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1. Tumor Cell-free DNA for Cancer Screening | Effective Health Care (EHC) Program
   effectivehealthcare.ahrq.gov/products/cell-free-dna

2. Key Question Tumor Cell-free DNA for Cancer Screening (pdf file)
   effectivehealthcare.ahrq.gov/sites/default/files/related_files/cell-free-dna-key-question.pdf
   September 18, 2023 - Key Question Tumor Cell-free DNA for Cancer Screening 1 Key Question Tumor Cell-free DNA for Cancer … this technology for cancer screening.13 2 A report on the available evidence on tumor cell-free … Draft Key Question KQ1: What is the (a) efficacy and (b) safety of circulating tumor cell-free DNA screening … Population: Asymptomatic adults at average- or high-risk for cancer Intervention: Circulating tumor cell-free

3. Key Questions Comment Form for Tumor Cell-free DNA for Cancer Screening | Effective Health Care (EHC) Program
   effectivehealthcare.ahrq.gov/products/form/cell-free-dna

4. Amyloidosis | Effective Health Care (EHC) Program
   effectivehealthcare.ahrq.gov/health-topics/amyloidosis
   May 02, 2011 - Serum-Free Light Chain Analysis for the Diagnosis, Management, and Prognosis of Plasma Cell Dyscrasias … Research Protocol Archived May 2, 2011 Serum Free Light Chain Analysis for the … Dyscrasias: Future Research Needs Systematic Review Archived September 19, 2012 Serum Free

5. Serum free light chain analysis for the diagnosis | Effective Health Care (EHC) Program
   effectivehealthcare.ahrq.gov/get-involved/nominated-topics/serum-free-light-chain-analysis-for-the-diagnosis
   June 17, 2009 - Serum free light chain analysis for the diagnosis Serum Free Light Chain Analysis for the Diagnosis

6. Serum-Free Light Chain Analysis for the Diagnosis, Management, and Prognosis of Plasma Cell Dyscrasias | Effective Health Care (EHC) Program
   effectivehealthcare.ahrq.gov/products/plasma-cell-dyscrasias-sflc-assay/research-protocol
   May 02, 2011 - Research Protocol Aug. 23, 2012 Systematic Review Jun. 28, 2013 Disposition of Comments Report Serum-Free … NSMM]). 1 In two-thirds of patients with NSMM, a monoclonal protein can be identified by the serum-free … Serum free light chain measurements move to center stage. Clin Chem 2005; 51: 805-7. … Highly sensitive, automated immunoassay for immunoglobulin free light chains in serum and urine. … Serum reference intervals and diagnostic ranges for free kappa and free lambda immunoglobulin light chains

7. Serum Free Light Chain Analysis for the Diagnosis, Management, and Prognosis of Plasma Cell Dyscrasias | Effective Health Care Program
   effectivehealthcare.ahrq.gov/products/plasma-cell-dyscrasias-sflc-assay
   May 02, 2011 - Serum Free Light Chain Analysis for the Diagnosis, Management, and Prognosis of Plasma Cell Dyscrasias … Topic Initiated May 02, 2011 Research Protocol Archived Serum-Free … Cell Dyscrasias August 23, 2012 Systematic Review Archived Serum Free

8. Immune System and Disorders | Effective Health Care (EHC) Program
   effectivehealthcare.ahrq.gov/health-topics/immune-system-and-disorders
   July 16, 2013 - and Above Living with HIV/AIDS Research Protocol Archived March 3, 2016 Serum-Free … Prognosis of Plasma Cell Dyscrasias Research Protocol Archived May 2, 2011 Serum Free … Dyscrasias: Future Research Needs Systematic Review Archived September 19, 2012 Serum Free

9. Key Questions: Treatment of Stage I-III Squamous Cell Carcinoma (SCC) of the Anal Canal (pdf file)
   effectivehealthcare.ahrq.gov/sites/default/files/related_files/anal-cancer-key-questions.pdf
   January 01, 2018 - survival  Colostomy-free survival (KQ1, KQ3, KQ5)  Local control  Pathologic complete response … Fractionation schemes Outcomes Overall survival Disease-free survival Colostomy-free survival Local … Other dose de-escalation Outcomes Overall survival Disease-free survival Colostomy-free survival … response Salvage rate Sphincter preservation Acute and late toxicity Overall survival Disease-free … survival Colostomy-free survival Local control Pathologic complete response Salvage rate Sphincter

10. Effective Health Care Program
    effectivehealthcare.ahrq.gov/health-topics/c%C3%A1ncer-0
    December 08, 2017 - Trials Evaluating Treatment for Infertility Research Report June 28, 2017 Serum-Free … Prognosis of Plasma Cell Dyscrasias Research Protocol Archived May 2, 2011 Serum Free

11. Progression-Free Survival: What Does it Mean for Psychological Well-being or Quality of Life? | Effective Health Care Program
    effectivehealthcare.ahrq.gov/products/survival-quality
    April 12, 2013 - Progression-Free Survival: What Does it Mean for Psychological Well-being or Quality of Life? … Topic Initiated April 12, 2013 Research Report Progression-Free

12. Serum Free Light Chain Analysis for the Diagnosis, Management, and Prognosis of Plasma Cell Dyscrasias: Future Research Needs | Effective Health Care Program
    effectivehealthcare.ahrq.gov/products/plasma-cell-dyscrasias-sflc-assay-future
    September 19, 2012 - Serum Free Light Chain Analysis for the Diagnosis, Management, and Prognosis of Plasma Cell Dyscrasias … Initiated September 19, 2012 Systematic Review Archived Serum Free

13. Evidence-based Practice Center Systematic Review Protocol (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/plasma-cell-dyscrasias-sflc-assay_research-protocol.pdf
    May 02, 2011 - myeloma Nonsecretory myeloma Smoldering multiple myeloma  Malignant plasma cells produce free … The normal plasma-cell production of free light chains is from 0.5 to 1.0 g/day.5 The detection of free … Serum free light chain measurements move to center stage. Clin Chem 2005; 51: 805-7. 5. … Highly sensitive, automated immunoassay for immunoglobulin free light chains in serum and urine. … Serum reference intervals and diagnostic ranges for free kappa and free lambda immunoglobulin light

14. Launch of SRDR Features Major Upgrades for the AHRQ-Funded Open-Access Publicly-Available Tool for Systematic Review Producers | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/news/srdr-plus-launch
    This new version, called SRDR+ , is a free, powerful, online, collaborative system for extracting and … SRDR+ features major upgrades for: Researchers  as a free platform for extracting, archiving, and sharing

15. Serum Free Light Chain Analysis for the Diagnosis, Management, and Prognosis of Plasma Cell Dyscrasias: Future Research Needs (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/plasma-cell-dyscrasias-sflc-assay-future_research.pdf
    September 01, 2012 - Serum free light chains for monitoring multiple myeloma. … Serum free light chains for monitoring multiple myeloma. … Serum free light chain measurements move to center stage. … Appraisal of immunoglobulin free light chain as a marker of response. … of the serum free light chain response definitions.

16. Progression-Free Survival: What Does It Mean for Psychological Well-Being or Quality of Life? | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/survival-quality/research
    April 12, 2013 - Progression-Free Survival: What Does It Mean for Psychological Well-Being or Quality of Life? … Structured Abstract Background Progression-free survival (PFS), defined as the time from random assignment … The four studies demonstrated better QOL or disease symptoms among patients who remained progression-free … association with OS; and (3) the extent to which improvement in QOL measures associated with progression-free

17. Methods Research Report - Progression-Free Survival: What Does It Mean for Psychological Well-Being or Quality of Life? (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/survival-quality_research.pdf
    April 01, 2013 - Methods Research Report - Progression-Free Survival: What Does It Mean for Psychological Well-Being or … Ideally, studies would be free from bias. … Issues in using progression-free survival when evaluating oncology products. … The value of progression-free survival to patients with advanced-stage cancer. … OR "progression free survival" OR "progression-free survival" OR "time to progression" AND (("Quality

18. Search-Strategies Research (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/search-strategies_research.pdf
    June 01, 2012 - Of the 25 peer reviewers invited to participate, 24 completed the initial free-form round of reviews … , and 15 completed either the PRESS review or a second free-form review as part of our control group … Free-form Review Form Appendix C. PRESS Review Form Appendix D. … Objective 3: Compare PRESS instrument to free form evaluations. … Free-Form Review Form Appendix C. PRESS Review Form Appendix D.

19. Vascular Diseases | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/health-topics/vascular-diseases
    August 16, 2010 - on Chronic Disease Outcomes and Risks Systematic Review June 21, 2018 Serum-Free … Prognosis of Plasma Cell Dyscrasias Research Protocol Archived May 2, 2011 Serum Free … Dyscrasias: Future Research Needs Systematic Review Archived September 19, 2012 Serum Free

20. Peer Review of Search Strategies | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/search-strategies/research
    June 07, 2012 - Specific Aims : Evaluate whether the PRESS instrument or no-instrument (‘free-form’ evaluations) is … Each TEPR was assigned to either the control group who only wrote “free-form” reviews or to the group … who initially wrote a “free-form” review, then trained using the PRESS Instrument, and finally completed … Of the 25 peer reviewers invited to participate, 24 completed the initial free-form round of reviews, … and 15 completed either the PRESS review or a second free-form review as part of our control group.