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101. CER 220: Disposition of Comments Report for Comparative Effectiveness of Analgesics To Reduce Acute Pain in the Prehospital Setting (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cer-220-disposition-comments-analgesics-prehospital-setting.pdf
     September 03, 2019 - TEP reviewer #1 Methods Page 28, Line 16: The use of only 2 reviewers to grade the strength of evidence … Each conclusion is accompanied with a SOE grade to further qualify our certainty of the conclusion.

102. Comparative Effectiveness of Treatment for Open-Angle Glaucoma | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/glaucoma-treatment/research-protocol
     December 01, 2019 - We will use an evidence grading scheme recommended by the GRADE Working Group, 13 adapted by AHRQ in … is evaluated by at least one randomized controlled trial and by observational studies, our evidence grade … If an outcome is evaluated by one or no randomized controlled trials, our evidence grade will be based … Effectiveness Reviews 14 and by Owens and colleagues. 15 For each outcome of interest, two reviewers will grade

103. Methods-Guide-Chapter-Prioritization-And-Selection-Of-Harms-For-Inclusion-In-Systematic-Reviews (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/prioritization-selection-of-harms.pdf
     February 01, 2018 - using GRADE methods to prioritize harms, and few had experience applying a formal GRADE prioritization … GRADE guidelines: 2. Framing the question and deciding on important outcomes. … GRADE guidelines: 12. Preparing Summary of Findings tables—binary outcomes. … Do you use GRADE or another formal process to prioritize which harms to review? … • Don’t use GRADE or grading scale.

104. Medical Therapies for Locally Advanced Gastric Adenocarcinoma (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/gastric-cancers-protocol.pdf
     January 01, 2024 - 3, 4, 5) • Direct mild treatment adverse events (grade 1, 2) • Indirect adverse events from treatment … long-term opioid use for pain management) N/A Timing All KQs: Any follow-up duration for grade … 3-5 or indirect adverse events and quality of life; minimum of 1 year for grade 1-2 adverse events … Grade 1-2 AEs will be characterized as mild, and grades 3-5 characterized as moderate. … otherwise.21 Grading the Strength of Evidence (SOE) for Major Comparisons and Outcomes: We will grade

105. Comparison of Effects as Evidence Evolves From Single Trials to High-Quality Bodies of Evidence | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/grades-predictive-values/white-paper-2015
     November 01, 2017 - Skip to main content An official website of the Department of Health & Human Services Careers Contact Us Español FAQs Effective Health Care Program Powered by the Evidence-based Practice Centers …

106. Interventions to Modify Healthcare Provider Adherence to Asthma Guidelines | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/asthma-provider-adherence/research-protocol
     December 01, 2019 - Grading the Strength of Evidence for Each Key Question Two reviewers independently will grade the strength … We will classify evidence pertaining to KQs 1–3 into four basic categories: 1) “high” grade (indicating … further research is very unlikely to change our confidence in the estimate of the effect); 2) “moderate” grade … research may change our confidence in the estimate of the effect and may change the estimate); 3) “low” grade … confidence in the estimate of the effect and is likely to change the estimate); and 4) “insufficient” grade

107. Comparative Effectiveness and Safety of Analgesics for Osteoarthritis – An Update to the 2006 Report | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/osteoarthritis-pain/research-protocol
     December 01, 2019 - No pharmaceutical grade formulation is approved by the FDA. … Accordingly, this report will focus on studies of nonpharmaceutical grade preparations available in the … Studies of pharmaceutical-grade glucosamine and chondroitin will also be included, however; they will … further research is very unlikely to change our confidence in the estimate of effect; (2) “moderate” grade … research may change our confidence in the estimate of effect and may change the estimate; (3) “low” grade

108. Nephropathy-Contrast-Induced Executive-2016 (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/nephropathy-contrast-induced_executive-2016.pdf
     January 01, 2016 - Following the guidance of the GRADE (Grading of Recommendations Assessment, Development and Evaluation … The body of evidence was considered high grade if study limitations were low and there were no problems … GRADE guidelines 6. Rating the quality of evidence--imprecision.

109. Template for Reports Developed (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/menopause_research-protocol.pdf
     March 25, 2012 - primary evidence base34 (supplemented by any more recent RCTs and observational studies when the GRADE … members concur that if obtained, evidence could impact results meaningfully (i.e., alter evidence GRADE … Moreover, all observational data are considered lesser (low) GRADE strength.45 The perspective here … based on the Evidence-based Practice Center (EPC) approach,32,33 which is conceptually similar to the GRADE … GRADE guidelines: 3. Rating the quality of evidence. J Clin Epidemiol 2011;64(4):401-6.

110. Acs-Pci-Adjunctive-Devices Research-Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/acs-pci-adjunctive-devices_research-protocol.pdf
     July 01, 2010 - patent coronary vessels—often defined as (1) a thrombolysis in myocardial infarction (TIMI) flow grade … vessel patency and the absence of dissection, spasm or distal macroembolus, or (2) a myocardial blush grade … pertaining to each key question will be classified into three broad categories: high, moderate, or low grade … Definitions for grading the strength of evidence Grade Definition High There is high confidence that … syndrome EPC Evidence-based Practice Center MACE major adverse cardiac event MBG myocardial blush grade

111. Diagnosis of Celiac Disease: Current State of the Evidence (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/celiac-disease_clinician.pdf
     July 01, 2016 - * The overall evidence grade was assessed based on the ratings for the following domains: study limitations … Marsh grade 1 or grade 2 lesions—in the absence of clinical or serological evidence—are nonspecific … Marsh grade 3 lesions are the classic celiac disease lesions and are characteristic but not diagnostic

112. Improving the Management of Menopausal Symptoms in Perimenopausal and Early Postmenopausal Women: A Systematic Review (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/menopausal-symptoms-protocol.pdf
     October 15, 2024 - Preventive Services Task Force recommends against use of HT to prevent chronic conditions (Grade D).9 … ) Working Group.45 We will grade the SOE for KQ 1 outcomes from RCT bodies of evidence separately from … Otherwise, we will assign an overall SOE grade for each comparison and outcome as high, moderate, low … To grade the SOE, we will consider the domains of consistency, precision, directness, study limitations … GRADE Guidance 34: update on rating imprecision using a minimally contextualized approach.

113. Layout 1 (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/acs-pci-adjunctive-devices_executive.pdf
     December 01, 2011 - (MBG): An angiographic method of grading myocardial tissue perfusion ranging from grade 0 to grade 3 … In grade 1, the dye slowly enters but fails to exit the microvasculature. … In grade 2, there is delayed entry and exit of dye from the microvasculature. … In grade 3, there is normal entry and exit of dye from the microvasculature. … A grade of 0 is defined as complete occlusion of the infarct- related artery.

114. Glaucoma-Treatment Research-Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/glaucoma-treatment_research-protocol.pdf
     November 16, 2010 - We will use an evidence grading scheme recommended by the GRADE Working Group,13 adapted by AHRQ in … evaluated by at least one randomized controlled trial and by observational studies, our evidence grade … If an outcome is evaluated by one or no randomized controlled trials, our evidence grade will be based … Effectiveness Reviews14 and by Owens and colleagues.15 For each outcome of interest, two reviewers will grade

115. Total Worker Health® (TWH) | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/worker-health/research-protocol
     December 01, 2019 - Grading the Strength of Evidence for Major Comparisons and Outcomes We will grade the strength of evidence … based on the guidance established for the Evidence-based Practice Center Program. 23 Developed to grade … We will grade the strength of evidence related to all outcomes relevant to KQ 2. Table 3. … Definitions of the grades of overall strength of evidence Grade Definition Source:

116. Antipsychotics for the Prevention and Treatment of Delirium: A Systematic Review | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/antipsychotics/research-protocol
     January 01, 2019 - Strength of Evidence (SOE) for Major Comparisons and Outcomes At the completion of our review, we will grade … We will classify evidence pertaining to the Key Questions into four categories: (1) "high" grade (indicating … further research is very unlikely to change our confidence in the estimate of the effect); (2) "moderate" grade … research could change our confidence in the estimate of the effect and may change the estimate); (3) "low" grade … confidence in the estimate of the effect and is likely to change the estimate); and (4) "insufficient" grade

117. Disposition of Comments for Strategies To Prevent Weight Gain Among Adults (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/weight-gain-prevention_disposition-comments.pdf
     March 25, 2013 - We reported our findings consistent with GRADE. … in the grading of the evidence Evidence was graded consistent with the EPC Methods Guide using GRADE … We have graded outcomes consistent with the EPC Methods Guide, which is based upon the GRADE system … We used GRADE as stated in the EPC Methods Guide. … Observational studies are given a lower starting SOE according to GRADE.

118. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/adhd_research-protocol.pdf
     August 10, 2010 - Preschoolers with ADHD may continue to have difficulties with attention, learning and behavior in grade … Evidence for Each Key Question We will assess the overall strength of the body of the evidence using the GRADE … certainty surrounding an effect estimate for a specific outcome) There are factors recommended by the GRADE … importance of the outcome being evaluated) that may be taken into consideration when assigning a GRADE … Grade Working Group.

119. Arthritis-Psoriatric Executive (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/arthritis-psoriatric_executive.pdf
     April 01, 2012 - Summary of findings Key Comparisons Efficacy and Effectiveness Strength of Evidence Grade Harms … Strength of Evidence Grade Oral DMARDs Leflunomide No head-to-head studies met inclusion criteria; … Summary of findings (continued) Key Comparisons Efficacy and Effectiveness Strength of Evidence Grade … Harms Strength of Evidence Grade Biologic DMARDs (continued) Biologic No head-to-head trials met

120. Methods White Paper: Improving the Utility of Evidence Synthesis for Decision Makers in the Face of Insufficient Evidence (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/improving-utility-evidence-synthesis-white-paper.pdf
     April 01, 2021 - unacceptable deficiencies, precluding reaching a conclusion.”1 By contrast, the lowest category of GRADE … analysis; c. the unique setting of coverage decisions; d. making guideline recommendations using GRADE … GRADE Working Group. 2013. 3. … Acronyms AHRQ Agency for Healthcare Research and Quality EPC Evidence-based Practice Center GRADE … disorder What SGA may have lower major AEs over short- or long-term treatment Marching across GRADE