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  1. www.uspreventiveservicestaskforce.org/home/getfilebytoken/cED9Pf3PNUHRUptzXQza-n
    April 01, 2016 - Hubbard, PhD Background: Estimates of risk for radiation-induced breast can- cer from mammography screening … This approach provided estimates of breast cancer incidence and mortality with and without screening … to contextualize estimates of radiation-induced breast cancer cases. … Estimates of the probability distribution of cumulative radiation dose at each age among women from the … Radiation-induced breast cancer incidence was combined with breast cancer survival estimates from the
  2. www.uspreventiveservicestaskforce.org/home/getfilebytoken/aHpXYasjc3n6zhaTtoWMwK
    August 01, 2016 - Pooled estimates of sensitivity and specificity of the most commonly used test at the manufacturer’s … At higher cutpoints, pooled estimates were 95% (95% CI, 91%-97%) and 89% (95% CI, 82%-93%), respectively … Pooled estimates of sensitivity and specificity were 99% (95% CI, 97%-100%) and 81% (95% CI, 68%-90%) … Estimates for specificity were highly variable, ranging from 41% to 97.5%. … The pooled estimates of sensitivity and specificity were 95% (95% CI, 91%-97%) and 89% (95% CI, 82%-93%
  3. www.uspreventiveservicestaskforce.org/home/getfilebytoken/ZcuLSXJZXLz9Y2LECTWqVJ
    November 01, 2009 - Estimates of overdiagnosis vary from 1% to 10%. … We calculated estimates from a random-effects model under the Bayesian data analytic framework by using … Eight studies report estimates of overdiagnosis using different methods (16). … None of these studies provide estimates specific to U.S. samples. … Estimates of the magnitude of overdiagnosis vary depending on the analytic approach used.
  4. www.uspreventiveservicestaskforce.org/uspstf/document/comparative-effectiveness-of-antiviral-treatment-for-hepatitis-c-virus-infection-in-adults-a-systematic-review/hepatitis-c-screening-2013
    November 15, 2012 - Excluding 2 poor-quality trials had little effect on pooled estimates 24 , 30 . … for harms similar to the estimates based on all trials 21 , 30 , 31 . … Although all studies reported adjusted risk estimates, only 8 60 , 21 , 63 , 67-70 , 73 evaluated 5 … Therefore, estimates of benefit may be exaggerated, although it is not possible to determine to what … Estimates and conclusions based on small numbers of trials should also be interpreted cautiously.
  5. www.uspreventiveservicestaskforce.org/uspstf/about-uspstf/methods-and-processes/procedure-manual/procedure-manual-appendix-viii-standardization-outcome-tables
    July 01, 2017 - Parameter estimates: Important parameters should be provided, as appropriate: Screening results
  6. www.uspreventiveservicestaskforce.org/uspstf/document/final-modeling-study18/colorectal-cancer-screening
    May 18, 2021 - Objective: To provide updated model-based estimates of the benefits, burden, and harms of colorectal … 2 additional complications per 1000 persons (ranges are across screening strategies, based on mean estimates … was higher for White men compared with the total population (86 vs 81 cases per 1000, respectively; estimates … Because of this age dependency, which is the result of model structure and calibration, MISCAN estimates … Nevertheless, model-based estimates are important because they provide patients and their clinicians
  7. www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary-collaborative-modeling-of-us-breast-cancer-/breast-cancer-screening-january-2016
    January 11, 2016 - The model results for overdiagnosis are not directly comparable with other published estimates 8 , 63 … Eighth, the analysis did not include screening program costs or utility estimates specific to some of … Benefits and harms of mammography screening after age 74 years: model estimates of overdiagnosis. … A reality check for overdiagnosis estimates associated with breast cancer screening. … Because the models are estimating mortality reduction with actual screening, model estimates are most
  8. www.uspreventiveservicestaskforce.org/uspstf/sites/default/files/inline-files/lets-talk-about-it-aspirin-cvd-prevention-guide.pdf
    April 26, 2022 - This online tool estimates a patient’s risk for developing heart disease and stroke based on factors
  9. www.uspreventiveservicestaskforce.org/home/getfilebytoken/k2QHcwuK4NkvxFXhvGrbwY
    May 01, 2004 - However, the studies for which all of these estimates are based reported small numbers of cancer cases … was estimated at 80%, with false-positive rates of 0.1% to 0.6% based on 3 studies.15,16,18 All these estimates … of surgery, based on reports from published studies.14 Discussion The HTA systematic review applied estimates … 6 Screening for Ovarian Cancer: Brief Evidence Update 125-based screening, 80%; however, these estimates … The studies in which these estimates are based were not RCTs of screening, did not report mortality outcomes
  10. www.uspreventiveservicestaskforce.org/uspstf/document/modeling-report/lung-cancer-screening-december-2013
    July 30, 2013 - Each model estimates screening effectiveness based on a different set of equations that are key in predicting … Model F estimates cure rates that depend on sex, tumor stage, and histology. … Model S estimates the probability of lethal metastases as a function of tumor size, histology, and sex … These breast and colorectal cancer estimates are solely from Model E (used in prior comparative analyses … Chapter 2: Birth-cohort-specific estimates of smoking behaviors for the U.S. population.
  11. www.uspreventiveservicestaskforce.org/home/getfilebytoken/2Wc3FRHpVDPX2jT_WzjEXX
    July 31, 2020 - Modeling estimates that screen- ing with sDNA-FIT annually results in additional colonoscopy bur- den … See modeling report12,13 for additional details and model-specific estimates. … See modeling report12,13 for additional details and model-specific estimates. … Based on av- eraging estimates across the 3 models, if screening were performed from ages 45 to 75 years … Personalizing age of cancer screening cessation based on comorbid conditions: model estimates of harms
  12. www.uspreventiveservicestaskforce.org/uspstf/document/final-modeling-report/breast-cancer-screening-2009
    November 15, 2009 - However, it is not feasible to conduct additional trials to get more precise estimates of the mortality … The models begin with estimates of breast cancer incidence and mortality trends without screening and … The other 3 models (E, M, and W) use the BCSC data as a guide and to fit sensitivity estimates from this … Model estimates for the oldest age groups also have more uncertainty compared with estimates for ages … First, our models provide estimates of the average benefits and harms expected across a cohort of women
  13. www.uspreventiveservicestaskforce.org/home/getfilebytoken/CC7S5LxbFmoHh5ZmMxJWkM
    February 01, 2016 - Estimates From Observational Studies Unadjusted estimates from 13 observational stud- ies included in … Estimates from other studies fall within this overall broad range. … Studies are highly heterogeneous, and estimates vary depending on the analytic approach. … Interpreting overdiagnosis estimates in population-based mammography screening. … Estimates of overdiagnosis of invasive breast cancer associated with screening mammography.
  14. www.uspreventiveservicestaskforce.org/uspstf/recommendation/colorectal-cancer-screening
    May 18, 2021 - gained than annual high-sensitivity gFOBT or sDNA-FIT every 3 years. 12 , 13 Additionally, modeling estimates … Modeling estimates that screening with sDNA-FIT annually results in additional colonoscopy burden compared … Based on averaging estimates across the 3 models, if screening were performed from ages 45 to 75 years … Personalizing age of cancer screening cessation based on comorbid conditions: model estimates of harms … See modeling report 12 , 13 for additional details and model-specific estimates. c Because of imprecision
  15. www.uspreventiveservicestaskforce.org/uspstf/document/modeling-study/lung-cancer-screening
    March 09, 2021 - The estimates for the range of benefits and harms across the 4 CISNET models appear in eTables 5 and … These estimates show similar patterns as those for the whole population; however, there were higher increases … The analysis estimates that screening strategies for individuals aged 50 or 55 years through aged 80
  16. www.uspreventiveservicestaskforce.org/home/getfilebytoken/473PPVwoRhapCkN9SC-rue
    May 18, 2021 - OBJECTIVE To provide updated model-based estimates of the benefits, burden, and harms of colorectal cancer … 2 additional complications per 1000 persons (ranges are across screening strategies, based on mean estimates … higher for White men com- pared with the total population (86 vs 81 cases per 1000, respec- tively; estimates … Because of this age dependency, which is the result of model structure and calibration, MISCAN estimates … Nevertheless, model-based estimates are impor- tant because they provide patients and their clinicians
  17. www.uspreventiveservicestaskforce.org/uspstf/about-uspstf/methods-and-processes/procedure-manual/procedure-manual-section-6-methods-arriving-recommendation
    July 06, 2017 - would cause health problems (rarely 100%). 6.5.4 Conceptual Confidence Limits As previously noted, estimatesEstimates from direct and indirect evidence may be included in outcomes tables in order to provide the … The Task Force usually derives qualitative, rather than precise, estimates of opportunity costs. … When outcomes tables are used to present benefits, estimates for harms will also always be presented. … Because of the uncertainty and variability in the evidence used to make these estimates, the Task Force
  18. www.uspreventiveservicestaskforce.org/uspstf/recommendation/statin-use-in-adults-preventive-medication
    August 23, 2022 - Clinicians should recognize that predictions of 10-year CVD events using the Pooled Cohort Equations are estimates … CI, 0.85 to 2.25] vs 0.99 [95% CI, 0.71 to 1.39], respectively, for cardiovascular mortality), but estimates … between statin therapy and myopathy or rhabdomyolysis, although these events were uncommon, so the estimates
  19. www.uspreventiveservicestaskforce.org/home/getfilebytoken/vTJ_Zj3TAkhx45wWUDtNyt
    May 01, 2021 - Clinicians should recognize that pre- dictions of 10-year CVD events using the Pooled Cohort Equations are estimates … CI, 0.85 to 2.25] vs 0.99 [95% CI, 0.71 to 1.39], respectively, for cardiovascular mor- tality), but estimates … between statin therapy and myopathy or rhabdomyolysis, although these events were uncommon, so the estimates
  20. www.uspreventiveservicestaskforce.org/home/getfilebytoken/MLeu_yFpPwzcZwKG6fw5ZY
    April 26, 2022 - OBJECTIVE To provide updated model-based estimates of the net balance in benefits and harms from routine … These estimates ranged from 0.4 (95% CI, −6.1 to 6.9) to 52.4 (95% CI, 43.9 to 60.9) life-years per 1000 … Effect estimates for the use of low-dose aspirin were taken from an updated systematic review that was … Replication in other simulation models can further inform reliability of estimates. … Estimates of benefits and harms of prophylactic use of aspirin in the general population.

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