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  1. effectivehealthcare.ahrq.gov/sites/default/files/pdf/trauma-child-interventions_research-protocol.pdf
    March 26, 2012 - anxiety disorder that can be diagnosed in children at least 1 month after exposure to a traumatic event … by having frequent memories of it (or in young children, reenacting the event through play), having … and frightening dreams, or developing repeated physical or emotional symptoms when reminded of the event … To establish the diagnosis, a clinician needs to establish that a traumatic event preceded onset of … CISD is an intervention that targets individuals who have recently been exposed to a traumatic event
  2. Layout 1 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/related_files/cancer-anemia_executive.pdf
    May 01, 2006 - Hb Meta-analysis increase >2 mg/dL (95% CI) not done1 3.42 (3.03, 3.86)2 3.36 (2.48, 4.56) Pooled event … 950 Pooled relative risk (95% CI) 1.10 (0.93, 1.29)2 0.63 (0.59, 0.67)2 0.61 (0.52, 0.72) Pooled event … 314 Pooled relative risk (95% CI) 0.86 (0.61, 1.21) 1.69 (1.36, 2.10) 1.44 (0.47, 4.43)3 Pooled event … patients treated with epoetin or darbepoetin experienced a thromboembolic event, compared with 4 percent … However, trials varied widely in thromboembolic event rates: 0 percent to 30 percent among treated patients
  3. effectivehealthcare.ahrq.gov/sites/default/files/pdf/acs-depression-research-protocol-amended.pdf
    February 15, 2017 - § Within 3 months of hospitalization for an acute ACS event • Settings: o Primary, specialty, … Adults who received a criterion-based diagnosis of depression and are within 3 months of an ACS event … • Repeat ACS event … § Within 3 months of hospitalization for an acute ACS event § Beyond 3 months of hospitalization … outcomes • Response or remission • Cardiac-related outcomes • Cardiac mortality • Repeat ACS event
  4. Prognostic Tests (ppt file)

    effectivehealthcare.ahrq.gov/sites/default/files/related_files/medical-test-reviews-prognostic.ppt
    June 01, 2012 - Outcomes Time-dependent probabilities (time-to-event curves) of what is being predicted, changes or … One table is for those who did experience the outcome event within a particular time period. … The other table is for those who did not experience the outcome event. … This version calculates three different probabilities of the outcome event occurring: in the group of … probability of the event, and the followup time.
  5. Prognostic Tests (ppt file)

    effectivehealthcare.ahrq.gov/sites/default/files/medical-test-reviews-prognostic.ppt
    June 01, 2012 - Outcomes Time-dependent probabilities (time-to-event curves) of what is being predicted, changes or … One table is for those who did experience the outcome event within a particular time period. … The other table is for those who did not experience the outcome event. … This version calculates three different probabilities of the outcome event occurring: in the group of … probability of the event, and the followup time.
  6. Layout 1 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/related_files/ace-inhibitor-arb-update_executive.pdf
    June 01, 2011 - This may reflect low event rates among otherwise healthy patients and relatively few studies with extended … ARB); event rates were very low or zero for all studies; this limited Insufficient our ability to accurately … In the four studies that did report episodes of ARB) angioedema, this adverse event was observed only … large databases with sufficient sample sizes to obtain more precise estimates of this rare but serious event … rates, overall adverse event rates, and withdrawals due to adverse events, withdrawal rates, and switch
  7. effectivehealthcare.ahrq.gov/sites/default/files/ch_9-user-guide-to-ocer_130129.pdf
    September 21, 2012 - the standard deviation of the outcome in each trial arm; when the outcome is the occurrence of an event … (e.g., death), then an assumed event rate in the control group is necessary. … If the assumed event rate in the control group is combined with the specified treatment effect of interest … , then one can calculate the expected event rate in each group if the minimum clinically important … It is recommended that estimates of standard deviations and event rates used in study size calculations
  8. Han (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/han.pdf
    December 26, 2012 - costs Slide 15: Communicating  uncertainty in clinical evidence: conceptual problems • Single-­‐event … events • Conceptual problem: objective probability does not exist here o Idea of objective “single-­‐event … conventional representations do not explicitly represent indeterminacy • Important  in domain of single-­‐event
  9. effectivehealthcare.ahrq.gov/sites/default/files/methodsguide_conductingquantitativesynthesis.pdf
    October 01, 2010 - Approaches of Indirect Comparison The naïve indirect comparison—where the summary event rate for each … For time to event data, the measure is hazard ratio (HR), and most commonly estimated from the Cox … All these models could be used to combine measures for continuous, count and time to event data, as … Rate ratio should be used for count data and hazard ratios for time-to-event data. … Practical methods for incorporating summary time-to-event data into meta- analysis.
  10. effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-quantitative-synthesis_methods.pdf
    October 01, 2010 - Approaches of Indirect Comparison The naïve indirect comparison—where the summary event rate for each … For time to event data, the measure is hazard ratio (HR), and most commonly estimated from the Cox … All these models could be used to combine measures for continuous, count and time to event data, as … Rate ratio should be used for count data and hazard ratios for time-to-event data. … Practical methods for incorporating summary time-to-event data into meta- analysis.
  11. effectivehealthcare.ahrq.gov/products/acs-depression/research-protocol
    August 31, 2016 - both unstable angina and myocardial infarction (MI)] and are within 3 months of an identifying ACS event … interest: During hospitalization/at discharge Within 30 days of hospitalization for an acute ACS event … Within 3 months of hospitalization for an acute ACS event Settings Primary, specialty, inpatient … Within 3 months of hospitalization for an acute ACS event Beyond 3 months of hospitalization for … an acute ACS event Settings Primary, specialty, inpatient Analytic Framework Figure 1.
  12. effectivehealthcare.ahrq.gov/sites/default/files/pdf/ptsd-adult-treatment_research-protocol.pdf
    December 20, 2011 - threatened death or serious injury, or other threat to one’s physical integrity; or witnessing an event … • Acting or feeling as if the traumatic event were recurring • Distress at internal or external … , rather than the event itself, determines an individual’s mood. … Impact of event scale: a measure of subject stress. Psychosom Med. 1979;41(3):209-18. … • Requires patient to associate each symptom with a specific traumatic event.
  13. effectivehealthcare.ahrq.gov/sites/default/files/knowledge-brief-2-methods-public-deliberation-130213.pdf
    February 01, 2013 - deliberation on participants has been assessed through surveys or interviews before and after a deliberative event … solidarity, and anticipated post-meeting activity related to deliberation issues. 5 Post-event … participants’ deliberative experience, including their perceptions of whether participating in the event … However, it may be difficult to assess whether a specific deliberative event had a direct effect on
  14. effectivehealthcare.ahrq.gov/sites/default/files/related_files/knowledge-brief-2-methods-public-deliberation-130213.pdf
    February 01, 2013 - deliberation on participants has been assessed through surveys or interviews before and after a deliberative event … solidarity, and anticipated post-meeting activity related to deliberation issues. 5 Post-event … participants’ deliberative experience, including their perceptions of whether participating in the event … However, it may be difficult to assess whether a specific deliberative event had a direct effect on
  15. effectivehealthcare.ahrq.gov/products/antipsychotics-adults/research-protocol
    December 01, 2010 - We will not assume that an adverse event occurred unless a specific number of events are reported. … subgroup, we will report the number of studies that provide data for any event within the subgroup. … The dose of each medication that is associated with an adverse event will be recorded to facilitate a … dose-related adverse-event analysis. … In the event that studies cannot be pooled, evidence tables will be produced and a narrative summary
  16. effectivehealthcare.ahrq.gov/sites/default/files/pdf/antipsychotics-adults_research-protocol.pdf
    December 01, 2010 - We will not assume that an adverse event occurred unless a specific number of events are reported. … subgroup, we will report the number of studies that provide data for any event within the subgroup. … The dose of each medication that is associated with an adverse event will be recorded to facilitate … a dose- related adverse-event analysis. … Summary of Protocol Amendments In the event of protocol amendments, the date of each amendment will
  17. effectivehealthcare.ahrq.gov/sites/default/files/related_files/vaccines-safety-protocol-130325.pdf
    September 18, 2012 - of safety,9 including postlicensure safety surveillance conducted by the FDA,10 the Vaccine Adverse Event … This report evaluated the scientific evidence for event-vaccine relationships and covered many vaccines … Internet-based reporting to the vaccine adverse event reporting system: a more timely and complete way … Tdap = Tetanus, diphtheria, and acellular pertussis VAERS = Vaccine Adverse Event Reporting System … Adverse events of interest, included in electronic search terms Adverse event Vaccine type Acute
  18. effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0365_10-28-2010.pdf
    January 01, 2010 - Is there evidence that the type of traumatic event and degree/type of exposure affects the development … ) and PTSD are similar psychological disorders that develop in response to exposure to a traumatic event
  19. effectivehealthcare.ahrq.gov/sites/default/files/pdf/ehc-presentation-quantitative-synthesis-chapter-3.pdf
    February 01, 2018 - Low-event-rate meta-analyses of clinical trials: implementing good practices. Stat Med. 2016. … dx.doi.org/10.1002/sim.6844 http://dx.doi.org/10.1002/sim.2528 • The Peto method performs best when event … overestimate confidence intervals in small studies with low heterogeneity • Peto method ► Best when event … Low-event-rate meta-analyses of clinical trials: implementing good practices.
  20. Layout 1 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/related_files/gerd-2005_executive.pdf
    January 01, 2005 - Higher adverse event rates were described for PPIs than for H2RAs or placebo. … PPIs (1 RCT): no direct comparative adverse event data reported in this study; in surgical group, 3.7% … the surgical group; 4.5% developed dysphagia that persisted for > 3 months after surgery; adverse event … There are no direct comparative adverse event data for endoscopic vs. laparoscopic procedures.

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