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effectivehealthcare.ahrq.gov/products/renal-disease-therapies/abstract
March 31, 2011 - We will also utilize models to allow for causal estimates of exposure in presence of time varying confounders … We will look for consistency and precision of the estimates across the studies as a means of validating
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effectivehealthcare.ahrq.gov/products/liver-cancer/research
October 23, 2014 - effects of the reference standard used and study, patient, tumor, and technical characteristics on estimates … Moderate strength-of-evidence ratings were primarily limited to estimates of diagnostic accuracy for … Across imaging modalities, factors associated with lower estimates of sensitivity included use of explanted
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effectivehealthcare.ahrq.gov/products/hypertension-pulmonary-arterial/research
April 25, 2013 - Random-effects models were used to compute summary estimates of effect where several similar studies … provided estimates. … Echocardiography estimates of pulmonary artery pressures (sPAP, tricuspid gradient [TG], and tricuspid
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effectivehealthcare.ahrq.gov/products/indirect-comparisons/research-2013
January 10, 2013 - Ignoring missing data or correlation between outcomes can produce biased MTC estimates leading to high … , to traditional contrast-based approaches, and thus in obtaining more precise and robust parameter estimates
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/horizon-scan_research-2015.pdf
January 01, 2015 - on
some interventions, we provided a range or high and low estimates. … If we exclude the cost estimates for these infrastructure
interventions, the total estimate for the … Published estimates of 2013 expenditures on U.S. health care were about $3 trillion. … Our estimates
indicate the market could be slightly higher than that. … by the National Cancer; therefore, only estimates of BCC incidence and
prevalence are available.
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effectivehealthcare.ahrq.gov/sites/default/files/methodsguide_chou_assessing_harms_when_comparing.pdf
November 01, 2008 - Be cautious about drawing conclusions on harms when events are rare and estimates
of risk are imprecise … Unpublished clinical trials tend to report lower estimates of treatment benefits than published
trials … In more than one-half of the comparisons
assessed, estimates of relative or absolute risk varied more … Empirical data are lacking on how use of different
selection criteria affects estimates of harms. … In drug trials, use of an independent external endpoint committee may provide
less biased estimates
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-harms_methods.pdf
November 01, 2008 - Be cautious about drawing conclusions on harms when events are rare and estimates
of risk are imprecise … Unpublished clinical trials tend to report lower estimates of treatment benefits than published
trials … In more than one-half of the comparisons
assessed, estimates of relative or absolute risk varied more … Empirical data are lacking on how use of different
selection criteria affects estimates of harms. … In drug trials, use of an independent external endpoint committee may provide
less biased estimates
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/medical-test-reviews-prognostic.ppt
June 01, 2012 - Conduct meta-analyses of estimates of outcome probabilities. … The estimates of absolute risk in different groups are more relevant. … The precision of estimates may not be reported. … Meta-analysis can provide more precise estimates . … Step 5: Meta-analysis of Estimates of Outcome Probabilities (2 of 2)
There are methods to combine estimates
-
effectivehealthcare.ahrq.gov/sites/default/files/medical-test-reviews-prognostic.ppt
June 01, 2012 - Conduct meta-analyses of estimates of outcome probabilities. … The estimates of absolute risk in different groups are more relevant. … The precision of estimates may not be reported. … Meta-analysis can provide more precise estimates . … Step 5: Meta-analysis of Estimates of Outcome Probabilities (2 of 2)
There are methods to combine estimates
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-future-value-of-information_research.pdf
June 01, 2011 - These VOI estimates can inform decisions about the design and priority
of those studies. … Comparison of VOI Estimates Across Limited Modeling Studies ..................................21
Table … Comparison of VOI Estimates Across No Modeling Studies..........................................22 … These estimates can aid in the
design and prioritization of those studies. … Janssen and Koffijberg (2009)10
focused on the construction of VOI estimates with independent estimates
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-metaanalysis_methods.pdf
July 01, 2012 - Other times, when the sensitivity or specificity estimates
vary widely or when the test threshold varies … Because of the above, the current thinking is that, in general, the study estimates of
sensitivity and … Recommended Approaches
Which Metrics to Meta-Analyze
For each study, the estimates of sensitivity … Predictive values are dependent on prevalence estimates. … Estimates are based on a bivariate meta-regression using the time
interval as a predictor.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/hypertension-pulmonary-arterial_executive.pdf
April 01, 2013 - Estimates are
often inaccurate compared with RHC; up to 60 percent of
echocardiography estimates were … We present summary estimates
and confidence intervals in our data synthesis. … Taken in
combination with the decision algorithm, and in patients
with echocardiographic estimates … Most effect
estimates were precise (mPAP, PVR, cardiac index,
RAP, 6MWD), but estimates for PCWP were … Most effect estimates were
precise (mPAP, PVR, cardiac index, RAP, 6MWD), but
estimates for PCWP were
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/version-2-risk-of-reinfection-from-SARSCoV2_0.pdf
December 31, 2022 - We examined the relationship between these
factors and protection estimates but lacked sufficient data … We subsequently found a high degree of concordance between our calculated risk
estimates and the rates … We generated uncorrected estimates for comparison. … Protection estimates (1 – RR) can be interpreted as the proportion or
percentage of infections that … Baseline Factors
Age, Sex, and Race
In the Denmark study, there was no difference in the estimates
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effectivehealthcare.ahrq.gov/products/instrumental-variable-methods/research
May 14, 2010 - In the first stage, one estimates the parameters in (2) by least squares. … In the second stage one estimates the parameters in (3) by least squares after replacing the confounded … Split-sample Instrumental Variables Estimates of the Return to Schooling. … IV approaches based on the Wald estimator or linear structural equation models yield estimates of an … ivreg and ivreg2 will yield equal point estimates and standard errors, but ivreg2 offers much more in
-
effectivehealthcare.ahrq.gov/sites/default/files/s103.pdf
October 01, 2007 - to covariates or potential outcomes,
we can estimate the censoring distributions using Kaplan–Meier
estimates … where the treatment-specific censoring distribution Ka(t) typ-
ically is estimated using Kaplan–Meier estimates … stratify the sample into
clearly defined subgroups before constructing the inverse
probability-weighted estimates … formulas, researchers can
use 2 methods to calculate standard errors of inverse proba-
bility-weighted estimates … model, but
further empirical work is needed to better understand the
behavior of these standard error estimates
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/instrumental-variable-methods_research.pdf
April 01, 2010 - In the first stage, one estimates the parameters in (2)
by least squares. … In the second stage one estimates the parameters in (3) by least squares after
replacing the confounded … Split-sample
Instrumental Variables Estimates of the
Return to Schooling. … IV approaches based on the Wald estimator or linear structural equation
models yield estimates of an … ivreg and ivreg2 will yield equal point estimates and standard errors, but ivreg2 offers much
more
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/breast-biopsy-executive.pdf
December 01, 2009 - The strength
of evidence supporting the quantitative estimates of the
frequency of complications is low … The model is based on the point estimates of accuracy
from our analyses and do not incorporate estimates … of
uncertainty of the point estimates. … The ratings of low strength of evidence apply to the
individual estimates of accuracy for each type of … characteristics.
3 Primarily ADH lesions.
4 Estimates based on other literature reviews.
-
effectivehealthcare.ahrq.gov/sites/default/files/s108.pdf
October 01, 2007 - Results: Estimates of the population causal hazard ratio based on
IPW were consistently unbiased across … However, Cox propor-
tional hazards regression estimates population-level (mar-
ginal) associations. … Parameter estimates generated by IPW
are interpretable as population-level causal effects, linked to … These crude
HR estimates exhibited bias that ranged from 0.45 to 0.47. … biased
than all of the Cox proportional hazards regression estimates.
-
effectivehealthcare.ahrq.gov/products/quantitative-synthesis-expanded-methods/methods
March 13, 2013 - Note: Vertical lines indicate the estimates for the entire set of 10 studies. … It is not unusual for estimates based on a handful of early studies to shift considerably over time as … all estimates. … In the results, a graphical summary of individual and combined study effect estimates will have to be … combined study estimates based on the type of data and choice of effect measure.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/bladder-cancer-muscle-invasive_executive.pdf
June 01, 2015 - Tumor Characteristics
• No study evaluated how estimates of effectiveness
of bladder-sparing therapy … Patient Characteristics
• No study evaluated how estimates of effectiveness
of bladder-sparing therapy … Patient Characteristics
• No trial evaluated how estimates of harms associated
with NAC or AC vary … Neoadjuvant
chemotherapy:
effectiveness
Low
Four trials found no clear differences in estimates
of … Effectiveness Insufficient
No trial evaluated how estimates of harms associated
with NAC or AC vary