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effectivehealthcare.ahrq.gov/products/patient-safety-drug-data/abstract
January 01, 2005 - Data Development for Patient Safety — A Pilot Study using Medicare Part B Drug Data
Abstract January 1, 2005
Topic Abstract
Medicare administrative claims data offer a valuable informational source for the surveillance of adverse drug events, but there are substantial challenges in exploiting these d…
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/white-paper-library-asthma.pdf
April 01, 2019 - Standardized Library of Asthma Outcome Measures
Research White Paper
Standardized Library of Asthma Outcome Measures
Research White Paper
Standardized Library of Asthma Outcome Measures
Prepared for:
Agency for Healthcare Research and Quality
Center for Outcomes and Ev…
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effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/white-paper-library-asthma.pdf
April 01, 2019 - Standardized Library of Asthma Outcome Measures
Research White Paper
Standardized Library of Asthma Outcome Measures
Research White Paper
Standardized Library of Asthma Outcome Measures
Prepared for:
Agency for Healthcare Research and Quality
Center for Outcomes and Ev…
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0407_01-20-2011.pdf
January 01, 2011 - Effective Health Care
Topic Number: 0343
Document Completion Date: 3-23-11
1
Results of Topic Selection Process & Next Steps
Peripheral artery disease (PAD) will go forward for refinement as a systematic review. The scope of
this topic, including populations, interventions, comparators, and out…
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/juvenile-arthritis-dmards_disposition-comments.pdf
September 01, 2011 - We have added the following
sentence as a Key Point: “Adverse event
rates may be underestimated by … In adverse event
analysis, page 45, why weren't open label run-in phase data in the
withdrawal studies … In the adverse event analysis,
we only included data from the RCT phases
of multiphase studies in order … Some examples of
imbalances in adverse event rates that favor the safety of placebo
over adalimumab … We have added the following
sentence as a Key Point for KQ3: “Adverse
event rates may be underestimated
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/antipsychotic-medicine-cardiovascular-elderly_research.pdf
February 01, 2009 - myocardial infarction 60 (0.66) 96 (0.70) 99 (1.08) 151 (1.10) 164 (1.79) 249 (1.81)
Cerebrovascular event … Acute myocardial Infarction 0.93 (0.66, 1.32) 1.00 (0.76, 1.30) 1.03 (0.85, 1.27)
Cerebrovascular event … Acute myocardial infarction 0.89 (0.59, 1.33) 1.02 (0.75, 1.40) 1.16 (0.91, 1.48)
Cerebrovascular event
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effectivehealthcare.ahrq.gov/products/sodium-potassium/research-protocol
March 01, 2017 - mortality
Stroke, coronary heart disease, myocardial infarction
Number of patients with any CVD event … a study reports more than one outcome in this category, we will abstract data for only one type of event … mortality
Stroke
Coronary heart disease
Myocardial infarction
Number of patients with any CVD event … mortality
Stroke
Coronary heart disease
Myocardial infarction
Number of patients with any CVD event … : e.g., mean/median 24-h urinary excretion, status
Outcomes: type and definition (e.g., any CVD event
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effectivehealthcare.ahrq.gov/products/weight-loss-surgery/research
June 05, 2013 - Current Page Topic Timeline Mar. 10, 2008 Topic Suggestion Dec. 14, 2010 Research Protocol Jun. 5, 2013 Systematic Review Sep. 12, 2013 Disposition of Comments Report Bariatric Surgery and Nonsurgical Therapy in Adults With Metabolic Conditions and a Body Mass Index of 30.0 to 34.9 kg/m²
Systematic Review Archived…
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effectivehealthcare.ahrq.gov/products/angina-heart-attack-treatments/research
November 04, 2013 - Current Page Topic Timeline Oct. 25, 2011 Topic Initiated Dec. 13, 2012 Research Protocol Nov. 4, 2013 Systematic Review Feb. 13, 2014 Disposition of Comments Report Antiplatelet and Anticoagulant Treatments for Unstable Angina/Non–ST Elevation Myocardial Infarction
Systematic Review Archived November 4, 2013 Web …
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effectivehealthcare.ahrq.gov/products/rheumatoid-arthritis-medicine-update/final-report-update-2018
July 16, 2018 - Current Page Topic Timeline Mar. 29, 2017 Topic Initiated May. 24, 2017 Research Protocol Jul. 16, 2018 Systematic Review Drug Therapy for Early Rheumatoid Arthritis: A Systematic Review Update
Systematic Review July 16, 2018 Download Main Document PDF 23.9 MB
Related Files Download Disposition of Com…
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effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/main-apps-surv-rept-1-acute-pain.pdf
February 01, 2022 - NSAID
Opioid increased risk of:
Any adverse event: RR
1.72 (95% CI 1.29 to 2.28)
Nausea: RR 2.72 … acetaminophen
Opioids increased risk of:
Any adverse event: RR
1.43 (95% CI 0.87 to 2.37)
Nausea … Opioids were associated with
increased likelihood of any adverse event (34% vs. 9%, RR 3.62, 95% CI … Topical ibuprofen was
associated with decreased likelihood of any adverse event, although the estimate … Opioids were
associated with increased likelihood of any adverse event (11 trials, pooled RR 1.72, 95%
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/rfviia.pptx
May 01, 2010 - pageaction=displayproduct&productID=450
Mean Differences in Mortality and Thromboembolic Event Rates … Mean Differences in Mortality and Thromboembolic Event Rates by Study and rFVIIa Indication
This figure … The mean differences in event rates for the direct (patient-centered) outcomes of total mortality and … The figures show mean differences in mortality and thromboembolic event rates, respectively, for each … harms of rFVIIa, our findings include:
There was no effect of rFVIIa on mortality or thromboembolic event
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effectivehealthcare.ahrq.gov/sites/default/files/rfviia.pptx
May 01, 2010 - pageaction=displayproduct&productID=450
Mean Differences in Mortality and Thromboembolic Event Rates … Mean Differences in Mortality and Thromboembolic Event Rates by Study and rFVIIa Indication
This figure … The mean differences in event rates for the direct (patient-centered) outcomes of total mortality and … The figures show mean differences in mortality and thromboembolic event rates, respectively, for each … harms of rFVIIa, our findings include:
There was no effect of rFVIIa on mortality or thromboembolic event
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/gastric-cancer-key-questions.pdf
January 01, 2020 - Key Questions - Optimal Medical Treatments for Non-Metastatic Gastric Cancers
Optimal Medical Treatments for Non-Metastatic Gastric Cancers
Background
Gastric cancer is the fifth most common cancer worldwide, and most frequent cause of cancer death in
some countries (Sung et al., 2021). In the US, the rate of n…
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/treatment-resistant-depression_executive.pdf
September 01, 2011 - depression (TRD) with strength of evidence for Tier 1 (TRD) for KQ 4c,
withdrawals due to adverse event … Adverse event reporting is quite
limited and tends to cover only a short time span; what
reporting does
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effectivehealthcare.ahrq.gov/products/glucocorticoid-injections/clinician
June 29, 2016 - A Randomized Trial of Epidural Glucocorticoid Injections for Spinal Stenosis: A Brief Summary of Findings for Clinicians
Clinician Summary June 29, 2016 Download Main Document PDF 134.6 KB
Description of This Summary
This is a summary of an original research article published in The New England Jour…
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/binge-eating_clinician.pdf
May 01, 2016 - Management and Outcomes of Binge-Eating Disorder in Adults: Current State of the Evidence
Management and Outcomes of Binge-Eating Disorder
in Adults: Current State of the Evidence
Focus of This Summary
This is a summary of a systematic review evaluating the evidence regarding the effectiveness, comparative effectiv…
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/executive-summary-2017-schizophrenia-adult.pdf
January 01, 2017 - Although clozapine is often reserved for
treatment-resistant patients, due to the serious adverse
event … Given the variation in specific adverse event profiles
across the SGAs, withdrawals due to adverse events … All-cause mortality is a rare event, but it is still an
important outcome to evaluate as SGAs continue … SGA comparisons
Overall Adverse Events • Overall adverse event rates favored
SGAs when comparing haloperidol … with aripiprazole
• Overall adverse event rates favored SGAs when comparing
haloperidol with risperidone
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-surveillance-report-3.pdf
May 01, 2022 - • Other key adverse event outcomes (i.e., psychosis, cannabis use disorder, cognitive
deficits) … ) Insufficient (1)
Abbreviations: CBD = cannabidiol; CBDV = cannabidivarin; SAE = serious adverse event … ; SOE = strength of evidence; THC =
tetrahydrocannabinol; WAE = withdrawal due to adverse event. … ; SOE = strength of evidence; THC = tetrahydrocannabinol; WAE = withdrawal due to adverse event … ; SOE = strength of evidence; THC = tetrahydrocannabinol; WAE = withdrawal due to adverse event
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-surveillance-report-3_0.pdf
May 01, 2022 - • Other key adverse event outcomes (i.e., psychosis, cannabis use disorder, cognitive
deficits) … ) Insufficient (1)
Abbreviations: CBD = cannabidiol; CBDV = cannabidivarin; SAE = serious adverse event … ; SOE = strength of evidence; THC =
tetrahydrocannabinol; WAE = withdrawal due to adverse event. … ; SOE = strength of evidence; THC = tetrahydrocannabinol; WAE = withdrawal due to adverse event … ; SOE = strength of evidence; THC = tetrahydrocannabinol; WAE = withdrawal due to adverse event