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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/TND_0316_03-12-2009.pdf
January 01, 2009 - Effective Health Care
Topic Number(s): 0128
Document Completion Date: 6-12-09
1
Results of Topic Selection Process & Next Steps
Self-measured blood pressure monitoring will go forward for refinement as a systematic review. The
scope of this topic, including populations, interventions, comparato…
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/TND-0648-140819.pdf
June 24, 2014 - Topic 0549 Diagnosis and Management of Gout NSD _SJ Clean
Diagnosis and Management of Gout
Nomination Summary Document
Results of Topic Selection …
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/transparency-neuropathy_research-protocol.pdf
September 01, 2016 - • Adverse event and deaths.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/depression-pregnancy-postpartum_research-protocol.pdf
March 29, 2013 - weight gain, metabolic syndrome, gastrointestinal symptoms,
and loss of libido)
• Overall adverse-event … there was important differential loss to followup or overall
high loss to followup; the adequacy of event … Summary of Protocol Amendments
In the event of protocol amendments, the date of each amendment will
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/colorectal-surgery-preparation_executive.pdf
April 01, 2014 - In most studies adverse
event definitions were not clearly described, making it
impossible to consistently … limited
in the following ways:
• Most studies enrolled small numbers of patients and
reported low event
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/weight-loss-surgery_executive.pdf
June 01, 2013 - There were only 20 instances in
which 100 or more patients contributed data to a particular
adverse event … Additionally, in 76 percent
of instances, only a single study contributed data to a
particular adverse event
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/colorectal-surgery-preparation_disposition-comments.pdf
April 30, 2014 - to
sample size requirements for superiority and non-
inferiority designs, over plausible baseline event … in the Discussion section
can give some perspective on what is an
“adequate” sample size for the event … Given the small event rates, the
absolute diffs may be pretty tiny. … We have also
provided power calculations that make direct use
of the event rate information to estimate … to derive absolute risk differences
requires the specification of the baseline odds
(and baseline event
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/renal-artery-stenosis_overview.pdf
June 24, 2014 - CER 5 Renal Artery Stenosis NSD SJ Clean
Renal Artery Stenosis
Nomination Summary Document
Results of Topic Selection Process & Next Steps
§ The topic, Renal Artery Stenosis,…
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/plasma-cell-dyscrasias-sflc-assay_executive.pdf
August 01, 2012 - The overall and event-free survival rates were significantly
lower among patients with higher (> 75 … mg/dL) versus
those with lower (≤ 75 mg/dL) SFLC concentrations
(overall survival: p=0.016, event-free … Overall and event-free survival did not differ between
patients with and those without a normal SFLC … However, a normal SFLC ratio at 3 months
post treatment was significantly associated with longer
event-free … between the tertiles of percentage
reductions in serum and urine M protein values and overall
or event-free
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/vitamin-d-calcium_research-protocol.pdf
September 13, 2013 - For upper limit
(adverse event [AE]) outcomes, we will include any adverse effects of high intake in … Summary of Protocol Amendments
In
the
event
of
protocol
amendments,
the
date
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/assessing-applicability.ppt
January 01, 2009 - nonadherence, adverse drug events, no response)
Events rates markedly different than in community Event … Next, compare the event rates in the treatment and control groups to community averages. … In both scenarios, there is a significant reduction in the odds of the event with therapy and no statistical
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/dietary-supplements_research-protocol.pdf
December 15, 2010 - In the event that
multiple relevant, good-quality reviews are located that address a similar research … Data Synthesis
Outcomes may be categorized as binary, continuous, count, or time-to-event data. … When event rates are <1 percent, the Peto odds ratio method will be used. … What is a Serious Adverse Event? Updated December
15, 2010.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/type-2-diabetes-medications-update_surveillance.pdf
December 31, 2013 - Metformin was associated with twice as many
GI adverse event rates as were second-
generation sulfonylureas … Adverse event rates were similar; hypoglycemic events occurred at a low
frequency.
35 … Adverse event rates were comparable across treatment arms. … Do Not
Know
Metformin was associated with twice as many GI adverse event rates as
were second-generation
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/psoriasis-chronic_executive.pdf
November 01, 2012 - Questionnaire Disability Index; HRQoL = health-related quality of life; MACE = major adverse cardiovascular event … , differential loss to followup, overall
loss to followup, use of intention to treat, blinding of
event … confounding, baseline
differences, method to ascertain exposure, methods
to ascertain outcomes, blinding of event … Index
HRQoL health-related quality of life
IL Interleukin
MACE major adverse cardiovascular event
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/ace-inhibitor-arb-future_research.pdf
March 01, 2012 - renal insufficiency or development of dialysis
dependence.
3
Impact of changing trends in outcome event … This may reflect low event rates among
otherwise healthy patients and relatively few studies with extended … Although several studies collected data on angioedema, the event
rates were very low or zero for all … In the four
studies that did report episodes of angioedema, this adverse event
was observed only in … Impact of changing trends in outcome event rates over time on the
comparative effectiveness of ACEI,
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/renal-update_research-protocol.pdf
January 15, 2015 - lipid-lowering drugs)
• Surgical repair
Outcomes
• Mortality, all cause
• Kidney function
o Event … therapy)
o Categorical (eg, better/worse)
o Continuous (ie, GFR, CrCl, SCr)
• Blood pressure
o Event
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/atrial-fibrillation-ablation_surveillance.pdf
May 16, 2013 - There were 84
studies that reported at least one adverse event
associated with RFA. … percent to 5 percent (median
1 percent) of patients in the 70 studies that reported
this adverse event … Atrioesophageal fistula was reported in 26 studies:
5 studies reported 1 case each, with event rates … embolism n=1 (0.17%)
15.2% vs. 2.4%, p<0.001 [KMA]
(CHADS2 score > 2 as a predictor of adverse event … pulmonary vein ablation; CPVA-CM= circumferential pulmonary vein ablation circular mapping; AE=adverse event
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/type-2-diabetes-insulin_executive.pdf
September 01, 2008 - Layout 1
Background and Key
Questions
Although oral antidiabetic agents are used
as first-line agents in patients with type 2
diabetes, insulin is required in a significant
number of patients at some stage during
the management of diabetes to maintain
optimal glycemic control. Insulin use has
been suggested as a fir…
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/thromboembolism-update_research-protocol.pdf
February 17, 2016 - Untitled
Source: www.effectivehealthcare.ahrq.gov
Published online: February 17, 2016
Evidence-based Practice Center Systematic Review Protocol
Project Title: Systematic Review Update of
Venous Thromboembolism Prophylaxis in Orthopedic Surgery
I. Background and Objectives for the Systematic Review
Ma…
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/cancer-anemia-update_research-protocol.pdf
June 16, 2010 - Time to event data, e.g., overall survival, will be calculated as hazard
ratios (HR) based on individual … OR “adverse effect*” OR “adverse drug reaction*” OR “side effect*” OR “toxic
effect*” OR “adverse event