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effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND-0765-150129.pdf
November 03, 2014 - children aged 2-4 years have hearing
loss due to middle ear effusion.2
§ The most common adverse event
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/antidepressants-update_executive.pdf
December 01, 2011 - On
average, 63 percent of patients in efficacy trials
experienced at least one adverse event. … Comparative Harms and Adherence of
Immediate- Versus Extended-Release
Formulations (KQ 4b)
Overall, adverse-event … Likewise, adverse-event rates were similar between
paroxetine IR and paroxetine CR, as well as venlafaxine
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/osteoarthritis-pain-2006_executive.pdf
January 01, 2006 - similar average blood pressure changes may not
necessarily correspond with similar likelihoods of
an event … generally
consistent with our conclusions:
• A fair-quality meta-analysis of arrhythmia and
renal event
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/rapid-response-cardio-dental.pdf
July 01, 2023 - evidence supporting the efficacy of
specific types of dental care that are intended to reduce adverse event … In
the rare event of a device infection due to an oral pathogen,
it is most likely to have arisen from … a bacteremia from a
common daily event such as toothbrushing or chewing food. … suggests that antibiotic
prophylaxis for dental procedures
is of little or no value in the rare
event … due
to an oral pathogen, it is most
likely to have arisen from a
bacteremia from a common daily
event
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/mhs-IV-patient-family-engagement.pdf
July 01, 2023 - EHC Protocol: Addressing Social Isolation To Improve Health of Older Adults: A Rapid Evidence Review
Evidence-based Practice Center Rapid Response Protocol
Project Title: Making Healthcare Safer IV: Patient and Family
Engagement
Review Questions
1. What is the frequency and severity of harms addre…
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/juvenile-arthritis-dmards_executive.pdf
September 01, 2011 - Recently published
studies of adverse event reporting databases provide
indirect evidence that suggests … A review of other
study designs revealed marked differences in the rate
and type of adverse event by
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/type-2-diabetes-medications-update_executive.pdf
March 01, 2011 - or
thiazolidinediones.
7
Outcomes of Interest
Overall, few studies contained sufficient data on event … We recommend improvements in adverse event
and long-term outcome reporting, with predefined
outcomes … (continued)
Gastrointestinal Moderate Metformin was associated with twice as many GI adverse event rates
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/type-2-diabetes-medications-2007_executive.pdf
January 01, 2007 - Only one study reported an adverse event of
thrombocytopenia and leucopenia, making comparisons
between … cholecystitis compared with placebo in a pooled analysis.
data
NA FDA data were consistent with the adverse event
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/plant-based-chronic-pain-review-jan-2020.pdf
January 01, 2020 - Two reported that a higher proportion of
patients in the cannabis groups experienced any adverse event … The long-term cohort study
found the incidence of any adverse event and of SAEs was similar between … While effects on pulmonary function are not a specified
adverse event for this review, the study also … reported, but more
patients in the dronabinol group than the placebo group experienced an adverse event … The proportion of patients reporting any adverse event was 35 percent with nabilone and 47
percent with
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effectivehealthcare.ahrq.gov/products/vaccine-safety/research
July 01, 2014 - Current Page Topic Timeline Aug. 31, 2012 Topic Initiated Oct. 22, 2012 Research Protocol Jul. 1, 2014 Systematic Review Oct. 8, 2014 Disposition of Comments Report Safety of Vaccines Used for Routine Immunization in the United States
Systematic Review Archived July 1, 2014 Web Version [NLM Site] Download Main Doc…
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/sleep-apnea_executive.pdf
July 01, 2011 - No adverse event with potentially long-
term consequences was reported.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/recombinant-factor-viia_executive.pdf
May 01, 2010 - evaluate evidence of harm from rFVIIa in
noncomparative studies, we described the unadjusted
summary event … rates for mortality and thromboembolic
events from the noncomparative studies, as well as
event rates … Thromboembolic event risk differences
(rFVIIa minus usual care)
• There was no effect of rFVIIa on mortality … • rFVIIa use was associated with a higher
thromboembolic event rate (risk difference 0.053;
95 percent … and thromboembolic events could not be
evaluated due to limited reported events (one
thromboembolic event
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/main-apps-surv-rept-1-acute-pain.pdf
May 01, 2022 - NSAID
Opioid increased risk of:
Any adverse event: RR
1.72 (95% CI 1.29 to 2.28)
Nausea: RR 2.72 … acetaminophen
Opioids increased risk of:
Any adverse event: RR
1.43 (95% CI 0.87 to 2.37)
Nausea … Opioids were associated with
increased likelihood of any adverse event (34% vs. 9%, RR 3.62, 95% CI … Topical ibuprofen was
associated with decreased likelihood of any adverse event, although the estimate … Opioids were
associated with increased likelihood of any adverse event (11 trials, pooled RR 1.72, 95%
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/rheumatoid-arthritis-2007_executive.pdf
January 01, 2007 - Layout 1
Background
Rheumatoid and psoriatic arthritis are
among the most disabling forms of
arthritis. Rheumatoid arthritis (RA), which
affects 1 percent of the U.S. adult
population (or upwards of 2 million
individuals), is an autoimmune disease that
involves inflammation of the synovium (a
thin layer of tissue lin…
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effectivehealthcare.ahrq.gov/products/medicine-safety-call-center/research
December 02, 2009 - Community Pharmacy/Call Center Assessment of Medication Effectiveness & Safety
Research Report December 2, 2009 Download Main Document PDF 442.6 KB
This report is available in PDF (443 kB) only. People using assistive technology may not be able to fully access information in this file. For assistance,…
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/juvenile-arthritis-dmards_disposition-comments.pdf
September 01, 2011 - We have added the following
sentence as a Key Point: “Adverse event
rates may be underestimated by … In adverse event
analysis, page 45, why weren't open label run-in phase data in the
withdrawal studies … In the adverse event analysis,
we only included data from the RCT phases
of multiphase studies in order … Some examples of
imbalances in adverse event rates that favor the safety of placebo
over adalimumab … We have added the following
sentence as a Key Point for KQ3: “Adverse
event rates may be underestimated
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/breast-biopsy-update_executive.pdf
September 01, 2014 - experiencing each of the
aforementioned outcomes was less than 1.5 percent; in 75
percent of studies the event … Selective outcome and analysis reporting likely
– Few studies reported bleeding requiring treatment; the event … Selective outcome and analysis reporting likely
– Few studies reported bleeding requiring treatment; the event … consistency
– Individual studies did not provide adequate information for precise
estimation of the event … Random effects meta-analysis
of event outcome in the framework of the generalized linear mixed
model
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effectivehealthcare.ahrq.gov/products/sodium-potassium/research-protocol
March 01, 2017 - mortality
Stroke, coronary heart disease, myocardial infarction
Number of patients with any CVD event … a study reports more than one outcome in this category, we will abstract data for only one type of event … mortality
Stroke
Coronary heart disease
Myocardial infarction
Number of patients with any CVD event … mortality
Stroke
Coronary heart disease
Myocardial infarction
Number of patients with any CVD event … : e.g., mean/median 24-h urinary excretion, status
Outcomes: type and definition (e.g., any CVD event
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effectivehealthcare.ahrq.gov/products/ptsd-adult-treatment-update/research-2018
May 17, 2018 - Current Page Topic Timeline Mar. 29, 2017 Topic Initiated May. 24, 2017 Research Protocol May. 17, 2018 Systematic Review Psychological and Pharmacological Treatments for Adults With Posttraumatic Stress Disorder: A Systematic Review Update
Systematic Review May 17, 2018 Download Main Document PDF 6.7 MB
…
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effectivehealthcare.ahrq.gov/products/patient-safety-databases-prescriptions/research
August 26, 2008 - An adverse event is any injury caused by medical care or treatment. … An adverse drug event (ADE) is an injury involving medication use. … For example, to quantify the risk of an adverse event occurring at the rate of 2 per 10,000 per year … Because some subjects will not have the experienced the event before the end of the followup, they are … If we focus on more granular outcomes by examining specific drugs and/or specific adverse event codes