-
effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/research-gaps-womens-health-22.pdf
April 01, 2022 - , or prevalent
vertebral fracture criteria. … • Randomized controlled trials comparing risk of
clinical fracture endpoints for osteoporosis drugs … • Randomized controlled trials comparing risk of
clinical fracture endpoints to compare sequential … • Randomized controlled trials comparing risk of
clinical fracture endpoints to compare anabolic … PreventionApril 23, 2019https://effectivehealthcare.ahrq.gov/products/osteoporosis-fracture-prevention
-
effectivehealthcare.ahrq.gov/products/osteoporosis-vibration-therapy/research-protocol
December 09, 2010 - Fractures can also cause pain, height loss, and functional disability, and individuals that suffer from a fracture … 2008 Clinician's Guide to Prevention and Treatment of Osteoporosis and the World Health Organization Fracture … Clinical risk factors for fracture in postmenopausal osteoporotic women: a review of the recent literature … mineral content as outcome of interest (yes or no)
Measures used to assess bone mineral content
Fracture … as outcome of interest (yes or no)
Measures used to assess fracture
Quality of life as outcome of
-
effectivehealthcare.ahrq.gov/sites/default/files/vte-protocol-8-4-10.pdf
February 01, 2008 - Question 2: In patients undergoing major orthopedic surgery (hip surgery, hip fracture
surgery, or knee … Question 3: In patients undergoing major orthopedic surgery (hip surgery, hip fracture
surgery, or knee … surgery); patients undergoing major orthopedic surgery (total knee or hip
replacement, hip fracture … THR.mp
14. hip prosthesis/
15. hip prosthesis.mp
16. hip fracture surgery.mp
17. … (fracture fixation, internal/ OR fracture fixation, intramedullary/) AND (femur OR
femor* OR tibia*
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/blood-clots-hip-knee-surgery_research-protocol.pdf
February 01, 2008 - Question 2: In patients undergoing major orthopedic surgery (hip surgery, hip fracture
surgery, or knee … Question 3: In patients undergoing major orthopedic surgery (hip surgery, hip fracture
surgery, or knee … surgery); patients undergoing major orthopedic surgery (total knee or hip
replacement, hip fracture … THR.mp
14. hip prosthesis/
15. hip prosthesis.mp
16. hip fracture surgery.mp
17. … (fracture fixation, internal/ OR fracture fixation, intramedullary/) AND (femur OR
femor* OR tibia*
-
effectivehealthcare.ahrq.gov/sites/default/files/mcda-johnson.pdf
August 27, 2012 - Probability
viral load is
undetectable
8.2 10.0 5.6 6.9
5-year
treatment –
related risk of
a fracture … Probability
viral load is
undetectable
8.2 10.0 5.6 6.9
5-year
treatment –
related risk of
a fracture … Physicians
Turkish
Patients
Turkish
Physicians
Notes:
5-year
treatment –
related risk of
a fracture … 5.0 3.9 3.4 3.8 Least important:
Weight of
evidence
Weight of
evidence
Fracture risk
Fracture
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-265-radiation-bone-disease-summary.pdf
August 01, 2023 - Various
(post-RT to
30 weeks)
No difference
+ No evidence No evidence
Harms/AEs – Pathological
Fracture … ; New SCC
(Effect Size/SOE)a
Any time No difference + No evidence
No difference
+
(fracture)b … c Re-irradiation or pathologic fracture, cord compression.
4
Table B. … Size/SOE)a
Post-RT to 26
weeks
No difference
+
No difference
+
Harms/AEs – Pathological Fracture … Quality of Life
(Effect Size/SOE)a 8 weeks
No difference
+ No evidence
Harms/AEs – Pathological Fracture
-
effectivehealthcare.ahrq.gov/sites/default/files/cer-247-interventional-treatments-acute-chronic-pain-evidence-summary_0.pdf
September 01, 2021 - Vertebral Augmentation Procedures
Vertebroplasty
• Vertebroplasty for vertebral compression fracture … • Vertebroplasty was not associated with increased risk of incident vertebral fracture at
12 months … events was
sparse and imprecise but did not indicate increased risk (SOE: moderate for vertebral
fracture … Kyphoplasty
• Kyphoplasty for vertebral compression fracture (2 trials, N=434) was associated with … • Evidence on incident or worsening vertebral fracture was inconsistent and imprecise,
based on
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-247-interventional-treatments-acute-chronic-pain-evidence-summary.pdf
September 01, 2021 - Vertebral Augmentation Procedures
Vertebroplasty
• Vertebroplasty for vertebral compression fracture … • Vertebroplasty was not associated with increased risk of incident vertebral fracture at
12 months … events was
sparse and imprecise but did not indicate increased risk (SOE: moderate for vertebral
fracture … Kyphoplasty
• Kyphoplasty for vertebral compression fracture (2 trials, N=434) was associated with … • Evidence on incident or worsening vertebral fracture was inconsistent and imprecise,
based on
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-247-interventional-treatments-acute-chronic-pain-evidence-summary_0.pdf
September 01, 2021 - Vertebral Augmentation Procedures
Vertebroplasty
• Vertebroplasty for vertebral compression fracture … • Vertebroplasty was not associated with increased risk of incident vertebral fracture at
12 months … events was
sparse and imprecise but did not indicate increased risk (SOE: moderate for vertebral
fracture … Kyphoplasty
• Kyphoplasty for vertebral compression fracture (2 trials, N=434) was associated with … • Evidence on incident or worsening vertebral fracture was inconsistent and imprecise,
based on
-
effectivehealthcare.ahrq.gov/get-involved/nominated-topics/multimodal-pain-management-for-post-hip-surgery
February 29, 2008 - Future Research Needs for the Treatment of Common Hip Fractures Pain Management Interventions for Hip Fracture
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/assessing-applicability-quiz.ppt
September 02, 2013 - In addition, bone mineral density is a surrogate end point for the risk of bone fracture, which limits … In addition, bone mineral density is a surrogate end point for the risk of bone fracture, which limits … In addition, bone mineral density is a surrogate end point for the risk of bone fracture, which limits … In addition, bone mineral density is a surrogate end point for the risk of bone fracture, which limits
-
effectivehealthcare.ahrq.gov/sites/default/files/assessing-applicability-quiz.ppt
September 02, 2013 - In addition, bone mineral density is a surrogate end point for the risk of bone fracture, which limits … In addition, bone mineral density is a surrogate end point for the risk of bone fracture, which limits … In addition, bone mineral density is a surrogate end point for the risk of bone fracture, which limits … In addition, bone mineral density is a surrogate end point for the risk of bone fracture, which limits
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/osteoporosis-vibration-therapy_technical-brief.pdf
January 01, 2020 - this topic already includes some discussion of vibration therapy to increase bone mass and
decrease fracture … Subgroups with differing risks for osteoporotic fracture, severity of osteoporosis,
and contraindications … Low-
frequency vibratory exercise reduces the risk
of bone fracture more than walking: a
randomized … Assessment of
Fracture Risk and Its Application to
Screening for Postmenopausal Osteoporosis. … Measure
of
Fracture
Quality
of Life
Quality
of Life
Measure
Other Outcomes
Gusi, 200621
-
effectivehealthcare.ahrq.gov/health-topics/bone-diseases
November 15, 2011 - Whole-Body Vibration Therapy for Osteoporosis
Technical Brief
Archived
November 15, 2011
Treatment To Prevent Fractures in Men and Women With Low Bone Density or Osteoporosis: Update of a 2007 Report
Systematic Review
Archived
March 28, 2012
Technical Brief: Whole Body Vibr…
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/blood-clots-hip-knee-surgery_executive.pdf
March 01, 2012 - surgical procedures including total hip
replacement (THR), total knee
replacement (TKR), and hip fracture … KQ 2: In patients undergoing major orthopedic surgery
(total hip or knee replacement or hip fracture … KQ 3: In patients undergoing major orthopedic surgery
(total hip or knee replacement or hip fracture … KQ 6: In patients undergoing major orthopedic surgery
(total hip or knee replacement or hip fracture … Hip Fracture Surgery (HFS): The surgical procedure to
treat hip fracture.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-265-radiation-bone-disease-disposition-comments.pdf
August 29, 2023 - Indications for surgery for each also
tend to be different, e.g., pathologic fracture in the femur is … Pathologic fracture in the spine
vertebral body is not always treated surgically, and often it is not … The listed
exclusion criterion for this study
was: Previous radiation therapy to
the fracture site … Author’s Table 1 lists
femoral and humeral fracture sites
in addition to “other” (7% vs. 3%)
which … While all of this infers that
treatment was of nonspine
fracture/impending fractures, it it’s
not
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/cer-215-depression-older-adults-executive-summary.pdf
March 01, 2019 - antidepressant
7 RCTs8,10-15
1 OBS26
Any AE, bleed-UGI, blood pressure, cognitive function, falls,
fracture
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-215-depression-older-adults-executive-summary.pdf
March 01, 2019 - antidepressant
7 RCTs8,10-15
1 OBS26
Any AE, bleed-UGI, blood pressure, cognitive function, falls,
fracture
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/breast-cancer-medications_executive.pdf
September 01, 2009 - Insufficient
+ ++
All-cause death3 No difference No difference No difference Insufficient
+++ +++
Vertebral fracture … No difference No difference 7 (5, 9) 44 (25, 61)
+ +++ ++
Nonvertebral fracture Insufficient 3 (0.2
-
effectivehealthcare.ahrq.gov/products/hip-feature-treatment-future
September 27, 2010 - Future Research Needs for the Treatment of Common Hip Fractures
Timeline
September 13, 2010
Topic Initiated
September 27, 2010
Systematic Review
Archived
Future Research Needs for the Treatment of Common Hip Fractures