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1. App-G-Surv-Report-2-Nonopioid-Pharmacol-Chronic-Pain (xls file)
   effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-g-surv-report-2-nonopioid-pharmacol-chronic-pain.xlsx
   May 29, 2025 - Unclear Yes Yes Yes Yes Yes Yes Fair Horne, 2020 and Hewitt, 2020 Yes Yes Yes Yes Yes Yes Yes Yes Good … Hudson Yes Yes Yes Yes Yes Yes Yes Yes Good Hussain Unclear Unclear Yes Yes Yes Unclear Unclear Yes … Fair Khasbage, 2021 Yes Yes No No Yes Yes Yes Yes Good Langford, 2013 Yes Yes Yes Yes Yes Yes Yes … Yes Good Lee, 2020 Yes Unclear Unclear Unclear Yes Yes Yes Yes Fair Shahid, 2019 Unclear Unclear No

2. App-F-Surv-Report-3-Acute-Pain (xls file)
   effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-f-surv-report-3-acute-pain.xlsx
   May 29, 2025 - Quality (Good, Fair, Poor) Akgol Gur, 2020 Yes Unclear Yes Yes Yes Yes Yes No/Yes No Yes Yes Poor Bloom … Yes Yes Fair Cooper, 2021 Yes Yes Yes Unclear Yes Yes Yes No/No Yes; for safety only Yes; 4.6% Yes Good … No No No Yes Fair Desjardins, 2020 Yes Yes Yes Yes Yes Yes Yes No/No Yes; full analysis set No Yes Good … Yes No No No Yes No/No Yes No Yes Fair Friedman, 2021 Yes Yes Yes Yes Yes Yes Yes No/No Yes No Yes Good … Unclear Unclear Yes No Yes Fair Vallecillo, 2021 Yes Yes Yes Yes Yes Yes Yes No/No Yes Yes; 2.7% Yes Good

3. App-F-Surv-Report-2-Acute-Pain (xls file)
   effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-f-surv-report-2-acute-pain.xlsx
   May 29, 2025 - Quality (Good, Fair, Poor) Akgol Gur, 2020 Yes Unclear Yes Yes Yes Yes Yes No/Yes No Yes Yes Poor Bloom … Yes Yes Fair Cooper, 2021 Yes Yes Yes Unclear Yes Yes Yes No/No Yes; for safety only Yes; 4.6% Yes Good … No No No Yes Fair Desjardins, 2020 Yes Yes Yes Yes Yes Yes Yes No/No Yes; full analysis set No Yes Good … Yes No No No Yes No/No Yes No Yes Fair Friedman, 2021 Yes Yes Yes Yes Yes Yes Yes No/No Yes No Yes Good … Unclear Unclear Yes No Yes Fair Vallecillo, 2021 Yes Yes Yes Yes Yes Yes Yes No/No Yes Yes; 2.7% Yes Good

4. App-G-Surv-Report-3-Nonopioid-Pharmacol-Chronic-Pain (xls file)
   effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-g-surv-report-3-nonopioid-pharmacol-chronic-pain.xlsx
   May 29, 2025 - Unclear Yes Yes Yes Yes Yes Yes Fair Horne, 2020 and Hewitt, 2020 Yes Yes Yes Yes Yes Yes Yes Yes Good … Hudson Yes Yes Yes Yes Yes Yes Yes Yes Good Hussain Unclear Unclear Yes Yes Yes Unclear Unclear Yes … Fair Khasbage, 2021 Yes Yes No No Yes Yes Yes Yes Good Langford, 2013 Yes Yes Yes Yes Yes Yes Yes … Yes Good Lee, 2020 Yes Unclear Unclear Unclear Yes Yes Yes Yes Fair Shahid, 2019 Unclear Unclear No

5. App-F2-Surv-Report-2-Nonopioid-Pharmacol-Chronic-Pain (xls file)
   effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-f2-surv-report-2-nonopioid-pharmacol-chronic-pain.xlsx
   May 29, 2025 - Placebo 12 Short 2 33 0 33 NR NR NR NR NR NR NR NR 1 33 33 NR NR NR NR NR NR NR 0 33 33 Hudson, 2021 Good … Short NR NR 4 99 NR NR NR NR NR NR NR NR 86 99 102 Sweating 31 99 102 58 99 102 NR NR NR Hudson, 2021 Good … NR NR NR NR NR NR NR NR NR NR NR Tired 85 129 153 66 122 153 NR NR NR Horne, 2020 and Hewitt, 2020 Good … NR NR NR NR NR NR NR NR NR NR NR Tired 68 120 153 32 114 153 NR NR NR Horne, 2020 and Hewitt, 2020 Good … NR NR NR NR NR NR NR NR NR NR NR Drowsy 64 124 153 NR NR NR NR NR NR Horne, 2020 and Hewitt, 2020 Good

6. P A W S, Prescription for Antibiotics or Wait and See: Ear Infections: Are Antibiotics the Right Choice for You? (pdf file)
   effectivehealthcare.ahrq.gov/sites/default/files/ebc-challenge-2ndplace-paws.pdf
   May 29, 2025 - Your path to good health begins with visiting your retail health provider. … Follow Your Path to Good Health 1. … Your health care provider will help you decide if medicine is a good choice for you. 3. … availa- ble to assist you with questions or concerns and is committed to helping you on your path to good

7. App-F2-Surv-Report-3-Nonopioid-Pharmacol-Chronic-Pain (xls file)
   effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-f2-surv-report-3-nonopioid-pharmacol-chronic-pain.xlsx
   May 29, 2025 - Placebo 12 Short 2 33 0 33 NR NR NR NR NR NR NR NR 1 33 33 NR NR NR NR NR NR NR 0 33 33 Hudson, 2021 Good … Short NR NR 4 99 NR NR NR NR NR NR NR NR 86 99 102 Sweating 31 99 102 58 99 102 NR NR NR Hudson, 2021 Good … NR NR NR NR NR NR NR Tired 85 129 153 66 122 153 NR NR NR 25 113 153 Horne, 2020 and Hewitt, 2020 Good … NR NR NR NR NR NR NR Tired 68 120 153 32 114 153 NR NR NR 12 110 153 Horne, 2020 and Hewitt, 2020 Good … NR NR NR NR NR NR NR NR Drowsy 64 124 153 NR NR NR NR NR NR NR NR NR Horne, 2020 and Hewitt, 2020 Good

8. Cer-240-Acute-Pain-Appendix-F (xls file)
   effectivehealthcare.ahrq.gov/sites/default/files/cer-240-acute-pain-appendix-f.xlsx
   May 29, 2025 - Yes Yes Yes Yes Yes No No Unclear Yes Fair Bondarsky, 2013 Yes Yes Yes Yes Yes Yes Yes No Yes No Yes Good … Unclear Yes Yes Yes Yes Yes No Yes No Yes Fair Breivik, 1999 Yes Yes Yes Yes Yes Yes Yes No No No Yes Good … Yes Yes Yes Yes Yes No Unclear Yes Yes Fair da Silva, 2015 Yes Yes Yes Yes Yes Yes Yes No Yes No Yes Good … Yes Yes No No No Yes No Yes Yes Yes Fair Hancock, 2007 Yes Yes Yes Yes Yes Yes Yes No Yes Yes Yes Good … Hasegawa, 2013 Yes Unclear Yes Yes No Yes Yes No Yes No Yes Good He, 2013 Method NR Yes Yes Unclear

9. Nonopioid Pharmacologic Treatments for Chronic Pain: Appendix G (xls file)
   effectivehealthcare.ahrq.gov/sites/default/files/nonopioid-chronic-pain-apg.xlsx
   January 01, 2019 - Selective Outcomes Reporting Quality Rating Abou-Raya 2012 Yes Unclear Yes Yes Yes Yes Yes; Yes Yes Good … Yes Yes Yes Unclear Unclear No (33%); Yes No Fair Backonja 2008 Yes Yes Yes Yes Yes Yes Yes; Yes Yes Good … LOCF) No (26%); No (20% vs. 32%) No Fair Chappell 2009a Yes Yes Yes Yes Yes Yes No (25%); Yes Yes Good … Puljak, 2017 Yes Yes; Yes Yes Yes; Yes Yes Yes Yes Good Rostom, 2005 Unclear Yes; Yes Yes Yes; No … No Yes but not published Yes Fair Welsch, 2018 Yes Yes; Yes Yes Yes; Yes Yes Yes Yes Good

10. App-F-Surv-Rept-1-Acute-Pain (xls file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-f-surv-rept-1-acute-pain.xlsx
    May 29, 2025 - Quality (Good, Fair, Poor) Akgol Gur, 2020 Yes Unclear Yes Yes Yes Yes Yes No/Yes No Yes Yes Poor Bloom … No No No Yes Fair Desjardins, 2020 Yes Yes Yes Yes Yes Yes Yes No/No Yes; full analysis set No Yes Good … Yes No No No Yes No/No Yes No Yes Fair Friedman, 2021 Yes Yes Yes Yes Yes Yes Yes No/No Yes No Yes Good

11. Disposition of Comments_Systematic Review: The Relationship of Digestible Carbohydrate Intake With Cardiovascular Disease, Type 2 Diabetes, Obesity, and Body Composition (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/effect-dietary-digestible-disposition-comments_0.pdf
    March 03, 2025 - Thank you Jonathan Clinthorne, Simply Good Foods Methods As stated in our February 2024 comments … Jonathan Clinthorne, Simply Good Foods Results We reiterate our concerns that the results from this … Jonathan Clinthorne, Simply Good Foods Conclusion No Comment. Thank you. … Jonathan Clinthorne, Simply Good Foods Reference No Comment. Thank you. … Jonathan Clinthorne, Simply Good Foods Abbreviations No Comment. Thank you.

12. Cer-238-Cervical-Ripening-Appendix-G (xls file)
    effectivehealthcare.ahrq.gov/sites/default/files/cer-238-cervical-ripening-appendix-g.xlsx
    May 29, 2025 - 1999 Yes Yes Yes Yes Yes No Yes Yes Unclear Fair McKenna, 2004b Yes Yes Yes Yes Yes Yes Yes Yes Yes Good … 2017 Yes No No Unclear Yes Yes Yes Yes No Fair PonMalar, 2017 Yes Yes Yes Yes Yes Yes Yes Yes Yes Good … 2001 Yes No No Unclear Unclear Yes Yes Yes Yes Fair Smith, 1996 Yes Yes Yes Yes Yes Yes Yes Yes Yes Good … Stitely, 2000 Yes Yes Yes Yes No Yes Yes Yes Yes Good Wilkinson, 2015a Yes Yes No Unclear Yes Yes

13. Nonopioid Pharmacologic Treatments for Chronic Pain: Appendix F2 (xls file)
    effectivehealthcare.ahrq.gov/sites/default/files/nonopioid-chronic-pain-apf2_0.xlsx
    January 01, 2018 - 12 Short 9 153 1 153 NR NR NR NR 6 153 NR Somnolence 4 153 NR Hyperhidrosis 0 153 NR Murakami, 2015 Good … mg/d 14 Short 14 196 1 196 NR NR NR NR 42 194 196 Somnolence 51 194 196 NR NR NR NR Murakami, 2015 Good … Duloxetine 60 mg/d 12 Short 5 116 4 116 NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR Raskin, 2005 Good … Duloxetine 120 mg/d 12 Short 14 116 2 116 NR NR NR NR NR NR NR NR NR NR NR NR NR NR NR Raskin, 2005 Good … Short 7 128 2 128 NR NR NR NR 3 128 128 Somnolence 3 128 NR Hyperhidrosis 0 128 NR Abou-Raya, 2012 Good

14. Omega-3 Fatty Acids and Cardiovascular Disease: A Review of the Research for Adults (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/fatty-acids-cardiovascular-disease_consumer.pdf
    July 01, 2017 - You may have heard that omega-3 fatty acids are good for your heart. … Slightly raise good cholesterol Do not raise good cholesterol LDL (“bad”) cholesterol level? … – Slightly raise HDL (“good”) cholesterol level. … High levels of good cholesterol lower the risk of CV disease. … – Do not raise good cholesterol. – Do not lower bad cholesterol.

15. App-G-Surv-Report-1-Nonopioid-Pharmacol-Chronic-Pain (xls file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-g-surv-report-1-nonopioid-pharmacol-chronic-pain.xlsx
    May 29, 2025 - , 2020 Unclear Unclear Yes Yes Yes Yes Yes Yes Fair Langford, 2013 Yes Yes Yes Yes Yes Yes Yes Yes Good … Hussain Unclear Unclear Yes Yes Yes Unclear Unclear Yes Fair Hudson Yes Yes Yes Yes Yes Yes Yes Yes Good

16. App-E-Surv-Report-2-Nonopioid-Pharmacol-Chronic-Pain (xls file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-e-surv-report-2-nonopioid-pharmacol-chronic-pain.xlsx
    May 29, 2025 - Placebo 12 Hospital Langford, 2013 UK, Czech Republic, Canada, Spain, France Placebo-controlled Good … Amitriptyline 25 mg 12 None Khasbage, 2020 India Head-to-Head Good NPP (DPN) Age, mean: 54.5 Female … Characteristics N Randomized N Analyzed Intervention Duration (Weeks) Funding Source Hudson, 2021 New Zealand Good … GaPP2 Good Chronic pelvic pain Age, mean: 30.3 Female: 100% Race: White: 97% Black: 0.3% Asian: 2%

17. App-F1-Surv-Report-2-Nonopioid-Pharmacol-Chronic-Pain (xls file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-f1-surv-report-2-nonopioid-pharmacol-chronic-pain.xlsx
    May 29, 2025 - 95% CI 1.1 -1.25 -0.85 89 -2.2 SD, 95% CI 1.5 -2.45 -1.5 NR NR NR NR NR NR NR NR NR Khasbage, 2021 Good … SD 17.2 NR NR 43 43 Mean difference at end of study 5.232 95% CI NR -1.7 12.17 0.137 Langford, 2013 Good … NPP (DPN) PGB/GBP Gabapentin 300 mg/day ≥50% decrease on VAS 12 Short 43 43 43 Khasbage, 2021 Good … NPP (DPN) SNRI Duloxetine 60 mg/day ≥50% decrease on VAS 12 Short 43 43 43 Langford, 2013 Good NPP ( … THC/CBD THC 2.7 mg and CBD 2.5 mg spray ≥30% improvement on NRS 14 Short 83 167 167 Langford, 2013 Good

18. App-E-Surv-Report-3-Noninvasive-Nonpharma (xls file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-e-surv-report-3-noninvasive-nonpharma.xlsx
    January 01, 2022 - Reporting Quality Alqualo-Costa 2021 OA Yes Yes Yes No Yes No Yes Unclear Yes Yes Yes Yes Yes Yes Good … Yes Yes Fair Karakas 2020 OA Yes Yes Yes Yes Yes Unclear Yes Unclear Yes No (21%) Yes Yes Yes Yes Good … Yes Yes Yes Yes Yes Yes Fair Lam 2021 OA Yes Yes Yes Unclear Yes No Yes Yes Yes Yes Yes Yes Yes Yes Good … No Yes Yes Yes Yes Poor Reichenback 2022 OA Yes Yes Yes Yes Yes No Yes Yes Yes Yes Yes Yes Yes Yes Good

19. App-E-Surv-Report-3-Nonopioid-Pharmacol-Chronic-Pain (xls file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-e-surv-report-3-nonopioid-pharmacol-chronic-pain.xlsx
    May 29, 2025 - Placebo 12 Hospital Langford, 2013 UK, Czech Republic, Canada, Spain, France Placebo-controlled Good … Amitriptyline 25 mg 12 None Khasbage, 2020 India Head-to-Head Good NPP (DPN) Age, mean: 54.5 Female … Characteristics N Randomized N Analyzed Intervention Duration (Weeks) Funding Source Hudson, 2021 New Zealand Good … GaPP2 Good Chronic pelvic pain Age, mean: 30.3 Female: 100% Race: White: 97% Black: 0.3% Asian: 2%

20. App-F2-Surv-Report-1-Nonopioid-Pharmacol-Chronic-Pain (xls file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-f2-surv-report-1-nonopioid-pharmacol-chronic-pain.xlsx
    May 29, 2025 - Placebo 12 Short 2 33 0 33 NR NR NR NR NR NR NR NR 1 33 33 NR NR NR NR NR NR NR 0 33 33 Hudson, 2021 Good … Short NR NR 4 99 NR NR NR NR NR NR NR NR 86 99 102 Sweating 31 99 102 58 99 102 NR NR NR Hudson, 2021 Good … Cognitive Effects: Specific AE Cognitive Effects: n Cognitive Effects: N N Randomized Langford, 2013 Good … Short 14 167 2 167 34 167 167 13 167 167 16 167 167 12 167 167 Depression 2 167 167 Langford, 2013 Good