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  1. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/TND_0316_03-12-2009.pdf
    January 01, 2009 - Effective Health Care Topic Number(s): 0128 Document Completion Date: 6-12-09 1 Results of Topic Selection Process & Next Steps  Self-measured blood pressure monitoring will go forward for refinement as a systematic review. The scope of this topic, including populations, interventions, comparato…
  2. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/TND-0648-140819.pdf
    June 24, 2014 - Topic 0549 Diagnosis and Management of Gout NSD _SJ Clean Diagnosis and Management of Gout Nomination Summary Document Results of Topic Selection …
  3. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/transparency-neuropathy_research-protocol.pdf
    September 01, 2016 - • Adverse event and deaths.
  4. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/depression-pregnancy-postpartum_research-protocol.pdf
    March 29, 2013 - weight gain, metabolic syndrome, gastrointestinal symptoms, and loss of libido) • Overall adverse-event … there was important differential loss to followup or overall high loss to followup; the adequacy of event … Summary of Protocol Amendments In the event of protocol amendments, the date of each amendment will
  5. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/colorectal-surgery-preparation_executive.pdf
    April 01, 2014 - In most studies adverse event definitions were not clearly described, making it impossible to consistently … limited in the following ways: • Most studies enrolled small numbers of patients and reported low event
  6. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/weight-loss-surgery_executive.pdf
    June 01, 2013 - There were only 20 instances in which 100 or more patients contributed data to a particular adverse event … Additionally, in 76 percent of instances, only a single study contributed data to a particular adverse event
  7. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/colorectal-surgery-preparation_disposition-comments.pdf
    April 30, 2014 - to sample size requirements for superiority and non- inferiority designs, over plausible baseline event … in the Discussion section can give some perspective on what is an “adequate” sample size for the event … Given the small event rates, the absolute diffs may be pretty tiny. … We have also provided power calculations that make direct use of the event rate information to estimate … to derive absolute risk differences requires the specification of the baseline odds (and baseline event
  8. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/renal-artery-stenosis_overview.pdf
    June 24, 2014 - CER 5 Renal Artery Stenosis NSD SJ Clean Renal Artery Stenosis Nomination Summary Document Results of Topic Selection Process & Next Steps § The topic, Renal Artery Stenosis,…
  9. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/plasma-cell-dyscrasias-sflc-assay_executive.pdf
    August 01, 2012 - The overall and event-free survival rates were significantly lower among patients with higher (> 75 … mg/dL) versus those with lower (≤ 75 mg/dL) SFLC concentrations (overall survival: p=0.016, event-free … Overall and event-free survival did not differ between patients with and those without a normal SFLC … However, a normal SFLC ratio at 3 months post treatment was significantly associated with longer event-free … between the tertiles of percentage reductions in serum and urine M protein values and overall or event-free
  10. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/vitamin-d-calcium_research-protocol.pdf
    September 13, 2013 - For upper limit (adverse event [AE]) outcomes, we will include any adverse effects of high intake in … Summary of Protocol Amendments   In  the  event  of  protocol  amendments,  the  date
  11. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/assessing-applicability.ppt
    January 01, 2009 - nonadherence, adverse drug events, no response) Events rates markedly different than in community Event … Next, compare the event rates in the treatment and control groups to community averages. … In both scenarios, there is a significant reduction in the odds of the event with therapy and no statistical
  12. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/dietary-supplements_research-protocol.pdf
    December 15, 2010 - In the event that multiple relevant, good-quality reviews are located that address a similar research … Data Synthesis Outcomes may be categorized as binary, continuous, count, or time-to-event data. … When event rates are <1 percent, the Peto odds ratio method will be used. … What is a Serious Adverse Event? Updated December 15, 2010.
  13. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/type-2-diabetes-medications-update_surveillance.pdf
    December 31, 2013 - Metformin was associated with twice as many GI adverse event rates as were second- generation sulfonylureas … Adverse event rates were similar; hypoglycemic events occurred at a low frequency. 35 … Adverse event rates were comparable across treatment arms. … Do Not Know Metformin was associated with twice as many GI adverse event rates as were second-generation
  14. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/psoriasis-chronic_executive.pdf
    November 01, 2012 - Questionnaire Disability Index; HRQoL = health-related quality of life; MACE = major adverse cardiovascular event … , differential loss to followup, overall loss to followup, use of intention to treat, blinding of event … confounding, baseline differences, method to ascertain exposure, methods to ascertain outcomes, blinding of event … Index HRQoL health-related quality of life IL Interleukin MACE major adverse cardiovascular event
  15. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/ace-inhibitor-arb-future_research.pdf
    March 01, 2012 - renal insufficiency or development of dialysis dependence. 3 Impact of changing trends in outcome event … This may reflect low event rates among otherwise healthy patients and relatively few studies with extended … Although several studies collected data on angioedema, the event rates were very low or zero for all … In the four studies that did report episodes of angioedema, this adverse event was observed only in … Impact of changing trends in outcome event rates over time on the comparative effectiveness of ACEI,
  16. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/renal-update_research-protocol.pdf
    January 15, 2015 - lipid-lowering drugs) • Surgical repair Outcomes • Mortality, all cause • Kidney function o Event … therapy) o Categorical (eg, better/worse) o Continuous (ie, GFR, CrCl, SCr) • Blood pressure o Event
  17. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/atrial-fibrillation-ablation_surveillance.pdf
    May 16, 2013 - There were 84 studies that reported at least one adverse event associated with RFA. … percent to 5 percent (median 1 percent) of patients in the 70 studies that reported this adverse event … Atrioesophageal fistula was reported in 26 studies: 5 studies reported 1 case each, with event rates … embolism n=1 (0.17%) 15.2% vs. 2.4%, p<0.001 [KMA] (CHADS2 score > 2 as a predictor of adverse event … pulmonary vein ablation; CPVA-CM= circumferential pulmonary vein ablation circular mapping; AE=adverse event
  18. Layout 1 (pdf file)

    effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/type-2-diabetes-insulin_executive.pdf
    September 01, 2008 - Layout 1 Background and Key Questions Although oral antidiabetic agents are used as first-line agents in patients with type 2 diabetes, insulin is required in a significant number of patients at some stage during the management of diabetes to maintain optimal glycemic control. Insulin use has been suggested as a fir…
  19. Untitled (pdf file)

    effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/thromboembolism-update_research-protocol.pdf
    February 17, 2016 - Untitled   Source: www.effectivehealthcare.ahrq.gov Published online: February 17, 2016 Evidence-based Practice Center Systematic Review Protocol Project Title: Systematic Review Update of Venous Thromboembolism Prophylaxis in Orthopedic Surgery I. Background and Objectives for the Systematic Review Ma…
  20. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/cancer-anemia-update_research-protocol.pdf
    June 16, 2010 - Time to event data, e.g., overall survival, will be calculated as hazard ratios (HR) based on individual … OR “adverse effect*” OR “adverse drug reaction*” OR “side effect*” OR “toxic effect*” OR “adverse event

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