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effectivehealthcare.ahrq.gov/sites/default/files/grading.ppt
January 01, 2013 - quantity of evidence, directness (or indirectness) of evidence, consistency of evidence, and precision of estimates … Includes considerations of:
Statistical significance for effect estimates
Confidence intervals for those … effect estimates
Four Required Domains: Precision
Precision is the degree of certainty surrounding … These estimates were consistent, direct, and precise. … Had these estimates been precise and consistent (i.e., a narrower CI for the RCT, consistent cohort studies
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/ehc-presentation-quantitative-synthesis-chapter-4.pdf
July 01, 2019 - Learning objective
Statistical heterogeneity
• Statistical heterogeneity occurs when estimates across … According to the 2019 Cochrane handbook, I2 describes the percentage of the variability in
effect estimates
-
effectivehealthcare.ahrq.gov/sites/default/files/cer-242-radiation-therapy-brain-metastases-evidence-summary.pdf
June 01, 2021 - quality of life, functional status, and cognitive function were often too limited to
determine effect estimates … neurocognitive decline and two favored the SRS alone group
compared to SRS plus WBRT but summary effect estimates … memantine and
hippocampal avoidance WBRT have only been reported in individual studies and
summary estimates
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/cancer-ovarian-contraceptives_research-protocol.pdf
March 13, 2012 - The model will allow greater flexibility in exploring the potential effects of
these issues on estimates … For each outcome, we will use currently available estimates of lifetime
risk, prevalence of OC use, … and relative risk (or relative risk reduction) for that
outcome in OC users to generate estimates of … and cervical cancer, MI, stroke)
• Death from these other conditions
We will summarize these estimates … that provide any relevant data for model parameterization can be used to
provide initial parameter estimates
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cancer-pancreas_executive.pdf
September 01, 2014 - ranging from 85 percent to 93 percent and specificity
estimates ranging from 94 percent to 100 percent … )
• For diagnosis using MRI, three systematic reviews
yielded sensitivity estimates of 84 percent to … 86 percent
and specificity estimates of 82 percent to 91 percent.20-22
(Strength of evidence from … )
• For diagnosis using PET/CT, three systematic reviews
yielded sensitivity estimates of 87 percent … to 90
percent and specificity estimates of 80 percent to 85
percent.20,23,24 (Strength of evidence
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-grading-evidence_methods.pdf
November 01, 2013 - They look for consistency in direction of effect estimates in relation to the line that
distinguishes … For example, if all studies except one show estimates of effect in
the same direction, but the CI for … that one study overlaps the CIs for the estimates of effect in the
other studies, then this body of … Precision of outcome data estimates is
incompletely or not reported. … SMD estimates ranged from 0.13 to
0.94.
-
effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/pdf/epc-child-adolesc-mental-health-grand-rounds.pptx
May 22, 2025 - Multiple approaches showed promising diagnostic performance (e.g., using parental rating scales), but estimates … Attachment-Based Family Therapy (ABFT) 2 RCTs
195 patients 2 studies with high risk
Imprecise estimates … patients 2 studies with moderate risk and 2 studies with high risk
Small body of evidence, imprecise estimates … Interventions 3 RCTs
267 patients
3 studies with moderate risk
Small body of evidence, imprecise estimates … patients 2 studies with moderate risk and 2 studies with high risk Small body of evidence, imprecise estimates
-
effectivehealthcare.ahrq.gov/sites/default/files/ch_2-user-guide-to-ocer_130129.pdf
January 01, 2011 - Confounding leads to biased treatment
effect estimates unless controlled for
by design (randomization … Nondifferential
measurement error in exposures and
outcomes tends to bias treatment effect
estimates … To do
so, the design uses controls as in a case-control
design but estimates a case-crossover odds … Description
As with the case-crossover design, the self-
controlled case-series design estimates the … Evidence of bias in estimates of influenza vaccine
effectiveness in seniors.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/bereaved-persons-research-executive-summ.pdf
March 01, 2025 - /A Insufficient
Peer Support Depression symptoms Both studies reported positive effects, but
the estimates … Insufficient
Self-help
intervention
Quality of life Both studies reported positive effects, but
the estimates … Comprehensive
Provider Support
Quality of life Both studies reported positive effects, but
the estimates
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cell-free-dna-executive-summary.pdf
May 01, 2025 - retrospective cohort;
and
5 prospective cohorts
(109,177)
Sensitivity range: 0.095 to 0.998 (25
estimates … from 17 studies);
Specificity range: 0.657 to 1.0 (25
estimates from 17 studies);
AUC range: 0.52 … to 1.0 (18 estimates
from 11 studies)
Sensitivity and AUC were lower in
prediagnostic performance
-
effectivehealthcare.ahrq.gov/sites/default/files/considerations-for-statistical-chapter-10.pptx
January 01, 2013 - However, the DRS estimates the probability or rate of disease occurrence as a function of the covariates … If subjects with missing data differ from subjects with complete data, then exposure estimates may be
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/dietary-protein-intake-disposition-comments.pdf
November 22, 2024 - development of a single
standardized and validated method
to determine protein and amino acid
requirement estimates
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-bias_methods.pdf
July 01, 2012 - data analysis, applicability, whether ethics approval is specified, and
5-2
whether sample size estimates … Therefore, demographic
features or disease severity may lead to variations in estimates of test
performance … Context bias
Prevalence of the target condition varies according to setting and may affect
estimates … to be
positive more frequently in settings with higher disease prevalence, which may
also affect estimates … over time as a result of
technological improvement or the experience of the operator of the test,
estimates
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/ehc-presentation-quantitative-synthesis-chapter-3.pdf
February 01, 2018 - Quantitative Synthesis Chapter 3. Choice of Statistical Model for Combining Studies
Quantitative Synthesis
Chapter 3. Choice of Statistical Model for Combining Studies
Prepared for:
The Agency for Healthcare Research and Quality (AHRQ)
Training Modules for Systematic Reviews Methods Guide
www.ahrq.gov
Presenter…
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND-485-09-03-2013.pdf
January 01, 2013 - advance care plan
Key Questions
from Nominator:
Will a decision aid, using individualized estimates
-
effectivehealthcare.ahrq.gov/sites/default/files/estimation-and-reporting_chapter-3.pptx
January 01, 2013 - Slide 1
Estimation and Reporting of Heterogeneity of Treatment Effects in Observational Comparative Effectiveness Research
Prepared for:
Agency for Healthcare Research and Quality (AHRQ)
www.ahrq.gov
Estimation and Reporting of Heterogeneity of Treatment Effects in Observational Comparative Effectiveness Research
…
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/obsessive-compulsive-disorder-disposition-comments.pdf
December 06, 2024 - In an NMA, effect estimates combine
both direct and indirect estimates, adding complexity, since most
-
effectivehealthcare.ahrq.gov/sites/default/files/suppl-2-user-guide-to-ocer_130129.pdf
January 01, 2011 - covariate selection is to generate conditional
exchangeability, thereby allowing unbiased
causal effect estimates
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-grading-strength_methods.pdf
July 01, 2009 - of
evidence, directness (or indirectness) of evidence, consistency of evidence, and precision of
estimates … , EPCs should also present
information that will help decisionmakers judge the risk of bias in the estimates … strength
from different types of studies—specifically on the four required domains—and it displays
estimates … Had
these estimates been precise and consistent (e.g., narrower CI for the RCT, consistent cohort
studies
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/transparency-infertility_research.pdf
June 01, 2017 - ............................... 7
v
Background and Objectives
Selective reporting can bias estimates … CT.gov for detecting selective
reporting, and to determine the impact of selective reporting on the estimates … Therefore, our project coordinator sent regular
queries to co-investigators asking for estimates of … These estimates were tracked in an Excel spreadsheet.