-
effectivehealthcare.ahrq.gov/products/methods-balancing-harms-benefits/research
February 13, 2014 - Evaluation of the Benefits and Harms of Aspirin for Primary Prevention of Cardiovascular Events: A Comparison of Quantitative Approaches
Research Report February 13, 2014 Web Version [NLM Site] Download Main Document PDF 342.5 KB
People using assistive technology may not be able to fully access informat…
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/scarce-resources-protocol.pdf
January 01, 2013 - 2012
AHRQ evidence review identified strategies for allocating medical resources in a mass casualty
event
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/gaps-pain-management.pdf
January 01, 2023 - short-term adverse events versus
nonopioid pharmacologic therapy for acute pain,
including any adverse event … Pain during the week or
month following the inciting event and
persistent opioid use were rarely reported
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/coronary-stents-outcomes_research.pdf
January 01, 2010 - resulted in release of two special FDA
advisories in 2006,7,8 as well as subsequent studies refining event … In the rare event that a single ACC-NCDR® record could
Effective Health Care Research Report Number … Death was the
only event defined both during the index PCI procedure (using ACC-NCDR®
information) … of repeat revascularization in our population (24%) may be due to not censoring
patients after an event … Unadjusted and adjusted results from time-to-event analyses for prespecified
endpoints.
-
effectivehealthcare.ahrq.gov/products/headaches-pregnancy/protocol
November 12, 2019 - or harm or harms or harmful or toxic or injurious or serious or fatal) AND (effect* or reaction* or event … or harm or harms or harmful or toxic or injurious or serious or fatal) AND (effect* or reaction* or event
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/headaches-pregnancy.pdf
March 23, 2019 - harm or harms or harmful or toxic or injurious or serious or fatal) AND (effect* or reaction* or
event … or harm or harms or
harmful or toxic or injurious or serious or fatal) AND (effect* or reaction* or event
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/ace-inhibitor-arb-update-surveillance-160328.pdf
March 28, 2016 - .$$
•$ May$reflect$low$event$rates$among$otherwise$healthy$patients$and$relatively$few$studies$
with … &ACEI&or&ARB)&
$
Although$several$studies$collected$data$on$angioedema,$the$event$rates$were$very$low … $From$these,$38$
deaths$and$13$strokes$were$
reported.$$
•$ May$reflect$low$event$rates$
among$otherwise … &ACEI&or&
ARB)&
$
Although$several$studies$collected$data$
on$angioedema,$the$event$rates$were$
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/renal-artery-stenosis_executive-2007.pdf
January 01, 2007 - Layout 1
This report is an update to a Comparative
Effectiveness Review on management
strategies for renal artery stenosis (RAS)
from October 2006. The systematic review
included all studies of patients with
atherosclerotic RAS (ARAS) that
compared two or more interventions. It
also reviewed recent prospective cohort…
-
effectivehealthcare.ahrq.gov/sites/default/files/back-pain-treatment_research_executive.pdf
February 01, 2016 - found skeletal muscle relaxants for acute LBP to
be associated with increased risk of any adverse event … Low One trial found no differences between ultrasound vs. sham
ultrasound in risk of any adverse event
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/sodium-potassium_research-protocol.pdf
April 18, 2017 - mortality
o Stroke, coronary heart disease, myocardial infarction
o Number of patients with any CVD event … study reports more than one
outcome in this category, we will abstract data for only one type of
event … disease mortality
Stroke
Coronary heart disease
Myocardial infarction
Number of patients with any CVD event … follow up:
mean/median 24-h urinary
excretion , status
Outcomes: type and definition
(e.g., any CVD event … intervention vs control
e.g., RR (CI) % reaching prespecified BP goal
CVD
e.g., RR (CI) any CVD event
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/peripheral-artery-disease-treatment_executive.pdf
May 01, 2013 - Nonfatal MI
SOE=Insufficient
2 RCTs, 497 patients
Inconclusive evidence due to low event rates in … Nonfatal stroke
SOE=Insufficient
3 RCTs, 1932 patients
Inconclusive evidence due to low event rates
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/anal-cancer-draft-report.pdf
October 31, 2023 - One RCT (n=110) reported one grade 4
event in CRT vs zero grade 4 events in
RT alone. … Insufficient
Overall late
harms
1; RCTs; n=310 5 events in 5FU + MMC arm vs. 1
event in 5FU arm … One RCT
(n=682) reported grade 3 toxicity
frequency of 2 events in MMC arm vs.
1 event in cisplatin … No
significant difference was found in CR, progression-free or event-free survival between arms. … Neither NRSI reported comparisons for acute or late toxicity event rates.
Table 25.
-
effectivehealthcare.ahrq.gov/sites/default/files/arthritis-horizon-scan-high-impact-1506.pdf
June 01, 2015 - , versus 55.7% given placebo; serious adverse event
rates were 1.6%, 2.4% and 4.1%, respectively.5 … Similar adverse event rates were reported for secukinumab 75 mg (57.5%), 150
3
mg (62.5%), and … However, some experts were concerned about the
adverse event rates reported.12,15 Some experts also … research expert
noted concerns over renal adverse events, which could require additional adverse-event … in
the pooled secukinumab group and 58.2% of patients in the placebo group reported an adverse
event
-
effectivehealthcare.ahrq.gov/products/colorectal-surgery-preparation/research-protocol
March 26, 2013 - This cutoff is chosen to ensure that studies can estimate low event rates with adequate precision. … evaluate (and if statistical analyses are deemed appropriate, to estimate more precisely) the adverse event … Study-level or summary estimates of event rates will also be used to contextualize the relative effects … In the event of protocol amendments, the date of each amendment will be accompanied by a description
-
effectivehealthcare.ahrq.gov/sites/default/files/cer-221-copd-evidence-summary.pdf
October 01, 2019 - Evidence Summary: Pharmacologic and Nonpharmacologic Therapies in Adult Patients With Exacerbation of COPD
Purpose of Review
To evaluate the effectiveness and harms of pharmacologic and
nonpharmacologic treatments for exacerbations of chronic
obstructive pulmonary disease.
Key Messages
• Antibiotic therapy in…
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/administrative-data-validity_research.pdf
January 01, 2007 - deemed the gold standard, this definition was used during the review process to validate each putative event
-
effectivehealthcare.ahrq.gov/sites/default/files/upenn-final-report-2005-certs-ce-supplement.pdf
January 01, 2005 - deemed the gold standard, this definition was used during the review process to validate each putative event
-
effectivehealthcare.ahrq.gov/products/nonopioid-chronic-pain/protocol
March 01, 2019 - or severity of pain, underlying pain condition, presence of medical and psychiatric comorbidities, event
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/nonopioid-pharm-chronic-pain-protocol.pdf
February 01, 2019 - or severity of pain, underlying pain condition, presence of
medical and psychiatric comorbidities, event
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/hip-fracture-pain.ppt
May 01, 2011 - AHRQ Publication No. 11-EHC022-EF
http://effectivehealthcare.ahrq.gov/hippain.cfm
Overall, adverse event … Adverse Events Influenced by Pain Management Interventions
Overall, adverse event rates were similar