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  1. effectivehealthcare.ahrq.gov/sites/default/files/pdf/high-cholestorol-medicines-update_research-protocol.pdf
    December 31, 2013 - adherence as defined by the study investigator  SAEs as defined by the study investigator (e.g., an event … hospitalization, disability, or a birth defect)  Participants experiencing at least one adverse event … ; withdrawal due to an adverse event; cancer; serum AST and/or serum ALT elevated ≥ 3 times the ULN … For sparse-data meta-analysis, we will employ the Peto odds ratio method when event rates are less than … When between-event rates are between 5 to 10 percent, substantial differences between the N of two arms
  2. effectivehealthcare.ahrq.gov/sites/default/files/related_files/plant-based-chronic-pain-appendix-f1-f4-jan-2020.xlsx
    January 01, 2020 - Adverse Event Intervention B, N of Any Adverse Event (numerator) Intervention B, N Analyzed for Any … Event (numerator) Intervention A, N Analyzed for Serious Adverse Event (denominator) Intervention A, … % with Serious Adverse Event Intervention B, N of Serious Adverse Event (numerator) Intervention B, … to Adverse Event (denominator) Intervention A, % with Withdrawals due to Adverse Event Intervention B … Adverse Event (denominator) Intervention B, % with Withdrawals due to Adverse Event Intervention A,
  3. S5 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/s5.pdf
    October 01, 2007 - such adverse events.13 The National Electronic Injury Surveillance System-Cooperative Adverse Drug Event … severity and impact; controlling confounding by factors that influ- ence the occurrence of the adverse event … Evaluation and overview of the National Electronic Injury Surveillance System-Cooperative Ad- verse Drug Event … A simulation-based evaluation of methods to estimate the impact of an adverse event on hospital length
  4. effectivehealthcare.ahrq.gov/sites/default/files/related_files/arthritis-psoriatric_surveillance.pdf
    March 01, 2013 - Overall adverse event profiles appeared to be similar for biologic DMARDs and placebo. … point, all patients had received golimumab for at least 28 weeks. 78.2% had at least one adverse event … Legend: ACR: American College of Rheumatology; AE(s): Adverse Event(s); CER: Comparative Effectiveness … Legend: ACR: American College of Rheumatology; AE(s): Adverse Event(s); CER: Comparative Effectiveness … Overall adverse event profiles appeared to be similar for biologic DMARDs and placebo.
  5. effectivehealthcare.ahrq.gov/products/stroke-atrial-fibrillation/research-protocol
    January 30, 2012 - inhibitors, and considerations for restarting anticoagulation therapy in patients after a hemorrhagic event … therapy or performing a procedural intervention as a stroke prevention strategy following a hemorrhagic event … heart failure, coronary artery disease, and high cholesterol); patients with prior stroke (by type of event … heart failure, coronary artery disease, and high cholesterol) Patients with prior stroke (by type of event … bridging strategies KQ 6: Other strategies for resuming anticoagulation therapy after a hemorrhagic event
  6. effectivehealthcare.ahrq.gov/sites/default/files/related_files/blood-clots-hip-knee-surgery_surveillance.pdf
    December 01, 2012 - /total # (%)]: 43/792 (5.4%) versus 35/785 (4.5%) Symptomatic VTE [# of pts with event/total # … ]: 0/1,001 (0.0%) versus 4/992 (0.4%); 0.06 Symptomatic non-fatal PE[# of pts with event/total … Death [# of pts with event/total # (%); p- value]: 0/1,001 (0.0%) versus 1/992 (0.1%); p=0.50 … ]: 2/942 (0.2%) versus 4/951 (0.4%); p= 0.69 Symptomatic VTE[# of pts with event/total # (%)]: … 2/942 (0.2%) versus 2/951 (0.2%) Death [# of pts with event/total # (%)]: 0/942 (0.0%) versus
  7. effectivehealthcare.ahrq.gov/sites/default/files/pdf/antidepressants-seniors-pneumonia_research.pdf
    May 01, 2008 - The index date for cases was the date of the case event. … For persons with more than one case event, we included only the first event. … defined above), who had not yet experienced the relevant study outcome before the corresponding case’s event … This is analogous to time-to-event analyses of cohort studies, and ensures the interpretability of the … An analysis of administrative data found that proximate clinical event ratios provided a systematic
  8. effectivehealthcare.ahrq.gov/sites/default/files/toc.pdf
    January 01, 2007 - Evaluation and Overview of the National Electronic Injury Surveillance System- Cooperative Adverse Drug Event … A Simulation-Based Evaluation of Methods to Estimate the Impact of an Adverse Event on Hospital Length
  9. effectivehealthcare.ahrq.gov/sites/default/files/pdf/stroke-afib-update_research-protocol-amended.pdf
    October 27, 2017 - Age • Sex • Race/ethnicity • Presence of heart disease • Type of AF • Previous thromboembolic event … dementia) o When in therapeutic range o When non-adherent to medication o Previous thromboembolic event … patient characteristics; clinical settings; diagnostic tools; and intermediate, final, and adverse event … Example factors include narrow eligibility criteria and exclusion of those with comorbidities, event … outcome*[tiab])) OR (unwanted[tiab] AND (interaction*[tiab] or response*[tiab] or effect*[tiab] or event
  10. effectivehealthcare.ahrq.gov/products/transparency-neuropathy/research
    July 28, 2017 - differed in the number enrolled (8 studies, 32%), the primary outcome (14 studies, 56%), and adverse event
  11. effectivehealthcare.ahrq.gov/sites/default/files/pdf/depression-childhood-protocol.pdf
    August 06, 2018 - characteristics, history of previous treatment, comorbid conditions, exposure to a traumatic life event … AE = adverse event; BDI = Beck Depression Inventory; CAS: The Child Assessment Schedule; CBT = cognitive … of the sample (adolescent vs. younger children), comorbid conditions, exposure to a traumatic life event … ] OR mortality[SH] OR poisoning[SH] OR toxicity[SH] OR adverse effect*[Title/Abstract] OR adverse event … OR MW “drug effects” OR MW mortality OR MW poisoning OR MW toxicity OR adverse effect* OR adverse event
  12. effectivehealthcare.ahrq.gov/sites/default/files/selecting-evidence-quiz.ppt
    September 02, 2013 - for testing hypotheses of whether one intervention is associated with a greater risk for an adverse event … suited for testing hypotheses that one intervention is associated with a greater risk for an adverse event
  13. effectivehealthcare.ahrq.gov/sites/default/files/related_files/selecting-evidence-quiz.ppt
    September 02, 2013 - for testing hypotheses of whether one intervention is associated with a greater risk for an adverse event … suited for testing hypotheses that one intervention is associated with a greater risk for an adverse event
  14. effectivehealthcare.ahrq.gov/sites/default/files/considerations-for-statistical-chapter-10.pptx
    January 01, 2013 - (mixed) linear regression, GLMM, GEE Repeated measures ANOVA (MANOVA), GLMM, GEE GLMM, GEE Time to event … Cox proportional hazards regression Variance-adjusted Cox model or shared frailty model     Time to event … Time-to-event data with variable followup and censoring of study outcomes are commonly investigated in … For time-to-event study outcomes, time-dependent Cox regression models can be used to account for time-varying … Dependent variables or outcomes (continuous or categorical, single or repeated measure, and time to event
  15. effectivehealthcare.ahrq.gov/products/adhd-medicines-risks/abstract
    January 01, 2005 - Food and Drug Administration review of its Adverse Event Reporting System (AERS) for cases of sudden
  16. S81 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/s81.pdf
    October 01, 2007 - Poisoning and adverse event codes designed for the targeted ADEs had low sensitivities and, when forced … These fields included adverse event codes. … In contrast to current AHRQ PSIs, none of the models included aggregate variables limited to adverse event … the HOCTA models, questions remain about responsiveness of PSIs to changes in rates of the targeted event … Adverse drug event trigger tool: a practical methodology for measuring medication related harm.
  17. effectivehealthcare.ahrq.gov/sites/default/files/related_files/angina-heart-attack-treatments_executive.pdf
    January 01, 2014 - • Prasugrel showed a reduction in the event rate of the above composite outcome at 30 days (moderate … Low (1 RCT; 18,624 patients) Compared with clopidogrel (7.7%), ticagrelor (7.9%) had similar event … UFH: SOE = Low (2 observational studies; 29,017 patients) Lower event rates with enoxaparin … There was low SOE that use of PPIs was associated with higher event rates for the following outcomes … rates of cardiovascular mortality usually dominate the event rates for total mortality.
  18. effectivehealthcare.ahrq.gov/products/renal-disease-therapies/abstract
    March 31, 2011 - primarily mediated by changes in blood pressure, but differs by underlying comorbidity and type of CVD event
  19. effectivehealthcare.ahrq.gov/sites/default/files/web-based_willis_respondent.pdf
    January 01, 2009 - Setting  realistic  expectations  and  communicating  prior  to  a  significant  event
  20. effectivehealthcare.ahrq.gov/products/nsaids-safety-data-mining/research
    December 02, 2009 - Introduction Bayesian data mining methods have been used to evaluate drug safety signals from adverse event

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