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  1. www.uspreventiveservicestaskforce.org/uspstf/document/modeling-study/lung-cancer-screening
    March 09, 2021 - The estimates for the range of benefits and harms across the 4 CISNET models appear in eTables 5 and … These estimates show similar patterns as those for the whole population; however, there were higher increases … The analysis estimates that screening strategies for individuals aged 50 or 55 years through aged 80
  2. www.uspreventiveservicestaskforce.org/home/getfilebytoken/ZcuLSXJZXLz9Y2LECTWqVJ
    November 01, 2009 - Estimates of overdiagnosis vary from 1% to 10%. … We calculated estimates from a random-effects model under the Bayesian data analytic framework by using … Eight studies report estimates of overdiagnosis using different methods (16). … None of these studies provide estimates specific to U.S. samples. … Estimates of the magnitude of overdiagnosis vary depending on the analytic approach used.
  3. www.uspreventiveservicestaskforce.org/home/getfilebytoken/aHpXYasjc3n6zhaTtoWMwK
    August 01, 2016 - Pooled estimates of sensitivity and specificity of the most commonly used test at the manufacturer’s … At higher cutpoints, pooled estimates were 95% (95% CI, 91%-97%) and 89% (95% CI, 82%-93%), respectively … Pooled estimates of sensitivity and specificity were 99% (95% CI, 97%-100%) and 81% (95% CI, 68%-90%) … Estimates for specificity were highly variable, ranging from 41% to 97.5%. … The pooled estimates of sensitivity and specificity were 95% (95% CI, 91%-97%) and 89% (95% CI, 82%-93%
  4. www.uspreventiveservicestaskforce.org/home/getfilebytoken/cLuJZx55Z6ApzYv836rkSp
    February 23, 2009 - decision making is strongly encouraged with individuals whose risk is close to (either above or below) the estimates
  5. www.uspreventiveservicestaskforce.org/home/getfilebytoken/473PPVwoRhapCkN9SC-rue
    May 18, 2021 - OBJECTIVE To provide updated model-based estimates of the benefits, burden, and harms of colorectal cancer … 2 additional complications per 1000 persons (ranges are across screening strategies, based on mean estimates … higher for White men com- pared with the total population (86 vs 81 cases per 1000, respec- tively; estimates … Because of this age dependency, which is the result of model structure and calibration, MISCAN estimates … Nevertheless, model-based estimates are impor- tant because they provide patients and their clinicians
  6. www.uspreventiveservicestaskforce.org/uspstf/document/postmenopausal-hormone-replacement-therapy-for-primary-preve/v2-menopausal-hormone-therapy-preventive-medicatio
    August 21, 2002 - We used adjusted relative risk (RR) estimates when available or calculated them when possible. … We also used population-based estimates of incidence and mortality. 22-29 We stratified event rates … Eight published meta-analyses 71-78 of breast cancer incidence provided different risk estimates. … The applicability of population estimates when risks are determined for individuals is unknown. … Our estimates do not account for racial and ethnic differences or important risk factors.
  7. www.uspreventiveservicestaskforce.org/uspstf/document/postmenopausal-hormone-replacement-therapy-for-primary-preve/menopausal-hormone-therapy-preventive-medication-2002-2005
    August 21, 2002 - We used adjusted relative risk (RR) estimates when available or calculated them when possible. … We also used population-based estimates of incidence and mortality. 22-29 We stratified event rates … Eight published meta-analyses 71-78 of breast cancer incidence provided different risk estimates. … The applicability of population estimates when risks are determined for individuals is unknown. … Our estimates do not account for racial and ethnic differences or important risk factors.
  8. www.uspreventiveservicestaskforce.org/home/getfilebytoken/sQ7hREGwnBm8Wh-LEFWP4F
    October 01, 2002 - We used adjusted relative risk (RR) estimates when available or calculated them when possible. … We also used population-based estimates of incidence and mortality.22-29 We stratified event rates by … Eight published meta-analyses71-78 of breast cancer incidence provided different risk estimates. … The applicability of population estimates when risks are determined for individuals is unknown. … Our estimates do not account for racial and ethnic differences or important risk factors.
  9. www.uspreventiveservicestaskforce.org/uspstf/recommendation/statin-use-in-adults-preventive-medication
    August 23, 2022 - Clinicians should recognize that predictions of 10-year CVD events using the Pooled Cohort Equations are estimates … CI, 0.85 to 2.25] vs 0.99 [95% CI, 0.71 to 1.39], respectively, for cardiovascular mortality), but estimates … between statin therapy and myopathy or rhabdomyolysis, although these events were uncommon, so the estimates
  10. www.uspreventiveservicestaskforce.org/uspstf/document/comparative-effectiveness-of-antiviral-treatment-for-hepatitis-c-virus-infection-in-adults-a-systematic-review/hepatitis-c-screening-2013
    November 15, 2012 - Excluding 2 poor-quality trials had little effect on pooled estimates 24 , 30 . … for harms similar to the estimates based on all trials 21 , 30 , 31 . … Although all studies reported adjusted risk estimates, only 8 60 , 21 , 63 , 67-70 , 73 evaluated 5 … Therefore, estimates of benefit may be exaggerated, although it is not possible to determine to what … Estimates and conclusions based on small numbers of trials should also be interpreted cautiously.
  11. www.uspreventiveservicestaskforce.org/home/getfilebytoken/vTJ_Zj3TAkhx45wWUDtNyt
    May 01, 2021 - Clinicians should recognize that pre- dictions of 10-year CVD events using the Pooled Cohort Equations are estimates … CI, 0.85 to 2.25] vs 0.99 [95% CI, 0.71 to 1.39], respectively, for cardiovascular mor- tality), but estimates … between statin therapy and myopathy or rhabdomyolysis, although these events were uncommon, so the estimates
  12. www.uspreventiveservicestaskforce.org/uspstf/document/RecommendationStatementFinal/statin-use-in-adults-preventive-medication
    August 23, 2022 - Clinicians should recognize that predictions of 10-year CVD events using the Pooled Cohort Equations are estimates … CI, 0.85 to 2.25] vs 0.99 [95% CI, 0.71 to 1.39], respectively, for cardiovascular mortality), but estimates … between statin therapy and myopathy or rhabdomyolysis, although these events were uncommon, so the estimates
  13. www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary-collaborative-modeling-of-us-breast-cancer-/breast-cancer-screening-january-2016
    January 11, 2016 - The model results for overdiagnosis are not directly comparable with other published estimates 8 , 63 … Eighth, the analysis did not include screening program costs or utility estimates specific to some of … Benefits and harms of mammography screening after age 74 years: model estimates of overdiagnosis. … A reality check for overdiagnosis estimates associated with breast cancer screening. … Because the models are estimating mortality reduction with actual screening, model estimates are most
  14. www.uspreventiveservicestaskforce.org/home/getfilebytoken/TVsn4SVh_jtaeqSTyrz-Gp
    March 09, 2021 - The estimates for the range of benefits and harms across the 4 CISNET models appear in eTables 5 and … These estimates show similar patterns as those for the whole population; however, there were higher increases … The analy- sis estimates that screening strategies for individuals aged 50 or 55 years through aged 80
  15. www.uspreventiveservicestaskforce.org/home/getfilebytoken/k2QHcwuK4NkvxFXhvGrbwY
    May 01, 2004 - However, the studies for which all of these estimates are based reported small numbers of cancer cases … was estimated at 80%, with false-positive rates of 0.1% to 0.6% based on 3 studies.15,16,18 All these estimates … of surgery, based on reports from published studies.14 Discussion The HTA systematic review applied estimates … 6 Screening for Ovarian Cancer: Brief Evidence Update 125-based screening, 80%; however, these estimates … The studies in which these estimates are based were not RCTs of screening, did not report mortality outcomes
  16. www.uspreventiveservicestaskforce.org/uspstf/document/modeling-report/lung-cancer-screening
    July 30, 2013 - Each model estimates screening effectiveness based on a different set of equations that are key in predicting … Model F estimates cure rates that depend on sex, tumor stage, and histology. … Model S estimates the probability of lethal metastases as a function of tumor size, histology, and sex … These breast and colorectal cancer estimates are solely from Model E (used in prior comparative analyses … Chapter 2: Birth-cohort-specific estimates of smoking behaviors for the U.S. population.
  17. www.uspreventiveservicestaskforce.org/uspstf/document/modeling-report/lung-cancer-screening-december-2013
    July 30, 2013 - Each model estimates screening effectiveness based on a different set of equations that are key in predicting … Model F estimates cure rates that depend on sex, tumor stage, and histology. … Model S estimates the probability of lethal metastases as a function of tumor size, histology, and sex … These breast and colorectal cancer estimates are solely from Model E (used in prior comparative analyses … Chapter 2: Birth-cohort-specific estimates of smoking behaviors for the U.S. population.
  18. www.uspreventiveservicestaskforce.org/home/getfilebytoken/6dqHx6xQGq9GUv92rZUf2q
    August 01, 2022 - Statin Use for the Primary Prevention of Cardiovascular Disease in Adults The USPSTF recognizes that clinical decisions involve more considerations than evidence alone. Clinicians should understand the evidence but individualize decision making to the specific patient or situation. Clinician Summary of USP…
  19. www.uspreventiveservicestaskforce.org/home/getfilebytoken/Q4J7tsThw_6nwfB-p-f5Hp
    March 01, 2009 - Estimates of benefits and harms, especially at the borders of the shaded and unshaded areas, should … The estimates in Figure 2 were developed assum- ing that the men are not currently taking nonsteroidal … The estimates in Figure 4 were devel- oped assuming that women are not currently taking NSAIDs and are … Estimates of benefits and harms, especially at the borders of the shaded and unshaded areas, should … The estimates of the number of major bleeding events were assumed to be stable within age strata with
  20. www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary/bacterial-vaginosis-in-pregnancy-to-prevent-preterm-delivery-screening
    April 07, 2020 - Studies also reported outcomes for which pooled summary estimates could not be generated, including maternal … despite large sample sizes, the incidence of these types of events was rare, resulting in imprecise estimates … e Range of estimates across the 3 studies inconsistent for sensitivity but reasonably consistent for … j The 95% confidence region suggests reasonable precision for estimates of specificity but some imprecision … in estimates of sensitivity (eFigure 3 in the Supplement).

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