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effectivehealthcare-admin.ahrq.gov/sites/default/files/mcda-ijzerman.pdf
January 01, 2011 - Eigenvalue to obtain criteria (Ci) and level (Li) weights (1)
Clinical
benefit
Adverse
event … benefit 1 3 5
Matrix with
pairwise
comparisons
(4 criteria, 6
comparisons)
7
Adverse event … 13
Eigenvalue to obtain criteria (Ci) and level (Li) weights (2)
Clinical
benefit
Adverse
event … Treatment
impact
Co-
payment
Average
Clinical benefit 0.15 0.42 0.75 0.63 0.49
Adverse event … of treatment (drug requires
complex dosing schedule and
monitoring)
Side effects (any adverse event
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-prognostic_methods.pdf
July 01, 2012 - Outcomes Time-dependent probabilities (time-to-event curves) of what is being predicted, changes
or … In a two-by-two reclassification table of only subjects who
did not experience the event within the … Another formulation of the NRI calculates the probabilities of the predicted event
among those that … Reviewers should make sure the charactersitcs of prognostic groups,
definition of the outcome event, … overall probability of the event, and the followup time did not
vary substantially between studies.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/s96.pdf
October 01, 2007 - Evaluation and Overview of the National Electronic Injury
Surveillance System-Cooperative Adverse Drug Event … assess the performance of the National Electronic
Injury Surveillance System-Cooperative Adverse Drug Event … reaction reporting systems,
surveillance, drug safety
(Med Care 2007;45: S96–S102)
An adverse drug event … Drug
Event Surveillance project (NEISS-CADES). … The FDA safety information and adverse event reporting
program.
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/ijzerman_ahrq-webinar-mcda.pdf
January 01, 2011 - 11
Eigenvalue to obtain criteria (Ci) and level (Li) weights (1)
Clinical benefit Adverse event … Treatment impact Co-payment
Clinical benefit 1 3 5 7
Adverse event 1/3 1 1/3 1/5
Treatment impact … comparisons
Eigenvalue to obtain criteria (Ci) and level (Li) weights (2)
13
Clinical benefit Adverse event … Treatment impact Co-payment
Clinical benefit 0.15 0.42 0.75 0.63
Adverse event 0.05 0.14 0.05 0.02
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cer-266-cdd-executive-summary.pdf
November 01, 2023 - radiculopathy and 1-level disease (SOE: Low), but the likelihood of
experiencing any serious adverse event … Neurologic
complications:
Similar
(+)
ACDF = anterior cervical discectomy and fusion; AE = adverse event … imaging; NA = not applicable; NR = not reported; PEEK = polyetheretherketone; SAE = serious adverse
event … Limited evidence also suggests a
lower likelihood of experiencing any serious adverse event with ACDF
-
effectivehealthcare-admin.ahrq.gov/products/acs-depression/research-review-final
February 01, 2018 - comparative accuracy of tools for diagnosing depression in patients after an acute coronary syndrome event … validated criterion standard in adult patients within 3 months of an acute coronary syndrome (ACS) event … important depressive symptoms using a validated depression scale and who are within 3 months of an ACS event
-
effectivehealthcare-admin.ahrq.gov/products/ptsd-adult-treatment-update/research-protocol
December 01, 2019 - disorder (PTSD) involves a group of symptoms experienced after exposure to a potentially traumatic event … that may include re-experiencing the event; avoiding situations that trigger memories of the event; … Comparison by Criterion
Criterion A: Traumatic event that involved:
actual or threatened death … , rather than the event itself, determines an individual's mood. … Impact of event scale: a measure of subject stress. Psychosom Med. 1979;41(3):209-18.
-
effectivehealthcare-admin.ahrq.gov/products/cervical-degenerative-disease/research
February 01, 2024 - radiculopathy and 1-level disease (SOE: Low), but the likelihood of experiencing any serious adverse event … associated with a lower likelihood of reoperation and slightly lower likelihood of any serious adverse event … Limited evidence also suggests a lower likelihood of experiencing any serious adverse event with ACDF … ACDF = anterior cervical discectomy and fusion; AE = adverse event; BMP-2 = bone morphogenetic protein … disease; NA = not applicable; NR = not reported; PEEK = polyetheretherketone; SAE = serious adverse event
-
effectivehealthcare-admin.ahrq.gov/products/antipsychotics-children/research-protocol
December 01, 2019 - Each event will be counted as if it represents a unique individual. … number of people having an adverse event. … If a study mentions an adverse event in the discussion but does not report data on that adverse event … We will not assume an adverse event occurred unless a specific number of events are reported. … dose-adverse event analysis.
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/diagnostic-error-executive-summary.pdf
August 01, 2023 - Some of these patients suffer an
adverse event because of the incorrect diagnosis (~2.0%), and some … translates to about 1 in 18 ED patients
receiving an incorrect diagnosis, 1 in 50 suffering an adverse event … United States that 7.4 million (5.7%) patients are misdiagnosed, 2.6 million
(2.0%) suffer an adverse event … The overall (not disease-specific), per ED visit, potentially preventable
diagnostic adverse event rates … 5.7 percent of patients would be misdiagnosed, just 2.0 percent would suffer some sort of
adverse event
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/app-d-opioid-chronic-pain-surveill-report-1.xlsx
September 30, 2015 - Abbreviations: AE = adverse event; BMI = body mass index; CI = confidence interval; COWS = Clinical Opiate … primary care provider; RCT = randomized controlled trial; RR = relative risk; SAE = serious adverse event … D
Any opioid-related event: 5.3% vs. 6.1% vs. 3.4% vs. 3.6%, p<0.0001
Suicide (fatal or nonfatal): 1.0% … HR 1.67 (95% CI 1.51 to 1.84)
Safety event hospitalizations
A vs. B vs. … B) Controls: (n=2,311), patients without an opioid-related adverse event, 1:1 matching based on age
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cer-220-analgesics-acute-pain-summary.pdf
September 01, 2019 - Analytic framework
Abbreviations: AE=adverse event; KQ=Key Question
Data Sources
We searched MEDLINE … versus opioids) and outcomes (pain severity, pain
presence, time to analgesic effect, any adverse
event … to 10 pain
scale, 5 minutes for time to analgesia, 10 percent
absolute difference for any adverse event … The IN route
was also common in studies reporting adverse
event outcomes for the comparison of opioids … Insufficient No data No clinically
important
difference (+)
No data Insufficient
Any adverse
event
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/registries-guide-2nd-edition_disposition-comments.pdf
March 03, 2010 - We still may not know if it's the
drug/device or the underlying condition causing a particular event … Do they mean adverse event?
We changed this term to adverse event. … to calculate an unbiased, generalizable
adverse event rate associated with the exposure of interest, … We changed this term to adverse event. … The time
constraints of physicians and surgeons further inhibit adverse event
reporting.
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effectivehealthcare-admin.ahrq.gov/products/management-infantile-epilepsy/research
March 01, 2023 - 26/204) no conclusion insufficient SOE Click to show data on adverse events for Lamotrigine Adverse Event … but none were LEV-related. 32 had a "serious" event and 2/32 were LEV-related no conclusion insufficient … frequency no conclusion insufficient SOE Click to show data on adverse events for Rufinamide Adverse Event … (33/88) no conclusion insufficient SOE Click to show data on adverse events for Vigabatrin Adverse Event … no conclusion insufficient SOE Click to show data on adverse events for Other Interventions Adverse Event
-
effectivehealthcare-admin.ahrq.gov/products/cancer-venous-thrombosis-anticoagulation/abstract
December 01, 2019 - have multiple events during the observation period, complicating the calculation of rates for any one event … The investigators will explore sophisticated statistical methods for measuring event rates most accurately
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/stent-clopidogrel-practice_research.pdf
March 01, 2009 - Landmark analyses were performed among patients who were event-free
(no death, myocardial infarction … Among drug-eluting stent patients who were event-free at six months,
clopidogrel use was a significant … Among drug-eluting stent patients who
were event-free at twelve months, clopidogrel use continued to … Similarly, patients who were
event-free at 12 months and completed the 12-month follow-up contact, … the four groups revealed disparities in event rates.
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/app-d-opioid-chronic-pain-surveillance-report-2.xlsx
September 30, 2015 - Abbreviations: AE = adverse event; BMI = body mass index; CI = confidence interval; COWS = Clinical Opiate … primary care provider; RCT = randomized controlled trial; RR = relative risk; SAE = serious adverse event … D
Any opioid-related event: 5.3% vs. 6.1% vs. 3.4% vs. 3.6%, p<0.0001
Suicide (fatal or nonfatal): 1.0% … HR 1.67 (95% CI 1.51 to 1.84)
Safety event hospitalizations
A vs. B vs. … B: Controls: (n=2,311), patients without an opioid-related adverse event, 1:1 matching based on age
-
effectivehealthcare-admin.ahrq.gov/products/trauma-child-interventions/research-protocol
December 01, 2019 - by having frequent memories of it (or in young children, reenacting the event through play), having … and frightening dreams, or developing repeated physical or emotional symptoms when reminded of the event … To establish the diagnosis, a clinician needs to establish that a traumatic event preceded onset of the … Although acute stress disorder (ASD) can be diagnosed in children immediately after the traumatic event … CISD is an intervention that targets individuals who have recently been exposed to a traumatic event.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/s89.pdf
October 01, 2007 - Control and Prevention (CDC) and Food
and Drug Administration (FDA) and, for drugs, the FDA
Adverse Event … Cases in the 42 d
After the Index Event
(Meningococcal Vaccination or
Preventive Visit) by Week 106 … Cases of Facial Paralysis in
the 42 d After the Index Event (Meningococcal
Vaccination or Preventive … Poisson sequential sampling modified towards maximal safety in
adverse event monitoring. … A maximized sequential probability ratio test for drug and
vaccine adverse event surveillance.
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effectivehealthcare-admin.ahrq.gov/products/methods-guidance-harms/methods
May 01, 2020 - , when a significant proportion of published trials fail to report an important or critical adverse event … If a specific adverse event is not reported, it is generally safer for CER authors to assume that they … Serious adverse event
Any adverse event with serious medical consequences, including death, hospital … Severe adverse event
An adverse event whose intensity is considered severe (including "nonserious" … Did the author(s) specify the NUMBER for each TYPE of harmful event for each study group?