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  1. Layout 1 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/related_files/breast-abnormalities-tests_executive.pdf
    February 01, 2006 - ratio 0.33 NC 0.16 0.21 Negative predictive value at 20% prevalence 92.4% NC 96.2% 95.0% Stability of estimates … likelihood ratio NC 0.41 NC NC Negative predictive value at 20% prevalence NC 90.7% NC NC Stability of estimates … likelihood ratio NC NC NC NC Negative predictive value at 20% prevalence NC NC NC NC Stability of estimates
  2. effectivehealthcare.ahrq.gov/sites/default/files/related_files/infantile-hemangioma_disposition-comments.pdf
    January 15, 2016 - We have emphasized in our discussion of meta-analysis findings that the estimates provide relative ranking … We have also noted in the report’s Conclusions that the estimates provided are most important as relative … The estimates provide a relative ranking of anticipated rates of lesion clearance among treatment options … Therefore, the difference between any two estimates is the comparative effectiveness. … Peer reviewer #4 Results Figure 6, note that estimates of sigma are typically smaller for smaller effect
  3. S23 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/s23.pdf
    October 01, 2007 - examples of communicating benefits and harms for well-known therapeutics, illustrating that relative risk estimates … Although the estimates might change when more information from other studies becomes available, the public … For the most part, the articles discuss relative estimates (relative risks or odds ratios; Fig. 1). … Relative risk estimates are not helpful for communicating the chance of experiencing an event (either … benefit or a harm).9,29 In our scenario, relative risk estimates cannot accurately depict the chance
  4. effectivehealthcare.ahrq.gov/sites/default/files/pdf/hepatic-fibrosis_white-paper.pdf
    April 01, 2014 - Results from these studies therefore could not be included in summary estimates for sensitivity and … specificity, resulting in less robust and potentially biased estimates. … is obtained and how that information affects the conclusions of the systematic review, including estimates … The additional data enabled somewhat more robust estimates for diagnostic accuracy at commonly used … Although the effects on summary estimates were relatively small in most cases, the changes had important
  5. effectivehealthcare.ahrq.gov/sites/default/files/pdf/asthma-immunotherapy-2011_research.pdf
    January 01, 2011 - Precision of the estimates 5±2 13. … Reliability of the estimates. … Reliability of the estimates. … Reliability of the estimates. … B Mean and standard error of estimates reported C Numeric value of estimates not reported (
  6. effectivehealthcare.ahrq.gov/sites/default/files/related_files/primary-healthcare-spending-disposition-comments.pdf
    May 17, 2024 - but only mention one (PCC) and focus primarily on state estimates. … We have clarified the number of reports and estimates we found throughout the report. … KI Reviewer 1 General Comments In the abstract it says you found 3 national estimates but elsewhere … We will revise the text to clarify what estimates we are referring to. … I believe MA also may include this method for its non-claims estimates.
  7. effectivehealthcare.ahrq.gov/sites/default/files/sensitivity-analysis-chapter-11.pptx
    January 01, 2013 - differences in the time window during which exposure is determined can lead to changes in study effect estimates … adjustment, may provide insight into which covariates have relatively greater influences on effect estimates … analysis is based on different assumptions than conventional approaches and may build confidence in estimates … For example, Samy Suissa (2008) illustrated how the choice of cohort definition can affect effect estimates … also consider the method of covariate adjustment to see if it might result in changes in the effect estimates
  8. effectivehealthcare.ahrq.gov/sites/default/files/pdf/dementia-databases-methods_research.pdf
    May 01, 2008 - is estimated that as many as 75% of all persons with dementia will eventually reside in the NH. 7 Estimates … The aim of this project was to provide nationally representative estimates of the prevalence of the … The MCBS survey weights are used to project national estimates for each measure. … Data from claims provided slightly higher estimates of dementia cases than self/proxy reports in the … Alzheimer disease in the US population: Prevalence estimates using the 2000 census.
  9. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cancer-ovarian-contraceptives_executive.pdf
    June 01, 2013 - Relative risk estimates were derived from the meta-analyses and other age-specific and race-specific … Depending on the analysis, each model run included 5,000 to 1,000,000 simulated individuals; estimates … Decision Analysis: Benefits and Harms of OC Use and Ovarian Cancer Risk Using the point estimates from … of their effect on mortality derived from a model are even more uncertain than estimates for incident … Because these data are cross-sectional, estimates for older women reflect cohorts that were relatively
  10. effectivehealthcare.ahrq.gov/sites/default/files/related_files/risk-cardiovascular-disease.pdf
    January 01, 2023 - meta-analysis is appropriate (i.e., more than 2 studies address the same PICOTS and provide point estimates … If meta-analysis is deemed appropriate, we plan to use random-effects models to pool estimates from … comparison have high or unclear risk of bias or when sensitivity analyses show a substantial difference in estimates … derived from high or unclear risk of bias studies versus estimates derived from studies at low risk … Cardiovascular Disease Projections in the United States Based on the 2020 Census Estimates.
  11. effectivehealthcare.ahrq.gov/sites/default/files/exposure-definition-and-measurement_chapter-4.pptx
    January 01, 2013 - appropriate for defining exposure Provide evidence of validity of the operational definition of exposure with estimates … Evidence of validity may be provided by estimates of sensitivity, specificity, or positive predictive … This measurement error can result in biased estimates either away from or towards the null, making the … Evidence of validity may be provided by estimates of sensitivity, specificity, or positive predictive … Evidence of validity may be provided by estimates of sensitivity, specificity, or positive predictive
  12. S149 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/s149.pdf
    October 01, 2007 - This choice can lead to unstable estimates due to small sample sizes, especially for skewed data such … Construct estimates of treatment effects such as absolute E{Y(EEE)} � E{Y(III)}or relative E{Y(EEE)}/ … The outcome estimates were qualitatively similar to the results pre- sented in the article. … However, estimates from our methodology should approximate the upper limit of effec- tiveness of a medication … Best estimates of diabetes prevalence in the Department of Veterans Affairs based on computerized patient
  13. effectivehealthcare.ahrq.gov/sites/default/files/related_files/evidence-summary-cer-195-uterine-fibroids-final.pdf
    December 01, 2017 - We calculated meta-estimates of the probability of leiomyosarcoma for all relevant studies and by study … Lack of precision means these estimates are not credibly different. … Some recent estimates in the literature find otherwise. … Uncertainty in estimates of prevalence and evolving data about methods for tissue extraction and their … Our estimates and that of Pritts and colleagues10 find that the estimates are lower in data from more
  14. effectivehealthcare.ahrq.gov/sites/default/files/related_files/progestogens-preterm-birth_executive.pdf
    September 01, 2012 - Meta-Analysis We conducted a Bayesian meta-analysis to provide aggregate estimates of the effectiveness … We calculated meta-analysis estimates by using RCTs grouped by progestogen formulation (17OHP, oral, … For neonatal mortality, aggregate estimates indicated no formulation was effective at reducing risk … However, all formulations were effective at reducing the risk of preterm birth (meta-estimates: OR17OHP … In general, studies have also been too small to provide valid estimates of factors that may modify
  15. effectivehealthcare.ahrq.gov/products/choice-of-mean/white-paper
  16. effectivehealthcare.ahrq.gov/sites/default/files/related_files/progestogens-preterm-birth-disposition-121205.pdf
    September 07, 2012 - As above, we find the aggregate estimates of benefit among those with prior preterm birth to be squarely … We take some reassurance that providing summary evidence is sufficient since the meta-estimates for … Meta-estimates added to results section. … Point estimates and 95% confidence intervals are not consistently reported. … A summary table including all meta-estimates might be helpful.
  17. effectivehealthcare.ahrq.gov/sites/default/files/pdf/coronary-stents-outcomes_research.pdf
    January 01, 2010 - were based upon Kaplan-Meier estimates for treatment-specific censoring distributions; whereas adjusted … estimates were based upon weights that were functions of Kaplan-Meier censoring estimates and propensity … score estimates.17,18 Adjusted hazard ratios were calculated according to the inverse probability … These models served to validate the adjusted hazard ratio estimates from the IPW Cox regression model … Such misclassification and underreporting should be non- differential, however, and should bias our estimates
  18. S131 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/s131.pdf
    October 01, 2007 - of restrictions for use in pharmacoepidemiology and examines to what extent they change rate ratio estimates … RR estimates adjusted for age and sex also steadily increased. … For all earlier restrictions, it is less clear how much the observed change in RR estimates result from … We found that this change resulted in an observable but not substantial change in RR estimates in our … A, Unadjusted mortality rate ratio estimates; B, Multi- variate adjusted mortality rate ratio estimates
  19. effectivehealthcare.ahrq.gov/sites/default/files/related_files/heart-failure-natriuretic-peptide_disposition-comments.pdf
    November 20, 2013 - Empirical Bayes estimates generated in a hierarchical summary ROC analysis agreed closely with those … For diagnostic questions this means either ‘can the sensitivity and specificity estimates found in … or ‘do these sensitivity and specificity estimates tell me that the patient will benefit from this … What is the direction of sensitivity estimates, for example? … But sensitivity and specificity estimates lay between 0% and 100%.
  20. effectivehealthcare.ahrq.gov/sites/default/files/related_files/grading.ppt
    January 01, 2010 - quantity of evidence, directness (or indirectness) of evidence, consistency of evidence, and precision of estimates … Includes considerations of: Statistical significance for effect estimates Confidence intervals for those … effect estimates Four Required Domains: Precision Four Required Domains: Precision Precision is the … These estimates were consistent, direct, and precise. … Had these estimates been precise and consistent (i.e., a narrower CI for the RCT, consistent cohort studies

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