-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/ace-inhibitor-arb-future_research.pdf
March 01, 2012 - renal insufficiency or development of dialysis
dependence.
3
Impact of changing trends in outcome event … This may reflect low event rates among
otherwise healthy patients and relatively few studies with extended … Although several studies collected data on angioedema, the event
rates were very low or zero for all … In the four
studies that did report episodes of angioedema, this adverse event
was observed only in … Impact of changing trends in outcome event rates over time on the
comparative effectiveness of ACEI,
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/psoriasis-chronic_executive.pdf
November 01, 2012 - Questionnaire Disability Index; HRQoL = health-related quality of life; MACE = major adverse cardiovascular event … , differential loss to followup, overall
loss to followup, use of intention to treat, blinding of
event … confounding, baseline
differences, method to ascertain exposure, methods
to ascertain outcomes, blinding of event … Index
HRQoL health-related quality of life
IL Interleukin
MACE major adverse cardiovascular event
-
effectivehealthcare.ahrq.gov/products/juvenile-arthritis-dmards/research
September 26, 2011 - Current Page Topic Timeline Jan. 14, 2008 Topic Suggestion Mar. 9, 2010 Research Protocol Sep. 26, 2011 Systematic Review Jan. 4, 2012 Disposition of Comments Report Jul. 3, 2013 Surveillance Report Disease-Modifying Antirheumatic Drugs (DMARDs) in Children With Juvenile Idiopathic Arthritis (JIA)
Systematic Review…
-
effectivehealthcare.ahrq.gov/products/juvenile-arthritis-dmards/research-protocol
March 09, 2010 - We will review the quarterly data files from the United States Food and Drug Administration Adverse Event … TEP
Technical Expert Panel
TNF
Tumor Necrosis Factor
Summary of Protocol Amendments
In the event
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/renal-update_research-protocol.pdf
January 15, 2015 - lipid-lowering drugs)
• Surgical repair
Outcomes
• Mortality, all cause
• Kidney function
o Event … therapy)
o Categorical (eg, better/worse)
o Continuous (ie, GFR, CrCl, SCr)
• Blood pressure
o Event
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/atrial-fibrillation-ablation_surveillance.pdf
May 16, 2013 - There were 84
studies that reported at least one adverse event
associated with RFA. … percent to 5 percent (median
1 percent) of patients in the 70 studies that reported
this adverse event … Atrioesophageal fistula was reported in 26 studies:
5 studies reported 1 case each, with event rates … embolism n=1 (0.17%)
15.2% vs. 2.4%, p<0.001 [KMA]
(CHADS2 score > 2 as a predictor of adverse event … pulmonary vein ablation; CPVA-CM= circumferential pulmonary vein ablation circular mapping; AE=adverse event
-
effectivehealthcare.ahrq.gov/products/type-2-diabetes-medications-update/research-protocol
April 05, 2010 - Current Page Topic Timeline Feb. 1, 2010 Topic Initiated Apr. 5, 2010 Research Protocol Mar. 15, 2011 Systematic Review May. 27, 2014 Surveillance Report Comparative Effectiveness and Safety of Oral Diabetes Medications for Adults With Type 2 Diabetes: An Update of the 2007 Report
Research Protocol Archived April …
-
effectivehealthcare.ahrq.gov/products/procalcitonin/research-protocol
April 26, 2011 - Current Page Topic Timeline Jun. 17, 2009 Topic Suggestion Apr. 26, 2011 Research Protocol Oct. 5, 2012 Systematic Review Dec. 10, 2012 Disposition of Comments Report Procalcitonin for Diagnosis and Management of Sepsis
Research Protocol Archived April 26, 2011 Download Main Document PDF 313.1 KB
On …
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/thromboembolism-update_research-protocol.pdf
February 17, 2016 - Untitled
Source: www.effectivehealthcare.ahrq.gov
Published online: February 17, 2016
Evidence-based Practice Center Systematic Review Protocol
Project Title: Systematic Review Update of
Venous Thromboembolism Prophylaxis in Orthopedic Surgery
I. Background and Objectives for the Systematic Review
Ma…
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/type-2-diabetes-insulin_executive.pdf
September 01, 2008 - Layout 1
Background and Key
Questions
Although oral antidiabetic agents are used
as first-line agents in patients with type 2
diabetes, insulin is required in a significant
number of patients at some stage during
the management of diabetes to maintain
optimal glycemic control. Insulin use has
been suggested as a fir…
-
effectivehealthcare.ahrq.gov/products/stroke-afib-update/research-protocol
July 07, 2017 - , dementia)
When in therapeutic range
When non-adherent to medication
Previous thromboembolic event … patient characteristics; clinical settings; diagnostic tools; and intermediate, final, and adverse event … Example factors include narrow eligibility criteria and exclusion of those with comorbidities, event … Atrial fibrillation in patients with first-ever stroke: frequency, antithrombotic treatment before the event
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/cancer-anemia-update_research-protocol.pdf
June 16, 2010 - Time to event data, e.g., overall survival, will be calculated as hazard
ratios (HR) based on individual … OR “adverse effect*” OR “adverse drug reaction*” OR “side effect*” OR “toxic
effect*” OR “adverse event
-
effectivehealthcare.ahrq.gov/sites/default/files/assessing-the-risk-of-bias_draft-report.pdf
June 02, 2011 - Since many harms are not anticipated (the severity, the type of event -especially rare events,
the … timing of the event, etc.), many studies do not specify exact protocols to actively capture
events. … There is also the issue of establishing an association between the event and the
intervention. … Is there a plausible biological mechanism linking the intervention to the adverse event? … Did the author(s) specify the NUMBER for each TYPE of harmful event for each study group?
15.
-
effectivehealthcare.ahrq.gov/products/procalcitonin/research
October 05, 2012 - Current Page Topic Timeline Jun. 17, 2009 Topic Suggestion Apr. 26, 2011 Research Protocol Oct. 5, 2012 Systematic Review Dec. 10, 2012 Disposition of Comments Report Procalcitonin-Guided Antibiotic Therapy
Systematic Review Archived October 5, 2012 Web Version [NLM Site] Download Main Document PDF 2.1 MB
…
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/nephropathy-contrast-induced_clinician.pdf
August 01, 2016 - Contrast-Induced Nephropathy (CIN): Current State of the Evidence on Contrast Media and Prevention of CIN
Focus of This Summary
This is a summary of two systematic reviews. One review evaluated the evidence regarding the comparative effects of
different contrast media in patients requiring diagnostic imaging studies…
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/head-neck-cancer_executive.pdf
May 01, 2010 - Layout 1
Background
Head and neck cancers, specifically those
arising in the oral cavity, larynx,
hypopharynx, oropharynx, nasopharynx,
paranasal sinuses/nasal cavity, salivary
glands, and occult primaries, account for
approximately 3 to 5 percent of cancers in
the United States. According to the
National Comprehens…
-
effectivehealthcare.ahrq.gov/products/osteoarthritis-pain/research-protocol
August 05, 2010 - NSAIDs—nonaspirin, nonselective NSAIDs, or simply nonselective NSAIDs
Summary of Protocol Amendments
In the event
-
effectivehealthcare.ahrq.gov/products/weight-loss-surgery/research-protocol
December 14, 2010 - In the event that data are lacking, an assessment should be made to determine which key variables influence … Summary of Protocol Amendments
In the event of protocol amendments, the date of each amendment will
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/inguinal-hernia_executive.pdf
August 01, 2012 - 1
Comparative Effectiveness Review
Number 70
Surgical Options for Inguinal Hernia:
Comparative Effectiveness Review
Executive Summary
Background
An inguinal hernia is a protrusion of
abdominal contents into the inguinal
canal through an abdominal wall defect.
The lifetime rate of inguinal hernia is
25 perc…
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-performance_methods.pdf
July 01, 2012 - information on the presence or absense of the
condition of interest, or predict the occurrence of a future event