KQ1 and KQ2 (continued) Key Question, Comparison, and Outcome … Summary GRADE strength of evidence for KQ1 and KQ2 (continued) Key Question, Comparison, and Outcome … Summary GRADE strength of evidence for KQ1 and KQ2 (continued) Key Question, Comparison, and Outcome … The GRADE Working Group. BMC Health Serv Res. 2004 Dec 22;4(1):38. PMID: 15615589. 38.

128. Medication-Therapy-Management Executive (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/medication-therapy-management_executive.pdf
     November 01, 2014 - of greatest importance to decisionmakers and those commonly reported in the literature; we did not grade … Definitions of the grades of overall strength of evidence Grade Definition High High confidence that … KQ 1 was descriptive in nature, so we did not grade strength of evidence. … GRADE guidelines 6. Rating the quality of evidence--imprecision. … GRADE guidelines: 4. Rating the quality of evidence--study limitations (risk of bias).

129. Weight-Gain-Prevention Executive (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/weight-gain-prevention_executive.pdf
     January 01, 2020 - We used four domains to yield a final evidence grade: Risk of Bias, Consistency, Directness, and Precision … We classified evidence pertaining to Key Questions 1 through 6 into four categories: (1) “high” grade … research is very unlikely to change our confidence in the estimate of the effect); (2) “moderate” grade … The team members discussed the process they used to grade the evidence throughout the report writing … When a team member felt the evidence grade was questionable, this comparison-outcome evidence grade

130. Genitourinary Syndrome of Menopause | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/genitourinary-syndrome/protocol
     March 01, 2024 - Because this organization uses Grading of Recommendations Assessment, Development and Evaluation (GRADE … ) 28 for rating evidence certainty, we will use the GRADE approach to assess the overall quality of … We will GRADE the 8 consensus outcomes identified in the Core Outcomes in Menopause (COMMA) review. 29 … Guyatt GH OA, Kunz R, Vist GE, Falck-Ytter Y, Schünemann HJ; GRADE Working Group. … GRADE guidelines: 11.

131. Medical Therapies for Locally Advanced Gastric Adenocarcinoma (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/gastric-cancers-protocol-amended.pdf
     February 07, 2025 - 3, 4, 5) • Direct mild treatment adverse events (grade 1, 2) • Indirect adverse events from treatment … long-term opioid use for pain management) N/A Timing All KQs: Any follow-up duration for grade … 3-5 or indirect adverse events and quality of life; minimum of 1 year for grade 1-2 adverse events … Grade 1-2 AEs will be characterized as mild, and grades 3-5 characterized as moderate. … otherwise.21 Grading the Strength of Evidence (SOE) for Major Comparisons and Outcomes: We will grade

132. Medical Therapies for Locally Advanced Gastric Adenocarcinoma | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/gastric-cancers/protocol
     February 01, 2025 - assessment Quality of life, using validated scales Direct moderate-severe treatment adverse events (grade … 3, 4, 5) Direct mild treatment adverse events (grade 1, 2) Indirect adverse events from treatment (e.g … .., long-term opioid use for pain management) N/A Timing All KQs:   Any follow-up duration for grade … 3-5 or indirect adverse events and quality of life; minimum of 1 year for grade 1-2 adverse events; minimum … Grade 1-2 AEs will be characterized as mild, and grades 3-5 characterized as moderate.

133. Evidence Report on the (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/measuring-blood-pressure_research-protocol.pdf
     April 11, 2011 - Each Key Question We will follow the AHRQ Methods Guide for Comparative Effectiveness Reviews to grade … For each outcome (or set of outcomes), we will assign a grade for the strength of evidence: high, moderate

134. Healthcare Delivery of Clinical Preventive Services for People With Disabilities | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/people-with-disabilities/research
     October 01, 2024 - used independent dual review to determine inclusion of studies related to 20 preventive services with Grade … A or Grade B recommendations by the U.S.

135. Comparative Effectiveness of Drug Therapy for Psoriatic Arthritis in Adults – An Update to the 2007 Report | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/arthritis-psoriatric/research-protocol
     December 01, 2019 - based on the standard methods of the EPCs, which use a revised version of the approach devised by the GRADE … Developed to grade the quality of evidence and the strength of recommendations, this approach incorporates … quality of evidence and the strength of recommendations I: Critical appraisal of existing approaches: The GRADE

136. Diagnosis of Celiac Disease: Current State of the Evidence | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/celiac-disease/clinician
     December 01, 2019 - Marsh grade 1 or grade 2 lesions--in the absence of clinical or serological evidence--are nonspecific … Marsh grade 3 lesions are the classic celiac disease lesions and are characteristic but not diagnostic … * The overall evidence grade was assessed based on the ratings for the following domains: study limitations

137. Assessing-The-Risk-Of-Bias-In-Systematic-Reviews-Of-Health-Care-Interventions (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/product/pdf/assessing-the-risk-of-bias-in-systematic-reviews-of-health-care-interventions-01.pdf
     May 01, 2005 - from randomized controlled trials a high grade. … GRADE guidelines 6. Rating the quality of evidence- imprecision. … GRADE guidelines: 8. Rating the quality of evidence- indirectness. … GRADE guidelines: 7. Rating the quality of evidence- inconsistency. … GRADE guidelines: 5. Rating the quality of evidence-publication bias.

138. Quantitative Synthesis: Chapter 5. Network Meta-Analysis (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/ehc-presentation-quantitative-synthesis-chapter-5.pdf
     February 01, 2018 - GRADE guidelines: 7. Rating the quality of evidence—inconsistency. … Rating strength of evidence • Original EPC and GRADE evidence was simple and involved rating down all … • More recently, GRADE published a new approach based on evaluating strength of evidence separately … GRADE guidelines: 7. Rating the quality of evidence—inconsistency. … A GRADE Working Group approach for rating the quality of treatment effect estimates from network meta-analysis

139. Antipsychotics for the Prevention and Treatment of Delirium: A Systematic Review (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/delirium-research-protocol.pdf
     June 01, 2018 - Strength of Evidence (SOE) for Major Comparisons and Outcomes At the completion of our review, we will grade … We will classify evidence pertaining to the Key Questions into four categories: (1) “high” grade (indicating … research is very unlikely to change our confidence in the estimate of the effect); (2) “moderate” grade … could change our confidence in the estimate of the effect and may change the estimate); (3) “low” grade … confidence in the estimate of the effect and is likely to change the estimate); and (4) “insufficient” grade

140. Comparative Effectiveness and Safety of Oral Diabetes Medications for Adults With Type 2 Diabetes: An Update of the 2007 Report | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/type-2-diabetes-medications-update/research-protocol
     December 01, 2019 - Grading the Evidence for Each Key Question At the completion of our review, we will grade the quantity … will classify evidence pertaining to Key Questions 1, 2 and 3, into four basic categories: (1) “high” grade … further research is very unlikely to change our confidence in the estimate of the effect); (2) “moderate” grade … research may change our confidence in the estimate of the effect and may change the estimate); (3) “low” grade … confidence in the estimate of the effect and is likely to change the estimate); and (4) “insufficient” grade