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  1. effectivehealthcare.ahrq.gov/products/patient-safety-drug-data/abstract
    January 01, 2005 - Data Development for Patient Safety — A Pilot Study using Medicare Part B Drug Data Abstract January 1, 2005 Topic Abstract Medicare administrative claims data offer a valuable informational source for the surveillance of adverse drug events, but there are substantial challenges in exploiting these d…
  2. effectivehealthcare.ahrq.gov/sites/default/files/pdf/white-paper-library-asthma.pdf
    April 01, 2019 - Standardized Library of Asthma Outcome Measures Research White Paper Standardized Library of Asthma Outcome Measures Research White Paper Standardized Library of Asthma Outcome Measures Prepared for: Agency for Healthcare Research and Quality Center for Outcomes and Ev…
  3. effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/white-paper-library-asthma.pdf
    April 01, 2019 - Standardized Library of Asthma Outcome Measures Research White Paper Standardized Library of Asthma Outcome Measures Research White Paper Standardized Library of Asthma Outcome Measures Prepared for: Agency for Healthcare Research and Quality Center for Outcomes and Ev…
  4. effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0407_01-20-2011.pdf
    January 01, 2011 - Effective Health Care Topic Number: 0343 Document Completion Date: 3-23-11 1 Results of Topic Selection Process & Next Steps  Peripheral artery disease (PAD) will go forward for refinement as a systematic review. The scope of this topic, including populations, interventions, comparators, and out…
  5. effectivehealthcare.ahrq.gov/sites/default/files/related_files/juvenile-arthritis-dmards_disposition-comments.pdf
    September 01, 2011 - We have added the following sentence as a Key Point: “Adverse event rates may be underestimated by … In adverse event analysis, page 45, why weren't open label run-in phase data in the withdrawal studies … In the adverse event analysis, we only included data from the RCT phases of multiphase studies in order … Some examples of imbalances in adverse event rates that favor the safety of placebo over adalimumab … We have added the following sentence as a Key Point for KQ3: “Adverse event rates may be underestimated
  6. effectivehealthcare.ahrq.gov/sites/default/files/pdf/antipsychotic-medicine-cardiovascular-elderly_research.pdf
    February 01, 2009 - myocardial infarction 60 (0.66) 96 (0.70) 99 (1.08) 151 (1.10) 164 (1.79) 249 (1.81) Cerebrovascular event … Acute myocardial Infarction 0.93 (0.66, 1.32) 1.00 (0.76, 1.30) 1.03 (0.85, 1.27) Cerebrovascular event … Acute myocardial infarction 0.89 (0.59, 1.33) 1.02 (0.75, 1.40) 1.16 (0.91, 1.48) Cerebrovascular event
  7. effectivehealthcare.ahrq.gov/products/sodium-potassium/research-protocol
    March 01, 2017 - mortality Stroke, coronary heart disease, myocardial infarction Number of patients with any CVD event … a study reports more than one outcome in this category, we will abstract data for only one type of event … mortality Stroke Coronary heart disease Myocardial infarction Number of patients with any CVD event … mortality Stroke Coronary heart disease Myocardial infarction Number of patients with any CVD event … : e.g., mean/median 24-h urinary excretion, status Outcomes: type and definition (e.g., any CVD event
  8. effectivehealthcare.ahrq.gov/products/weight-loss-surgery/research
    June 05, 2013 - Current Page Topic Timeline Mar. 10, 2008 Topic Suggestion Dec. 14, 2010 Research Protocol Jun. 5, 2013 Systematic Review Sep. 12, 2013 Disposition of Comments Report Bariatric Surgery and Nonsurgical Therapy in Adults With Metabolic Conditions and a Body Mass Index of 30.0 to 34.9 kg/m² Systematic Review Archived…
  9. effectivehealthcare.ahrq.gov/products/angina-heart-attack-treatments/research
    November 04, 2013 - Current Page Topic Timeline Oct. 25, 2011 Topic Initiated Dec. 13, 2012 Research Protocol Nov. 4, 2013 Systematic Review Feb. 13, 2014 Disposition of Comments Report Antiplatelet and Anticoagulant Treatments for Unstable Angina/Non–ST Elevation Myocardial Infarction Systematic Review Archived November 4, 2013 Web …
  10. effectivehealthcare.ahrq.gov/products/rheumatoid-arthritis-medicine-update/final-report-update-2018
    July 16, 2018 - Current Page Topic Timeline Mar. 29, 2017 Topic Initiated May. 24, 2017 Research Protocol Jul. 16, 2018 Systematic Review Drug Therapy for Early Rheumatoid Arthritis: A Systematic Review Update Systematic Review July 16, 2018 Download Main Document PDF 23.9 MB Related Files Download Disposition of Com…
  11. effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/main-apps-surv-rept-1-acute-pain.pdf
    February 01, 2022 - NSAID Opioid increased risk of: Any adverse event: RR 1.72 (95% CI 1.29 to 2.28) Nausea: RR 2.72 … acetaminophen Opioids increased risk of: Any adverse event: RR 1.43 (95% CI 0.87 to 2.37) Nausea … Opioids were associated with increased likelihood of any adverse event (34% vs. 9%, RR 3.62, 95% CI … Topical ibuprofen was associated with decreased likelihood of any adverse event, although the estimate … Opioids were associated with increased likelihood of any adverse event (11 trials, pooled RR 1.72, 95%
  12. effectivehealthcare.ahrq.gov/sites/default/files/related_files/rfviia.pptx
    May 01, 2010 - pageaction=displayproduct&productID=450 Mean Differences in Mortality and Thromboembolic Event Rates … Mean Differences in Mortality and Thromboembolic Event Rates by Study and rFVIIa Indication This figure … The mean differences in event rates for the direct (patient-centered) outcomes of total mortality and … The figures show mean differences in mortality and thromboembolic event rates, respectively, for each … harms of rFVIIa, our findings include: There was no effect of rFVIIa on mortality or thromboembolic event
  13. effectivehealthcare.ahrq.gov/sites/default/files/rfviia.pptx
    May 01, 2010 - pageaction=displayproduct&productID=450 Mean Differences in Mortality and Thromboembolic Event Rates … Mean Differences in Mortality and Thromboembolic Event Rates by Study and rFVIIa Indication This figure … The mean differences in event rates for the direct (patient-centered) outcomes of total mortality and … The figures show mean differences in mortality and thromboembolic event rates, respectively, for each … harms of rFVIIa, our findings include: There was no effect of rFVIIa on mortality or thromboembolic event
  14. effectivehealthcare.ahrq.gov/sites/default/files/related_files/gastric-cancer-key-questions.pdf
    January 01, 2020 - Key Questions - Optimal Medical Treatments for Non-Metastatic Gastric Cancers Optimal Medical Treatments for Non-Metastatic Gastric Cancers Background Gastric cancer is the fifth most common cancer worldwide, and most frequent cause of cancer death in some countries (Sung et al., 2021). In the US, the rate of n…
  15. Layout 1 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/related_files/treatment-resistant-depression_executive.pdf
    September 01, 2011 - depression (TRD) with strength of evidence for Tier 1 (TRD) for KQ 4c, withdrawals due to adverse event … Adverse event reporting is quite limited and tends to cover only a short time span; what reporting does
  16. effectivehealthcare.ahrq.gov/products/glucocorticoid-injections/clinician
    June 29, 2016 - A Randomized Trial of Epidural Glucocorticoid Injections for Spinal Stenosis: A Brief Summary of Findings for Clinicians Clinician Summary June 29, 2016 Download Main Document PDF 134.6 KB Description of This Summary This is a summary of an original research article published in The New England Jour…
  17. effectivehealthcare.ahrq.gov/sites/default/files/pdf/binge-eating_clinician.pdf
    May 01, 2016 - Management and Outcomes of Binge-Eating Disorder in Adults: Current State of the Evidence Management and Outcomes of Binge-Eating Disorder in Adults: Current State of the Evidence Focus of This Summary This is a summary of a systematic review evaluating the evidence regarding the effectiveness, comparative effectiv…
  18. effectivehealthcare.ahrq.gov/sites/default/files/related_files/executive-summary-2017-schizophrenia-adult.pdf
    January 01, 2017 - Although clozapine is often reserved for treatment-resistant patients, due to the serious adverse event … Given the variation in specific adverse event profiles across the SGAs, withdrawals due to adverse events … All-cause mortality is a rare event, but it is still an important outcome to evaluate as SGAs continue … SGA comparisons Overall Adverse Events • Overall adverse event rates favored SGAs when comparing haloperidol … with aripiprazole • Overall adverse event rates favored SGAs when comparing haloperidol with risperidone
  19. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-surveillance-report-3.pdf
    May 01, 2022 - • Other key adverse event outcomes (i.e., psychosis, cannabis use disorder, cognitive deficits) … ) Insufficient (1) Abbreviations: CBD = cannabidiol; CBDV = cannabidivarin; SAE = serious adverse event … ; SOE = strength of evidence; THC = tetrahydrocannabinol; WAE = withdrawal due to adverse event. … ; SOE = strength of evidence; THC = tetrahydrocannabinol; WAE = withdrawal due to adverse event … ; SOE = strength of evidence; THC = tetrahydrocannabinol; WAE = withdrawal due to adverse event
  20. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-surveillance-report-3_0.pdf
    May 01, 2022 - • Other key adverse event outcomes (i.e., psychosis, cannabis use disorder, cognitive deficits) … ) Insufficient (1) Abbreviations: CBD = cannabidiol; CBDV = cannabidivarin; SAE = serious adverse event … ; SOE = strength of evidence; THC = tetrahydrocannabinol; WAE = withdrawal due to adverse event. … ; SOE = strength of evidence; THC = tetrahydrocannabinol; WAE = withdrawal due to adverse event … ; SOE = strength of evidence; THC = tetrahydrocannabinol; WAE = withdrawal due to adverse event

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