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effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0320_06-17-2009.pdf
January 01, 2009 - Completion Date: 3-24-10
1
Results of Topic Selection Process & Next Steps
Serum free … Summary:
The nominator presents a series of questions for a review on the effectiveness of serum
free … are interested in multiple
myeloma (MM), including nonsecretory multiple myeloma (NSMM), and either free … Population(s): Any patient diagnosed with one of the B-plasma cell dyscrasias (i.e.,
MM, free light … Serum Free Light Chain Assay Analysis
Nomination Summary Document
http://effectivehealthcare.ahrq.gov
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-259-partial-breast-irradiation-executive-summary.pdf
January 01, 2023 - breast irradiation (WBI) in terms of ipsilateral breast recurrence (IBR),
overall survival, and cancer-free … 10, and over 10 years (high SOE), with no difference in
overall survival (low to high SOE), cancer-free … survival (high SOE), or
mastectomy-free survival (low to high SOE). … IORT showed no difference in overall survival,
cancer-free survival, or mastectomy-free survival (low … interstitial brachytherapy
compared with WBI showed no difference in IBR, overall survival, cancer-free
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/anal-cancer-draft-report.pdf
October 31, 2023 - No
significant difference was found in CR, progression-free or event-free survival between arms. … Insufficient
IMRT vs. 3D
CRT
Locoregional recurrence-
free, distant metastasis-free,
and colostomy-free … Insufficient
Overall, disease-specific,
disease-free, and relapse-
free survival
1; NRSI; n=424 … high-dose boost (20-25 Gy;
total dose, 65-70 Gy)
Overall, disease-free,
colostomy-free, and disease … none
Overall, progression-free,
colostomy-free, and disease-
specific survival
1; RCT; n=940 No
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/plasma-cell-dyscrasias-sflc-assay_executive.pdf
August 01, 2012 - 1
Comparative Effectiveness Review
Number 73
Serum Free Light Chain Analysis for the
Diagnosis, Management … expanded
clone of malignant plasma cells produces
an excess of either intact immunoglobulin
or free … Serum free light
chains for monitoring multiple myeloma. … Serum free light chain measurements move
to center stage. … Prognostic
value of serum free light chain ratio at diagnosis in multiple
myeloma.
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effectivehealthcare.ahrq.gov/sites/default/files/mcda-johnson.pdf
August 27, 2012 - Calculation
Renal Cell Carcinoma
Image: Bar chart showing 3 month, 5-month, and 10-month progression-free … Patients rank
toxicity against progression-free survival in second-line treatment of advanced renal … Patients rank
toxicity against progression-free survival in second-line treatment of advanced renal … Calculation
Renal Cell Carcinoma
Image: Bar chart showing 3 month, 5-month, and 10-month progression-free … Patients rank
toxicity against progression-free survival in second-line treatment of advanced renal
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effectivehealthcare.ahrq.gov/products/plasma-cell-dyscrasias-sflc-assay/research
August 23, 2012 - Research Protocol Aug. 23, 2012 Systematic Review Jun. 28, 2013 Disposition of Comments Report Serum Free … Structured Abstract
Objectives
To summarize the literature regarding the role of the serum free light
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effectivehealthcare.ahrq.gov/sites/default/files/cer-242-radiation-therapy-brain-metastases-evidence-summary.pdf
June 01, 2021 - We did not detect effects of
hippocampal sparing WBRT on overall survival, disease-free survival, or … A Technical Expert Panel advised on key outcomes: overall survival, disease-free
survival, deaths due … and we did not detect effects of memantine
or hippocampal sparing WBRT on overall survival, disease-free … postoperative WBRT specifically (overall survival HR
0.93; CI 0.68 to 1.27; 4 RCTs; low SoE; disease-free … There was insufficient evidence for important outcomes including disease-free
survival, intracranial
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/episodic-migraine-surveillance-report-2.pdf
June 01, 2022 - Lasmiditan 100 mg
Pain free at 2 hours Poor/None RR: 1.78; 95% CI: 1.58 to 2.00; I²
=N/A
Pain free … Placebo
Pain free at 2 hours Poor/None RR: 4.93; 95% CI: 4.12 to 5.91; I²
=N/A
Pain free at 2 hours … Lasmiditan 100 mg
Disability free 2 hours RR: 1.32; 95% CI: 0.83 to 2.08; I² =N/A
Disability free … Placebo Disability free 2 hours RR: 1.90; 95% CI: 1.14 to 3.18; I² =N/A
Disability free 24 hours … Placebo Disability free 2 hours RR: 1.44; 95% CI: 0.83 to 2.52; I² =N/A
Disability free 24 hours
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effectivehealthcare.ahrq.gov/news/fhir-formatted-citation-files
FHIR-formatted Citation Files for Systematic Reviews
SRDR+ , an AHRQ-funded tool, is a free
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/surveillance-report-3-noninvasive-nonpharma.pdf
August 01, 2022 - scale, restored function, and
function scale at 2 hours; pain
free, sustained pain free and
pain … and pain relief
at 2 hours, and sustained
pain free at 24 hours and 48
hours. … There was no
significant difference in
pain relief and pain free at 2
hours. … pain free at 2 days. … There was no significant difference in pain relief and pain
free at 2 hours.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/episodic-migraine-surveillance-report-3.pdf
August 01, 2022 - scale, restored function, and
function scale at 2 hours; pain
free, sustained pain free, and
pain … and pain relief
at 2 hours, and sustained
pain free at 24 hours and 48
hours. … There was no
significant difference in
pain relief and pain free at 2
hours. … pain free at 2 days. … There was no significant difference in pain relief and pain
free at 2 hours.
-
effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/episodic-migraine-surveillance-report-2.pdf
June 01, 2022 - Lasmiditan 100 mg
Pain free at 2 hours Poor/None RR: 1.78; 95% CI: 1.58 to 2.00; I²
=N/A
Pain free … Placebo
Pain free at 2 hours Poor/None RR: 4.93; 95% CI: 4.12 to 5.91; I²
=N/A
Pain free at 2 hours … Lasmiditan 100 mg
Disability free 2 hours RR: 1.32; 95% CI: 0.83 to 2.08; I² =N/A
Disability free … Placebo Disability free 2 hours RR: 1.90; 95% CI: 1.14 to 3.18; I² =N/A
Disability free 24 hours … Placebo Disability free 2 hours RR: 1.44; 95% CI: 0.83 to 2.52; I² =N/A
Disability free 24 hours
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effectivehealthcare.ahrq.gov/products/epilepsy-medicine/research
December 21, 2011 - Results
Patients given newer antiepileptic medications were less likely to be seizure free for 6–12 … There was no significant difference in the risk of being seizure free for the study duration when newer … antiepileptic medications were compared against phenytoin or valproic acid, or the risk of being seizure free
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/episodic-migraine-surveillance-report-1.pdf
June 01, 2022 - , restored function, and
function scale at 2 hours; pain
free, sustained pain free, and
pain relief … sustained
pain free at 1 day and at 2
days. … There was
also no difference in terms of sustained pain free at 2 days. … at 2 hours
and 1 day, and sustained pain free at 1 day and 2 days. … pain free at 2 days.
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effectivehealthcare.ahrq.gov/news/srdr-plus-online-training
EPC) program launched SRDR+ , an updated version of the Systematic Review Data Repository (SRDR), a free
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effectivehealthcare.ahrq.gov/products/renal-cancer/clinician
July 18, 2017 - evidence low] )
( [evidence insufficient] )
Similar
( [evidence low] )
Local Recurrence-Free … evidence medium] )
Favors RN
( [evidence low] )
( [evidence insufficient] )
Metastasis-Free … RR of mortality 0.33 (0.25 to 0.44)
[evidence low]
Metastasis-free survival
8 (2,462)
Similar … results
RR of metastasis 1.53 (0.27 to 8.63)
[evidence medium]
Local recurrence-free survival … survival
2 (217)
Similar results
NA
[evidence low]
Local recurrence-free survival
2 (217
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/renal-cancer_clinician.pdf
July 01, 2017 - ��)
Overall Survival at 5 Years Favors PN (���)b Similar (���) (���) Similar (���)
Local Recurrence-Free … Survival Favors PN (���) Similar (���) Favors RN (���) (���)
Metastasis-Free Survival Similar (���) … 1.53 (0.27 to 8.63) ���
Local recurrence-free
survival
14 (3,916) Better with PN. … 13 (2,513) Similar results RR of metastasis 0.35 (0.08 to 1.46) ���
Local recurrence-free
survival … 2 (217) Similar results NA ���
Local recurrence-free
survival
2 (217) Better results with RN, but
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effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/surveillance-report-3-noninvasive-nonpharma.pdf
August 01, 2022 - scale, restored function, and
function scale at 2 hours; pain
free, sustained pain free and
pain … and pain relief
at 2 hours, and sustained
pain free at 24 hours and 48
hours. … There was no
significant difference in
pain relief and pain free at 2
hours. … pain free at 2 days. … There was no significant difference in pain relief and pain
free at 2 hours.
-
effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/episodic-migraine-surveillance-report-3.pdf
August 01, 2022 - scale, restored function, and
function scale at 2 hours; pain
free, sustained pain free and
pain … and pain relief
at 2 hours, and sustained
pain free at 24 hours and 48
hours. … There was no
significant difference in
pain relief and pain free at 2
hours. … pain free at 2 days. … There was no significant difference in pain relief and pain
free at 2 hours.
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0443_06-01-2011.pdf
January 01, 2011 - imaging modalities
alone or in combination for improvements in tumor staging, prediction of tumor-free … modalities alone or in combination
Outcome(s): Appropriate tumor staging, accurate prediction of tumor-free