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effectivehealthcare.ahrq.gov/sites/default/files/fraenkel.pdf
May 29, 2025 - Preferences
• Specific probabilities vs Gist
o R example
• Average vs individualized probability estimates … Atrial Fibrillation
Slide 27: Know the
Numbers
• Atrial Fibrillation
o Individualized probability estimates
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/hepatitis-c_executive.pdf
November 01, 2012 - Relative risk
estimates ranged from 1.01 to 1.33 in the four trials and may
have varied in part due … Relative risk estimates ranged from 0.89 to 1.2.
Moderate
11
Table A. … for SVR in men vs. women, and no clear
difference in relative risk estimates for Black vs. non-Black … Three trials that restricted enrollment to patients with genotype
1 infection reported risk estimates … for risk of harms that were
similar to the risk estimates based on all trials.
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/instrumental-variable-methods_research.pdf
April 01, 2010 - In the first stage, one estimates the parameters in (2)
by least squares. … In the second stage one estimates the parameters in (3) by least squares after
replacing the confounded … Split-sample
Instrumental Variables Estimates of the
Return to Schooling. … IV approaches based on the Wald estimator or linear structural equation
models yield estimates of an … ivreg and ivreg2 will yield equal point estimates and standard errors, but ivreg2 offers much
more
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effectivehealthcare.ahrq.gov/sites/default/files/ch_11-user-guide-to-ocer_130129.pdf
January 03, 2012 - Often these assumptions
are reasonable and, even when violated, may result
in unchanged effect estimates … Alternately, effect estimates may vary with changes
in the outcome definition. … Samy Suissa illustrated how the choice of cohort
definition can affect effect estimates in his
paper … If
there is an impact on the estimates for this sort of
transformation, it can make sense to try a … The example
estimates the association between different
statin medications with this biomarker.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/dietary-supplements_executive.pdf
April 01, 2012 - Adults Taking
Cardiovascular Drugs
Executive Summary
Background
The American Heart Association
estimates … Do the effect estimates of clinical cardiovascular
outcomes vary by age, ethnicity, gender, or health … Do the effect estimates of harms outcomes vary by age,
ethnicity, gender, or health status?
b. … Do the effect estimates of pharmacokinetic outcomes
vary by age, ethnicity, gender, or health status … • The study reported effect estimates that did not reflect
a comparison of supplement plus drug(s
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/breast-abnormalities-tests-update_executive.pdf
February 01, 2012 - For example, if a clinician
estimates a woman’s risk of malignancy as greater than
50 percent, most … Therefore, we used the
estimates of accuracy and various clinical scenarios to
address the implicit … These estimates of accuracy
were all judged to be supported by a low strength of
evidence. … Improving the precision of the estimates of accuracy
or upgrading the strength of evidence rating in … Information from more
granular groupings of women will allow estimates of test
accuracy to be more
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-balancing-harms-benefits_research-2012.pdf
January 01, 2012 - Comparisons The estimates of effect from a study may reflect the beneficial effect of one intervention … concerning harm tend to have more uncertainty
compared with estimates of benefit. … The fifth step consists of
sensitivity analyses to explore the effects of changing the estimates or … However, the ―T‖ score has no uncertainty
estimates. … The reviewers need
to indicate the time periods that relate to the estimates.
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/depression-postpartum-screening_research-protocol.pdf
May 01, 2013 - Incidence estimates for the first 3
postpartum months were up to 6.5 percent for major depression alone … We will present summary estimates, standard
errors, and confidence intervals. … An
example of such a subgroup analysis would be a comparison of effectiveness estimates for RCTs
versus … observational studies or a comparison of estimates of the association between a history of
intimate … Specific benefits include
estimates of treated depression, maternal and infant health care visits, and
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effectivehealthcare.ahrq.gov/sites/default/files/s116.pdf
October 01, 2007 - to estimate treatment effects; how-
ever, IV methods require strong assumptions to yield consistent
estimates … cian was unassociated with major medical comorbidities in the
current patient, suggesting that the IV estimates … study outcome and also influence
treatment choice, standard statistical methods may result in
biased estimates … This model
yielded adjusted estimates of risk differences. … Even if these condi-
tions are met, however, IV methods can result in biased
estimates of treatment effects
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/appendicitis_executive.pdf
December 01, 2015 - .58,59 We used the model estimates to
calculate summary positive and negative likelihood ratios
(LRs … Estimates of
test performance often appeared to be affected by
characteristics of study design that … Summary estimates of test performance of laboratory values for the
diagnosis of acute appendicitis … CT
had high sensitivity (summary estimates ranging from
0.95 to 1) and specificity (0.91 to 0.99 … Summary estimates of test performance of diagnostic imaging
for acute appendicitis
Test Population
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effectivehealthcare.ahrq.gov/sites/default/files/s103.pdf
October 01, 2007 - to covariates or potential outcomes,
we can estimate the censoring distributions using Kaplan–Meier
estimates … where the treatment-specific censoring distribution Ka(t) typ-
ically is estimated using Kaplan–Meier estimates … stratify the sample into
clearly defined subgroups before constructing the inverse
probability-weighted estimates … formulas, researchers can
use 2 methods to calculate standard errors of inverse proba-
bility-weighted estimates … model, but
further empirical work is needed to better understand the
behavior of these standard error estimates
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effectivehealthcare.ahrq.gov/sites/default/files/ch_10-user-guide-to-ocer_130129.pdf
January 01, 2011 - selection procedure to use,
whether to base selection upon p-values or change
in exposure parameter estimates … stepwise regression has limitations
that can lead to underestimation of standard
errors for exposure estimates … However, the
DRS estimates the probability or rate of disease
occurrence as a function of the covariates … treatment effects across individuals
also are commonly employed to obtain causally
interpretable estimates … If subjects with missing data differ
from subjects with complete data, then exposure
estimates may
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/diagnostic-error-executive-summary.pdf
August 01, 2023 - estimates. … present 95 percent confidence
intervals (CIs); otherwise, we present plausible range (PR) bounds for key estimates … Preventable harm rate estimates derived from two studies conducted at academic centers
(1 in Canada, … Studies of disease-specific error rates were sufficient for meta-analysis (n=6) or at least
point estimates
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/liver-cancer_executive.pdf
October 01, 2014 - Most likelihood ratio estimates fell into
or near the “moderately useful” range (positive likelihood … One study that
directly compared use of Doppler vs. no Doppler showed no clear effect on
estimates … Lesion depth and body mass index had no effect on
estimates of sensitivity.
Table C. … Estimates were similar when studies that used diffusion-weighted
imaging were excluded. … of diagnostic accuracy and
found no clear effects on estimates.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/hepatitis-c_surveillance.pdf
December 01, 2015 - Relative risk estimates: 0.89 to 1.2. … Women: No difference in relative risk estimates for SVR
•! Blacks vs. … Non-Black patients: No clear difference in relative risk estimates. … Relative risk estimates: 0.89 to
1.2. … Non-Black patients: No
clear difference in relative risk
estimates.
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/hepatitis-c_surveillance.pdf
December 01, 2015 - Relative risk estimates: 0.89 to 1.2. … Women: No difference in relative risk estimates for SVR
•! Blacks vs. … Non-Black patients: No clear difference in relative risk estimates. … Relative risk estimates: 0.89 to
1.2. … Non-Black patients: No
clear difference in relative risk
estimates.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/angina-heart-attack-treatments_executive.pdf
January 01, 2014 - We present summary estimates, standard errors, and CIs
in our data synthesis. … Summary strength of evidence and effect estimates:
upstream versus deferred glycoprotein inhibitor … Summary strength of evidence and effect estimates:
upstream versus deferred glycoprotein inhibitor … Summary strength of evidence and effect estimates:
clopidogrel upstream (pretreatment) and deferred … Summary strength of evidence and effect estimates:
clopidogrel upstream (pretreatment) and deferred
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/bladder-cancer-non-muscle-invasive_executive.pdf
October 01, 2015 - When few studies were available for an analysis,
we used the moment estimates of correlation between … Estimates
from one trial for progression (RR, 2.11; 95% CI, 0.40
to 11.06), noncancer mortality (RR … epirubicin: All-
cause mortality
Low Estimates favored BCG for all-cause mortality,
but differences … epirubicin:
Progression
Low Estimates favored BCG for bladder cancer
progression, but differences … lower doses, but most estimates were imprecise
and did not reach statistical significance.
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effectivehealthcare.ahrq.gov/sites/default/files/s5.pdf
October 01, 2007 - testing
stages.17 Some debate continues about the strengths and
limitations of risk adjustment versus IV estimates … IV estimates are useful in assess-
ing the effect of treatment rate changes, but decisionmakers
need … Increasing
restrictions will change rate ratio estimates and reduce bias in
studies of treatment effects … benefit from using these approaches in examining com-
parative effectiveness or safety or developing estimates … Heterogeneity and the interpretation of
treatment effect estimates from risk adjustment and instrumental
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-205-predictors-trauma-care-evidence-summary.pdf
April 01, 2018 - In cases with few studies, lack of data, or
when data were only available as adjusted risk estimates … Tables A, B, and C consolidate the key estimates of the
predictive utility of each identified measure … When we were able to pool
data, the pooled estimates are given in bold; when data
were not pooled, … However, the out-of-hospital estimates are from
fewer studies and patients and the estimates are less … While the diversity
across the studies meant heterogeneity was high in the
pooled estimates and the