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21. Long-Term Drug Therapy and Drug Holidays for Osteoporotic Fracture Prevention | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/osteoporosis-fracture-prevention/research-protocol

22. CERs Report cover (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/hip-feature-treatment-future_research.pdf
    September 23, 2010 - that resulted from low energy trauma, and fracture type. … sliding hip screw Femoral shaft fracture Risk of femoral shaft fracture related to Gamma nails … for displaced FN fracture NCT00859378 cement vs. … Revised hip fracture research agenda Measurement Issues 1. … What predicts short time-to-recovery after hip fracture?

23. Evidence-based Practice Center Systematic Review Protocol (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/osteoporosis-bone-fracture_research-protocol.pdf
    May 14, 2010 - , race/ethnicity, previous clinical vertebral fracture, previous fracture due to minimal trauma (i.e … ., previous osteoporotic fracture), any fracture sustained over the age of 50, rheumatoid arthritis, … b) How does bone density monitoring predict anti-fracture benefits during pharmacotherapy? … • Outcomes - We propose using fracture incidence as the outcome. … Assessment of fracture risk. Osteoporos Int 2005;16(6):581-9. 6.

24. Disposition of Comments for Treatment To Prevent Fractures in Men and Women With Low Bone Density or Osteoporosis -- Update of a 2007 Report (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/osteoporosis-bone-fracture_disposition-comments.pdf
    March 01, 2012 - (like spine or hip fracture). … risk but not the risk of non-vertebral or hip fracture. … , defined as a history of osteoporotic fracture, or multiple risk factors for fracture; or patients … Among the risks for fracture, one of the strongest is prior fracture, independent of BMD We have … Rather it is the HR associated with the effect of prior fracture on subsequent fracture; the text was

25. Evidence-based Practice Center Systematic Review Protocol (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/hip-fracture-pain_research-protocol.pdf
    December 09, 2009 - Review Protocol Project Title: Comparative Effectiveness of Pain Management Interventions for Hip Fracture … World-wide projections for hip fracture. Osteoporos Int 1997;7:407-13. 4. … Functional recovery after hip fracture. Arch Phys Med Rehabil 1987;68:735-40. 6. … Determinants of recovery 12 months after hip fracture: the importance of psychosocial factors. … Haentjens P, Autier P, Barette M, et al, for the Belgian Hip Fracture Study Group.

26. Layout 1 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/hip-fracture-pain_espanol.pdf
    August 01, 2011 - Incluso una lesión menor puede hacer que este hueso se fracture. … 9 Fuente La información de esta guía proviene del informe Pain Management Interventions for Hip Fracture

27. Effective Health Care (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0265_02-29-2008.pdf
    January 01, 2008 - the nominator that narrowed the scope of the nomination to multi-modal pain management for post-hip fracture … In older adults (≥ 50 years) admitted to hospital following acute hip fracture, what is the comparative … and hip fracture repair? … In older adults (≥ 50 years) admitted to hospital following acute hip fracture, what is the comparative … associated with pharmacologic and nonpharmacologic pain management interventions following acute hip fracture

28. White Paper_Supplementing Systematic Review Findings With Healthcare System Data: Pilot Projects From the Agency for Healthcare Research and Quality Evidence-based Practice Center Program (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/pilot-projects-supplementing-white-paper.pdf
    December 01, 2024 - All pilot project topics addressed clinical questions: infantile epilepsy, migraine, and hip fracture … fracture prevention to inform health system protocol updates. 6 3. … Very few older adults with hip fracture were taking BPM at fracture admission, and this was consistent … patients who were not taking bone protective medication at the time of fracture admission. … Long- Term Drug Therapy and Drug Holidays for Osteoporosis Fracture Prevention: A Systematic Review

29. Untitled (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/thromboembolism-update_research-protocol.pdf
    February 17, 2016 - describes three surgical procedures including total hip replacement, total knee replacement, and hip fracture … Finally, all questions related to orthopedic surgeries other than TKR, THR, and hip fracture surgery … For each of three surgeries (THR, TKR, and hip fracture surgery) and for two outcomes (total DVT and … surgery or hfs or (("Fracture Fixation, Internal"[Mesh] or "Fracture Fixation, Intramedullary"[Mesh … surgery or hfs or ((Fracture Fixation Internal or Fracture Fixation Intramedullary) and (hip femur

30. AHRQ's Evidence-based Practice Center Division Annual Report 2019: Solving the Puzzle for Evidence-Based Decision Making (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/pdf/epc-year-in-review-2019.pdf
    January 01, 2019 - Reduce Acute Pain in the Prehospital Setting Long-Term Drug Therapy and Drug Holidays for Osteoporosis Fracture … effectivehealthcare.ahrq.gov/products/acute-pain-ems/research https://effectivehealthcare.ahrq.gov/products/osteoporosis-fracture-prevention … Prehospital Setting Long-Term Drug Therapy and Drug Discontinuations and Holidays for Osteoporosis Fracture … annals.org/aim/fullarticle/2731605/long-term-drug-therapy-drug-discontinuations-holidays-osteoporosis-fracture-prevention … Evaluating Natural Experiments in Obesity; January 2019 Appropriate Use of Drug Therapies for Osteoporotic Fracture

31. VTE Surveillance Assessment_49_low_SPI (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/blood-clots-hip-knee-surgery_surveillance.pdf
    December 01, 2012 - In patients undergoing major orthopedic surgery (total hip or knee replacement or hip fracture surgery … In patients undergoing major orthopedic surgery (total hip or knee replacement or hip fracture surgery … In patients who had major orthopedic surgery (total hip or knee replacement, hip fracture surgery), … In patients undergoing major orthopedic surgery (total hip or knee replacement, hip fracture surgery … In patients undergoing major orthopedic surgery (total hip or knee replacement, hip fracture surgery

32. Osteoporosis-Vibration-Therapy Research-Protocol (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/osteoporosis-vibration-therapy_research-protocol.pdf
    January 01, 2020 - Fractures can also cause pain, height loss, and functional disability, and individuals that suffer from a fracture … 2008 Clinician's Guide to Prevention and Treatment of Osteoporosis and the World Health Organization Fracture … Clinical risk factors for fracture in postmenopausal osteoporotic women: a review of the recent literature … Low-frequency vibratory exercise reduces the risk of bone fracture more than walking: a randomized controlled … as outcome of interest (yes or no) Measures used to assess fracture Quality of life as outcome of

33. Evidence Report on the (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/vte-protocol-8-4-10.pdf
    February 01, 2008 - Question 2: In patients undergoing major orthopedic surgery (hip surgery, hip fracture surgery, or knee … Question 3: In patients undergoing major orthopedic surgery (hip surgery, hip fracture surgery, or knee … surgery); patients undergoing major orthopedic surgery (total knee or hip replacement, hip fracture … THR.mp 14. hip prosthesis/ 15. hip prosthesis.mp 16. hip fracture surgery.mp 17. … (fracture fixation, internal/ OR fracture fixation, intramedullary/) AND (femur OR femor* OR tibia*

34. Evidence Report on the (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/blood-clots-hip-knee-surgery_research-protocol.pdf
    February 01, 2008 - Question 2: In patients undergoing major orthopedic surgery (hip surgery, hip fracture surgery, or knee … Question 3: In patients undergoing major orthopedic surgery (hip surgery, hip fracture surgery, or knee … surgery); patients undergoing major orthopedic surgery (total knee or hip replacement, hip fracture … THR.mp 14. hip prosthesis/ 15. hip prosthesis.mp 16. hip fracture surgery.mp 17. … (fracture fixation, internal/ OR fracture fixation, intramedullary/) AND (femur OR femor* OR tibia*

35. Assessing Applicability: Interactive Case Study Quiz (ppt file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/assessing-applicability-quiz.ppt
    May 29, 2025 - In addition, bone mineral density is a surrogate end point for the risk of bone fracture, which limits … In addition, bone mineral density is a surrogate end point for the risk of bone fracture, which limits … In addition, bone mineral density is a surrogate end point for the risk of bone fracture, which limits … In addition, bone mineral density is a surrogate end point for the risk of bone fracture, which limits

36. Assessing Applicability: Interactive Case Study Quiz (ppt file)
    effectivehealthcare.ahrq.gov/sites/default/files/assessing-applicability-quiz.ppt
    May 29, 2025 - In addition, bone mineral density is a surrogate end point for the risk of bone fracture, which limits … In addition, bone mineral density is a surrogate end point for the risk of bone fracture, which limits … In addition, bone mineral density is a surrogate end point for the risk of bone fracture, which limits … In addition, bone mineral density is a surrogate end point for the risk of bone fracture, which limits

37. The Use of Conjoint Analysis to Elicit Patient Preferences in Selecting Treatment Endpoints (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/mcda-johnson.pdf
    August 27, 2012 - Probability viral load is undetectable 8.2 10.0 5.6 6.9 5-year treatment – related risk of a fracture … Probability viral load is undetectable 8.2 10.0 5.6 6.9 5-year treatment – related risk of a fracture … Physicians Turkish Patients Turkish Physicians Notes: 5-year treatment – related risk of a fracture … 5.0 3.9 3.4 3.8 Least important: Weight of evidence Weight of evidence Fracture risk Fracture

38. Executive Summary: Radiation Therapy for Metastatic Bone Disease: Effectiveness and Harms (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-265-radiation-bone-disease-summary.pdf
    August 01, 2023 - Various (post-RT to 30 weeks) No difference + No evidence No evidence Harms/AEs – Pathological Fracture … ; New SCC (Effect Size/SOE)a Any time No difference + No evidence No difference + (fracture) … c Re-irradiation or pathologic fracture, cord compression. 4 Table B. … Size/SOE)a Post-RT to 26 weeks No difference + No difference + Harms/AEs – Pathological Fracture … Quality of Life (Effect Size/SOE)a 8 weeks No difference + No evidence Harms/AEs – Pathological Fracture

39. Evidence Summary_Comparative Effectiveness Review No. 247_Interventional Treatments for Acute and Chronic Pain: Systematic Review (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-247-interventional-treatments-acute-chronic-pain-evidence-summary_0.pdf
    September 01, 2021 - Vertebral Augmentation Procedures Vertebroplasty • Vertebroplasty for vertebral compression fracture … • Vertebroplasty was not associated with increased risk of incident vertebral fracture at 12 months … events was sparse and imprecise but did not indicate increased risk (SOE: moderate for vertebral fracture … Kyphoplasty • Kyphoplasty for vertebral compression fracture (2 trials, N=434) was associated with … • Evidence on incident or worsening vertebral fracture was inconsistent and imprecise, based on

40. Whole-Body Vibration Therapy for Osteoporosis (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/osteoporosis-vibration-therapy_technical-brief.pdf
    January 01, 2020 - this topic already includes some discussion of vibration therapy to increase bone mass and decrease fracture … Subgroups with differing risks for osteoporotic fracture, severity of osteoporosis, and contraindications … Low- frequency vibratory exercise reduces the risk of bone fracture more than walking: a randomized … Assessment of Fracture Risk and Its Application to Screening for Postmenopausal Osteoporosis. … Measure of Fracture Quality of Life Quality of Life Measure Other Outcomes Gusi, 200621