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  1. effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND-0765-150129.pdf
    November 03, 2014 - children aged 2-4 years have hearing loss due to middle ear effusion.2 § The most common adverse event
  2. Layout 1 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/related_files/antidepressants-update_executive.pdf
    December 01, 2011 - On average, 63 percent of patients in efficacy trials experienced at least one adverse event. … Comparative Harms and Adherence of Immediate- Versus Extended-Release Formulations (KQ 4b) Overall, adverse-event … Likewise, adverse-event rates were similar between paroxetine IR and paroxetine CR, as well as venlafaxine
  3. Layout 1 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/related_files/osteoarthritis-pain-2006_executive.pdf
    January 01, 2006 - similar average blood pressure changes may not necessarily correspond with similar likelihoods of an event … generally consistent with our conclusions: • A fair-quality meta-analysis of arrhythmia and renal event
  4. effectivehealthcare.ahrq.gov/sites/default/files/related_files/rapid-response-cardio-dental.pdf
    July 01, 2023 - evidence supporting the efficacy of specific types of dental care that are intended to reduce adverse event … In the rare event of a device infection due to an oral pathogen, it is most likely to have arisen from … a bacteremia from a common daily event such as toothbrushing or chewing food. … suggests that antibiotic prophylaxis for dental procedures is of little or no value in the rare event … due to an oral pathogen, it is most likely to have arisen from a bacteremia from a common daily event
  5. effectivehealthcare.ahrq.gov/sites/default/files/related_files/mhs-IV-patient-family-engagement.pdf
    July 01, 2023 - EHC Protocol: Addressing Social Isolation To Improve Health of Older Adults: A Rapid Evidence Review Evidence-based Practice Center Rapid Response Protocol Project Title: Making Healthcare Safer IV: Patient and Family Engagement Review Questions 1. What is the frequency and severity of harms addre…
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    effectivehealthcare.ahrq.gov/sites/default/files/related_files/juvenile-arthritis-dmards_executive.pdf
    September 01, 2011 - Recently published studies of adverse event reporting databases provide indirect evidence that suggests … A review of other study designs revealed marked differences in the rate and type of adverse event by
  7. Layout 1 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/related_files/type-2-diabetes-medications-update_executive.pdf
    March 01, 2011 - or thiazolidinediones. 7 Outcomes of Interest Overall, few studies contained sufficient data on event … We recommend improvements in adverse event and long-term outcome reporting, with predefined outcomes … (continued) Gastrointestinal Moderate Metformin was associated with twice as many GI adverse event rates
  8. Layout 1 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/related_files/type-2-diabetes-medications-2007_executive.pdf
    January 01, 2007 - Only one study reported an adverse event of thrombocytopenia and leucopenia, making comparisons between … cholecystitis compared with placebo in a pooled analysis. data NA FDA data were consistent with the adverse event
  9. effectivehealthcare.ahrq.gov/sites/default/files/related_files/plant-based-chronic-pain-review-jan-2020.pdf
    January 01, 2020 - Two reported that a higher proportion of patients in the cannabis groups experienced any adverse event … The long-term cohort study found the incidence of any adverse event and of SAEs was similar between … While effects on pulmonary function are not a specified adverse event for this review, the study also … reported, but more patients in the dronabinol group than the placebo group experienced an adverse event … The proportion of patients reporting any adverse event was 35 percent with nabilone and 47 percent with
  10. effectivehealthcare.ahrq.gov/products/vaccine-safety/research
    July 01, 2014 - Current Page Topic Timeline Aug. 31, 2012 Topic Initiated Oct. 22, 2012 Research Protocol Jul. 1, 2014 Systematic Review Oct. 8, 2014 Disposition of Comments Report Safety of Vaccines Used for Routine Immunization in the United States Systematic Review Archived July 1, 2014 Web Version [NLM Site] Download Main Doc…
  11. Layout 1 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/related_files/sleep-apnea_executive.pdf
    July 01, 2011 - No adverse event with potentially long- term consequences was reported.
  12. Layout 1 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/related_files/recombinant-factor-viia_executive.pdf
    May 01, 2010 - evaluate evidence of harm from rFVIIa in noncomparative studies, we described the unadjusted summary event … rates for mortality and thromboembolic events from the noncomparative studies, as well as event rates … Thromboembolic event risk differences (rFVIIa minus usual care) • There was no effect of rFVIIa on mortality … • rFVIIa use was associated with a higher thromboembolic event rate (risk difference 0.053; 95 percent … and thromboembolic events could not be evaluated due to limited reported events (one thromboembolic event
  13. effectivehealthcare.ahrq.gov/sites/default/files/related_files/main-apps-surv-rept-1-acute-pain.pdf
    May 01, 2022 - NSAID Opioid increased risk of: Any adverse event: RR 1.72 (95% CI 1.29 to 2.28) Nausea: RR 2.72 … acetaminophen Opioids increased risk of: Any adverse event: RR 1.43 (95% CI 0.87 to 2.37) Nausea … Opioids were associated with increased likelihood of any adverse event (34% vs. 9%, RR 3.62, 95% CI … Topical ibuprofen was associated with decreased likelihood of any adverse event, although the estimate … Opioids were associated with increased likelihood of any adverse event (11 trials, pooled RR 1.72, 95%
  14. Layout 1 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/related_files/rheumatoid-arthritis-2007_executive.pdf
    January 01, 2007 - Layout 1 Background Rheumatoid and psoriatic arthritis are among the most disabling forms of arthritis. Rheumatoid arthritis (RA), which affects 1 percent of the U.S. adult population (or upwards of 2 million individuals), is an autoimmune disease that involves inflammation of the synovium (a thin layer of tissue lin…
  15. effectivehealthcare.ahrq.gov/products/medicine-safety-call-center/research
    December 02, 2009 - Community Pharmacy/Call Center Assessment of Medication Effectiveness & Safety Research Report December 2, 2009 Download Main Document PDF 442.6 KB This report is available in PDF (443 kB) only. People using assistive technology may not be able to fully access information in this file. For assistance,…
  16. effectivehealthcare.ahrq.gov/sites/default/files/related_files/juvenile-arthritis-dmards_disposition-comments.pdf
    September 01, 2011 - We have added the following sentence as a Key Point: “Adverse event rates may be underestimated by … In adverse event analysis, page 45, why weren't open label run-in phase data in the withdrawal studies … In the adverse event analysis, we only included data from the RCT phases of multiphase studies in order … Some examples of imbalances in adverse event rates that favor the safety of placebo over adalimumab … We have added the following sentence as a Key Point for KQ3: “Adverse event rates may be underestimated
  17. effectivehealthcare.ahrq.gov/sites/default/files/related_files/breast-biopsy-update_executive.pdf
    September 01, 2014 - experiencing each of the aforementioned outcomes was less than 1.5 percent; in 75 percent of studies the event … Selective outcome and analysis reporting likely – Few studies reported bleeding requiring treatment; the event … Selective outcome and analysis reporting likely – Few studies reported bleeding requiring treatment; the event … consistency – Individual studies did not provide adequate information for precise estimation of the event … Random effects meta-analysis of event outcome in the framework of the generalized linear mixed model
  18. effectivehealthcare.ahrq.gov/products/sodium-potassium/research-protocol
    March 01, 2017 - mortality Stroke, coronary heart disease, myocardial infarction Number of patients with any CVD event … a study reports more than one outcome in this category, we will abstract data for only one type of event … mortality Stroke Coronary heart disease Myocardial infarction Number of patients with any CVD event … mortality Stroke Coronary heart disease Myocardial infarction Number of patients with any CVD event … : e.g., mean/median 24-h urinary excretion, status Outcomes: type and definition (e.g., any CVD event
  19. effectivehealthcare.ahrq.gov/products/ptsd-adult-treatment-update/research-2018
    May 17, 2018 - Current Page Topic Timeline Mar. 29, 2017 Topic Initiated May. 24, 2017 Research Protocol May. 17, 2018 Systematic Review Psychological and Pharmacological Treatments for Adults With Posttraumatic Stress Disorder: A Systematic Review Update Systematic Review May 17, 2018 Download Main Document PDF 6.7 MB …
  20. effectivehealthcare.ahrq.gov/products/patient-safety-databases-prescriptions/research
    August 26, 2008 - An adverse event is any injury caused by medical care or treatment. … An adverse drug event (ADE) is an injury involving medication use. … For example, to quantify the risk of an adverse event occurring at the rate of 2 per 10,000 per year … Because some subjects will not have the experienced the event before the end of the followup, they are … If we focus on more granular outcomes by examining specific drugs and/or specific adverse event codes

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